Search

Pancreatic cancer (PC) is one of the most fatal and chemoresistant malignancies with a poor prognosis. The current therapeutic options for PC have not achieved satisfactory results due to drug resistance. Therefore, it is urgent to develop novel treatment strategies with enhanced efficacy. This study sought to investigate the anticancer effect of gemcitabine and XCT790, an estrogen-related receptor alpha (ERRα) inverse agonist, as monotherapies or in combination for the treatment of PC. Here we demonstrated that the drug combination synergistically suppressed PC cell viability, its proliferative, migratory, invasive, apoptotic activities, and epithelial-to-mesenchymal transition (EMT), and it triggered G0/G1 cell cycle arrest and programmed cell death in vitro. In addition, in vivo assays using xenograft and mini-PDX (patient-derived xenograft) models further confirmed the synergistic antitumor effect between gemcitabine and XCT790 on PC. Mechanistically, gemcitabine and XCT790 suppressed PC by inhibiting ERRα and MEK/ERK signaling pathway. In conclusion, our current study demonstrated for the first time that gemcitabine combined with XCT790 displayed synergistic anticancer activities against PC, suggesting that their combination might be a promising treatment strategy for the therapy of PC.

Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), which we find to be an independent prognostic marker in GBC. Functional analysis indicates that lncRNA‐PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA‐PAGBC competitively binds to the tumour suppressive microRNAs miR‐133b and miR‐511. This competitive role of lncRNA‐PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA‐PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.

The solar adsorption water tube was put forward in this research paper, which producing water from atmosphere with solar energy. When the ambient temperature range is 30.7°C-41.6 °C and the solar transient radiation range is 284 W/m2-1007 W/m2, a solar adsorption water tube could produce 78ml water after adsorbed 10m3 air. The highest temperature of the adsorption bed can reach to 200°Cin the process of desorption.

The solar cooling tube and the economic analysis were studied for supplying cooling and heating capacity on the building. The following conclusion could be drown: The refrigerating output of a single solar cooling tube was about 2 W to 13 W varying with the time. And the unit made up by 20 solar cooling tubes could supply about 3.96 MJ cooling capacity and 10.73 MJ heating capacity. The investment of the solar cooling tube combined with average 20m2 building is about 46000 RMB at present price and the fixed number of years necessary for redemption is about 7.5 years.

The thermal vacuum method was used to test the adsorption performance of compound adsorbent. This thermal vacuum method, without vacuum pump, can expel the air of system up to its partial pressure, lower than 2 Pa. the adsorption performance of 13X zeolite and some compound adsorbent were tested by this way. Conclusions can be drawn as following: the adsorption capacity of 13X measured by this way has the less difference (