279 results on '"Hai-Yang Wang"'
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2. The first two complete mitochondrial genomes for the genus Anagyrus (Hymenoptera, Encyrtidae) and their phylogenetic implications
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Cheng-Hui Zhang, Hai-Yang Wang, Yan Wang, Zhi-Hao Chi, Yue-Shuo Liu, and Guo-Hao Zu
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Zoology ,QL1-991 - Abstract
Anagyrus, a genus of Encyrtidae (Hymenoptera, Chalcidoidea), represents a successful group of parasitoid insects that attack various mealybug pests of agricultural and forestry plants. Until now, only 20 complete mitochondrial genomes have been sequenced, including those in this study. To enrich the diversity of mitochondrial genomes in Encyrtidae and to gain insights into their phylogenetic relationships, the mitochondrial genomes of two species of Anagyrus were sequenced, and the mitochondrial genomes of these species were compared and analyzed. Encyrtid mitochondrial genomes exhibit similarities in nucleotide composition, gene organization, and control region patterns. Comparative analysis of protein-coding genes revealed varying molecular evolutionary rates among different genes, with six genes (ATP8, ND2, ND4L, ND6, ND4 and ND5) showing higher rates than others. A phylogenetic analysis based on mitochondrial genome sequences supports the monophyly of Encyrtidae; however, the two subfamilies, Encyrtinae and Tetracneminae, are non-monophyletic. This study provides valuable insights into the phylogenetic relationships within the Encyrtidae and underscores the utility of mitochondrial genomes in the systematics of this family.
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- 2024
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3. A method to detect uniformity of road base course based on impact imaging technology
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Xing-Guang Chen, Hao Luo, Shao-Kong Feng, and Hai-Yang Wang
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Impact imaging method ,Pavement base course ,Concealed disease ,Detection method ,Uniformity ,Medicine ,Science - Abstract
Abstract The damage of road base course has the characteristics of strong concealment and difficulty in detecting. For this reason, the impact imaging method has been used for detection of road base course. This paper discussed systematically collection points setting, excitation mode and data processing method. Through the application in testing for highway pavement base before and after grouting maintenance, the results show that the method is simple and accurate. The detection results can be displayed in a two-dimensional image form and it is easy to be used in road maintenance. This method can be used to identify and locate the damages of the pavement base, to judge the uniformity of the pavement base structure. It can also be used to evaluate the effectiveness of internal damage after grouting repairing.
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- 2024
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4. Correlation and underlying brain mechanisms between rapid eye movement sleep behavior disorder and executive functions in Parkinson’s disease: an fNIRS study
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Lu Ren, Xiaoxue Yin, Hai-Yang Wang, Xinqing Hao, Da Wang, Feng Jin, Tingting Zhang, Tao Li, Tingting Zhou, and Zhanhua Liang
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Parkinson’s disease ,fNIRS ,executive function ,rapid eye movement sleep behavior disorder ,prefrontal cortex ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
PurposeRapid eye movement sleep behavior disorder (RBD) affects 30%–40% of patients with Parkinson’s disease (PD) and has been linked to a higher risk of cognitive impairment, especially executive dysfunction. The aim of this study was to investigate the brain activation patterns in PD patients with RBD (PD-RBD+) compared to those without RBD (PD-RBD−) and healthy controls (HCs), and to analyze the correlation between changes in cerebral cortex activity and the severity of RBD.MethodsWe recruited 50 PD patients, including 30 PD-RBD+, 20 PD-RBD−, and 20 HCs. We used functional near infrared spectroscopy during a verbal fluency task (VFT-fNIRS) and clinical neuropsychological assessment to explore the correlation between PD-RBD+ and executive function and changes in neural activity.ResultsThe VFT-fNIRS analysis revealed a significant reduction in activation among PD-RBD+ patients across multiple channels when compared to both the PD-RBD− and HC groups. Specifically, PD-RBD+ patients exhibited diminished activation in the bilateral dorsolateral prefrontal cortex (DLPFC) and the right ventrolateral prefrontal cortex (VLPFC) relative to their PD-RBD− counterparts. Furthermore, compared to the HC group, PD-RBD+ patients displayed reduced activation specifically in the right DLPFC. Significantly, a noteworthy negative correlation was identified between the average change in oxygenated hemoglobin concentration (ΔHbO2) in the right DLPFC of PD-RBD+ patients and the severity of their RBD.ConclusionOur study offers compelling evidence that RBD exacerbates cognitive impairment in PD, manifested as executive dysfunction, primarily attributed to reduced prefrontal activation. These aberrations in brain activation may potentially correlate with the severity of RBD.
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- 2024
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5. Remote cerebellar hemorrhage following repeated lumbar punctures
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Hai-Yang Wang, Zerui Hu, Jinming Han, Dongsen Wang, and Qingjian Wu
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Remote cerebellar hemorrhage ,Repeated lumbar punctures ,Meningoencephalitis ,Zebra sign ,MRI ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background Remote cerebellar hemorrhage (RCH) is a rare complication in neurosurgery. No case of RCH secondary to repeated lumbar punctures (LPs) has been previously reported. Case presentation A 49-year-old man presented with impaired consciousness following persistent fever. Cerebrospinal fluid examination showed high opening pressure, elevated white blood cells, increased protein level, and decreased glucose level, resulting in a diagnosis of bacterial meningoencephalitis. Treatment with repeated LPs and intrathecal injection of ceftriaxone resulted in an improvement in neurological symptoms. However, on day 31 of treatment, brain magnetic resonance image (MRI) showed streaky bleeding in bilateral cerebellum (zebra sign), leading to a diagnosis of RCH. Close observation and repeated brain MRI imaging without specific treatments led to the absorption of bilateral cerebellar hemorrhage, and the patient was discharged with improved neurological symptoms. Repeated brain MRI scans one month after discharge showed that bilateral cerebellar hemorrhage had improved, and had disappeared one year after discharge. Conclusion We reported a rare occurrence of LPs-induced RCH presenting as isolated bilateral inferior cerebellar hemorrhage. Clinicians should be vigilant of the risk factors for RCH, closely monitoring patients' clinical symptoms and neuroimaging findings to determine the need for specialized treatment. Furthermore, this case highlights the importance of ensuring the safety of LPs and managing any potential complications appropriately.
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- 2023
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6. A self-fused hydrogel for the treatment of glottic insufficiency through outstanding durability, extracellular matrix-inducing bioactivity and function preservation
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Chen-Yu Zou, Juan-Juan Hu, Dan Lu, Qian-Jin Li, Yan-Lin Jiang, Rui Wang, Hai-Yang Wang, Xiong-Xin Lei, Jesse Li-Ling, Hui Yang, and Hui-Qi Xie
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Glottic insufficiency ,Self-fusion ,Hydrogel ,Extracellular matrix ,Physiological function ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Injection laryngoplasty with biomaterials is an effective technique to treat glottic insufficiency. However, the inadequate durability, deficient pro-secretion of extracellular matrix (ECM) and poor functional preservation of current biomaterials have yielded an unsatisfactory therapeutic effect. Herein, a self-fusing bioactive hydrogel comprising modified carboxymethyl chitosan and sodium alginate is developed through a dual-crosslinking mechanism (photo-triggered and dynamic covalent bonds). Owing to its characteristic networks, the synergistic effect of the hydrogel for vocal folds (VFs) vibration and phonation is adequately demonstrated. Notably, owing to its inherent bioactivity of polysaccharides, the hydrogel could significantly enhance the secretion of major components (type I/III collagen and elastin) in the lamina propria of the VFs both in vivo and in vitro. In a rabbit model for glottic insufficiency, the optimized hydrogel (C1A1) has demonstrated a durability far superior to that of the commercially made hyaluronic acid (HA) Gel. More importantly, owing to the ECM-inducing bioactivity, the physiological functions of the VFs treated with the C1A1 hydrogel also outperformed that of the HA Gel, and were similar to those of the normal VFs. Taken together, through a simple-yet-effective strategy, the novel hydrogel has demonstrated outstanding durability, ECM-inducing bioactivity and physiological function preservation, therefore has an appealing clinical value for treating glottic insufficiency.
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- 2023
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7. Corrigendum: Unveiling the key genes, environmental toxins, and drug exposures in modulating the severity of ulcerative colitis: a comprehensive analysis
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Yao Wang, Hao Zhuang, Xiao-han Jiang, Rui-han Zou, Hai-yang Wang, and Zhi-ning Fan
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ulcerative colitis ,microarray ,biomarker ,genomics ,bioinformatics ,Immunologic diseases. Allergy ,RC581-607 - Published
- 2023
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8. Interactions between the gut micro-community and transcriptome of Culex pipiens pallens under low-temperature stress
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Wen-Xiang Lv, Peng Cheng, Jing-Jing Lei, Hui Peng, Chuan-Hui Zang, Zi-Wei Lou, Hong-Mei Liu, Xiu-Xia Guo, Hai-Yang Wang, Hai-Fang Wang, Chong-Xing Zhang, Li-Juan Liu, and Mao-Qing Gong
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16S rRNA ,Transcriptome ,Culex pipiens pallens ,Low temperature ,Interaction ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Culex pipiens pallens (Diptera: Culicidae) can survive at low temperature for long periods. Understanding the effects of low-temperature stress on the gut microflora and gene expression levels in Cx. pipiens pallens, as well as their correlation, will contribute to the study of the overwintering mechanism of Cx. pipiens pallens. Methods The gut bacteria were removed by antibiotic treatment, and the survival of Cx. pipiens pallens under low-temperature stress was observed and compared with the control group. Then, full-length 16S rRNA sequencing and the Illumina HiSeq X Ten sequencing platform were used to evaluate the gut microflora and gene expression levels in Cx. pipiens pallens under low-temperature stress. Results Under the low-temperature stress of 7 °C, the median survival time of Cx. pipiens pallens in the antibiotic treatment group was significantly shortened by approximately 70% compared to that in the control group. The species diversity index (Shannon, Simpson, Ace, Chao1) of Cx. pipiens pallens decreased under low-temperature stress (7 °C). Non-metric multidimensional scaling (NMDS) analysis divided all the gut samples into two groups: control group and treatment group. Pseudomonas was the dominant taxon identified in the control group, followed by Elizabethkingia and Dyadobacter; in the treatment group, Pseudomonas was the dominant taxon, followed by Aeromonas and Comamonas. Of the 2417 differentially expressed genes (DEGs), 1316 were upregulated, and 1101 were downregulated. Functional GO terms were enriched in 23 biological processes, 20 cellular components and 21 molecular functions. KEGG annotation results showed that most of these genes were related to energy metabolism-related pathways. The results of Pearson’s correlation analysis showed a significant correlation between the gut microcommunity at the genus level and several DEGs. Conclusions These results suggest that the mechanism of adaptation of Cx. pipiens pallens to low-temperature stress may be the result of interactions between the gut bacterial community and transcriptome. Graphical Abstract
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- 2023
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9. Unveiling the key genes, environmental toxins, and drug exposures in modulating the severity of ulcerative colitis: a comprehensive analysis
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Yao Wang, Hao Zhuang, Xiao-han Jiang, Rui-han Zou, Hai-yang Wang, and Zhi-ning Fan
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ulcerative colitis ,microarray ,biomarker ,genomics ,bioinformatics ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundAs yet, the genetic abnormalities involved in the exacerbation of Ulcerative colitis (UC) have not been adequately explored based on bioinformatic methods.Materials and methodsThe gene microarray data and clinical information were downloaded from Gene Expression Omnibus (GEO) repository. The scale-free gene co-expression networks were constructed by R package “WGCNA”. Gene enrichment analysis was performed via Metascape database. Differential expression analysis was performed using “Limma” R package. The “randomForest” packages in R was used to construct the random forest model. Unsupervised clustering analysis performed by “ConsensusClusterPlus”R package was utilized to identify different subtypes of UC patients. Heat map was established using the R package “pheatmap”. Diagnostic parameter capability was evaluated by ROC curve. The”XSum”packages in R was used to screen out small-molecule drugs for the exacerbation of UC based on cMap database. Molecular docking was performed with Schrodinger molecular docking software.ResultsVia WGCNA, a total 77 high Mayo score-associated genes specific in UC were identified. Subsequently, the 9 gene signatures of the exacerbation of UC was screened out by random forest algorithm and Limma analysis, including BGN,CHST15,CYYR1,GPR137B,GPR4,ITGA5,LILRB1,SLFN11 and ST3GAL2. The ROC curve suggested good predictive performance of the signatures for exacerbation of UC in both the training set and the validation set. We generated a novel genotyping scheme based on the 9 signatures. The percentage of patients achieved remission after 4 weeks intravenous corticosteroids (CS-IV) treatment was higher in cluster C1 than that in cluster C2 (54% vs. 27%, Chi-square test, p=0.02). Energy metabolism-associated signaling pathways were significantly up-regulated in cluster C1, including the oxidative phosphorylation, pentose and glucuronate interconversions and citrate cycle TCA cycle pathways. The cluster C2 had a significant higher level of CD4+ T cells. The”XSum”algorithm revealed that Exisulind has a therapeutic potential for UC. Exisulind showed a good binding affinity for GPR4, ST3GAL2 and LILRB1 protein with the docking glide scores of –7.400 kcal/mol, –7.191 kcal/mol and –6.721 kcal/mol, respectively.We also provided a comprehensive review of the environmental toxins and drug exposures that potentially impact the progression of UC.ConclusionUsing WGCNA and random forest algorithm, we identified 9 gene signatures of the exacerbation of UC. A novel genotyping scheme was constructed to predict the severity of UC and screen UC patients suitable for CS-IV treatment. Subsequently, we identified a small molecule drug (Exisulind) with potential therapeutic effects for UC. Thus, our study provided new ideas and materials for the personalized clinical treatment plans for patients with UC.
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- 2023
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10. Survival in patients with Parkinson’s disease: a ten-year follow-up study in northern China
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Song Wang, Tao Li, Tingting Zhou, Lanlan Pu, Hai-Yang Wang, Xiaoxue Yin, Xinqing Hao, Lu Ren, and Zhanhua Liang
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Parkinson’s disease ,Survival ,Prognostic factors ,Mortality ,Standardized mortality ratio ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Background A thorough understanding of the factors that influence patient survival in Parkinson’s disease (PD) will aid in prognosis prediction and provide a new direction for disease modification treatment. Currently, there are no standardized mortality ratio (SMR) data for PD patients in the northern Chinese mainland. The main focus of this study was to determine which factors in the prospectively collected baseline characteristics can affect the survival of PD patients. In addition, for the first time, we investigated the SMR of PD patients in northern China. Methods Between 2009 and 2012, 218 PD patients were continuously recruited from the movement disorder clinic of the First Affiliated Hospital of Dalian Medical University and followed up until death or May 31, 2021. The prespecified prognostic variables were demographics, clinical features, lifestyle factors, and drug dose prospectively collected at baseline. To determine the independent predictors of survival during follow-up, the Cox proportional hazards model was used. Kaplan–Meier analysis was applied to estimate the overall survival curve and to compare survival between layers based on statistically significant predictors. The SMR of this northern Chinese mainland PD cohort was calculated. Results After a mean follow-up of 9.58 ± 2.27 years, 50 patients (22.90%) died. Factors that could individually predict shortened survival during follow-up included older age at onset (hazard ratio [HR] 1.10, 95% confidence interval [CI] 1.06–1.15), Hoehn and Yahr (H&Y) stage ≥ 3 (HR 9.36, 95% CI 2.82–31.03) and severe cognitive impairment (HR 6.18, 95% CI 2.75–13.88). Univariate Cox regression revealed that a certain amount of physical activity was associated with better survival (HR 0.41, 95% CI 0.22–0.74), while fatigue was associated with an increased risk of death (HR 2.54, 95% CI 1.37–4.70). The overall SMR was 1.32 (95% CI 0.98–1.74). Conclusions Older age at onset, higher baseline H&Y stage, and severe cognitive impairment have a negative impact on survival. The 10-year survival of PD patients is not significantly different from that of the general population in China.
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- 2022
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11. Corrigendum: Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition
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Xinqing Hao, Xiaofeng Huang, Xiaoxue Yin, Hai-Yang Wang, Ren Lu, Zhanhua Liang, and Chunli Song
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primary blepharospasm ,prepulse inhibition ,blink reflex ,sensory trick ,sensorimotor integration ,Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2023
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12. Clinical characteristics of anti-N-methyl-d-aspartate receptor encephalitis in patients with a long-term history of mental disorders
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Hai-Yang Wang, Xiao-Yu Yang, Jinming Han, Huakun Liu, Zhong-Rui Yan, and Zhanhua Liang
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Anti-N-methyl-d-aspartate receptor encephalitis ,Mental disorders ,Immunotherapy ,Medicine - Abstract
Abstract Background Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is an autoimmune disorder characterized by complex neuropsychiatric syndromes during disease onset. Although this disease has been well documented in the last decade, clinical characteristics of anti-NMDA receptor encephalitis in patients with long-term diagnostic history of mental disorders remain unclear. Methods Here, we reviewed and analyzed series of anti-NMDA receptor encephalitis patients with a long-term medical history of psychiatric disorders through a review of literature using PubMed, web of science and Embase database. In addition, we described a patient of anti-NMDA receptor encephalitis with a long-term history of major depressive disorder. Results A total of 14 patients with anti-NMDA receptor encephalitis and a long-term history of mental disorders were included in our study. We found that most patients were adult (92.9%) and female (78.6%). These patients often first visited a psychiatric department (71.43%). The mean disease course of psychiatric disorders was more than 9 years. Speech impairment (71.4%), abnormal behaviors (64.3%), and catatonia (64.3%) were the most common clinical symptoms. Most patients (85.7%) had a satisfactory prognosis after immunotherapy. Conclusion Anti-NMDA receptor encephalitis in individuals with mental disorders is an underestimated condition, yet it presents complex clinical symptoms. Mental and behavioral impairments are more frequently observed in newly diagnosed anti-NMDA receptor encephalitis patients with a long-term history of mental disorders than those without mental illness. A diagnosis of anti-NMDA receptor encephalitis should be considered when patients with mental illness show sudden fluctuations in psychiatric symptoms.
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- 2022
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13. Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition
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Xinqing Hao, Xiaofeng Huang, Xiaoxue Yin, Hai-Yang Wang, Ren Lu, Zhanhua Liang, and Chunli Song
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primary blepharospasm ,prepulse inhibition ,blink reflex ,sensory trick ,sensorimotor integration ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
ObjectiveWe aimed to analyze prepulse inhibition (PPI) impairment of the blink reflex in patients with primary blepharospasm (BSP).MethodsWe recruited 30 BSP patients and 20 gender- and age-matched healthy controls (HCs). Weak electrical stimulation was applied to the right index finger at interstimulus intervals (ISIs) of 120, 200, and 300 ms before the supraorbital nerve stimulation to investigate PPI size [PPI size = (1 – R2 area at prepulse trials/R2 area at baseline trials) × 100%].ResultsThe prepulse stimulus significantly inhibited the R2 component at the three ISIs in both groups, but less inhibition was shown in the BSP group (p < 0.05). In HCs, the prepulse stimulus induced prolonged R2 and R2c latencies at the three ISIs and increased the R1 amplitude at ISIs of 120 ms; these changes were absent in BSP patients. In the BSP group, patients with sensory tricks showed better PPI than patients without sensory tricks. Disease duration and motor symptom severity showed no significant correlation with PPI size.ConclusionIn BSP patients, PPI was impaired while R1 facilitation was absent. PPI size did not correlate with the motor symptom severity and disease duration. Patients with sensory tricks showed better PPI than those without sensory tricks.
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- 2023
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14. Pharyngeal desmoid fibromatosis in a female adolescent
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Zhong-jing Pan, Hai-yang Wang, Dan Lu, and Fei Chen
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Surgery ,RD1-811 - Published
- 2023
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15. The impact of anxiety on the cognitive function of informal Parkinson’s disease caregiver: Evidence from task-based and resting-state fNIRS
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Hai-Yang Wang, Lu Ren, Tao Li, Lanlan Pu, Xiaofeng Huang, Song Wang, Chunli Song, and Zhanhua Liang
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caregiver ,Parkinson’s disease ,anxiety ,cognitive function ,fNIRS ,Psychiatry ,RC435-571 - Abstract
Informal Parkinson’s disease (PD) caregivers are considered to experience high levels of caregiver burden, negatively affecting the health of caregivers. However, few studies explored the relationship between anxiety in caregiver burden and cognitive function in informal PD caregivers. Although, no study has even investigated the neural mechanisms underlying this connection. This study aimed to conduct comprehensive cognitive and clinical assessments and evaluate brain activity from task-based state and resting-state using functional near-infrared spectroscopy (fNIRS). A total of ten informal PD caregivers and 15 matched, healthy, non-caregivers were recruited. Comprehensive cognitive and clinical assessments were conducted to evaluate five cognitive domains and mental states. Neural activity induced by verbal fluency task (VFT) and brain connectivity during resting state were monitored, and their correlations with the neuropsychological and clinical tests were explored. Our results showed that compared to non-caregiver, an informal PD caregiver exhibited no difference in most cognitive domains of function but performed better in attentional function, along with higher levels of anxiety. Decreased activation over prefrontal regions during VFT and hypo-connectivity within the frontoparietal network (FPN) and between default mode network (DMN) and FPN in the resting state were confirmed in this study as a result of the negative effects of anxiety on the brain. Furthermore, Spearman’s correlation found that neural activity in FPN during task-based state and resting state was negatively correlated with the severity of anxiety. These findings indicate that despite normal or even better cognitive function, informal PD caregivers have impaired brain function, and this deficit in neural activity was related to anxiety.
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- 2022
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16. Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study
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Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xue-Lin Li, Yi Chang, Xiao-Pei Sun, and Bing-Wei Zhang
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Panic disorder ,Emotion regulation ,Implicit cognitive reappraisal ,fMRI ,Prefrontal cortex ,Medicine - Abstract
Abstract Background Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been performed to explore the underlying neuromechanism of cognitive reappraisal that occur on an unconscious level in PD patients. Methods Twenty-six patients with PD and 25 healthy controls (HC) performed a fully-verified event-block design emotional regulation task aimed at investigating responses of implicit cognitive reappraisal during an fMRI scan. Participants passively viewed negatively valanced pictures that were beforehand neutrally, positively, or adversely portrayed in the task. Results Whole-brain analysis of fMRI data showed that PD patients exhibited less activation in the right dorsolateral prefrontal cortex (dlPFC) and right dorsomedial prefrontal cortex (dmPFC) compared to HC, but presented greater activation in parietal cortex when negative pictures were preceded by positive/neutral vs negative descriptions. Simultaneously, interactive effects of Group × Condition were observed in the right amygdala across both groups. Furthermore, activation in dlPFC and dmPFC was is negatively correlated to severity of anxiety and panic in PD when negative images were preceded by non-negative vs negative descriptions. Conclusions Emotional dysregulation in PD is likely the result of deficient activation in dlPFC and dmPFC during implicit cognitive reappraisal, in line with impaired automatic top-down regulation. Correlations between severity of anxiety and panic attack and activation of right dlPFC and dmPFC suggest that the failure to engage prefrontal region during implicit cognitive reappraisal might be associated wtih the severity of anxiety and panic; such functional patterns might be the target of possible treatments.
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- 2021
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17. On the Role of Dynamical Cooling in the Dynamics of Circumbinary Disks
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Hai-Yang Wang, Xue-Ning Bai, and Dong Lai
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Accretion ,Hydrodynamics ,Hydrodynamical simulations ,Black hole physics ,Circumstellar disks ,Binary stars ,Astrophysics ,QB460-466 - Abstract
Hydrodynamical interactions between binaries and circumbinary disks (CBDs) play an important role in a variety of astrophysical systems, from young stellar binaries to supermassive black hole binaries. Previous simulations of CBDs have mostly employed locally isothermal equations of state. We carry out 2D viscous hydrodynamic simulations of CBDs around equal-mass, circular binaries, treating the gas thermodynamics by thermal relaxation toward equilibrium temperature (the constant- β cooling ansatz, where β is the cooling time in units of the local Keplerian time). As an initial study, we use the grid-based code Athena++ on a polar grid, covering an extended disk outside the binary co-orbital region. We find that with a longer cooling time, the accretion variability is gradually suppressed, and the morphology of the CBD becomes more symmetric. The disk also shows evidence of hysteresis behavior depending on the initial conditions. Gas cooling also affects the rate of angular momentum transfer between the binary and the CBD, where given our adopted disk thickness and viscosity ( H / r ∼ 0.1 and α ∼ 0.1), the binary orbit expands while undergoing accretion for most β values between 0 and 4.0 except over a narrow range of intermediate β values. The validity of using a polar grid excising the central domain is also discussed.
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- 2023
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18. A new protocol for long‐term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers
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Biao Zhang, Hai‐Yang Wang, Dong‐Xing Wang, Quan Zeng, Zeng Fan, Jia‐Fei Xi, Xue Nan, Li‐Juan He, Jun‐Nian Zhou, Xue‐Tao Pei, and Wen Yue
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cell surface markers ,chemically defined medium ,hepatocellular carcinoma ,in vitro culture model ,liver cancer stem cells ,Biology (General) ,QH301-705.5 - Abstract
Liver cancer stem cells (L‐CSCs) are considered to be an important therapeutic target for hepatocellular carcinoma (HCC). This study provides a new in vitro long‐term culture model for a specific subpopulation of L‐CSCs enriched by cell surface markers. We combined CD13, CD133 and EpCAM to selectively enrich L‐CSCs, which we then cultured in modified chemically defined medium. The enriched L‐CSCs exhibited enhanced proliferation, self‐renewal and long‐term clonal maintenance ability as compared with non‐CSCs. Compared with wild‐type hepatocellular carcinoma, the expression of stemness surface markers, oncogenes, drug resistance and tumorigenicity in enriched L‐CSCs was significantly increased. In summary, the subpopulation of L‐CSCs still maintains cancer stem cell‐related phenotypes after 14 days of culture.
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- 2020
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19. Importance of lipid ratios for predicting intracranial atherosclerotic stenosis
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Wen-Song Yang, Rui Li, Yi-Qing Shen, Xing-Chen Wang, Qing-Jun Liu, Hai-Yang Wang, Qi Li, Guo-En Yao, and Peng Xie
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Apo B/apo A-I ,Intracranial atherosclerotic stenosis ,Lipid ratios ,Remnant cholesterol ,Stroke ,Atherosclerosis ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population. Methods This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated. Results The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P
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- 2020
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20. Immunotherapy targeting glioma stem cells and its microenvironment
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Hai⁃yang WANG and Jun DONG
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glioma ,neoplastic stem cells ,tumor microenvironment ,immunotherapy ,review ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Glioma is the most prevailing primary malignant tumor in the central nervous system.Given that glioma stem cells (GSCs) and its microenvironment are pivotal for the occurrence and progressionof glioma, various targeted therapy including immunotherapy is promising to improve prognosis of glioma.Monoclonal antibodies could inhibit GSCs biological activity through specifically recognizing GSCs markers.GSCs tumor⁃related gene mutations lead to selective replication of oncolytic viruses in GSCs, which inhibitsproliferation of GSCs. The chimeric antigen receptor T cells (CAR ⁃ T) are activated in vitro, transferredback, and set off targeted immune cascade towards GSCs. Because of the high expression of activatedligand and low expression of major histocompatibility complexⅠ (MHC⁃Ⅰ)in GSCs, Natural killer (NK)cells have a promising anti⁃tumor performance. Furthermore, the inhibition of immune checkpoints in GSCsmicroenvironment plays a vital role in process of immune escape. So intervention of these immunecheckpoints has be a heated topic in tumor immunotherapy. Although the immunotherapy strategy targetingGSCs shows a certain effect to varying degrees, it is far from mature and needs to be further explored. DOI:10.3969/j.issn.1672⁃6731.2020.02.004
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- 2020
21. Toxoplasma gondii Antibodies in Raw Milk and Sera of Cows in China
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Yu-Min Liu, Yang-Yang Zhang, Lu Wang, Hai-Yang Wang, Chun-Hua Li, Yu-Hang Jiang, and Wu-Wen Sun
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cow milk ,Toxoplasma gondii ,seroprevalence ,China ,Medicine - Abstract
Toxoplasma gondii is a worldwide food-borne protozoa that has harmful influences on animal and human health. Raw milk containing T. gondii has been considered as one of the possible infectious sources for humans. Although China is one of the world’s leading milk consumers, there is still no study to investigate the seroprevalence of T. gondii in raw cow milk in China; especially for cows in rural areas. Thus, we conducted this study to examine the specific anti-T. gondii IgG-antibody in the raw milk and sera of domestic cows in China. In total, 894 cows were randomly selected from rural areas in northeastern China. The positive rate of T. gondii in the milk and serum samples were 6.38% (57/894) and 7.16% (64/894), respectively. Moreover, a history of abortion (OR = 2.03, 95% CI: 1.11–3.72, p = 0.022) was identified as the only risk factor for T. gondii infection in the studied cows. This study investigated the seroprevalence of T. gondii in the raw milk and sera of cows in China; it provided timely and useful data for public health and food safety, especially in rural areas.
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- 2022
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22. An updated meta-analysis evaluating limb management after total knee arthroplasty—what is the optimal method?
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Hai-yang Wang, Guang-shu Yu, Jie-hui Li, Shou-xiong Zhang, and Yan-bin Lin
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Total knee arthroplasty ,Mild flexion ,High flexion ,Duration of flexion ,Blood loss ,Range of motion ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Purpose Postoperative knee flexion protocol has been widely recognized as a highly attractive, simple, and cost-effective tactic to improve patient’s outcomes after primary total knee arthroplasty (TKA). However, optimal knee position and duration of knee flexion are still controversial. The purpose of this meta-analysis was to compare the effectiveness of different postoperative knee flexion protocols, as an aid to find out optimal limb management strategy following TKA. Methods We conducted a meta-analysis to identify the available and relevant randomized controlled trials (RCTs) with regard to the influence of different postoperative knee positions on clinical outcomes after primary TKA in electronic databases, including PubMed, EMBASE, the Cochrane Library, Web of Science, CNKI, Wanfang Med Online, and VIP, up to May 2018. In this meta-analysis, three major subgroups based on diverse postoperative knee flexion protocols were considered: long-term (≥ 24 h) high flexion (> 30°), short term ( 30°), and long-term (≥ 24 h) mild flexion (≤ 30°). The statistical analysis was performed using the Review Manager (RevMan) version 5.3 software. Results A total of 16 trials were finally included in this meta-analysis. The result of subgroup analysis indicated that keeping the knee in high flexion (> 30°) postoperatively for a long time (≥ 24 h) significantly reduced total blood loss (P 30°) postoperatively for a short time ( 30°) protocol could be an optimal limb management to reduce blood loss and blood transfusion requirements and facilitate early postoperative rehabilitation exercises in patients after primary TKA without increasing in complication rate.
- Published
- 2019
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23. Autoimmune glial fibrillary acidic protein astrocytopathy with lesions distributed predominantly in the entire spinal cord
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Xue-Lin Li, Jinming Han, Hao-Tian Zhao, You-Ming Long, Bing-Wei Zhang, and Hai-Yang Wang
- Subjects
Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy has been considered a novel central nervous system autoimmune disease characterized by relapse and responsiveness to corticosteroid with a specific GFAP-Immunoglobulin G (IgG) being noted in cerebrospinal fluid. We report the case of a 21-year-old girl presenting with dysuria and weariness, who subsequently developed blurry vision, slight dysphagia, slurred speech, and sensory abnormality. GFAP-IgG was detected in her cerebrospinal fluid. Magnetic resonance imaging using both T2-weighted and contrast-enhanced T1-weighted images revealed a rare finding of lesions distributed mainly in the entire spinal cord rather than typical brain lesions. After treating with corticosteroids, her clinical symptoms were alleviated, and the spinal cord lesion enhancement was reduced. Our observations extend the clinical spectrum of autoimmune GFAP astrocytopathy. We suggest that rare distributed lesions in the entire spinal cord in patients with autoimmune GFAP astrocytopathy cannot be ignored by neurologists. The identification of potential atypical lesions broadens the understanding of autoimmune GFAP astrocytopathy.
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- 2020
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24. Potential neurological symptoms of COVID-19
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Hai-Yang Wang, Xue-Lin Li, Zhong-Rui Yan, Xiao-Pei Sun, Jie Han, and Bing-Wei Zhang
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2020
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25. The complete chloroplast genome of Rhododendron platypodum (Ericaceae): an endemic and endangered species from China
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Li-Hui Ma, Hao-Xiang Zhu, Chao-Ying Wang, Ming-Yang Li, and Hai-Yang Wang
- Subjects
chloroplast genome ,rhododendron platypodum ,phylogenetic analysis ,ericaceae ,Genetics ,QH426-470 - Abstract
Rhododendron platypodum Diels (Ericaceae) is a Chinese endemic and endangered species with high ornamental value. Here the complete chloroplast (cp) genome of R. platypodum was assembled and characterized. The cp genome is in a total length of 201,047 bp with the typical quadripartite structure of angiosperms, containing two inverted repeats (IRs) of 44,650 bp separated by a large single-copy (LSC) region of 109,134 bp and a small single-copy (SSC) region of 2613 bp. The whole cp genome of R. platypodum contains 143 genes, including 93 protein-coding genes, 42 transfer RNA genes and 8 ribosomal RNA genes. Phylogenetic analysis based on the coding sequences of cp genome within the Ericaceae family suggests that R. platypodum is closely related to R. delavayi.
- Published
- 2021
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26. Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats.
- Author
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Yi-Yun Liu, Xin-Yu Zhou, Li-Ning Yang, Hai-Yang Wang, Yu-Qing Zhang, Jun-Cai Pu, Lan-Xiang Liu, Si-Wen Gui, Li Zeng, Jian-Jun Chen, Chan-Juan Zhou, and Peng Xie
- Subjects
Medicine ,Science - Abstract
Major depressive disorder is a serious mental disorder with high morbidity and mortality. The role of social stress in the development of depression remains unclear. Here, we used the social defeat stress paradigm to induce depression-like behavior in rats, then evaluated the behavior of the rats and measured metabolic changes in the prefrontal cortex using gas chromatography-mass spectrometry. Within the first week after the social defeat procedure, the sucrose preference test (SPT), open field test (OFT), elevated plus maze (EPM) and forced swim test (FST) were conducted to examine the depressive-like and anxiety-like behaviors. For our metabolite analysis, multivariate statistics were applied to observe the distribution of all samples and to differentiate the socially defeated group from the control group. Ingenuity pathway analysis was used to find the potential relationships among the differential metabolites. In the OFT and EPM, there were no significant differences between the two experimental groups. In the SPT and FST, socially defeated rats showed less sucrose intake and longer immobility time compared with control rats. Metabolic profiling identified 25 significant variables with good predictability. Ingenuity pathways analysis revealed that "Hereditary Disorder, Neurological Disease, Lipid Metabolism" was the most significantly altered network. Stress-induced alterations of low molecular weight metabolites were observed in the prefrontal cortex of rats. Particularly, lipid metabolism, amino acid metabolism, and energy metabolism were significantly perturbed. The results of this study suggest that repeated social defeat can lead to metabolic changes and depression-like behavior in rats.
- Published
- 2017
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27. Enzymatic Synthesis and Characterization of Thermosensitive Polyester with Pendent Ketoprofen
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Xiao-Qi Yu, Wei-Wei Zhang, Han Lai, Na Wang, Hai-Yang Wang, and Wan-Xia Wu
- Subjects
enzymatic synthesis ,CAL-B ,thermosensitive polyester ,ketoprofen ,PEG ,Organic chemistry ,QD241-441 - Abstract
Three linear polyesters with pendant ketoprofen were synthesized by copolymerization of polyethylene glycol (PEG) with malic acid (thiomalic acid or aspartic acid) using lipase B acrylic resin from Candida antarctica (CAL-B) at 90 °C respectively. These thermosensitive polyesters exhibit a lower critical solution temperature (LCST) at 10–12 °C. The in vitro study demonstrated that these polyesters could release ketoprofen in neutral and alkaline medium but showed hydrolytic stability in acid medium. These results suggest that, with pendant drugs, these thermosensitive polyesters have potential applications in biomedical materials.
- Published
- 2013
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28. Recombinant Tissue Plasminogen Activator Induces Neurological Side Effects Independent on Thrombolysis in Mechanical Animal Models of Focal Cerebral Infarction: A Systematic Review and Meta-Analysis.
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Mei-Xue Dong, Qing-Chuan Hu, Peng Shen, Jun-Xi Pan, You-Dong Wei, Yi-Yun Liu, Yi-Fei Ren, Zi-Hong Liang, Hai-Yang Wang, Li-Bo Zhao, and Peng Xie
- Subjects
Medicine ,Science - Abstract
Recombinant tissue plasminogen activator (rtPA) is the only effective drug approved by US FDA to treat ischemic stroke, and it contains pleiotropic effects besides thrombolysis. We performed a meta-analysis to clarify effect of tissue plasminogen activator (tPA) on cerebral infarction besides its thrombolysis property in mechanical animal stroke.Relevant studies were identified by two reviewers after searching online databases, including Pubmed, Embase, and ScienceDirect, from 1979 to 2016. We identified 6, 65, 17, 12, 16, 12 and 13 comparisons reporting effect of endogenous tPA on infarction volume and effects of rtPA on infarction volume, blood-brain barrier, brain edema, intracerebral hemorrhage, neurological function and mortality rate in all 47 included studies. Standardized mean differences for continuous measures and risk ratio for dichotomous measures were calculated to assess the effects of endogenous tPA and rtPA on cerebral infarction in animals. The quality of included studies was assessed using the Stroke Therapy Academic Industry Roundtable score. Subgroup analysis, meta-regression and sensitivity analysis were performed to explore sources of heterogeneity. Funnel plot, Trim and Fill method and Egger's test were obtained to detect publication bias.We found that both endogenous tPA and rtPA had not enlarged infarction volume, or deteriorated neurological function. However, rtPA would disrupt blood-brain barrier, aggravate brain edema, induce intracerebral hemorrhage and increase mortality rate.This meta-analysis reveals rtPA can lead to neurological side effects besides thrombolysis in mechanical animal stroke, which may account for clinical exacerbation for stroke patients that do not achieve vascular recanalization with rtPA.
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- 2016
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29. The Role of Glucose Metabolism on Porcine Oocyte Cytoplasmic Maturation and Its Possible Mechanisms.
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Bao Yuan, Shuang Liang, Jeong-Woo Kwon, Yong-Xun Jin, Shun-Ha Park, Hai-Yang Wang, Tian-Yi Sun, Jia-Bao Zhang, and Nam-Hyung Kim
- Subjects
Medicine ,Science - Abstract
In the present study, we investigated the potential role of glucose and pyruvate in the cytoplasmic maturation of porcine oocytes by investigating the effect of glucose and/or pyruvate supplementation, in the presence or absence of 10% porcine follicular fluid (PFF), on meiotic maturation and subsequent embryo development. In the absence of 10% PFF, without exogenous addition of glucose and pyruvate, the medium seemed unable to support maturation. In the presence of 10% PFF, the addition of 5.6 mM glucose and/or 2 mM pyruvate during in vitro maturation of cumulus enclosed oocytes increased MII oocyte and blastocyst rates. In contrast, oocytes denuded of cumulus cells were not able to take full advantage of the glucose in the medium, as only pyruvate was able to increase the MII rate and the subsequent early embryo developmental ability. Treatment of cumulus enclosed oocytes undergoing maturation with 200 μM dehydroepiandrosterone (DHEA), a pentose phosphate pathway inhibitor, or 2 μM iodoacetate (IA), a glycolysis inhibitor, significantly reduced GHS, intra-oocyte ATP, maternal gene expression, and MPF activity levels. DHEA was also able to increase ROS and reduce the levels of NADPH. Moreover, blastocysts of the DHEA- or IA-treated groups presented higher apoptosis rates and markedly lower cell proliferation cell rates than those of the non-treated group. In conclusion, our results suggest that oocytes maturing in the presence of 10% PFF can make full use of energy sources through glucose metabolism only when they are accompanied by cumulus cells, and that pentose phosphate pathway (PPP) and glycolysis promote porcine oocyte cytoplasmic maturation by supplying energy, regulating maternal gene expression, and controlling MPF activity.
- Published
- 2016
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30. [(1S,2S,3R,4R)-3-Hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]methyl[(E)-3-(trimethylsilyl)prop-2-enyl]selenonium bromide
- Author
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Qiang Zhang, Yi-Zhi Li, Yuan Gui, Zhi-Zhen Huang, and Hai-Yang Wang
- Subjects
Crystallography ,QD901-999 - Abstract
The title compound, a selenonium bromide, C17H33OSeSi+·Br−, was obtained from the reaction of enantiomerically pure 4,7,7-trimethyl-2-methylselanylbicyclo[2.2.1]heptan-3-ol and (3-bromopropenyl)trimethylsilane in acetone. Due to the chiral bicyclic substituent, the crystal structure is not centrosymmetric and has no symmetry plane, with four chiral C atoms in the cation. The asymmetric unit contains one selenonium cation and one bromide anion. C–H...Br and O–H...Br hydrogen bonds link the ions, forming a one-dimensional R-helical chain-like supramolecular structure.
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- 2008
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31. Feature aligned ship detection based on improved RPDet in SAR images
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Cong-An, Xu, Hang, Su, Long, Gao, Jun-Feng, Wu, Wen-Jun, Yan, Tao, Jian, and Hai-Yang, Wang
- Published
- 2022
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32. A novel SMC-PHD filter for multi-target tracking without clustering
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Cong-An, Xu, Li-Bo, Yao, Yu, Liu, Hang, Su, Hai-Yang, Wang, and Xiang-Qi, Gu
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- 2022
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33. Comprehensive analysis of the gut microbiome and post-translational modifications elucidates the route involved in microbiota-host interactions.
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Hai-Yang Wang, Lan-Xiang Liu, Xue-Yi Chen, Yang-Dong Zhang, Wen-Xia Li, Wen-Wen Li, Lian Wang, Xiao-Long Mo, Hong Wei, Ping Ji, and Peng Xie
- Subjects
GUT microbiome ,POST-translational modification ,PEARSON correlation (Statistics) ,FECAL analysis ,METAGENOMICS ,HOMEOSTASIS ,PROTEOMICS ,PROTEIN analysis ,DYSBIOSIS - Abstract
The gut microbiome interacts with the host to maintain body homeostasis, with gut microbial dysbiosis implicated in many diseases. However, the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain unclear. This study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any stimulation. We conducted succinylome analysis of hippocampal proteins in germ-free (GF) and specific pathogen-free (SPF) mice and metagenomic analysis of feces from SPF mice. These results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of mice. Subsequent bioinformatics analyses revealed 584 succinylation sites on 455 proteins, including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF mice. We constructed a panoramic map of gut microbiota-regulated succinylation, acetylation, and phosphorylation, and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular pathways. Pearson correlation analysis indicated that 13 taxa, predominantly belonging to the Bacteroidetes phylum, were correlated with the biological functions of post-translational modifications. Positive correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular pathways. This study highlights the hippocampal physiological changes induced by the absence of gut microbiota, and proteomic quantification of succinylation, phosphorylation, and acetylation, contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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34. Hydrodynamical simulations of circumbinary accretion: balance between heating and cooling.
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(王海洋), Hai-Yang Wang, (白雪宁), Xue-Ning Bai, (赖东), Dong Lai, and (林潮), Douglas N C Lin
- Subjects
- *
KINEMATIC viscosity , *EQUATIONS of state , *THERMODYNAMICS , *UNITS of time , *SUPERMASSIVE black holes - Abstract
Hydrodynamical interaction in circumbinary discs (CBDs) plays a crucial role in various astrophysical systems, ranging from young stellar binaries to supermassive black hole binaries in galactic centres. Most previous simulations of binary-disc systems have adopted locally isothermal equation of state. In this study, we use the grid-based code Athena++ to conduct a suite of two-dimensional viscous hydrodynamical simulations of circumbinary accretion on a Cartesian grid, resolving the central cavity of the binary. The gas thermodynamics is treated by thermal relaxation towards an equilibrium temperature (based on the constant − β cooling ansatz, where β is the cooling time in units of the local Keplerian time). Focusing on equal mass, circular binaries in CBDs with (equilibrium) disc aspect ratio H / R = 0.1, we find that the cooling of the disc gas significantly influences the binary orbital evolution, accretion variability, and CBD morphology, and the effect depends sensitively on the disc viscosity prescriptions. When adopting a constant kinematic viscosity, a finite cooling time (β ≳ 0.1) leads to a binary inspiral as opposed to an outspiral and the CBD cavity becomes more symmetric. When adopting a dynamically varying α-viscosity, binary inspiral only occurs within a narrow range of cooling time (corresponding to β around 0.5). [ABSTRACT FROM AUTHOR]
- Published
- 2023
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35. Effects of trihexyphenidyl on prefrontal executive function and spontaneous neural activity in patients with tremor-dominant Parkinson's disease: An fNIRS study
- Author
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Hai-Yang, Wang, Xinqing, Hao, Ren, Lu, Tao, Li, Lanlan, Pu, Wei, Liu, and Zhanhua, Liang
- Subjects
Executive Function ,Cognition ,Neurology ,Tremor ,Humans ,Parkinson Disease ,Neurology (clinical) ,Geriatrics and Gerontology ,Trihexyphenidyl - Abstract
The use of the anti-parkinsonian drug trihexyphenidyl (THP) to treat patients with Parkinson's disease (PD), particularly those with tremor-dominant PD (tdPD), has been well documented. Despite growing concerns about THP causing cognitive decline in tdPD patients, the underlying neural correlates remain unclear. Therefore, we investigated the effects of THP on prefrontal executive function and spontaneous neural activity in patients with tdPD by utilizing functional near-infrared spectroscopy (fNIRS).We recruited 30 patients with tdPD, including 15 patients receiving THP and 15 patients not receiving THP. We performed comprehensive neuropsychological and clinical assessments to evaluate each patient's cognitive function, mental status, and clinical symptoms. We measured brain activation elicited from the verbal fluency task (VFT) and changes in amplitude of low-frequency fluctuations (ALFF) at rest to investigate executive function and spontaneous neural activity, respectively. In addition, we examined the relationship between altered activation during task and resting state and neuropsychological and clinical data.Compared with tdPD patients not taking THP, tdPD patients taking THP showed no differences on neuropsychological tests. However, there was insufficient activity of the dorsolateral prefrontal cortex (DLPFC) during VFT and reduced ALFF values for the DLPFC, ventrolateral prefrontal cortex (VLPFC), and the orbitofrontal cortex (OFC) related to the frontoparietal network (FPN) at rest. Furthermore, ALFF values of the VLPFC were positively correlated with scores of multiple cognitive domain functions.These findings suggest that THP treatment may lead to prefrontal dysfunction in tdPD patients, attenuating brain activation in executive function and cognition-related spontaneous neural activity.
- Published
- 2022
36. Phytochrome B mediates dim-light-reduced insect resistance by promoting the ethylene pathway in rice
- Author
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Jie Huang, Ze-Yu Qiu, Jun He, Hao-Sen Xu, Kan Wang, Hua-Ying Du, Dong Gao, Wei-Ning Zhao, Quan-Guang Sun, Yong-Sheng Wang, Pei-Zheng Wen, Qi Li, Xiao-Ou Dong, Xian-Zhi Xie, Ling Jiang, Hai-Yang Wang, Yu-Qiang Liu, and Jian-Min Wan
- Subjects
Physiology ,Genetics ,Plant Science - Abstract
Increasing planting density is one of the most effective ways to improve crop yield. However, one major factor that limits crop planting density is the weakened immunity of plants to pathogens and insects caused by dim light (DL) under shade conditions. The molecular mechanism underlying how DL compromises plant immunity remains unclear. Here, we report that DL reduces rice (Oryza sativa) resistance against brown planthopper (BPH; Nilaparvata lugens) by elevating ethylene (ET) biosynthesis and signaling in a Phytochrome B (OsPHYB)-dependent manner. The DL-reduced BPH resistance is relieved in osphyB mutants, but aggravated in OsPHYB overexpressing plants. Further, we found that DL reduces the nuclear accumulation of OsphyB, thus alleviating Phytochrome Interacting Factor Like14 (OsPIL14) degradation, consequently leading to the up-regulation of 1-Aminocyclopropane-1-Carboxylate Oxidase1 (OsACO1) and an increase in ET levels. In addition, we found that nuclear OsphyB stabilizes Ethylene Insensitive Like2 (OsEIL2) by competitively interacting with EIN3 Binding F-Box Protein (OsEBF1) to enhance ET signaling in rice, which contrasts with previous findings that phyB blocks ET signaling by facilitating Ethylene Insensitive3 (EIN3) degradation in other plant species. Thus, enhanced ET biosynthesis and signaling reduces BPH resistance under DL conditions. Our findings provide insights into the molecular mechanism of the light-regulated ET pathway and host-insect interactions and potential strategies for sustainable insect management.
- Published
- 2022
37. Selective conversion of 2-methylfuran to 3-acetyl-1-propanol in water over Pd@HZSM-5 catalyst with balanced metal-acid cooperation
- Author
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Xin-Xin Fu, Jian-Peng Li, Zhuo-Qian Li, Yan Liu, Chen-Xiao Feng, Hai-Yang Wang, Zhi-Peng Zhao, Qiao-Yun Liu, Zhong-Yi Liu, and Zhi-Kun Peng
- Subjects
Physical and Theoretical Chemistry ,Catalysis - Published
- 2022
38. A Segmentation-Free Model for Heart Sound Feature Extraction.
- Author
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Hai-Yang Wang, Guang-Pei Li, Bin Bin Fu, Haodong Yao, and Ming-Chui Dong
- Published
- 2015
- Full Text
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39. Creation of two hyperactive variants of phytochrome B1 for attenuating shade avoidance syndrome in maize
- Author
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Yong-ping ZHAO, Bin-bin ZHAO, Guang-xia WU, Xiao-jing MA, Bao-bao WANG, De-xin KONG, Hong-bin WEI, and Hai-yang WANG
- Subjects
Food Animals ,Ecology ,Animal Science and Zoology ,Plant Science ,Agronomy and Crop Science ,Biochemistry ,Food Science - Published
- 2022
40. [Principles and implementation of the integrated management of 'mountain-river-forest-farmland-lake-grassland-sandland' in Horqin Sand Land, China]
- Author
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Zhi-Min, Liu, Hai-Bin, Yu, and Hai-Yang, Wang
- Abstract
Integrated management of "mountain-river-forest-farmland-lake-grassland-sandland" has become an important concept of ecological environment construction in arid areas. Although some major projects have been implemented in the sand areas, but the scientific and technical principles of integrated management are not clear and have not been fully reflected in these projects. Considering such cases, we discussed the challenges, scientific principles, technical principles and implementation priorities of the integrated management of Horqin Sand Land. In Horqin Sand Land, the relationships between forest and farmland, forest and forest, forest and water, farmland and water, forest and grassland, sand land and water, farmland and grassland were not well coordinated, resulting in resource imbalance and low ecologic services. The integrated management should follow scientific principles and laws, including aeolian sand movement law, grassland interface theory, water resource balance theory, biodiversity maintenance theory, landscape ecology theory, and ecosystem services. At the technical level, the principles of water-sediment relationship coordination, landscape design optimization, prevention and control technologies and modes multi-directional synergia, natural and man-made landscapes harmonies, "production-ecological" space layout balance should be highlighted. The key points of integrated management should focus on the function improvement of sand dunes and shelter forests, the efficiency improvement of farmlands and grasslands, the ecological conservation of lakes, the greening and beautification of human settlements, the ecological restoration of engineering projects. This review could provide reference for the integrated ecological environment construction in Horqin Sand Land and the sand areas of northern China.“山水林田湖草沙”一体化治理现已成为干旱区生态环境建设的重要理念,目前虽已有部分重大工程项目在沙区实施,但一体化治理的科学与技术原理尚不清晰,仍未在这些工程中充分体现。鉴于此,本文就科尔沁沙地一体化治理的挑战、科学原理、技术原理与实施重点进行了论述。在科尔沁沙地,林-田、林-林、林-水、田-水、林-草、沙-水、田-草等要素关系尚不很协调,导致资源失衡、服务功能低下。进行一体化治理应遵循风沙运动规律、草地界面理论、水资源平衡理论、生物多样性维持理论、景观生态学理论和生态系统服务功能等科学原理与规律。一体化治理技术层面应突出体现水-沙关系协调、景观设计优化、防治技术与模式多方位并重、自然与人为景观兼顾、“三生”空间布局均衡等原理。一体化治理的重点应置于沙丘和防护林功能提升、农田和草地增效、湖泊生态保育、人居环境绿化美化、工程项目生态修复上。本文可为科尔沁沙地以及整个三北地区的沙区一体化生态环境建设提供参考。.
- Published
- 2023
41. Engineering Accordion-Like Fe-Doped Nis2 Enabling High-Performance Aqueous Supercapacitors and Zn-Ni Batteries
- Author
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Hai-yang Wang and Zongcheng Miao
- Subjects
History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2023
42. Identification of crucial genes involved in pathogenesis of regional weakening of the aortic wall
- Author
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Hai Yang Wang, Hong Lin Zu, and Hong Wei Liu
- Subjects
Microarray ,Gene Expression Profiling ,Research ,Crucial genes ,MYLK ,General Medicine ,Computational biology ,Biology ,QH426-470 ,Gene Ontology ,Gene expression ,MYH11 ,Differentially expressed genes ,Vascular smooth muscle cells ,Genetics ,Humans ,Abdominal aortic aneurysm ,Gene Regulatory Networks ,MYL9 ,KEGG ,Vascular smooth muscle contraction ,Gene ,Aortic Aneurysm, Abdominal ,Weighted gene coexpression network analysis - Abstract
Background The diameter of the abdominal aortic aneurysm (AAA) is the most commonly used parameter for the prediction of occurrence of AAA rupture. However, the most vulnerable region of the aortic wall may be different from the most dilated region of AAA under pressure. The present study is the first to use weighted gene coexpression network analysis (WGCNA) to detect the coexpressed genes that result in regional weakening of the aortic wall. Methods The GSE165470 raw microarray dataset was used in the present study. Differentially expressed genes (DEGs) were filtered using the “limma” R package. DEGs were assessed by Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. WGCNA was used to construct the coexpression networks in the samples with regional weakening of the AAA wall and in the control group to detect the gene modules. The hub genes were defined in the significant functional modules, and a hub differentially expressed gene (hDEG) coexpression network was constructed with the highest confidence based on protein–protein interactions (PPIs). Molecular compound detection (MCODE) was used to identify crucial genes in the hDEG coexpression network. Crucial genes in the hDEG coexpression network were validated using the GSE7084 and GSE57691 microarray gene expression datasets. Result A total of 350 DEGs were identified, including 62 upregulated and 288 downregulated DEGs. The pathways were involved in immune responses, vascular smooth muscle contraction and cell–matrix adhesion of DEGs in the samples with regional weakening in AAA. Antiquewhite3 was the most significant module and was used to identify downregulated hDEGs based on the result of the most significant modules negatively related to the trait of weakened aneurysm walls. Seven crucial genes were identified and validated: ACTG2, CALD1, LMOD1, MYH11, MYL9, MYLK, and TPM2. These crucial genes were associated with the mechanisms of AAA progression. Conclusion We identified crucial genes that may play a significant role in weakening of the AAA wall and may be potential targets for medical therapies and diagnostic biomarkers. Further studies are required to more comprehensively elucidate the functions of crucial genes in the pathogenesis of regional weakening in AAA.
- Published
- 2021
43. Pharyngeal desmoid fibromatosis in a female adolescent: A case report
- Author
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Zhong-Jing, Pan, Hai-Yang, Wang, Dan, Lu, and Fei, Chen
- Published
- 2022
44. Mild encephalitis/encephalopathy with a reversible splenial lesion associated with respiratory syncytial virus infection in infants
- Author
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Hai-Yang Wang, Bing-Wei Zhang, Xue-Lin Li, Jinming Han, and Zhong-Rui Yan
- Subjects
medicine.medical_specialty ,Pathology ,Neurology ,business.industry ,Encephalopathy ,Splenium ,medicine.disease_cause ,medicine.disease ,Virus ,Lesion ,Cellular and Molecular Neuroscience ,Virology ,Rotavirus ,medicine ,Neurology (clinical) ,medicine.symptom ,Splenial ,business ,Encephalitis - Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinicoradiologic syndrome typically characterized by transient mild encephalitis or encephalopathy with reversible lesions being found in the splenium of corpus callosum (SCC) by magnetic resonance imaging (MRI). A variety of pathogens including influenza virus, rotavirus, and adenovirus associated with MERS have been reported. However, respiratory syncytial virus (RSV)-related MERS is relatively rare in infants. In this study, we report two Chinese infants who suffered from RSV-related MERS. Both infants manifested as fever, seizure, and altered states of consciousness with confirmed detections of RSV-RNA in the specimens from throat swab. Clinical symptoms/signs such as apnea and shallow breathing were also noted in these two infants. Furthermore, brain MRI images indicated reversible isolated lesions with transiently reduced diffusion in the SCC. Fortunately, both of these two infants recovered completely following treatment within a month. Our study suggests that RSV may serve as a novel causative agent for MERS in infants. Clinicians should focus more attention on RSV-related MERS in infants in order to improve early accurate diagnosis and therapeutic decision making.
- Published
- 2021
45. Neural basis of implicit cognitive reappraisal in panic disorder: an event-related fMRI study
- Author
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Cui-Hong Zhang, Guo-Qing Xu, Ming-Fei Ni, Xue-Lin Li, Yi Chang, Xiao-Pei Sun, Hai-Yang Wang, and Bing-Wei Zhang
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Cognitive model ,medicine.medical_specialty ,Emotions ,Posterior parietal cortex ,Implicit cognitive reappraisal ,Audiology ,behavioral disciplines and activities ,Prefrontal cortex ,050105 experimental psychology ,General Biochemistry, Genetics and Molecular Biology ,Cognitive reappraisal ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,mental disorders ,medicine ,Humans ,0501 psychology and cognitive sciences ,Brain Mapping ,Panic disorder ,Research ,Emotion regulation ,05 social sciences ,fMRI ,Panic ,General Medicine ,Emotional dysregulation ,medicine.disease ,Magnetic Resonance Imaging ,Anxiety ,Medicine ,medicine.symptom ,Psychology ,030217 neurology & neurosurgery ,psychological phenomena and processes - Abstract
Background Panic disorder (PD) is thought to be related with deficits in emotion regulation, especially in cognitive reappraisal. According to the cognitive model, PD patients’ intrinsic and unconscious misappraisal strategies are the cause of panic attacks. However, no studies have yet been performed to explore the underlying neuromechanism of cognitive reappraisal that occur on an unconscious level in PD patients. Methods Twenty-six patients with PD and 25 healthy controls (HC) performed a fully-verified event-block design emotional regulation task aimed at investigating responses of implicit cognitive reappraisal during an fMRI scan. Participants passively viewed negatively valanced pictures that were beforehand neutrally, positively, or adversely portrayed in the task. Results Whole-brain analysis of fMRI data showed that PD patients exhibited less activation in the right dorsolateral prefrontal cortex (dlPFC) and right dorsomedial prefrontal cortex (dmPFC) compared to HC, but presented greater activation in parietal cortex when negative pictures were preceded by positive/neutral vs negative descriptions. Simultaneously, interactive effects of Group × Condition were observed in the right amygdala across both groups. Furthermore, activation in dlPFC and dmPFC was is negatively correlated to severity of anxiety and panic in PD when negative images were preceded by non-negative vs negative descriptions. Conclusions Emotional dysregulation in PD is likely the result of deficient activation in dlPFC and dmPFC during implicit cognitive reappraisal, in line with impaired automatic top-down regulation. Correlations between severity of anxiety and panic attack and activation of right dlPFC and dmPFC suggest that the failure to engage prefrontal region during implicit cognitive reappraisal might be associated wtih the severity of anxiety and panic; such functional patterns might be the target of possible treatments.
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- 2021
46. Dual Aircraft Cooperative Cross Positioning Method for Ground Remote Control Signal Source
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Jia-nuo Xu, Zhi-cheng Yao, Jian Yang, and Hai-yang Wang
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- 2022
47. Early autoimmunity and outcome in virus encephalitis: a retrospective study based on tissue-based assay
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Ding Liu, Pei-Hao Lin, Hui-Lu Li, Jie Yang, Yong You, Xiao Yang, Li-Hong Jiang, Cai-Yu Ma, Lu-Fen Xu, Qing-Xia Zhang, Sha Liao, Han Chen, Jia-Jia Yue, Yu-Ying Lu, Chun Lian, Yin Liu, Zhan-Hang Wang, Jin-Long Ye, Wei Qiu, Ya-Qing Shu, Hai-Yang Wang, Hong-Li Liu, Yue Wang, Chun-Mei Duan, Huan Yang, Xiu-Ling Wu, Lu Zhang, Hui-Yu Feng, Huan Chen, Hou-Shi Zhou, Qian-Hui Xu, Gui-Xian Zhao, Teng-Fei Ou, Jin-Liang Wang, Yu-Hua Lu, Zhi-Feng Mao, Cong Gao, Jun Guo, Hong-Ya Zhang, Sheng Chen, Jing Li, and You-Ming Long
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Psychiatry and Mental health ,Surgery ,Neurology (clinical) - Abstract
To explore the autoimmune response and outcome in the central nervous system (CNS) at the onset of viral infection and correlation between autoantibodies and viruses.MethodsA retrospective observational study was conducted in 121 patients (2016–2021) with a CNS viral infection confirmed via cerebrospinal fluid (CSF) next-generation sequencing (cohort A). Their clinical information was analysed and CSF samples were screened for autoantibodies against monkey cerebellum by tissue-based assay. In situ hybridisation was used to detect Epstein-Barr virus (EBV) in brain tissue of 8 patients with glial fibrillar acidic protein (GFAP)-IgG and nasopharyngeal carcinoma tissue of 2 patients with GFAP-IgG as control (cohort B).ResultsAmong cohort A (male:female=79:42; median age: 42 (14–78) years old), 61 (50.4%) participants had detectable autoantibodies in CSF. Compared with other viruses, EBV increased the odds of having GFAP-IgG (OR 18.22, 95% CI 6.54 to 50.77, pp=0.003), more meningitis (26/61 (42.6%) vs 12/60 (20.0%), p=0.007) and higher follow-up modified Rankin Scale scores (1 (0–6) vs 0 (0–3), p=0.037) compared with antibody-negative patients. A Kaplan-Meier analysis revealed that autoantibody-positive patients experienced significantly worse outcomes (p=0.031).ConclusionsAutoimmune responses are found at the onset of viral encephalitis. EBV in the CNS increases the risk for autoimmunity to GFAP.
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- 2023
48. Feasibility and clinical benefits of the double-ProGlide technique for hemostasis after cryoballoon atrial fibrillation ablation with uninterrupted oral anticoagulants.
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Jia-Yin SUN, Chang-Bo XUAN, Hai-Liang YU, Hai-Yang WANG, Hong-Ya HAN, Zhi- Ming ZHOU, De-An JIA, Dong-Mei SHI, Yu-Jie ZHOU, and Shi-Wei YANG
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LENGTH of stay in hospitals ,FEMORAL vein ,SCIENTIFIC observation ,ACADEMIC medical centers ,ATRIAL fibrillation ,CATHETER ablation ,CRYOSURGERY ,ANTICOAGULANTS ,SURGICAL hemostasis ,MANN Whitney U Test ,FISHER exact test ,TREATMENT effectiveness ,COMPARATIVE studies ,ELECTROPHYSIOLOGY ,BIOLOGICAL laboratories ,T-test (Statistics) ,DESCRIPTIVE statistics ,RESEARCH funding ,DATA analysis software ,VASCULAR closure devices ,EVALUATION - Abstract
OBJECTIVE To access the efficacy and safety of the double-ProGlide technique for the femoral vein access-site closure in cryoballoon ablation with uninterrupted oral anticoagulants (OAC), and its impact on the electrophysiology laboratory time as well as hospital stay after the procedure in this observational study. METHODS Patients with atrial fibrillation undergoing cryoballoon ablation with uninterrupted OAC at Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China from May 2019 to May 2021 were enrolled in this study. From October 2020, double-ProGlide technique was consistently used for hemostasis (ProGlide group), and before that conventional manual compression was utilized (manual compression group). The occurrence of vascular and groin complications was accessed during the hospital stay and until the three-month follow-up. RESULTS A total of 140 participants (69.30% of male, mean age: 59.21 ± 10.29 years) were evaluated, 70 participants being in each group. Immediate hemostasis was achieved in all the patients with ProGlide closure. No major vascular complications were found in the ProGlide group while two major vascular complications were occurred in the manual compression group. The incidence of any groin complication was obviously higher in subjects with manual compression than patients with ProGlide devices (15.71% vs. 2.86%, P = 0.009). In addition, compared with the manual compression group, the ProGlide group was associated with significantly shorter total time in the electrophysiology laboratory [112.0 (93.3-128.8) min vs. 123.5 (107.3-158.3) min, P = 0.006], time from sheath removal until venous site hemostasis [3.8 (3.4-4.2) min vs. 8.0 (7.6-8.5) min, P < 0.001], bed rest time [8.0 (7.6-8.0) h vs. 14.1 (12.0-17.6) h, P < 0.001] and hospital stay after the procedure [13.8 (12.5-17.8) h vs. 38.0 (21.5-41.0) h, P < 0.001]. CONCLUSIONS Utilization of the double-ProGlide technique for hemostasis after cryoballoon ablation with uninterrupted OAC is feasible and safe, which has the clinical benefit in reducing the total electrophysiology laboratory time and the hospital stay length after the procedure. [ABSTRACT FROM AUTHOR]
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- 2023
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49. A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c-Myc Transcription Activity Inhibition in Liver Cancer
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Jun‐Nian Zhou, Biao Zhang, Hai‐Yang Wang, Dong‐Xing Wang, Ming‐Ming Zhang, Min Zhang, Xiao‐Kui Wang, Shi‐Yong Fan, Ying‐Chen Xu, Quan Zeng, Ya‐Li Jia, Jia‐Fei Xi, Xue Nan, Li‐Juan He, Xin‐Bo Zhou, Song Li, Wu Zhong, Wen Yue, and Xue‐Tao Pei
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Carcinoma, Hepatocellular ,General Chemical Engineering ,Liver Neoplasms ,General Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,Sorafenib ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Molecular Docking Simulation ,Mice ,Selenium ,Cell Line, Tumor ,Neoplastic Stem Cells ,Animals ,General Materials Science ,Selenium Compounds ,Early Detection of Cancer - Abstract
Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self-renewal and proliferation, such as Hedgehog, Notch, Wnt/β-catenin, TGF-β, and Myc, may be potential therapeutic targets. Here, a functional screening from the focused library with 365 compounds is performed by a step-by-step strategy. Among these candidate molecules, phenyl-2-pyrimidinyl ketone 4-allyl-3-amino selenourea (CU27) is chosen for further identification because it proves to be the most effective compound over others on CSC inhibition. Through ingenuity pathway analysis, it is shown CU27 may inhibit CSC through a well-known stemness-related transcription factor c-Myc. Gene set enrichment analysis, dual-luciferase reporter assays, expression levels of typical c-Myc targets, molecular docking, surface plasmon resonance, immunoprecipitation, and chromatin immunoprecipitation are conducted. These results together suggest CU27 binds c-Myc bHLH/LZ domains, inhibits c-Myc-Max complex formation, and prevents its occupancy on target gene promoters. In mouse models, CU27 significantly sensitizes sorafenib-resistant tumor to sorafenib, reduces the primary tumor size, and inhibits CSC generation, showing a dramatic anti-metastasis potential. Taken together, CU27 exerts inhibitory effects on CSC and CSC-associated traits in hepatocellular carcinoma (HCC) via c-Myc transcription activity inhibition. CU27 may be a promising therapeutic to treat sorafenib-resistant HCC.
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- 2022
50. [Distribution Characteristics of Heavy Metals in Farmland Soils Around Mining Areas and Pollution Assessment]
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Hai-Yang, Wang, Ling, Han, Dan-Ni, Xie, Hui-Juan, Hu, Zhi-Heng, Liu, and Zhen, Wang
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China ,Soil ,Farms ,Lead ,Metals, Heavy ,Soil Pollutants ,Mercury ,Environmental Pollution ,Risk Assessment ,Cadmium ,Environmental Monitoring - Abstract
In order to explore the spatial distribution and ecological risk of heavy metals in farmland soil around Tongguan Mining area, surface soil samples from Tongguan Mining area were collected in September 2020, and the contents and distribution characteristics of eight heavy metals (Pb, Cu, Cd, Hg, Cr, Ni, Zn, and As) in the samples were analyzed. The Nemerow comprehensive pollution index and potential ecological risk index were used to evaluate soil pollution. The results showed that the contents of the eight types of heavy metal elements in this area exceeded the standard, and the exceeding rates were 97.91%, 84.79%, 100%, 95.41%, 96.87%, 98.54%, 91.45%, and 28.95%, respectively. The variation coefficients of the eight heavy metals were ranked as HgPbCuCdZnAsNiCr. The variation coefficients of Hg, Pb, Cu, Cd, and Zn were all greater than 1. Correlation analysis showed that these five heavy metals were obviously correlated. In terms of spatial distribution, Pb, Cd, Cu, Hg, Zn, and As were distributed in patches, whereas Cr and Ni were distributed in flakes. The high values of Hg, Cd, Pb, Cu, and Zn were mainly distributed in the southern and central part of the study area. The comprehensive pollution of Nemerow showed that the severe pollution rate reached 87.91%, and the moderate pollution rate and the mild pollution rate were 9.58% and 2.5%, respectively; thus, the overall pollution was severe. The potential ecological risk index showed that Hg, Cd, Pb, and Cu were the main risk elements. The total potential ecological risk index showed that the proportion of samples with strong pollution was 97.08%, and the proportion of extremely strongly, very strongly, and strongly polluted samples were 55.63%, 27.08%, and 14.37%, respectively, indicating that the overall potential ecological risk in the study area was very strong. Combining the two pollution assessment methods, it can be seen that the heavy metal pollution around Tongguan mining area, primarily by Hg, Cd, and Pb, was serious. These results can provide data support for regional pollution control, soil remediation, and ecological protection. It is suggested that the state of soil heavy metal pollution and its transformation in various media should be monitored continuously in the future.
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- 2022
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