15 results on '"Hai-li Shen"'
Search Results
2. Role of N-Methyl-D-Aspartate Receptor NR2B Subunit in Inflammatory Arthritis-Induced Chronic Pain and Peripheral Sensitized Neuropathic Pain: A Systematic Review
- Author
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Yu Meng and Hai Li Shen
- Subjects
Anesthesiology and Pain Medicine - Abstract
Arthritis is a common clinical disease that affects millions of people in the world. The most common types of arthritis are osteoarthritis and rheumatoid arthritis. Inflammatory arthritis (IA), a chronic painful disease, is characterized by synovitis and cartilage destruction in the early stages. Pathologically, IA causes inflammatory changes in the joints and eventually leads to joint destruction. Pain is associated with inflammation and abnormal regulation of the nervous system pathways involved in pain promotion and inhibition. In addition, the occurrence of pain is associated with depression and anxiety. We found that there are many factors affecting pain, in addition to inflammatory factors, glutamate receptor may be the possible cause of long-term chronic pain caused by IA. N-methyl-d-aspartate receptor subunit 2B (NR2B) has been reported to involved in IA and nervous system diseases, especially peripheral neuropathic pain. In this review, we summarized the mechanisms of the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor in peripheral nerve sensitization during IA and chronic pain.
- Published
- 2022
3. Shanshui Poetry and Painting in Forming Outbound Tourists’ Perception of Destination Personality: A Netnographic Examination
- Author
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Hai-li Shen and Guo-fang Shi
- Subjects
Painting ,Poetry ,Aesthetics ,Perception ,media_common.quotation_subject ,Personality ,Art ,media_common - Published
- 2020
4. A simple method for removing low-density granulocytes to purify T lymphocytes from peripheral blood mononuclear cells
- Author
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Hanbo Yang, Yu-xin Song, Xiaoming Shu, Rui-xue Duo, Guochun Wang, Hai-li Shen, and Sigong Zhang
- Subjects
Adult ,Male ,0301 basic medicine ,Neutrophils ,T-Lymphocytes ,Cell Separation ,Peripheral blood mononuclear cell ,Dermatomyositis ,Article ,General Biochemistry, Genetics and Molecular Biology ,Flow cytometry ,Arthritis, Rheumatoid ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Cell Adhesion ,medicine ,Humans ,Lupus Erythematosus, Systemic ,General Pharmacology, Toxicology and Pharmaceutics ,Whole blood ,Autoimmune disease ,General Veterinary ,medicine.diagnostic_test ,business.industry ,General Medicine ,T lymphocyte ,Neutrophil extracellular traps ,Middle Aged ,Flow Cytometry ,medicine.disease ,Polymyositis ,030104 developmental biology ,Case-Control Studies ,Rheumatoid arthritis ,Immunology ,Leukocytes, Mononuclear ,Female ,business ,Granulocytes ,030215 immunology - Abstract
Objective: Low-density granulocytes (LDGs) can form neutrophil extracellular traps (NETs) spontaneously and excessively. When peripheral blood mononuclear cells (PBMCs) are used for studying T lymphocytes, LDGs contained in the PBMCs may decrease the threshold of activating T lymphocytes by forming NETs. This study focused on the profiles of LDGs in common autoimmune diseases and methods for removing LDGs from PBMCs. Methods: The percentages of LDGs in PBMCs from 55 patients with dermatomyositis (DM), 15 with polymyositis (PM), 42 with rheumatoid arthritis (RA), 25 with systemic lupus erythematosus (SLE), and 19 healthy controls were determined by flow cytometry. Three methods of removing LDGs were explored and compared. After removal, PBMCs from six patients with positive T-SPOT.TB were tested again to find out if LDGs contained in the PBMCs could influence T lymphocyte reactions. Results: Significantly higher LDG percentages were found in PBMCs from patients with DM ((8.41±10.87)%, P
- Published
- 2017
5. Enhancing Tourist Experience with Smart Tourism— A Case Study of Hangzhou
- Author
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Shun Ye, Wen-Yan Zhao, Qi-Jun Hou, Hai-Li Shen, Jun Zheng, and Zhuo-Wei Tian
- Subjects
Tourism marketing ,ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION ,GeneralLiterature_INTRODUCTORYANDSURVEY ,Value (economics) ,Business ,Destinations ,Marketing ,GeneralLiterature_MISCELLANEOUS ,Tourism ,Connotation - Abstract
The explosive growth of tourism requires destinations to redefine their role in the progress of value co-creation. Smart tourism destination (STD) came up as an efficient solution for enhancing tourism experiences and tourist satisfaction. However, bring smartness into tourism requires dynamic interaction among stakeholders in tourism ecosystems. This paper expounds the connotation of smart tourism, and provides insights for destination managers and policy makers on how they should use innovative technologies in STDs to improve the experience co-creation through a case study of Hangzhou.
- Published
- 2019
6. Clinical efficacy of low-dose rituximab on hematological abnormalities in patients with connective tissue disease
- Author
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Xiao-Yuan Wang, Li-ping Wang, Shao-hua Guo, Chun-yan Wang, and Hai-li Shen
- Subjects
medicine.medical_specialty ,Azathioprine ,Gastroenterology ,Antibodies, Monoclonal, Murine-Derived ,Mixed connective tissue disease ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Pharmacology (medical) ,Connective Tissue Diseases ,Pharmacology ,Lupus erythematosus ,business.industry ,Therapeutic effect ,medicine.disease ,Connective tissue disease ,Thrombocytopenia ,Sjogren's Syndrome ,Treatment Outcome ,Prednisolone ,Rituximab ,Anemia, Hemolytic, Autoimmune ,Autoimmune hemolytic anemia ,business ,medicine.drug - Abstract
Objective To evaluate the efficacy and safety of low-dose rituximab in the treatment of hematologic abnormalities in patients with connective tissue disease. Materials and methods A total of 13 patients with connective tissue disease who did not respond to prednisolone and multiple immunosuppressive agents, or their disease recurred after treatment, were given 100 mg of rituximab only combined with prednisolone once a week for 4 weeks. Then, the therapeutic effects and adverse reactions were respectively observed in the 13 patients. Results Rituximab showed good and rapid efficacy in the treatment of refractory thrombocytopenia and autoimmune hemolytic anemia caused by systemic lupus erythematosus, Sjogren's syndrome, and mixed connective tissue disease. Only 1 patient had urinary tract infection. During 24-month follow-up, disease recurred in 7 patients who still responded to azathioprine/Tripterygium wilfordii. Conclusion Low-dose rituximab has good efficacy and safety in the treatment of hematologic abnormalities in patients with connective tissue disease.
- Published
- 2019
7. Refractory adult-onset Still disease treated by tocilizumab combined with methotrexate
- Author
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Shao-hua Guo, Hai-li Shen, Chun-yan Wang, and Li-ping Wang
- Subjects
Adult ,Male ,safety ,musculoskeletal diseases ,medicine.medical_specialty ,Still's disease ,Administration, Oral ,Observational Study ,Still Disease ,adult-onset Still's disease ,Antibodies, Monoclonal, Humanized ,Gastroenterology ,methotrexate ,tocilizumab ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Tocilizumab ,Pharmacotherapy ,Refractory ,Prednisone ,Internal medicine ,Humans ,Medicine ,030212 general & internal medicine ,skin and connective tissue diseases ,Glucocorticoids ,business.industry ,General Medicine ,Middle Aged ,Treatment Outcome ,chemistry ,Adult-Onset Still Disease ,Antirheumatic Agents ,030220 oncology & carcinogenesis ,Administration, Intravenous ,Drug Therapy, Combination ,Female ,Methotrexate ,business ,Still's Disease, Adult-Onset ,Research Article ,medicine.drug - Abstract
Some patients have poor response to adult-onset Still disease (AOSD) traditional treatment, which easily recurs during the reduction of prednisone. We observed the efficacy and safety of tocilizumab combined with methotrexate (MTX) in the treatment of refractory AOSD, and to explore the possibility of reducing the dosage of tocilizumab after disease control. A total of 28 refractory AOSD cases who had an inadequate response to corticosteroids combined with at least 1 traditional immunosuppressive agent, and even large-dose prednisone could not relieve their conditions after recurrence, were selected in this study. They were treated with tocilizumab (intravenous 8 mg/kg) combined with MTX (oral 12.5 mg once a week). In detail, tocilizumab was firstly given every 4 weeks and after 6-month remission, it was then given every 8 weeks. Some items including body temperature, skin rash, joint swelling and pain, hepatosplenomegaly, blood routine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum ferritin, and dosage of prednisone were observed before treatment as well as 2, 4, 8, 12, 24, 36, and 48 weeks after treatment. The adverse reactions occurring during the treatment were recorded. The body temperature was normal, the skin rash as well as joint swelling and pain disappeared, and laboratory indexes including CRP, ESR, white blood cell, neutrophilic granulocyte, platelet, hemoglobin, and ferritin were significantly improved after 8-week treatment (all P
- Published
- 2019
8. [Correlation of DNase I in serum and synovial fluid with inflammatory activity in patients with rheumatoid arthritis]
- Author
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Xia-Yu, Xu, Wen-Fang, Yang, Si-Gong, Zhang, Qin, Zhao, Li-Jun, Linag, Xin, Wang, and Hai-Li, Shen
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Arthritis, Rheumatoid ,Arthritis, Gouty ,Case-Control Studies ,Osteoarthritis ,Synovial Fluid ,Deoxyribonuclease I ,Humans ,Spondylitis, Ankylosing - Abstract
To investigate the potential role of deoxyribonuclease I (DNase I) in the pathogenesis of rheumatoid arthritis (RA).DNase I activity was measured by radial enzyme-diffusion method in serum samples from 83 RA patients and 60 healthy volunteers and in the synovial fluid (SF) from 27 RA patients and 38 patients with other inflammatory arthritis. SF cfDNA level was measured with Pico Green Kit, and the correlation among DNase I activity, cfDNA level and clinical parameters of RA patients was analyzed.Serum DNase I activity was significantly lower in RA patients than in the healthy control subjects (0.3065∓0.1436 vs 0.4289∓0.1976 U/mL, P0.001), and was negatively correlated with ESR (r=-0.2862, P=0.0122), CRP (r=-0.2790, P=0.0184) and neutrophil cell counts (r=-0.287, P=0.011). SF DNase I activity was almost negative in patients with RA, ankylosing spondylitis (AS) and gouty arthritis (GA). SF cfDNA level in RA patients was significantly higher than that in patients with osteoarthritis (100.81∓142.98 vs 18.98∓31.40 µg/mL, P=0.002), but similar to that in patients with AS (45.85∓47.67 µg/mL, P=0.428) and GA (162.95∓97.49 µg/mL, P=0.132). In patients with inflammatory arthritis, SF cfDNA level was positively correlated with ESR (r=0.4106, P=0.0116) and CRP (r=0.5747, P=0.0002).Impairment of DNase I activity may be responsible for the enhanced NETs generation and plays a role in the pathogenesis of RA.
- Published
- 2016
9. [Progress on rheumatoid arthritis in elderly]
- Author
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Xin, Wang, Qin, Zhao, Zhao-da, Deng, Xiao-Yuan, Wang, Si-Gong, Zhang, and Hai-Li, Shen
- Subjects
Arthritis, Rheumatoid ,Tripterygium ,Anti-Inflammatory Agents, Non-Steroidal ,Age Factors ,Humans ,Medicine, Chinese Traditional ,Aged - Abstract
During choosing non-steroidal anti-inflammatory drugs(NSAIDs), risk factors should be evaluated in elder patients with rheumatoid arthritis. The present study focused on biological therapies, and elderly patients should be more concerned about the risk of infection when used it. Traditional Chinese medicine has advantages of obvious curative effect, especially for tripterygium wilfordii, large clinical trial on western and Chinese medical accurate drug strategies for old patients with rheumatoid arthritis. Old patients are easier to suffer from cardiac diseases and interstitial lung disease, rheumatoid arthritis could be controlled along with the treatment for coexistent disease. The incidence of rheumatoid arthritis in old patients is the same with other RA, and need to treat to target based on the aim of relieve pain and reduce activity of diseases, while the clinical charteristic and treatment target in elder patients with rheumatoid arthritis were not similar with other aged patient, so treatment standard target would vary with aging. Resent clinical studies excluded old patients, lead to lack of evidence-based medicine data. Clinical study for elder patients with rheumatoid arthritis are energetically carrying out, and could provide base and guide for clinical treatment.
- Published
- 2016
10. Abnormally increased low-density granulocytes in peripheral blood mononuclear cells are associated with interstitial lung disease in dermatomyositis
- Author
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Hai-li Shen, Guochun Wang, Qinglin Peng, Xiaoming Shu, and Sigong Zhang
- Subjects
0301 basic medicine ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Peripheral blood mononuclear cell ,Dermatomyositis ,Flow cytometry ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,medicine ,Low density ,Humans ,medicine.diagnostic_test ,business.industry ,Interstitial lung disease ,Neutrophil extracellular traps ,respiratory system ,Middle Aged ,medicine.disease ,Flow Cytometry ,respiratory tract diseases ,030104 developmental biology ,Lung disease ,Immunology ,Leukocytes, Mononuclear ,Female ,business ,Lung Diseases, Interstitial ,Biomarkers ,030215 immunology ,Granulocytes - Abstract
Objective: We previously found that neutrophil extracellular traps (NETs) were associated with interstitial lung disease (ILD) in dermatomyositis (DM) patients. However, it is unclear whether low-density granulocytes (LDGs), endowed with enhanced NET formation capabilities, contribute to the pathogenesis of ILD. This study aims to elucidate the relationship between LDGs and DM-associated ILD. Methods: We recruited 48 DM patients (28 with ILD) as well as 19 healthy volunteers for this study. The percentage of LDGs in peripheral blood mononuclear cells (PBMCs) was ascertained by flow cytometry. Plasma cfDNA was measured by using the Quant-iT PicoGreen dsDNA Kit and plasma LL-37 was tested by using the LL-37 ELISA kit. Results: The percentage of LDGs was 7.1 times higher in DM patients than in healthy controls. LDG percentage was 2.7 times higher in DM patients with ILD than in DM patients without ILD. Additionally, LDG percentage positively correlated with MYOACT lung disease activity scores, and NET/neutrophil-related marker levels (LL-37, cfDNA, MPO, and MMP-8) in the DM group were significantly higher than those in the control group. Conclusion: The abnormal increase of LDGs may exacerbate abnormal NET regulation and further contribute to the pathogenesis of ILD in DM patients by abnormally forming NETs.
- Published
- 2016
11. Amino acid transport system A is involved in inflammatory nociception in rats
- Author
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Jing Wang, Zhi-Ping Wang, Xu Xu, Cuifang Wang, Hai-Li Shen, Jing-Ling Ma, Bin Geng, and Hong Wang
- Subjects
Male ,Amino Acid Transport System A ,Inflammation ,Pharmacology ,Nociceptive Pain ,Rats, Sprague-Dawley ,Glial Fibrillary Acidic Protein ,medicine ,Animals ,Molecular Biology ,Pain Measurement ,chemistry.chemical_classification ,Central Nervous System Sensitization ,Behavior, Animal ,Dose-Response Relationship, Drug ,Chemistry ,General Neuroscience ,Nociceptors ,Transporter ,Spinal cord ,Rats ,Amino acid ,Posterior Horn Cells ,Nociception ,medicine.anatomical_structure ,Spinal Cord ,Anesthesia ,Hyperalgesia ,beta-Alanine ,Neurology (clinical) ,medicine.symptom ,Licking ,Developmental Biology ,Astrocyte - Abstract
Previous studies have indicated that central sensitization is a state of increased excitability of nociceptive neurons in the spinal dorsal horn following peripheral tissue injury and/or inflammation and astrocytes play an important role in the central sensitization. The current study investigated the role of amino acid transport system A in central sensitization and hyperalgesia induced by intraplantar injection of formalin in rats. Formalin (5%, 50μl) injected subcutaneously into the unilateral hindpaw pad induced typical biphase nociceptive behaviors, including licking/biting and flinching of the injected paw and an increase of glial fibrillary acid protein (GFAP, an activated astrocyte marker) expression in spinal dorsal horn, and these effects could be attenuated by intrathecal injection of the competitive inhibitor of amino acid system A transporter, methylaminoisobutyric acid (MeAIB, 0.1, 0.3, 0.5, and 0.7mmol), in a dose-dependent manner. Intrathecal injection of vehicle (PBS) had no effect on the formalin-induced nociceptive behaviors and increase of the GFAP. These findings suggest that amino acid transport system A is involved in inflammation-induced nociception, and inhibition of this transporter system results in inhibition of the central sensitization and hyperalgesia.
- Published
- 2012
12. Cytoskeletal reorganization mediates fluid shear stress-induced ERK5 activation in osteoblastic cells
- Author
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Hai‑li Shen, Yan‑chao Ma, Hui‑juan Cheng, Cui‑fang Wang, Ya‑yi Xia, Hua Han, Jing Wang, and Peng Li
- Subjects
MAPK/ERK pathway ,Osteoblasts ,Mechanosensation ,Kinase ,Down-Regulation ,Cell Biology ,General Medicine ,Biology ,Mechanotransduction, Cellular ,Cell biology ,Intracellular signal transduction ,Focal adhesion ,Mice ,Animals ,Stress, Mechanical ,Mechanotransduction ,Cytoskeleton ,Protein kinase A ,Cells, Cultured ,Mitogen-Activated Protein Kinase 7 - Abstract
Mechanotransduction is a complicated process, of which mechanosensation is the first step. Previous studies have shown that the cytoskeleton plays a crucial role in mechanosensation and the mediation of intracellular signal transduction. However, the mechanism of mechanotransduction in the bone remains elusive. Here, we investigated the potential involvement of a novel MAPK (mitogen-activated protein kinase) member, ERK5 (extracellular-signal-regulated kinase 5), in the response of osteoblastic cells to FSS (fluid shear stress). Our results demonstrated that ERK5 was rapidly phosphorylated in pre-osteoblastic MC3T3-E1 cells upon FSS, and the integrity and reorganization of the cytoskeleton were critical in this process, in which the cytoskeleton-dependent activation of FAK (focal adhesion kinase) may be involved in the activation of ERK5 induced by FSS. Moreover, we found that cytoskeletal disruption led to significant down-regulation of ERK5 phosphorylation, but had no effect on ERK5 nuclear localization. Furthermore, the cytoskeleton rapidly reorganized in response to FSS, but long-time fluid load, even at a physiological level, led to cytoskeletal disruption, suggesting that other pathways may be involved in long-term mechanotransduction. Taken together, our data provide new insight into the mechanisms of mechanosensation by highlighting the link between ERK5 activation and cytoskeletal reorganization in osteoblasts undergoing FSS.
- Published
- 2011
13. Arthroscopic operations in knee joint with early-stage tuberculosis
- Author
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Hai-li Shen, Jing Wang, Hua Han, Ya-Yi Xia, and Peng Li
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Knee Joint ,medicine.medical_treatment ,Biopsy ,Antitubercular Agents ,Pannus ,Synovectomy ,Continuous passive motion ,Injections, Intra-Articular ,Tuberculosis, Osteoarticular ,Arthroscopy ,medicine ,Isoniazid ,Humans ,Orthopedics and Sports Medicine ,medicine.diagnostic_test ,business.industry ,Synovial Membrane ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Exercise Therapy ,Plastic surgery ,medicine.anatomical_structure ,Orthopedic surgery ,Female ,Synovial membrane ,business - Abstract
Due to atypical clinical presentation, wide use of antibiotics and lack of specificity in diagnosis, misdiagnosis is common, and diagnosis of tubercular infection in a joint is increasingly difficult. The use of arthroscopy for the diagnosis and treatment of early-stage knee TB has rarely been reported. Through this case series we describe the usefulness of arthroscopy for the management of synovial tuberculosis of the knee joint.Synovectomy and synovial membrane biopsy were performed using arthroscopy in ten subjects suffering from synovial tuberculosis. This was combined with intra-articular isoniazid injection and systemic antituberculosis drugs.In all cases, continuous passive motion exercise was started 2 days after operation and they were followed up from 6 months to 3 years. The flexion angles 90 degrees +/- 5 degrees preoperatively increased to 120 degrees +/- 14 degrees in nine patients following surgery, the extension limit angle also improved from an average 20 degrees +/- 3 degrees preoperatively to 5 degrees +/- 1 degrees postoperatively. There was a significant difference in knee function index between preoperation and postoperation (t = 6.9, t = 6.3, P0.01). Japanese Institute of Plastic Surgery synovial disease treatment success criteria was also improved from 44.4 +/- 8.4 points before surgery to 81.5 +/- 10.4 following surgery (t = 8.749, P0.01). The joint swelling disappeared or was relieved after 2 months. No relapse of tuberculosis was found at the time of follow-up.Combined use of arthroscopy and antituberculosis medication appears to be advantageous for the management of early-stage synovial tuberculosis of the knee joint. Arthroscopic removal of the pannus allows better nutrition of the cartilage and thus greatly improves the joint function.
- Published
- 2009
14. Arthroscopic operations in knee joint with early-stage tuberculosis.
- Author
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Hai-li Shen, Yayi Xia, Peng Li, Jing Wang, and Hua Han
- Subjects
- *
ARTHROSCOPY , *KNEE surgery , *TUBERCULOSIS treatment , *LUNG surgery , *MYCOBACTERIAL diseases , *PREOPERATIVE care - Abstract
Due to atypical clinical presentation, wide use of antibiotics and lack of specificity in diagnosis, misdiagnosis is common, and diagnosis of tubercular infection in a joint is increasingly difficult. The use of arthroscopy for the diagnosis and treatment of early-stage knee TB has rarely been reported. Through this case series we describe the usefulness of arthroscopy for the management of synovial tuberculosis of the knee joint. Synovectomy and synovial membrane biopsy were performed using arthroscopy in ten subjects suffering from synovial tuberculosis. This was combined with intra-articular isoniazid injection and systemic antituberculosis drugs. In all cases, continuous passive motion exercise was started 2 days after operation and they were followed up from 6 months to 3 years. The flexion angles 90° ± 5° preoperatively increased to 120° ± 14° in nine patients following surgery, the extension limit angle also improved from an average 20° ± 3° preoperatively to 5° ± 1° postoperatively. There was a significant difference in knee function index between preoperation and postoperation ( t = 6.9, t = 6.3, P < 0.01). Japanese Institute of Plastic Surgery synovial disease treatment success criteria was also improved from 44.4 ± 8.4 points before surgery to 81.5 ± 10.4 following surgery ( t = 8.749, P < 0.01) . The joint swelling disappeared or was relieved after 2 months. No relapse of tuberculosis was found at the time of follow-up. Combined use of arthroscopy and antituberculosis medication appears to be advantageous for the management of early-stage synovial tuberculosis of the knee joint. Arthroscopic removal of the pannus allows better nutrition of the cartilage and thus greatly improves the joint function. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
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15. [One hepatic echinococcosis patient complicated with systemic sclerosis].
- Author
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Qin Z, Chun-Yan W, Hai-Li S, Xin W, Li-Jun L, and Jin-Yue L
- Subjects
- Echinococcosis, Hepatic diagnostic imaging, Echinococcosis, Hepatic surgery, Echocardiography, Doppler, Color, Follow-Up Studies, Humans, Male, Middle Aged, Tomography, X-Ray Computed, Echinococcosis, Hepatic complications, Scleroderma, Systemic complications
- Abstract
This article reports one hepatic echinococcosis patient complicated with systemic sclerosis. His clinical manifestations were the progressive fibrosis of the skin, sour regurgitation, and belching. The blood examination showed that eosinophils was reduced, and antinuclear antibody (ANA) was positive at 1:100 in cytoplasm particle type. He was given prednisone acetate 25 mg, q. d., aspirin 100 mg, q. d., centella triterpenes cream 12 mg t. i. d., esomeprazole 40 mg q. d., and domperidone 10 mg t. i. d. After one week, the Rodnan skin score reduced from 27 to 17. The liver hydatid cyst resection was performed, and the follow-up showed that his clinical manifestations improved and the Rodnan skin score reduced further.
- Published
- 2016
- Full Text
- View/download PDF
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