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Abstract Background The Continuum of care for reproductive, maternal, newborn, and child health includes integrated service delivery for mothers and children from pre-pregnancy to delivery, the immediate postnatal period, and childhood. In Ethiopia, the magnitude of antenatal care, skilled delivery, postnatal care, and immunization for children have shown improvement. Despite this, there was limited research on the percentage of mothers who have completed maternal and child continuum care. Objective To assess the Completion of Maternal and Child Health Continuum of Care and Associated Factors among women in Gode District, Shebele Zone, Eastern Ethiopia ,2022. Method A community-based cross-sectional study design applied from November 1–15, 2022. A stratified sampling method was applied. A woman who had two 14–24 months child preceding the data collection period were included in the study. An interviewer-administered semi-structured questioner had been used for data collection. Data collected by using kobo collect and analyzed using STATA version 17. Both Bivariable and multivariable logistic regression analyses were done. In multivariable analysis, variables having P-values ≤ 0.05 were taken as factors associated with the completion of the maternal and child health continuum of care. Result The Completion of maternal and child continuum of care was 13.5% (10.7-17.0%) in Gode district,2022. Accordingly, Husband occupation (Government employee) [AOR = 2.3, 95%CI 1.2–4.7] and perceived time to reach health facility (less than 30 min) [AOR = 2.96, 95%CI 1.2–7.5] were factors showing significant association with maternal and child health continuum of care among mothers in Gode district, Somali regional State;2022 at P-value ≤ 0.05. Conclusion and recommendation Only 13.5% of mothers in Gode district received all of the recommended maternal and child health services during their pregnancy, childbirth, and postpartum period. The study found that two factors were associated with a higher likelihood of receiving Maternal and child continuum of care: Government employed husband and perceived time to reach a health facility. Governments can play a key role in increasing the maternal and child health continuum of care by investing by making health care facility accessible.

Generation Z has graduated and in some cases is still in college according to Seemiller and Grace (2016), who define the generation range from 1995-2010. A defining characteristic of Generation Z is that they grew up with technology. They are so involved or comfortable with technology that they "expect" it. Parents lament the lack of reading and the enormous dependence on video, gaming, and visual methods of delivery. As a result, the delivery of a traditional course using lecture, quizzes, and tests is not perceived as a "good" course by students. It also likely that retention will be greater using non-traditional methods. This manuscript describes our use of student-prepared videos for a variety of student assignments.

Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity. This study aims to thoroughly evaluate a highly sensitive resazurin phenoxazine‐based cell viability potency assay (measurement of the cellular redox metabolism) for quantifying the cytotoxicity of NK‐EVs against leukaemia K562 cells (suspension model) and breast cancer MDA‐MB‐231 cells (adherent model) in vitro. The assay was evaluated based on common analytical parameters setforth by regulatory guidelines, including specificity, selectivity,accuracy, precision, linearity, range and stability. Our results revealed that this resazurin‐based cell viability potency assay reliably and reproducibly measured a dose‐response of NK‐EVs' cytotoxic activity against both cancer models. The assay showed precision with 5% and 20% variation for intra‐run and inter‐run variability. The assay signal showed specificity and selectivity of NK‐EVs against cancer target cells, as evidenced by the diminished viability of cancer cells following a 5‐hour treatment with NK‐EVs, without any detectable interference or background. The linearity analysis of target cancer cells revealed strong linearity for densities of 5000 K562 and 1000 MDA‐MB‐231 cells per test with a consistent range. Importantly, NK‐EVs' dose‐response for cytotoxicity showed a strong correlation (|ρ| ∼ 0.8) with the levels of known cytotoxic factors associated with the NK‐EVs' corona (FasL, GNLY, GzmB, PFN and IFN‐γ), thereby validating the accuracy of the assay. The assay also distinguished cytotoxicity changes in degraded NK‐EVs, indicating the ability of the assay to detect the potential loss of sample integrity. Compared to other commonly reported bioassays (i.e., flow cytometry, cell counting, lactate dehydrogenase release assay, DNA‐binding reporter assay and confluence assay), our results support this highly sensitive resazurin‐based viability potency assay as a high‐throughput and quantitative method for assessing NK‐EVs' cytotoxicity against both suspension and adherent cancer models for evaluating NK‐EVs' biotherapeutics. [ABSTRACT FROM AUTHOR]

Background Partograph is a simple, inexpensive & economical tool that provides a continuous graphical overview of labour and prevents prolonged and obstructed labor. The purpose of the study is to assess partograph utilization and associated factors among obstetric care givers in governmental health institutions of Jigjiga and Degehabur Towns, Somali Region, Ethiopia. Methods An institution based cross-sectional quantitative study was carried out among obstetric care givers who were working in governmental health institutions. Systematic random sampling with proportional to size allocation was used to recruit a total of 235 study participants. Self-administered questionnaire was used to collect data in this study. Three data collectors and one supervisor were recruited and trained to facilitate the data collection activities. Data were entered into Epi data software and exported into SPSS (23.0) for analysis. Descriptive statistics, bivariate and multivariate logistic regression were computed to determine proportions and significant association with partograph utilization among obstetric care givers. Result Less than half of obstetric care givers, 41% (95%CI: 34.5–46.9) had good partograph utilization to monitor progress of labor. Being female [AOR = 2.36, 95%CI:(1.03–5.44)], availability of partograph [AOR = 4.633, 95%CI: (1.698–12.640)], having good knowledge [AOR = 6.90, 95%CI:(2.62–18.18)], receiving on job training [AOR = 15.46, 95%CI:(6.95–34.42)] and positive attitude towards partograph [AOR = 2.99, 95%CI:(1.25–7.14)] were significantly associated with partograph utilization. Conclusion Partograph utilization in this study was low. Especial emphasizes and interventions should be given to periodic on job training that improve knowledge and attitude of obstetric care givers to increase partograph utilization.

Purpose: Sexual assault is a prevalent and persistent problem in the military, yet few studies have examined predictors of sexual offenses. The study aim was to determine pre-service factors associated with sexual offense conviction among U.S. Marines. Methods: This retrospective cohort study analyzed data from male active duty U.S. Marines (2003–2018). Pre-service factors were assessed using survey data from the Recruit Assessment Program, obtained prior to recruit training at the Marine Corps Recruit Depot, San Diego, California. These survey data were linked with sexual offense conviction data obtained from the Naval Criminal Investigative Service Consolidated Law Enforcement Operations Center. Results: Of the 146,307 participants, the majority were 18–19 years old (66.7%) and non-Hispanic, White (62.1%) with a high school education or less (76.8%); 107 received convictions for a sexual offense. In unadjusted analyses, race and ethnicity, parental education, type of primary caregiver, parental death, family economic status, childhood emotional trauma, childhood physical abuse, childhood sexual abuse, and unprotected sex were associated with a sexual offense conviction. In the final multivariable model, race and ethnicity (American Indian/Alaskan Native, odds ratio [OR]: 5.28, 95% confidence interval [CI]: 1.86–14.98; Hispanic, OR: 1.83, 95% CI: 1.06–3.18; multiracial/other, OR: 3.28, 95% CI: 1.56–6.89), education (≤ high school, OR: 2.65; 95% CI: 1.21–5.80), parental death (OR: 2.27; 95% CI: 1.16–4.45), unprotected sex (OR: 1.78; 95% CI: 1.03–3.05), and school suspension/expulsion (OR: 1.64; 95% CI: 1.02–2.65) were significant predictors of a subsequent sexual offense conviction. Conclusions: Results underscore the importance of understanding factors associated with sexual offense and highlight the large discrepancy between self-reported estimates of sexual assault and sexual offense convictions. Findings may inform the development of effective strategies to reduce sexual misconduct, such as technology-facilitated programs that provide private, targeted education; supportive assistance; and prevention materials to individuals who may have elevated sexual misconduct risk. [ABSTRACT FROM AUTHOR]

The research by Tekleab et al. (2005) illustrates the importance of key construct selection in the chain of relationships among justice (procedural and interactional), social exchange, and employee reactions. In our analysis, we closely replicated the authors' results, highlighting the pivotal role psychological contract violations (PCV) play in initiating turnover intentions that are followed by actual terminations. A longitudinal study offered the ability to make stronger inferences regarding causality in the relationships connecting justice, social exchange, and employee reactions, which is significantly more important in the gig economy. In replicating and developing alternative models, interactional justice was found to be very important in conditioning the leader-member exchange, which frames employees' perceptions about the efficacy of their managers in helping them succeed in their work, as well as perceived organizational support, which impact job satisfaction. These interconnected interactions are becoming more important as economies shift towards smart industrial product service system configurations accompanied by fast transitioning sociotechnical paradigm shifts such as Industry 4.0 and Industry 5.0. [ABSTRACT FROM AUTHOR]

This paper reviews and replicates Spreitzer's (1995) study entitled "Psychological empowerment in the workplace: Dimensions, measurement, and validation." We extended this work and present alternative solutions and insights. We propose seven alternative hypotheses and sub-hypotheses resulting in 14 alternative hypotheses to Spreitzer 's work (presented in the appendix for convenience). [ABSTRACT FROM AUTHOR]

Background: Common mental disorder (CMD) is prevalent in industrialized and non-industrialized countries. The prevalence of CMD among university students was 28.8-44.7% and attributed to several risk factors, such as schooling. The aim of this study was to assess the prevalence and risk factors of CMD. In addition, the association between CMD and academic performance was tested. Methods: Institution based cross-sectional study was conducted with 422 students at Debre Berhan university from March to April 2015. CMD was the primary outcome variable whereas academic performance was the secondary outcome variable. Kessler psychological distress (K10) scale was used to assess CMD. Bivariate and multiple logistic regression analysis were performed for modeling the primary outcome variable; independent samples T test and linear regression analysis were carried out for modeling the secondary outcome variable. The strength of association was interpreted using odds ratio and regression coefficient (β) and decision on statistical significance was made at a p value of 0.05. Data were entered using EPI-data version 3.1 software and analyzed using the Statistical Package for the Social Sciences (SPSS) version 20.01 software. Results: The prevalence of CMD was 63.1%. Field of study (p = 0.008, OR = 0.2, 95% CI 0.04-0.61), worshiping (p = 0.04, OR = 1.8, 95% CI 1.02-3.35), insomnia (p < 0.001, OR = 3.8, 95% CI 2.21-6.57), alcohol drinking (p = 0.006, OR = 2.7, 95% CI 1.33-5.66), and headache (p = 0.02, OR = 2.1, 95% CI 1.10-3.86) were identified risk factors for CMD. The mean cumulative grade point average of students with CMD was lower by 0.02 compared to those without CMD, but not statistically significant (p = 0.70, β = -0.02, 95% CI -0.15 to 0.10). CMD explained only 0.8% (r² = 0.008) of the difference in academic performance between students. Conclusions: At least three out of five students fulfilled CMD diagnostic criteria. The statistically significant risk factors were Feld of study, worshiping, insomnia, alcohol drinking, and headache. Moreover, there was no statistically significant association between CMD and academic performance. Undertaking integrated evidence-based intervention focusing on students with poor sleep quality, poor physical health, and who drink alcohol is essential if the present finding confirmed by a longitudinal study. [ABSTRACT FROM AUTHOR]

Introduction: U.S. military personnel have a high prevalence of alcohol misuse, which can adversely affect force readiness. The objective of this study was to identify pre-service predictors of new-onset alcohol misuse among male Marines., Methods: Data for this retrospective cohort study were collected from male U.S. Marines who completed a baseline survey at the beginning of military training from 2013 to 2021 and a standard health assessment 12-36 months later (n=28,337). An Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) score ≥4 indicated alcohol misuse. Independent predictors of alcohol misuse were evaluated using a modified Poisson regression to calculate adjusted risk ratios (aRRs) and 95% CIs. Analyses were conducted between 2022 and 2024., Results: The incidence of new-onset alcohol misuse was 16.3% (n=4,632). In the final multivariable model, the strongest predictor of new-onset alcohol misuse was turning 21 years old during the study period (aRR 3.70, 95% CI: 3.40-4.03). Pre-service tobacco use (aRR 1.32, 95% CI: 1.22-1.43) and some pre-service alcohol use (AUDIT-C score 1-3: aRR 1.32, 95% CI: 1.24-1.40) were also associated with new-onset alcohol misuse., Conclusions: Multiple pre-service predictors were associated with new-onset alcohol misuse in male Marines. These findings should be considered when screening for alcohol misuse and developing clinical interventions to mitigate adverse impacts of alcohol misuse in the military., Competing Interests: Declaration of Interests No conflicts of interest were reported by the authors of this paper. The study sponsors had no role in study design; collection, analysis, and interpretation of data; writing the report; nor the decision to submit the report for publication. No financial disclosures have been reported by the authors of this paper., (Copyright © 2024. Published by Elsevier Inc.)

Toxic epidermal necrolysis (TEN) is a rare, acute inflammatory skin reaction that results in skin blistering and extensive epidermal detachment. Stevens-Johnson syndrome (SJS) and TEN are unified aspects on a spectrum varying in the severity of vesiculobullous cutaneous eruptions with mucosal involvement of the oral cavity, genitourinary tract, gastrointestinal tract, and conjunctiva. The inciting event is usually caused by an exaggerated hypersensitivity reaction in response to triggering medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, urate-lowering drugs (such as allopurinol), anticonvulsants, and antipsychotics. We report a case of clindamycin-induced TEN in a 79-year-old African-American female following the recent administration of clindamycin for a developing sacral decubitus ulcer. However, lincosamide antibiotics like clindamycin are rarely associated with precipitating SJS or TEN. This report highlights the treatment and prognostic challenges faced throughout the patient's clinical course and seeks to highlight the importance of recognizing the development of SJS/TEN following novel drug administration and promptly addressing the management of the condition to improve long-term patient outcomes., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. HCA Healthcare Institutional Review Board issued approval 2024-189. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: This research was supported (in whole or in part) by the HCA Healthcare and/or an HCA Healthcare-affiliated entity. The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities., (Copyright © 2024, Scally et al.)