1. Irisin promotes hair growth and hair cycle transition by activating the GSK-3β/β-catenin pathway.
- Author
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Kim Y, Lee JM, Jang YN, Park AY, Kim SY, Kim BJ, and Lee JO
- Subjects
- Animals, Humans, Mice, Lymphoid Enhancer-Binding Factor 1 metabolism, Cell Proliferation, Wnt-5a Protein metabolism, Wnt Proteins metabolism, Male, Female, Proto-Oncogene Proteins, Fibronectins metabolism, Glycogen Synthase Kinase 3 beta metabolism, Wnt Signaling Pathway, Hair growth & development, beta Catenin metabolism, Hair Follicle growth & development, Hair Follicle metabolism, Mice, Inbred C57BL
- Abstract
Hair loss affects men and women of all ages. Myokines, which are mainly secreted by skeletal muscles during exercise, have numerous health benefits. VEGF, IGF-1, FGF and irisin are reprehensive myokines. Although VEGF, IGF-1 and FGF are positively associated with hair growth, few studies have researched the effects of irisin on hair growth. Here, we investigated whether irisin promotes hair growth using in vitro, ex vivo and in vivo patch assays, as well as mouse models. We show that irisin increases proliferation, alkaline phosphatase (ALP) activity and mitochondrial membrane potential in human dermal papilla cells (hDPCs). Irisin activated the Wnt/β-catenin signalling pathway, thereby upregulating Wnt5a, Wnt10b and LEF-1, which play an important role in hair growth. Moreover, irisin enhanced human hair shaft elongation. In vivo, patch assays revealed that irisin promotes the generation of new hair follicles, accelerates entry into the anagen phase, and significantly increases hair growth in C57BL/6 mice. However, XAV939, a Wnt/β-catenin signalling inhibitor, suppressed the irisin-mediated increase in hair shaft and hair growth. These results indicate that irisin increases hair growth via the Wnt/β-catenin pathway and highlight its therapeutic potential in hair loss treatment., (© 2024 The Author(s). Experimental Dermatology published by John Wiley & Sons Ltd.)
- Published
- 2024
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