1. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent.
- Author
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Li L, Hajam I, McGee JS, Tang Z, Zhang Y, Badey N, Mintzer E, Zhang Z, Liu GY, Church GM, and Wang Y
- Subjects
- Animals, Mice, Humans, S100 Calcium Binding Protein A7 metabolism, S100 Calcium Binding Protein A7 genetics, Calgranulin A genetics, Calgranulin A metabolism, Calgranulin B genetics, Calgranulin B metabolism, Transcriptome, S100 Proteins genetics, S100 Proteins metabolism, Carrier Proteins genetics, Carrier Proteins metabolism, Disease Models, Animal, Up-Regulation, Acne Vulgaris drug therapy, Acne Vulgaris genetics, Zinc therapeutic use, Zinc metabolism, Rosacea drug therapy, Rosacea genetics, Hidradenitis Suppurativa drug therapy, Hidradenitis Suppurativa genetics, Gene Expression Profiling
- Abstract
Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular parallels and disparities among these three disorders can yield invaluable insights for refined diagnostics, effective management, and targeted therapeutic interventions. In this report, we present a comparative analysis of transcriptomic data across these three diseases, elucidating differentially expressed genes and enriched pathways specific to each ailment, as well as those shared among them. Specifically, we identified multiple zinc-binding proteins (SERPINA1, S100A7, S100A8, S100A9 and KRT16) as consistently highly upregulated genes across all three diseases. Our hypothesis suggests that these proteins could bind and sequester zinc, potentially leading to localized zinc deficiency and heightened inflammation. We identified high-dose dietary zinc as a promising therapeutic approach and confirmed its effectiveness through validation in an acne mouse model., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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