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3. Synthesis of 1,5-Disubstituted 1 H-Tetrazole Derivatives via a Three-Component Reaction of Carbodiimides, Isocyanides, and Trimethylsilyl Azide.

Author

Kazemizadeh, Ali Reza, Hajaliakbari, Nasrin, Hajian, Roghayeh, Shajari, Nahid, and Ramazani, Ali

Abstract

The three-component reaction of isocyanides 1, carbodiimides 2, and trimethylsilyl azide ( 3) occurs at room temperature, and the produced 1,5-disubstituted 1 H-tetrazole derivatives 4 are formed in 81-98% yields ( Scheme 1, Table). The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions are observed. [ABSTRACT FROM AUTHOR]

Published
2012
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