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Abstract Phenomenological aspects of non-invertible symmetries, in particular the flavor structure of quarks and leptons, are studied. We start with a ℤ M discrete symmetry and gauge ℤ2 so as to obtain a non-invertible symmetry. We study which Yukawa textures can be derived from the non-invertible symmetries. Various textures can be realized and some of them cannot be realized by a conventional symmetry. For example, the nearest neighbor interaction texture as well as other interesting textures of quarks and leptons are obtained.

Abstract We study the flavor structures of zero-modes, which are originated from the modular symmetry on T 1 2 × T 2 2 $$ {T}_1^2\times {T}_2^2 $$ and its orbifold with magnetic fluxes. We introduce the constraint on the moduli parameters by τ 2 = Nτ 1, where τ i denotes the complex structure moduli on T i 2 $$ {T}_i^2 $$ . Such a constraint can be derived from the moduli stabilization. The modular symmetry of T 1 2 × T 2 2 $$ {T}_1^2\times {T}_2^2 $$ is SL 2 ℤ τ 1 × SL 2 ℤ τ 2 ⊂ Sp 4 ℤ $$ \textrm{SL}{\left(2,\mathbb{Z}\right)}_{\tau_1}\times \textrm{SL}{\left(2,\mathbb{Z}\right)}_{\tau_2}\subset \textrm{Sp}\left(4,\mathbb{Z}\right) $$ and it is broken to Γ0(N) × Γ0(N) by the moduli constraint. The wave functions represent their covering groups. We obtain various flavor groups in these models.

Abstract We discuss non-invertible symmetries in toroidal compactifications of higher dimensional Yang-Mills theory with magnetic fluxes, which can be regarded as an effective action of type IIB string theory with magnetized D-branes. Specifically, we derive fusion rules of discrete isometry operators, which are invariant under the ℤ N orbifold twist. It turns out that degenerate chiral zero-modes non-trivially transform under the non-invertible symmetries in the context of quantum mechanics. Hence, non-invertible symmetries correspond to flavor symmetries of chiral zero modes and determine their flavor structure. We explicitly show the representations and selection rules of chiral zero modes on their wave functions. These zero modes may correspond to generations of quarks and leptons in four-dimensional low-energy effective field theory.

Abstract We study the stabilization of a twisted modulus in Type IIB flux compactifications on a mirror of the rigid Calabi-Yau threefold. By analyzing the effective action of twisted and untwisted moduli, we find that three-form fluxes satisfying the tadpole cancellation conditions lead to supersymmetric AdS vacua. We also investigate swampland conjectures on this non-geometric background.

Abstract We study the realization of spontaneous CP violation through moduli stabilization. In modular flavor models, the source of CP violation is the vacuum expectation values of the complex structure moduli of toroidal compact space. We demonstrate that the combined effects of Type IIB flux compactifications with modular invariant couplings between the moduli and matter fields can induce spontaneous CP violation without or with supersymmetry breaking. Furthermore, some general properties of CP and modular invariant scalar potentials are presented. It is found that certain modifications or partial breakings of modular symmetry are useful in generating spontaneous CP violation.

Abstract We study the modular symmetry in heterotic string theory on Calabi-Yau threefolds. In particular, we examine whether moduli-dependent holomorphic Yukawa couplings are described by modular forms in the context of heterotic string theory with standard embedding. We find that SL(2, ℤ) modular symmetry emerges in asymptotic regions of the Calabi-Yau moduli space. The instanton-corrected holomorphic Yukawa couplings are then given by modular forms under SL(2, ℤ) or its congruence subgroups such as Γ0(3) and Γ0(4). In addition to the modular symmetry, it turns out that another coupling selection rule controls the structure of holomorphic Yukawa couplings. Furthermore, the coexistence of both the positive and negative modular weights for matter fields leads to a hierarchical structure of matter field Kähler metric. Thus, these holomorphic modular forms and the matter field Kähler metric play an important role in realizing a hierarchical structure of physical Yukawa couplings.

Abstract We study the well-known type IIA intersecting D-brane models on the T 6 / ℤ 2 × ℤ 2 ′ $$ {T}^6/\left({\mathbb{Z}}_2\times {\mathbb{Z}}_2^{\prime}\right) $$ orientifold via a machine-learning approach. We apply several autoencoder models with and without positional encoding to D6-brane configurations satisfying certain concrete models described in ref. [1] and attempt to extract some features which the configurations possess. We observe that the configurations cluster in two-dimensional latent layers of the autoencoder models and analyze which physical quantities are relevant to the clustering. As a result, it is found that tadpole charges of hidden D6-branes characterize the clustering. We expect that there is another important factor because a checkerboard pattern in two-dimensional latent layers is observed in the clustering.

Abstract We study primordial electromagnetic fields in effective actions of string theory. In contrast to a conventional scenario of producing primordial electromagnetic fields induced by the axion inflation, we deal with the Dirac-Born-Infeld action as a non-linear generation of Maxwell theory. It turns out that the intensity of generated electromagnetic fields is bounded from above by the string scale which can also be rewritten in terms of supersymmetry breaking scale in the context of type IIB Large Volume Scenario. The instability parameter ξ is constrained by the tadpole cancellation condition of D3-branes and a realization of hierarchy between the string scale and the Hubble scale of inflation. Hence, the magnetogenesis can be realized in the limited corner of the string landscape due to the O $$ \mathcal{O} $$ (1) value of the coefficient of Chern-Simons coupling.

We derive verifiable two-zero textures in the framework of a three-loop induced neutrino mass model applying a modular A4 symmetry for the lepton sector. Interestingly, the neutrino mass structure is determined by assignments of the right-handed charged-lepton particles only. We show all the possible texture patterns and demonstrate their analytical and numerical analyses. Finally, we mention a possibility of detection for doubly-charged boson via colliders that decays into specific modes due to the flavor symmetry.

Abstract We study structures of solutions for SUSY Minkowski F-term equations on two toroidal orientifolds with h 2,1 = 1. Following our previous study [1], with fixed upper bounds of a flux D3-brane charge N flux, we obtain a whole Landscape and a distribution of degeneracies of physically-distinct solutions for each case. In contrast to our previous study, we consider a non-factorizable toroidal orientifold and its Landscape on which SL(2, ℤ) is violated into a certain congruence subgroup, as it had been known in past studies. We find that it is not the entire duality group that a complex-structure modulus U enjoys but its outer semi-direct product with a “scaling” outer automorphism group. The fundamental region is enlarged to include the |U| < 1 region. In addition, we find that high degeneracy is observed at an elliptic point, not of SL(2, Z) but of the outer automorphism group. Furthermore, ℤ2-enhanced symmetry is realized on the elliptic point. The outer automorphism group is exceptional in the sense that it is consistent with a symplectic basis transformation of background three-cycles, as opposed to the outer automorphism group of SL(2, ℤ). We also compare this result with Landscape of another factorizable toroidal orientifold.

Abstract We propose an upper bound on the Atiyah-Singer index in the effective action of string theory. For E 8 × E 8 ′ $$ {E}_8^{\prime } $$ and SO(32) heterotic string theories on smooth Calabi-Yau threefolds with line bundles, we find that the tadpole cancellation and supersymmetry conditions lead to an upper bound on the generation number of quarks and leptons as well as Higgs doublets. By taking into account the observed value of four-dimensional gauge couplings and the supergravity approximation, we explicitly evaluate the bound on favorable complete intersection Calabi-Yau threefolds. The bound can be extended to Calabi-Yau threefolds in the Kreuzer-Skarke database. We also put the upper bound on the Atiyah-Singer index in Type IIB/F-theory compactifications.

Abstract Sequestering is a promising mechanism in 4D string models to reconcile high-scale inflation with low-energy supersymmetry. In this scenario the MSSM lives on branes at singularities and it is sequestered from the sources of supersymmetry breaking in the bulk. The soft-terms are suppressed with respect to the gravitino mass so that all moduli are heavy enough to avoid any cosmological moduli problem. In this paper we study stability bounds and flavour constraints on sequestered string models, finding that they can be satisfied if the soft-terms give rise to a mass spectrum typical of split supersymmetry with TeV-scale gauginos and sfermions around 107 GeV. When instead scalar and gaugino masses are of the same order of magnitude, large flavour changing neutral currents can be avoided only by pushing the soft-terms above 106 GeV. However this scenario is in tension with stability bounds due to the presence of charge and colour breaking vacua which could be populated in the early universe, and the possible emergence of directions along which the potential is unbounded from below.

Abstract We propose an interesting assignment of positive modular weights for fields in a modular non-Abelian discrete flavor symmetry. By this assignment, we can construct inverse seesaw and linear seesaw models without any additional symmetries which possess good testability in current experiments. At first, we discuss possibilities for positive modular weights from a theoretical point of view. Then we show concrete examples of inverse seesaw and linear seesaw scenarios applying modular A 4 symmetry as examples and demonstrate some predictions as well as consistency with experimental results such as neutrino masses and mixings.

Abstract We examine symmetries of chiral four-dimensional vacua of Type IIB flux compactifications with vanishing superpotential W = 0. We find that the N $$ \mathcal{N} $$ = 1 supersymmetric MSSM-like and Pati-Salam vacua possess enhanced discrete symmetries in the effective action below the mass scale of stabilized complex structure moduli and dilaton. Furthermore, a generation number of quarks/leptons is small on these vacua where the flavor, CP and metaplectic modular symmetries are described in the framework of eclectic flavor symmetry.

Abstract We propose a method to explore the flavor structure of quarks and leptons with reinforcement learning. As a concrete model, we utilize a basic value-based algorithm for models with U(1) flavor symmetry. By training neural networks on the U(1) charges of quarks and leptons, the agent finds 21 models to be consistent with experimentally measured masses and mixing angles of quarks and leptons. In particular, an intrinsic value of normal ordering tends to be larger than that of inverted ordering, and the normal ordering is well fitted with the current experimental data in contrast to the inverted ordering. A specific value of effective mass for the neutrinoless double beta decay and a sizable leptonic CP violation induced by an angular component of flavon field are predicted by autonomous behavior of the agent. Our finding results indicate that the reinforcement learning can be a new method for understanding the flavor structure.

Abstract We study slow-roll inflation model controlled by the modular flavor symmetry. In the model, the modulus field plays a role of inflaton and the introduction of the stabilizer field coupled to a modular form in the superpotential produces the inflaton potential. In order to generate the flat direction for the slow-roll inflation, we consider the Kähler potential corrected by the modular form. It is noted that the modulus field perpendicular to the inflaton direction is stabilized during the inflation. The model turns out to be consistent with the current observations and behaves similarly to the α-attractor models in some parameter spaces. The inflaton rolls down to the CP-symmetric vacuum at the end of inflation.

Abstract We investigate effects of the radiation and the moduli oscillation around the stabilized values on the evolution of a 6-dimensional spacetime compactified on S 2. In order to see the transition from the 5-dimensional space to the 3-dimensional one, we develop a procedure to pursue the spacetime evolution with appropriate approximations, which is valid until the spacetime behaves like 4-dimensional. In the case that the moduli stabilization process cannot be described in the context of the 4-dimensional effective theory, it takes quite a long time for the moduli oscillation to dominate the total energy density, in contrast to the conventional result obtained by the 4-dimensional effective theory approach. We also found that even if the moduli are set at the stabilized values, they start to oscillate due to the pressure in the extra space S 2 in some cases.

Abstract We revisit the modular weights in type IIB magnetized D-brane models. The simple analysis of wave function shows that the four-dimensional matter fields have the modular weight -1/2, but it may shift as one in type IIA intersecting D-brane models. For example, the localized gauge flux as well as the localized curvature can shift the modular weight in the magnetized D-brane models. Such corrections do not affect physical couplings such as physical Yukawa couplings. However, it leads to differences in supersymmetry breaking sfermion masses, which depend on the modular weights, although the A-term coefficients and the sum of sfermion masses squared seem to be the same between two models.

Abstract We study a symmetry breaking of residual flavor symmetries realized at fixed points of the moduli space. In the supersymmetric modular invariant theories, a small departure of the modulus from fixed points is required to realize fermion mass hierarchies and sizable CP-breaking effects. We investigate whether one can dynamically fix the moduli values in the vicinity of the fixed points in the context of Type IIB string theory. It is found that the string landscape prefers |δτ| ≃ 10 −5 for the deviation of the complex structure modulus from all fixed points and the CP-breaking vacuum is statistically favored. To illustrate phenomenological implications of distributions of moduli values around fixed points, we analyze the lepton sector on a concrete A 4 modular flavor model.

Abstract We study the lepton flavor violation (LFV), the leptonic magnetic moments (g − 2) μ, e and the electric dipole moment (EDM) of the electron in the Standard-Model Effective Field Theory with the Γ N modular flavor symmetry. We employ the stringy Ansatz on coupling structure that 4-point couplings of matter fields are written by a product of 3-point couplings of matter fields. We take the level 3 finite modular group, Γ3 for the flavor symmetry, and discuss the dipole operators at nearby fixed point τ = i, where observed lepton masses and mixing angles are well reproduced. Suppose the anomaly of the anomalous magnetic moment of the muon to be evidence of the new physics (NP), we have related it with (g − 2) e , LFV decays, and the electron EDM. It is found that the NP contribution to (g − 2) e is proportional to the lepton masses squared likewise the naive scaling. We also discuss the correlations among the LFV processes μ → eγ, τ → μγ and τ → eγ, which are testable in the future. The electron EDM requires the tiny imaginary part of the relevant Wilson coefficient in the basis of real positive charged lepton masses, which is related to the μ → eγ transition in our framework.

Abstract We investigate the time evolution of the background spacetime during the moduli stabilization process, which is assumed to occur in the radiation dominated era. The setup is basically the Salam-Sezgin model, but we add a potential term for the dilaton in order to stabilize the moduli completely. We numerically solve the higher-dimensional background field equations, including a case that the stabilization process cannot be described within the 4D effective theory. In contrast to the conventional 4D effective theory analysis, we find that when the mass scale of the stabilization is larger than the compactification scale, the radiation contribution to the total energy density remains to be non-negligible for a much longer time than the stabilization time scale. As a result, the non-compact 3D space expands slower than the matter dominated universe. We also find the equation of state for the radiation w rad remains to be smaller than 1/3 for a long time, which indicates that the radiation still feels the extra dimensions for a while even after the moduli are stabilized.

Abstract Background Cavitary lesions pathologically diagnosed as adenocarcinoma in situ (AIS) have been rarely reported. The examination of these type of lesions is necessary for a better understanding of the mechanisms underlying their formation and development of more efficient diagnostic and treatment strategies. Here, we present the case of a patient with cavitary lung carcinoma, diagnosed as AIS, who underwent partial resection. Case presentation A 72-year-old man presented with an abnormal shadow on chest radiography. Computed tomography findings showed a nodule in the right upper lobe, which was later diagnosed as an adenocarcinoma via transbronchial biopsy. A thin-walled cavity with partial thickening in the right lower lobe was also noted. We suspected that the thin-walled cavitary lesion was malignant, and performed wedge resection during a right upper lobectomy. AIS was diagnosed based on the histopathological findings of the thickened part of the thin-walled cavity. Conclusions This study highlights that, although rare, AIS may be observed in cavitary lung carcinoma cases, particularly in thin-walled lesions.

Abstract We examine a common origin of four-dimensional flavor, CP, and U(1) R symmetries in the context of heterotic string theory with standard embedding. We find that flavor and U(1) R symmetries are unified into the Sp(2h + 2, ℂ) modular symmetries of Calabi-Yau threefolds with h being the number of moduli fields. Together with the ℤ 2 CP $$ {\mathbb{Z}}_2^{\mathrm{CP}} $$ CP symmetry, they are enhanced to GSp(2h + 2, ℂ) ≃ Sp(2h + 2, ℂ) ⋊ ℤ 2 CP $$ {\mathbb{Z}}_2^{\mathrm{CP}} $$ generalized symplectic modular symmetry. We exemplify the S 3 , S 4 , T′, S 9 non-Abelian flavor symmetries on explicit toroidal orbifolds with and without resolutions and ℤ2 , S 4 flavor symmetries on three-parameter examples of Calabi-Yau threefolds. Thus, non-trivial flavor symmetries appear in not only the exact orbifold limit but also a certain class of Calabi-Yau three-folds. These flavor symmetries are further enlarged to non-Abelian discrete groups by the CP symmetry.

Abstract We study the minimal flavor violation in the context of string effective field theory. Stringy selection rules indicate that n-point couplings among fermionic zero-modes and lightest scalar modes in the string effective action are given by a product of Yukawa couplings which are regarded as spurion fields of stringy and geometrical symmetries. Hence, Yukawa couplings determine the dynamics of flavor and CP violations. This observation strongly supports the hypothesis of minimal flavor violation in the Standard Model effective field theory.

Abstract We investigate the vacuum structure of four-dimensional effective theory arising from Type IIB flux compactifications on a mirror of the rigid Calabi-Yau threefold, corresponding to a T-dual of the DeWolfe-Giryavets-Kachru-Taylor model in Type IIA flux compactifications. By analyzing the vacuum structure of this interesting corner of string landscape, it turns out that there exist perturbatively unstable de Sitter (dS) vacua in addition to supersymmetric and non-supersymmetric anti-de Sitter vacua. On the other hand, the stable dS vacua appearing in the low-energy effective action violate the tadpole cancellation condition, indicating a strong correlation between the existence of dS vacua and the flux-induced D3-brane charge (tadpole charge). We also find analytically that the tadpole charge constrained by the tadpole cancellation condition emerges in the scalar potential in a nontrivial way. Thus, the tadpole charge would restrict the existence of stable dS vacua, and this fact underlies the statement of the dS conjecture. Furthermore, our analytical and numerical results exhibit that distributions of O 1 $$ \mathcal{O}(1) $$ parameters in expressions of several swampland conjectures peak at specific values.

Abstract We study the impacts of matter field Kähler metric on physical Yukawa couplings in string compactifications. Since the Kähler metric is non-trivial in general, the kinetic mixing of matter fields opens a new avenue for realizing a hierarchical structure of physical Yukawa couplings, even when holomorphic Yukawa couplings have the trivial structure. The hierarchical Yukawa couplings are demonstrated by couplings of pure untwisted modes on toroidal orbifolds and their resolutions in the context of heterotic string theory with standard embedding. Also, we study the hierarchical couplings among untwisted and twisted modes on resolved orbifolds.

Abstract Background Chronic obstructive pulmonary disease (COPD) is an important risk factor for postoperative complications and mortality. To determine the effects of perioperative combination therapy, using a long-acting muscarinic antagonist (LAMA) and a long-acting β2 agonist (LABA), on preoperative lung function, postoperative morbidity and mortality, and long-term outcome in COPD patients. Methods Between January 2005 and October 2019, 130 consecutive patients with newly diagnosed COPD underwent surgery for lung cancer. We conducted a retrospective review of their medical record to evaluate that LAMA/LABA might be an optimal regimen for patients with COPD undergoing surgery for lung cancer. All patients were received perioperative rehabilitation and divided into 3 groups according to the type of perioperative inhaled therapy and management: LAMA/LABA (n = 64), LAMA (n = 23) and rehabilitation only (no bronchodilator) (n = 43). We conducted a retrospective review of their medical records. Results Patients who received preoperative LAMA/LABA therapy showed significant improvement in lung function before surgery (p

Abstract Background We used GORE DUALMESH for the reconstruction of diaphragms in patients with thoracic malignancies. Here, we report the results. Methods Between July 2015 and August 2017, diaphragm reconstruction using 2-mm GORE DUALMESH was performed in 7 patients undergoing surgical resection for thoracic malignancies. After resection of the diaphragm, the mesh was trimmed to the size of defect and placed with the smooth surface facing the chest cavity and the rough surface facing the abdomen. It was fixed with interrupted sutures consisting of synthetic monofilament nonabsorbable 1–0 to 2 threads. Results Indications for resection were malignant pleural mesothelioma and primary lung cancer in 5 and 2 patients, respectively. Patients with malignant pleural mesothelioma underwent pleurectomy with decortication; patients with primary lung cancer underwent lung lobectomy. Right and left diaphragm reconstruction was performed for 4 and 3 patients, respectively. Neither complications related to diaphragm reconstruction nor displacement of mesh occurred during a follow-up period ranging from 11 days to 37 months. Conclusions GORE DUALMESH is a good synthetic material for diaphragm reconstruction, because its smooth surface prevents adhesions to the lung and its rough surface allows adherence to abdominal tissue.

Abstract We study the moduli stabilization from the viewpoint of modular flavor symmetries. We systematically analyze stabilized moduli values in possible configurations of flux compactifications, investigating probabilities of moduli values and showing which moduli values are favorable from our moduli stabilization. Then, we examine their implications on modular symmetric flavor models. It is found that distributions of complex structure modulus τ determining the flavor structure are clustered at a fixed point with the residual ℤ3 symmetry in the SL(2, ℤ) fundamental region. Also, they are clustered at other specific points such as intersecting points between | τ | 2 = k/2 and Re τ = 0, ±1/4, ±1/2, although their probabilities are less than the ℤ3 fixed point. In general, CP-breaking vacua in the complex structure modulus are statistically disfavored in the string landscape. Among CP-breaking vacua, the values Re τ = ±1/4 are most favorable in particular when the axio-dilaton S is stabilized at Re S = ±1/4. That shows a strong correlation between CP phases originated from string moduli.

Abstract Background Spontaneous pneumothorax is a common problem globally. Bullas and blebs have been implicated in this problem, but the etiology of their formation is unknown. We aim to show the relation between a novel clinical finding, the pulmonary delayed inflation (PDI) sign, and the etiology of bulla and bleb formation in young patients. Methods We retrospectively analyzed data from 111 patients with pneumothorax and a control group of 27 patients. We evaluated the relation between the PDI sign and other clinical factors. Results The PDI sign was observed in 78 patients. Of these, 75 exhibited the PDI sign in only the upper lobe. Regardless of smoking status, patients 34 years of age or younger had a significantly higher incidence of the PDI sign than, patients 55 years of age or older and control patients. The inflation time in patients 34 years of age or younger, regardless of smoking status, was significantly longer than in patients 55 years of age or older and patients in the control group. There was no significant association between inflation time and the presence of asthma. Conclusions The novel PDI sign is seen in patients 34 years of age or younger. Because this sign may indicate a peripheral bronchial abnormality and may be related to the formation of blebs and bullae in young patients with spontaneous pneumothorax, it is possible that it can be used to develop effective treatments for pneumothorax in young patients.

Abstract We study the modular symmetry of zero-modes on T 1 2 × T 2 2 $$ {T}_1^2\times {T}_2^2 $$ and orbifold compactifications with magnetic fluxes, M 1 , M 2, where modulus parameters are identified. This identification breaks the modular symmetry of T 1 2 × T 2 2 $$ {T}_1^2\times {T}_2^2 $$ , SL(2, ℤ)1 × SL(2, ℤ)2 to SL(2, ℤ) ≡ Γ. Each of the wavefunctions on T 1 2 × T 2 2 $$ {T}_1^2\times {T}_2^2 $$ and orbifolds behaves as the modular forms of weight 1 for the principal congruence subgroup Γ(N), N being 2 times the least common multiple of M 1 and M 2. Then, zero-modes transform each other under the modular symmetry as multiplets of double covering groups of Γ N such as the double cover of S 4.

Abstract Background In spinocerebellar degeneration (SCD) patients, general and regional anesthesia may cause postoperative dysfunction of respiratory, nerve and muscle systems. We present the surgical case of thymoma developed in patient with SCD. Case presentation A 47-year-old woman with spinocerebellar degeneration was admitted because of a well-defined mass measuring 48 × 31 mm in anterior mediastinum. She showed limb, truncal, ocular, and speech ataxia; hypotonia; areflexia; sensory disturbances; and muscle weakness. Her eastern cooperative oncology group performance status was 4. Surgical resection was performed via video-assisted thoracic surgery and under general anesthesia only without epidural analgesia. The mass was diagnosed as type B1 thymoma without capsular invasion (Masaoka stage I). The patients got a good postoperative course by cooperation with anesthesiologists and neurologists in perioperative managements. She has been well over 3 years of follow-up. Conclusions In conclusion, careful surgical and anesthesia management is essential for providing an uneventful postoperative course in patients with SCD. Especially, selection of minimal invasive approach and avoid diaphragmatic nerve damage are the most important points in surgical procedures.

Abstract Background Good syndrome is a rare condition, manifesting as immunodeficiency due to hypogammaglobulinemia associated with thymoma. Herein, we present a patient with Good syndrome whose thymoma was resected after treatment of cytomegalovirus hepatitis. Case presentation The patient was a 45-year-old woman presenting with fever, cough, and nasal discharge, and was diagnosed with thymoma and hypogammaglobulinemia. She subsequently developed cytomegalovirus hepatitis that was treated by immunoglobulin. After resolution of the hepatitis, she underwent thymectomy through a left anterior thoracotomy. Her postoperative course was uneventful, and while receiving ongoing immunoglobulin therapy, she has been doing well without signs of infection. Conclusions Management of infections is important for patients with Good syndrome. To minimize the risk of perioperative infection, we should take care while planning the surgical approach and procedure.

Abstract We apply deep-learning techniques to the string landscape, in particular, SO(32) heterotic string theory on simply-connected Calabi-Yau threefolds with line bundles. It turns out that three-generation models cluster in particular islands specified by deep autoencoder networks and k-means++ clustering. Especially, we explore mutual relations between model parameters and the cluster with densest three-generation models (called “3-generation island”). We find that the 3-generation island has a strong correlation with the topological data of Calabi-Yau threefolds, in particular, second Chern class of the tangent bundle of the Calabi-Yau threefolds. Our results also predict a large number of Higgs pairs in the 3-generation island.

Abstract We examine the vacuum structure of 4D effective theories of moduli fields in spacetime compactifications with quantized background fluxes. Imposing the no-scale structure for the volume deformations, we numerically investigate the distributions of flux vacua of the effective potential in complex structure moduli and axio-dilaton directions for two explicit examples in Type IIB string theory and F-theory compactifications. It turns out that distributions of non-supersymmetric flux vacua exhibit a non-increasing functional behavior of several on-shell quantities with respect to the string coupling. We point out that this phenomena can be deeply connected with a previously-reported possible correspondence between the flux vacua in moduli stabilization problem and the attractor mechanism in supergravity, and our explicit demonstration implies that such a correspondence generically exist even in the framework of F-theory. In particular, we confirm that the solutions of the effective potential we explicitly evaluated in Type IIB and F-theory flux compactifications indeed satisfy the generalized form of the attractor equations simultaneously.

We explore the geometrical origin of CP and the spontaneous CP violation in Calabi-Yau compactifications. We find that the CP symmetry is identified with an outer automorphism of the symplectic modular group in the large complex structure regime of Calabi-Yau threefolds, thereby enlarging the symplectic modular group to their semidirect product group. The spontaneous CP violation is realized by the introduction of fluxes, whose effective action is invariant under CP as well as the discrete Z2 symmetry or Z4 R-symmetry. We explicitly demonstrate the spontaneous CP violation on a specific Calabi-Yau threefold.

Abstract We discuss the flavor structure in resolution of magnetized T 2 /ℤ2 orbifold models. The flavor structure of Yukawa couplings among chiral zero-modes is sensitive to radii of the resolved fixed points of T 2 /ℤ2 orbifold. We show in concrete models that the realistic mass hierarchy and mixing angles of the quark sector can be realized at certain values of blow-up radii, where the number of parameters in the blow-up model can be smaller than toroidal orbifold one.

Abstract We propose matter wavefunctions on resolutions of T 2/ℤ N singularities with constant magnetic fluxes. In the blow-down limit, the obtained wavefunctions of chiral zero-modes result in those on the magnetized T 2/ℤ N orbifold models, but the wavefunctions of ℤ N -invariant zero-modes receive the blow-up effects around fixed points of T 2/ℤ N orbifolds. Such blow-up effects change the selection rules and Yukawa couplings among the chiral zero-modes as well as the modular symmetry, in contrast to those on the magnetized T 2/ℤ N orbifold models.

Key message Spigot dropping is a rare but an intractable complication, because it is difficult to salvage a dropped spigot from the thoracic cavity. If the pneumothorax with a large fistula is recurrent, replacement with a larger size spigot may be recommended.

Abstract Introduction Surgery for acute empyema is associated with postoperative complications and relapse. Establishing a predictor for postoperative complications may improve prognosis. Objectives To demonstrate undernutrition as a predictor of complications after surgery for acute empyema. Methods We retrospectively analyzed 52 consecutive patients who underwent surgery for acute empyema from 2004 to 2019 and validated the correlation of undernutrition with serum albumin level, patient characteristics, hospital stay, and postoperative complications. Results The median preoperative serum albumin level was 2.4 g/dL (range: 1.1‐3.4). The levels in all patients were lower than the standard value (3.5 g/dL). Patients were divided into two groups based on the median serum albumin levels: the low serum albumin level group (group L, n = 28) and the high serum albumin level group (group H, n = 24). Group L patients were significantly older (64.5 vs 52.9 years, P = .002), had lower median body mass index (21.0 vs 24.2, P = .008), and significantly had Streptococcus anginosus group as the causative bacteria (50% vs 21%, P = .044). Their hospitalization duration was significantly longer (28.1 vs 14.8 days, P

We explore the scenario where both the strong CP and Cabbibo-Kobayashi-Maskawa (CKM) phases are determined by the same axion field. Such a scenario is naturally realized in string compactifications. We find that there exists parameter region to realize the tiny strong CP phase and observed CKM phase in magnetized D-brane models.

Abstract We study a direct flux breaking scenario in SO(32) heterotic string theory on general Calabi-Yau threefolds. The direct flux breaking, corresponding to hypercharge flux breaking in the F-theory context, allows us to derive the Standard Model in general Calabi-Yau compactifications. We present a general formula leading to the three generations of quarks and leptons and no chiral exotics in a background-independent way. As a concrete example, we show the three-generation model on a complete intersection Calabi-Yau threefold.

Abstract Background Myelodysplastic syndromes (MDS) are clonal stem cell disorders of the bone marrow. Most patients with MDS have a high risk of bleeding. Thrombocytopenia and defective platelet aggregation contribute to bleeding. We report a surgical case of a patient with lung cancer concomitant with MDS. Case presentation A 72-year-old man presented to our hospital because of an abnormal shadow on chest x-ray suggesting a primary lung cancer. A peripheral blood smear examination found giant platelets without thrombocytopenia. He was diagnosed with MDS by bone marrow biopsy, and showed defective platelet aggregation despite a normal bleeding time. The patient underwent left lower lobectomy and transfusion of platelets because of chest wall bleeding. Conclusions We demonstrated that ordering platelet preparations might be desirable for an MDS patient with defective platelet aggregation who will undergo surgery, even for a normal platelet count and bleeding time.

Abstract We search for the three-generation standard-like and/or Pati-Salam models from the SO(32) heterotic string theory on smooth, quotient complete intersection Calabi-Yau threefolds with multiple line bundles, each with structure group U(1). These models are S- and T-dual to intersecting D-brane models in type IIA string theory. We find that the stable line bundles and Wilson lines lead to the standard model gauge group with an extra U(1) B−L via a Pati-Salam-like symmetry and the obtained spectrum consists of three chiral generations of quarks and leptons, and vector-like particles. Green-Schwarz anomalous U(1) symmetries control not only the Yukawa couplings of the quarks and leptons but also the higher-dimensional operators causing the proton decay.

Abstract Background Some patients with thymoma present with a very large mass in the thoracic cavity. Although the most effective treatment for thymoma is surgical resection, it is difficult to perform because of the size of the tumor and the infiltration of tumor into the surrounding organs and vessels. We report a patient with a giant thymoma that was completely resected via a median sternotomy and left anterolateral thoracotomy. Case presentation A 63-year-old woman presented with a mass in the left thoracic cavity that was incidentally found on a chest X-ray. Chest computed tomography revealed a giant mass (16 × 10 cm) touching the chest wall and diaphragm and pressed against the heart and left upper pulmonary lobe. Complete resection was performed via a median sternotomy and left anterolateral thoracotomy. The tumor was histologically diagnosed as a WHO type B2 thymoma, Masaoka stage II. Conclusions Giant thymomas tend to grow expansively without invasion into surrounding organs and vessels. Surgical resection that employs an adequate approach must be considered, regardless of the size of the tumor.

We study moduli stabilization of the F-theory compactified on an elliptically fibered Calabi–Yau fourfold. Our setup is based on the mirror symmetry framework including brane deformations. The complex structure moduli dependence of the resulting 4D N=1 effective theory is determined by the associated fourfold period integrals. By turning on appropriate G-fluxes, we explicitly demonstrate that all the complex structure moduli fields can be stabilized around the large complex structure point of the F-theory fourfold.

Abstract Background We conducted a multicenter randomized study of adjuvant S-1 administration schedules for surgically treated pathological stage IB-IIIA non-small cell lung cancer patients. Methods Patients receiving curative surgical resection were centrally randomized to arm A (4 weeks of oral S-1 and a 2-week rest over 12 months) or arm B (2 weeks of S-1 and a 1-week rest over 12 months). The primary endpoints were completion of the scheduled adjuvant chemotherapy over 12 months, and the secondary endpoints were relative total administration dose, toxicity, and 3-year disease-free survival. Results From April 2005 to January 2012, 80 patients were enrolled, of whom 78 patients were eligible and assessable. The planned S-1 administration over 12 months was accomplished to 28 patients in 38 arm A patients (73.7%) and to 18 patients in 40 arm B patients (45.0%, p = 0.01). The average relative dose intensity was 77.2% for arm A and 58.4% for arm B (p = 0.01). Drug-related grade 3 adverse events were recorded for 11% of arm A and 5% of arm B (p = 0.43). Grade 1–3 elevation of bilirubin, alkaline phosphatase, aspartate aminotransferase, and alanine transaminase were more frequently recorded in arm A than in arm B. The 3-year disease-free survival rate was 79.0% for arm A and 79.3% for arm B (p = 0.94). Conclusions The superiority of feasibility of the shorter schedule was not recognized in the present study. The conventional schedule showed higher completion rates over 12 months (p = 0.01) and relative dose intensity of S-1 (p = 0.01). Toxicity showed no significant difference among the shorter schedule and the conventional schedule, except for grade 1–3 elevation of bilirubin. Trial registration This randomized multicenter study was retrospectively registered with the UMIN-CTR (UMIN000016086, registration date December 30, 2014).

It has been known for some time that a hermitian matrix model with a Penner-like potential yields as its large-N free energy the prepotential of N=2 Nf=2 SU(2) SUSY gauge theory. We give a rigorous proof that a unitary matrix model with the identical potential also yields the same prepotential, although the parameter identifications are slightly different. This result has been anticipated by Itoyama et al.