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16 results on '"Hajjiri, Zahraa"'

1. Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., Unruh, Mark L., Hannan, Mary, Chen, Jinsong, Hsu, Jesse, Zhang, Xiaoming, Saunders, Milda R., Brown, Julia, McAdams-DeMarco, Mara, Mohanty, Madhumita Jena, Vyas, Rahul, Hajjiri, Zahraa, Carmona-Powell, Eunice, Meza, Natalie, Porter, Anna C., Ricardo, Ana C., and Lash, James P.

Published
2024
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6. Angiotensin II type 1 receptor antibody-mediated kidney rejection unresponsive to treatment

Author

Allison, David, Hajjiri, Zahraa, Manon, Luis, Campbell-Lee, Sally, Sahni, and Setty, Suman

Subjects
Biomedical and clinical sciences, Health sciences, FOS: Health sciences
Abstract

Allograft rejection is a significant cause of renal transplant failure which needs prompt diagnosis and treatment for graft salvage. Angiotensin II type 1 receptor antibody-mediated rejection (AT1R-AMR) is increasingly being identified as the etiology of antibody-mediated rejection in kidney transplant recipients with allograft rejection but without detectable HLA antibodies. While some reports have suggested that AT1R-AMR may be refractory to standard therapy, others have reported improvement or stabilization of graft function. We present two patients in which anti-rejection therapy including therapeutic plasma exchange was unable to salvage the allograft.

Published
2023
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7. Contributors to Volume 1

Author

Advani, Shailesh, Akdur, Aydincan, Arriola, Kimberly Jacob, Arunachalam, Priya, Axelrod, David, Balamurugan, Appakalai N., Batra, Ramesh, Beebe, David S., Bellin, Melena D., Benedetti, Enrico, Bhardi, Elissa, Birjiniuk, Joav, Boletis, Ioannis N., Brayman, Kenneth L., Bregman, Adam, Burton, Victoria, Caicedo, Juan Carlos, Callender, Clive O., Carpenter, Jennifer, Carpenter, Dustin J., Cherry, Mark J., Cooper, Matthew, Cronin, David C., II, Davis, LaShara, Davis, Earnest J., Delmonico, Francis L., Di Cocco, Pierpaolo, Dor, Frank J.M.F., Downs, Elissa M., Einecke, Gunilla, Emamaullee, Juliet, Erhardt, A.J., Fan, Pang Yen, Farney, Alan, Fratti, Alberto, Freedman, Barry I., Gaber, A.O., Gaines, Malendie T., Gallon, Lorenzo, Ghahramani, Nasrollah, Gill, John S., Gill, Justin, Glannon, Walter, Gruessner, Rainer W.G., Gruessner, Angelika C., Gürlüler, Ercüment, Gutmann, Thomas, Haase-Kromwijk, Bernadette J.J.M., Haberal, Mehmet, Hajjiri, Zahraa Fayez, Halloran, Philip F., Han, Duck J., Hebert, Sean A., Hemke, Aline C., Ho, Erica, Hoitsma, Andries J., Hughes, Nancy Scheper, Ibrahim, Hassan N., Jay, Colleen, Kahn, Jeffrey, Kaisar, Maria, Kamei, Hideya, Kandaswamy, Raja, Kaufman, Dixon B., Kenmochi, Takashi, Kittle, Haley, Kiuchi, Tetsuya, Klitenic, Samantha B., Knight, Richard J., Kocak, Burak, Kodipad, Ahad Ahmed, Kumar, Suresh, Laftavi, Mark R., Land, Walter G., Langer, Robert, Lebovitz, Evan E., Lee-Riddle, Grace S., Levan, Macey L., Leventhal, Joseph R., Liou, H. Peter, Lonze, Bonnie E., Madill-Thomsen, Katelynn S., Maluf, Daniel G., Maple, Hannah, Marinaki, Smaragdi, Mas, Valeria R., Matas, Arthur J., Mathew, James M., Matossian, Debora, Mena-Gutierrez, Alejandra M., Menser, Terri, Modi, Pranjal, Mokshagundam, Sri Prakash L., Montgomery, Robert A., Muench, Dorothy, Mulligan, David, Murad, Dina N., Murillo, Ariana, Nahi, Skylar L., Najarian (deceased), John S., Narayanan, Siddharth, Nathan, Jaimie D., Nguyen, Hana, Nguyen, Anh Vinh T., Nishio-Lucar, Angie, Norin, Allen J., Olausson, Michael, Onishi, Yasuharu, Pankewycz, Oleh G., Papalois, Vassilios, Pengel, Liset, Petrochenkov, Egor, Pirenne, Jacques, Ploeg, Rutger, Radcliffe-Richards, Janet, Ramanathan, Karthik, Ratner, Lloyd E., Reeves-Daniel, Amber M., Ross, Lainie Friedman, Rule, Andrew D., Sakai, Tetsuro, Sakuma, Yasunaru, Samaga, Krishna Kumar, Schold, Jesse D., Schroeter, Andreas, Seth, Abhinav, Shapiro, A. M. James, Shenoy, Surendra, Siegler, Mark, Spaggiari, Mario, Spak, Cedric W., Steiner, Robert, Stern, Jeffrey M., Subba Rao, Budithi, Tanabe, Kazunari, Tantisattamo, Ekamol, Thistlethwaite, J. Richard, Toledo, Alexander H., Troppmann, Christoph, Tullius, Stefan G., Tzvetanov, Ivo, Verghese, Priya S., Wadström, Jonas, Warburton, Karen, Waterman, Amy D., West-Thielke, Patricia, Wood, Emily H., Yi, Stephanie G., and Yu, Jennifer

Published
2024
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15. Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Hannan, Mary, Chen, Jinsong, Hsu, Jesse, Zhang, Xiaoming, Saunders, Milda R., Brown, Julia, McAdams-DeMarco, Mara, Mohanty, Madhumita Jena, Vyas, Rahul, Hajjiri, Zahraa, Carmona-Powell, Eunice, Meza, Natalie, Porter, Anna C., Ricardo, Ana C., Lash, James P., Chen, Jing, Cohen, Debbie L., Feldman, Harold I., Go, Alan S., Nelson, Robert G., Rahman, Mahboob, Rao, Panduranga S., Shah, Vallabh O., and Unruh, Mark L.

Abstract

Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis-dependent CKD.

Published
2023
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16. Frailty and Cardiovascular Outcomes in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.

Author

Hannan M, Chen J, Hsu J, Zhang X, Saunders MR, Brown J, McAdams-DeMarco M, Mohanty MJ, Vyas R, Hajjiri Z, Carmona-Powell E, Meza N, Porter AC, Ricardo AC, and Lash JP

Subjects
Adult, Humans, Female, Middle Aged, Male, Cohort Studies, Prospective Studies, Frailty epidemiology, Frailty complications, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic epidemiology, Heart Failure epidemiology, Heart Failure complications, Atherosclerosis epidemiology, Atherosclerosis etiology
Abstract

Rationale & Objective: Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes in adults with kidney failure requiring dialysis. However, this relationship has not been thoroughly evaluated among those with non-dialysis-dependent CKD., Study Design: Prospective cohort study., Setting & Participants: 2,539 adults in the Chronic Renal Insufficiency Cohort Study., Exposure: Frailty status assessed using 5 criteria: slow gait speed, muscle weakness, low physical activity, exhaustion, and unintentional weight loss., Outcome: Atherosclerotic events, incident heart failure, all-cause death, and cardiovascular death., Analytical Approach: Cause-specific hazards models., Results: At study entry, the participants' mean age was 62 years, 46% were female, the mean estimated glomerular filtration rate was 45.4mL/min/1.73m 2 , and the median urine protein was 0.2mg/day. Frailty status was as follows: 12% frail, 51% prefrail, and 37% nonfrail. Over a median follow-up of 11.4 years, there were 393 atherosclerotic events, 413 heart failure events, 497 deaths, and 132 cardiovascular deaths. In multivariable regression analyses, compared with nonfrailty, both frailty and prefrailty status were each associated with higher risk of an atherosclerotic event (HR, 2.03 [95% CI, 1.41-2.91] and 1.77 [95% CI, 1.35-2.31], respectively) and incident heart failure (HR, 2.22 [95% CI, 1.59-3.10] and 1.39 [95% CI, 1.07-1.82], respectively), as well as higher risk of all-cause death (HR, 2.52 [95% CI, 1.84-3.45] and 1.76 [95% CI, 1.37-2.24], respectively) and cardiovascular death (HR, 3.01 [95% CI, 1.62-5.62] and 1.78 [95% 1.06-2.99], respectively)., Limitations: Self-report of aspects of the frailty assessment and comorbidities, which may have led to bias in some estimates., Conclusions: In adults with CKD, frailty status was associated with higher risk of cardiovascular events and mortality. Future studies are needed to evaluate the impact of interventions to reduce frailty on cardiovascular outcomes in this population., Plain-Language Summary: Frailty is common in individuals with chronic kidney disease (CKD) and increases the risk of adverse outcomes. We sought to evaluate the association of frailty status with cardiovascular events and death in adults with CKD. Frailty was assessed according to the 5 phenotypic criteria detailed by Fried and colleagues. Among 2,539 participants in the CRIC Study, we found that 12% were frail, 51% were prefrail, and 37% were nonfrail. Frailty status was associated with an increased risk of atherosclerotic events, incident heart failure, and death., (Copyright © 2023 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)

Published
2024
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