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Your search keyword '"Halan, Vivek"' showing total 9 results
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9 results on '"Halan, Vivek"'

1. Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain

Author

Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., and Macor, John E.

Published
2023
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4. Fluorescence-detection size-exclusion chromatography--an analytical technique with multiple applications

Author

Halan, Vivek, Maity, Sunit, Rathore, Anurag S., and Krull, Ira

Subjects
Crystallization -- Analysis, Fluorescence spectroscopy -- Analysis, Gel permeation chromatography -- Analysis, Chemistry
Abstract

In this installment, we discuss fluorescence-detection size exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologics. There are various techniques available for [...]

Published
2014

5. Fluorescence-detection size-exclusion chromatography--an analytical technique with multiple applications

Author

Halan, Vivek, Maity, Sunit, Rathore, Anurag S., and Krull, Ira

Subjects
Chromatography -- Methods -- Technology application, Nucleotide sequencing -- Methods -- Technology application, Fluorescein -- Methods -- Technology application, DNA sequencing -- Methods -- Technology application, Proteins -- Methods -- Technology application, Cells -- Methods -- Technology application, Neurophysiology -- Methods -- Technology application, Technology application, Chemistry, Science and technology
Abstract

In this instalment, we discuss fluorescence-detection size-exclusion chromatography (FSEC) technology and its implications in protein characterization, specifically the development and characterization of biologies. ********** There are various techniques available for [...]

Published
2015

8. The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

Author

Eastman, Kyle J., primary, Parcella, Kyle, additional, Yeung, Kap-Sun, additional, Grant-Young, Katharine A., additional, Zhu, Juliang, additional, Wang, Tao, additional, Zhang, Zhongxing, additional, Yin, Zhiwei, additional, Beno, Brett R., additional, Sheriff, Steven, additional, Kish, Kevin, additional, Tredup, Jeffrey, additional, Jardel, Adam G., additional, Halan, Vivek, additional, Ghosh, Kaushik, additional, Parker, Dawn, additional, Mosure, Kathy, additional, Fang, Hua, additional, Wang, Ying-Kai, additional, Lemm, Julie, additional, Zhuo, Xiaoliang, additional, Hanumegowda, Umesh, additional, Rigat, Karen, additional, Donoso, Maria, additional, Tuttle, Maria, additional, Zvyaga, Tatyana, additional, Haarhoff, Zuzana, additional, Meanwell, Nicholas A., additional, Soars, Matthew G., additional, Roberts, Susan B., additional, and Kadow, John F., additional

Published
2017
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9. Multimodal Chromatography for Purification of Biotherapeutics – A Review

Author

Halan, Vivek, Maity, Sunit, Bhambure, Rahul, and Rathore, Anurag S.

Abstract

Process chromatography forms the core of purification of biotherapeutics. The unparalleled selectivity that it offers over other alternatives combined with the considerable robustness and scalability make it the unit operation of choice in downstream processing. It is typical to have three to five chromatography steps in a purification process for a biotherapeutic. Generally, these steps offer different modes of separation such as ion-exchange, reversed phase, size exclusion, and hydrophobic interaction. In the past decade, multimodal chromatography has emerged as an alternative to the traditional modes. It involves use of more than one mode of separation and typically combines ion-exchange and hydrophobic interactions to achieve selectivity and sensitivity. Over the last decade, numerous authors have demonstrated the significant potential that multimode chromatography offers as a protein purification tool. This review aims to present key recent developments that have occurred on this topic together with a perspective on future applications of multimodal chromatography.

Published
2019
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