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2. Investigating the feasibility of recruitment to an observational, quality-of-life study of patients diagnosed with atrial fibrillation (AF) who have experienced a bleed while anticoagulated: EQUAL-AF feasibility study protocol

Author

Hutchings, Hayley A., Lanyon, Kirsty, Lister, Steven, Alikhan, Raza, Halcox, Julian, Holland, Gail, Hughes, Arfon, Jenkins, Rhys, Laing, Hamish, Lobban, Trudie, Owen, Diane, Pollock, Kevin G., Todd, Ceri, and Wareham, Kathie

Published
2022
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4. Adherence to the Atrial fibrillation Better Care pathway and the risk of adverse health outcomes in older care home residents with atrial fibrillation: a retrospective data linkage study 2003–18.

Author

Ritchie, Leona A, Harrison, Stephanie L, Penson, Peter E, Akbari, Ashley, Torabi, Fatemeh, Hollinghurst, Joe, Harris, Daniel, Oke, Oluwakayode B, Akpan, Asangaedem, Halcox, Julian P, Rodgers, Sarah E, Lip, Gregory Y H, and Lane, Deirdre A

Subjects
MYOCARDIAL infarction risk factors, TRANSIENT ischemic attack, HEMORRHAGIC stroke, CONFIDENCE intervals, MORTALITY, HEALTH outcome assessment, ATRIAL fibrillation, RETROSPECTIVE studies, RISK assessment, MEDICAL record linkage, NURSING care facilities, DRUGS, HOSPITAL care, RESEARCH funding, PATIENT compliance, ADVERSE health care events, HEMORRHAGE, LONGITUDINAL method, PROPORTIONAL hazards models, DISEASE risk factors
Abstract

Background The Atrial fibrillation Better Care (ABC) pathway is the gold-standard approach to atrial fibrillation (AF) management, but the effect of implementation on health outcomes in care home residents is unknown. Objective To examine associations between ABC pathway adherence and stroke, transient ischaemic attack, cardiovascular hospitalisation, major bleeding, mortality and a composite of all these outcomes in care home residents. Methods A retrospective cohort study of older care home residents (≥65 years) in Wales with AF was conducted between 1 January 2003 and 31 December 2018 using the Secure Anonymised Information Linkage Databank. Adherence to the ABC pathway was assessed at care home entry using pre-specified definitions. Cox proportional hazard and competing risk models were used to estimate the risk of health outcomes according to ABC adherence. Results From 14,493 residents (median [interquartile range] age 87.0 [82.6–91.2] years, 35.2% male) with AF, 5,531 (38.2%) were ABC pathway adherent. Pathway adherence was not significantly associated with risk of the composite outcome (adjusted hazard ratio, 95% confidence interval [CI]: 1.01 [0.97–1.05]). There was a significant independent association observed between ABC pathway adherence and a reduced risk of myocardial infarction (0.70 [0.50–0.98]), but a higher risk of haemorrhagic stroke (1.59 [1.06–2.39]). ABC pathway adherence was not significantly associated with any other individual health outcomes examined. Conclusion An ABC adherent approach in care home residents was not consistently associated with improved health outcomes. Findings should be interpreted with caution owing to difficulties in defining pathway adherence using routinely collected data and an individualised approach is recommended. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Incident atrial fibrillation and adverse clinical outcomes during extended follow-up of participants recruited to the Remote Heart Rhythm Sampling Using the AliveCor Heart Monitor to Screen for Atrial Fibrillation The REHEARSE-AF Study

Author

Ellins, Elizabeth A, primary, Wareham, Kathie, additional, Harris, Daniel E, additional, Hanney, Matthew, additional, Akbari, Ashley, additional, Gilmore, Mark, additional, Barry, James P, additional, Phillips, Ceri J, additional, Gravenor, Michael B, additional, and Halcox, Julian P, additional

Published
2023
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10. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Author

Franceschini, Nora, Giambartolomei, Claudia, de Vries, Paul S., Finan, Chris, Bis, Joshua C., Huntley, Rachael P., Lovering, Ruth C., Tajuddin, Salman M., Winkler, Thomas W., Graff, Misa, Kavousi, Maryam, Dale, Caroline, Smith, Albert V., Hofer, Edith, van Leeuwen, Elisabeth M., Nolte, Ilja M., Lu, Lingyi, Scholz, Markus, Sargurupremraj, Muralidharan, Pitkänen, Niina, Franzén, Oscar, Joshi, Peter K., Noordam, Raymond, Marioni, Riccardo E., Hwang, Shih-Jen, Musani, Solomon K., Schminke, Ulf, Palmas, Walter, Isaacs, Aaron, Correa, Adolfo, Zonderman, Alan B., Hofman, Albert, Teumer, Alexander, Cox, Amanda J., Uitterlinden, André G., Wong, Andrew, Smit, Andries J., Newman, Anne B., Britton, Annie, Ruusalepp, Arno, Sennblad, Bengt, Hedblad, Bo, Pasaniuc, Bogdan, Penninx, Brenda W., Langefeld, Carl D., Wassel, Christina L., Tzourio, Christophe, Fava, Cristiano, Baldassarre, Damiano, O’Leary, Daniel H., Teupser, Daniel, Kuh, Diana, Tremoli, Elena, Mannarino, Elmo, Grossi, Enzo, Boerwinkle, Eric, Schadt, Eric E., Ingelsson, Erik, Veglia, Fabrizio, Rivadeneira, Fernando, Beutner, Frank, Chauhan, Ganesh, Heiss, Gerardo, Snieder, Harold, Campbell, Harry, Völzke, Henry, Markus, Hugh S., Deary, Ian J., Jukema, J. Wouter, de Graaf, Jacqueline, Price, Jacqueline, Pott, Janne, Hopewell, Jemma C., Liang, Jingjing, Thiery, Joachim, Engmann, Jorgen, Gertow, Karl, Rice, Kenneth, Taylor, Kent D., Dhana, Klodian, Kiemeney, Lambertus A. L. M., Lind, Lars, Raffield, Laura M., Launer, Lenore J., Holdt, Lesca M., Dörr, Marcus, Dichgans, Martin, Traylor, Matthew, Sitzer, Matthias, Kumari, Meena, Kivimaki, Mika, Nalls, Mike A., Melander, Olle, Raitakari, Olli, Franco, Oscar H., Rueda-Ochoa, Oscar L., Roussos, Panos, Whincup, Peter H., Amouyel, Philippe, Giral, Philippe, Anugu, Pramod, Wong, Quenna, Malik, Rainer, Rauramaa, Rainer, Burkhardt, Ralph, Hardy, Rebecca, Schmidt, Reinhold, de Mutsert, Renée, Morris, Richard W., Strawbridge, Rona J., Wannamethee, S. Goya, Hägg, Sara, Shah, Sonia, McLachlan, Stela, Trompet, Stella, Seshadri, Sudha, Kurl, Sudhir, Heckbert, Susan R., Ring, Susan, Harris, Tamara B., Lehtimäki, Terho, Galesloot, Tessel E., Shah, Tina, de Faire, Ulf, Plagnol, Vincent, Rosamond, Wayne D., Post, Wendy, Zhu, Xiaofeng, Zhang, Xiaoling, Guo, Xiuqing, Saba, Yasaman, MEGASTROKE Consortium, Dehghan, Abbas, Seldenrijk, Adrie, Morrison, Alanna C., Hamsten, Anders, Psaty, Bruce M., van Duijn, Cornelia M., Lawlor, Deborah A., Mook-Kanamori, Dennis O., Bowden, Donald W., Schmidt, Helena, Wilson, James F., Wilson, James G., Rotter, Jerome I., Wardlaw, Joanna M., Deanfield, John, Halcox, Julian, Lyytikäinen, Leo-Pekka, Loeffler, Markus, Evans, Michele K., Debette, Stéphanie, Humphries, Steve E., Völker, Uwe, Gudnason, Vilmundur, Hingorani, Aroon D., Björkegren, Johan L. M., Casas, Juan P., and O’Donnell, Christopher J.

Published
2018
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11. Prevalence and outcomes of atrial fibrillation in older people living in care homes in Wales: a routine data linkage study 2003–2018

Author

Ritchie, Leona A, primary, Harrison, Stephanie L, additional, Penson, Peter E, additional, Akbari, Ashley, additional, Torabi, Fatemeh, additional, Hollinghurst, Joe, additional, Harris, Daniel, additional, Oke, Oluwakayode B, additional, Akpan, Asangaedem, additional, Halcox, Julian P, additional, Rodgers, Sarah E, additional, Lip, Gregory Y H, additional, and Lane, Deirdre A, additional

Published
2022
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12. Anticoagulation in older people with atrial fibrillation moving to care homes: a data linkage study

Author

Ritchie, Leona A, primary, Harrison, Stephanie L, additional, Penson, Peter E, additional, Akbari, Ashley, additional, Torabi, Fatemeh, additional, Hollinghurst, Joe, additional, Harris, Daniel, additional, Oke, Oluwakayode B, additional, Akpan, Asangaedem, additional, Halcox, Julian P, additional, Rodgers, Sarah E, additional, Lip, Gregory YH, additional, and Lane, Deirdre A, additional

Published
2022
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17. Anticoagulation in older people with atrial fibrillation moving to care homes: a data linkage study.

Author

Ritchie, Leona A, Harrison, Stephanie L, Penson, Peter E, Akbari, Ashley, Torabi, Fatemeh, Hollinghurst, Joe, Harris, Daniel, Oke, Oluwakayode B, Akpan, Asangaedem, Halcox, Julian P, Rodgers, Sarah E, Lip, Gregory YH, and Lane, Deirdre A

Subjects
ATRIAL fibrillation, OLDER people, ORAL medication, THROMBOEMBOLISM
Abstract

Background: Treatment decisions about oral anticoagulants (OACs) for atrial fibrillation (AF) are complex in older care home residents. Aim: To explore factors associated with OAC prescription. Design and setting: Retrospective cohort study set in care homes in Wales, UK, listed in the Care Inspectorate Wales Registry 2017/18. Method: Analysis of anonymised individual-level electronic health and administrative data was carried out on people aged ≥65 years entering a care home between 1 January 2003 and 31 December 2018, provisioned from the Secure Anonymised Information Linkage Databank. Results: Between 2003 and 2018, 14 493 people with AF aged ≥65 years became new residents in care homes in Wales and 7057 (48.7%) were prescribed OACs (32.7% in 2003 compared with 72.7% in 2018) within 6 months before care home entry. Increasing age and prescription of antiplatelet therapy were associated with lower odds of OAC prescription (adjusted odds ratio [aOR] 0.96 per 1-year age increase, 95% confidence interval [CI] = 0.95 to 0.96 and aOR 0.91, 95% CI = 0.84 to 0.98, respectively). Conversely, prior venous thromboembolism (aOR 4.06, 95% CI = 3.17 to 5.20), advancing frailty (mild: aOR 4.61, 95% CI = 3.95 to 5.38; moderate: aOR 6.69, 95% CI = 5.74 to 7.80; and severe: aOR 8.42, 95% CI = 7.16 to 9.90), and year of care home entry from 2011 onwards (aOR 1.91, 95% CI = 1.76 to 2.06) were associated with higher odds of an OAC prescription. Conclusion: There has been an increase in OAC prescribing in older people newly admitted to care homes with AF. This study provides an insight into the factors influencing OAC prescribing in this population. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Achievement of European Society of Cardiology/European Atherosclerosis Society lipid targets in very high-risk patients: Influence of depression and sex

Author

Ellins, Elizabeth A., primary, Harris, Daniel E., additional, Lacey, Arron, additional, Akbari, Ashley, additional, Torabi, Fatemeh, additional, Smith, Dave, additional, Jenkins, Geraint, additional, Obaid, Daniel, additional, Chase, Alex, additional, John, Ann, additional, Gravenor, Michael B., additional, and Halcox, Julian P., additional

Published
2022
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30. sj-pdf-1-cvd-10.1177_2048004020967578 - Supplemental material for Diagnostic performance of virtual fractional flow reserve derived from routine coronary angiography using segmentation free reduced order (1-dimensional) flow modelling

Author

Mohee, Kevin, Mynard, Jonathan P, Gauravsingh Dhunnoo, Davies, Rhodri, Perumal Nithiarasu, Halcox, Julian P, and Obaid, Daniel R

Subjects
Cardiology
Abstract

Supplemental material, sj-pdf-1-cvd-10.1177_2048004020967578 for Diagnostic performance of virtual fractional flow reserve derived from routine coronary angiography using segmentation free reduced order (1-dimensional) flow modelling by Kevin Mohee, Jonathan P Mynard, Gauravsingh Dhunnoo, Rhodri Davies, Perumal Nithiarasu, Julian P Halcox and Daniel R Obaid in JRSM Cardiovascular Disease

Published
2020
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33. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis

Author

Davies, Ruth, primary, Williams, Jessica, additional, Sime, Katie, additional, Jin, Hyun-Sun, additional, Thompson, Charlotte, additional, Jordan, Lauren, additional, Lang, Derek, additional, Halcox, Julian P, additional, Ellins, Elizabeth, additional, Jones, Gareth W, additional, Jones, Simon A, additional, Rose-John, Stefan, additional, Williams, Anwen, additional, and Choy, Ernest, additional

Published
2020
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35. COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

Author

Thygesen, Johan H, Tomlinson, Christopher, Hollings, Sam, Mizani, Mehrdad A, Handy, Alex, Akbari, Ashley, Banerjee, Amitava, Cooper, Jennifer, Lai, Alvina G, Li, Kezhi, Mateen, Bilal A, Sattar, Naveed, Sofat, Reecha, Torralbo, Ana, Wu, Honghan, Wood, Angela, Sterne, Jonathan A C, Pagel, Christina, Whiteley, William N, Sudlow, Cathie, Hemingway, Harry, Denaxas, Spiros, Abbasizanjani, Hoda, Ahmed, Nida, Ahmed, Badar, Akbari, Ashley, Akinoso-Imran, Abdul Qadr, Allara, Elias, Allery, Freya, Angelantonio, Emanuele Di, Ashworth, Mark, Ayyar-Gupta, Vandana, Babu-Narayan, Sonya, Bacon, Seb, Ball, Steve, Banerjee, Ami, Barber, Mark, Barrett, Jessica, Bennie, Marion, Berry, Colin, Beveridge, Jennifer, Birney, Ewan, Bojanić, Lana, Bolton, Thomas, Bone, Anna, Boyle, Jon, Braithwaite, Tasanee, Bray, Ben, Briffa, Norman, Brind, David, Brown, Katherine, Buch, Maya, Canoy, Dexter, Caputo, Massimo, Carragher, Raymond, Carson, Alan, Cezard, Genevieve, Chang, Jen-Yu Amy, Cheema, Kate, Chin, Richard, Chudasama, Yogini, Cooper, Jennifer, Copland, Emma, Crallan, Rebecca, Cripps, Rachel, Cromwell, David, Curcin, Vasa, Curry, Gwenetta, Dale, Caroline, Danesh, John, Das-Munshi, Jayati, Dashtban, Ashkan, Davies, Alun, Davies, Joanna, Davies, Gareth, Davies, Neil, Day, Joshua, Delmestri, Antonella, Denaxas, Spiros, Denholm, Rachel, Dennis, John, Denniston, Alastair, Deo, Salil, Dhillon, Baljean, Docherty, Annemarie, Dong, Tim, Douiri, Abdel, Downs, Johnny, Dregan, Alexandru, Ellins, Elizabeth A, Elwenspoek, Martha, Falck, Fabian, Falter, Florian, Fan, Yat Yi, Firth, Joseph, Fraser, Lorna, Friebel, Rocco, Gavrieli, Amir, Gerstung, Moritz, Gilbert, Ruth, Gillies, Clare, Glickman, Myer, Goldacre, Ben, Goldacre, Raph, Greaves, Felix, Green, Mark, Grieco, Luca, Griffiths, Rowena, Gurdasani, Deepti, Halcox, Julian, Hall, Nick, Hama, Tuankasfee, Handy, Alex, Hansell, Anna, Hardelid, Pia, Hardy, Flavien, Harris, Daniel, Harrison, Camille, Harron, Katie, Hassaine, Abdelaali, Hassan, Lamiece, Healey, Russell, Hemingway, Harry, Henderson, Angela, Herz, Naomi, Heyl, Johannes, Hidajat, Mira, Higginson, Irene, Hinchliffe, Rosie, Hippisley-Cox, Julia, Ho, Frederick, Hocaoglu, Mevhibe, Hollings, Sam, Horne, Elsie, Hughes, David, Humberstone, Ben, Inouye, Mike, Ip, Samantha, Islam, Nazrul, Jackson, Caroline, Jenkins, David, Jiang, Xiyun, Johnson, Shane, Kadam, Umesh, Kallis, Costas, Karim, Zainab, Kasan, Jake, Katsoulis, Michalis, Kavanagh, Kim, Kee, Frank, Keene, Spencer, Kent, Seamus, Khalid, Sara, Khawaja, Anthony, Khunti, Kamlesh, Killick, Richard, Kinnear, Deborah, Knight, Rochelle, Kolamunnage-Dona, Ruwanthi, Kontopantelis, Evan, Kurdi, Amanj, Lacey, Ben, Lai, Alvina, Lambarth, Andrew, Larzjan, Milad Nazarzadeh, Lawler, Deborah, Lawrence, Thomas, Lawson, Claire, Li, Qiuju, Li, Ken, Llinares, Miguel Bernabeu, Lorgelly, Paula, Lowe, Deborah, Lyons, Jane, Lyons, Ronan, Machado, Pedro, Macleod, Mary Joan, Macleod, John, Malgapo, Evaleen, Mamas, Mamas, Mamouei, Mohammad, Manohar, Sinduja, Mapeta, Rutendo, Martelli, Javiera Leniz, Martos, David Moreno, Mateen, Bilal, McCarthy, Aoife, Melville, Craig, Milton, Rebecca, Mizani, Mehrdad, Moncusi, Marta Pineda, Morales, Daniel, Mordi, Ify, Morrice, Lynn, Morris, Carole, Morris, Eva, Mu, Yi, Mueller, Tanja, Murdock, Lars, Nafilyan, Vahé, Nicholson, George, Nikiphorou, Elena, Nolan, John, Norris, Tom, Norris, Ruth, North, Laura, North, Teri-Louise, O'Connell, Dan, Oliver, Dominic, Oluyase, Adejoke, Olvera-Barrios, Abraham, Omigie, Efosa, Onida, Sarah, Padmanabhan, Sandosh, Palmer, Tom, Pasea, Laura, Patel, Riyaz, Payne, Rupert, Pell, Jill, Petitjean, Carmen, Pherwani, Arun, Pickrell, Owen, Pierotti, Livia, Pirmohamed, Munir, Priedon, Rouven, Prieto-Alhambra, Dani, Proudfoot, Alastair, Quinn, Terry, Quint, Jennifer, Raffetti, Elena, Rahimi, Kazem, Rao, Shishir, Razieh, Cameron, Roberts, Brian, Rogers, Caroline, Rossdale, Jennifer, Salim, Safa, Samani, Nilesh, Sattar, Naveed, Schnier, Christian, Schwartz, Roy, Selby, David, Seminog, Olena, Shabnam, Sharmin, Shah, Ajay, Shelton, Jon, Sheppard, James, Sinha, Shubhra, Skrypak, Mirek, Slapkova, Martina, Sleeman, Katherine, Smith, Craig, Sofat, Reecha, Sosenko, Filip, Sperrin, Matthew, Steeg, Sarah, Sterne, Jonathan, Stoica, Serban, Sudell, Maria, Sudlow, Cathie, Sun, Luanluan, Suseeladevi, Arun Karthikeyan, Sweeting, Michael, Sydes, Matt, Takhar, Rohan, Tang, Howard, Thygesen, Johan, Tilston, George, Tochel, Claire, Toit, Clea du, Tomlinson, Christopher, Toms, Renin, Torabi, Fatemeh, Torralbo, Ana, Townson, Julia, Tufail, Adnan, Tungamirai, Tapiwa, Varma, Susheel, Vollmer, Sebastian, Walker, Venexia, Wang, Tianxiao, Wang, Huan, Warwick, Alasdair, Watkinson, Ruth, Watson, Harry, Whiteley, William, Whittaker, Hannah, Wilde, Harry, Wilkinson, Tim, Williams, Gareth, Williams, Michelle, Williams, Richard, Withnell, Eloise, Wolfe, Charles, Wood, Angela, Wright, Lucy, Wu, Honghan, Wu, Jinge, Wu, Jianhua, Yates, Tom, Zaccardi, Francesco, Zhang, Haoting, Zhang, Huayu, and Zuccolo, Luisa

Abstract

Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.

Published
2022
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37. Contributors

Author

Aiello, Vera Demarchi, primary, Habshan, Fahad Al, additional, Anderson, Page A.W., additional, Anderson, Robert H., additional, Apitz, Christian, additional, Baker, Edward J., additional, Barron, David J., additional, Becker, Anton E., additional, Bédard, Elisabeth, additional, Benson, Lee N., additional, Blume, Elizabeth D., additional, Bonhoeffer, Philipp, additional, Bradley, Timothy J., additional, Braudis, Nancy J., additional, Brawn, William J., additional, Brizard, Christian, additional, Brown, Nigel, additional, Bruneau, Benoit G., additional, Bryant-Stephens, Tyra, additional, Burn, John, additional, Charakida, Marietta, additional, Cheung, Yiu-fai, additional, Colman, Jack M., additional, Daubeney, Piers E.F., additional, Davis, Andrew M., additional, Deanfield, John E., additional, Dearani, Joseph A., additional, Derrick, Graham, additional, Dipchand, Anne I., additional, Dominguez, Troy E., additional, Eastaugh, Lucas J., additional, Ebels, Tjark, additional, Elliott, Martin J., additional, Elliott, Perry, additional, Ellis, Toni, additional, Elzenga, Nynke, additional, English, Robert F., additional, Ettedgui, José A., additional, Friedman, Alan H., additional, Gandy, Kimberly L., additional, Gardiner, Helena M., additional, Gatzoulis, Michael A., additional, Grosse-Wortmann, Lars, additional, Gruber, Peter J., additional, Halcox, Julian P., additional, Haworth, Sheila G., additional, Hlavacek, Anthony M., additional, Hoffman, George M., additional, Horowitz, Estela S., additional, Hoschtitzky, J. Andreas, additional, Heroniz, Estela S., additional, Humpl, Tilman, additional, Hutter, Damian, additional, Jaeggi, Edgar T., additional, Jones, Timothy J.J., additional, Kaski, Juan Pablo, additional, Khambadkone, Sachin, additional, Kohr, Lisa M., additional, Lee, Whal, additional, Loukogeorgakis, Stavros P., additional, McBride, Michael G., additional, McCrindle, Brian W., additional, McNamara, Patrick J., additional, Mertens, Luc L., additional, Moorman, Antoon F.M., additional, Coelho Mota, Cleonice C., additional, Mussatto, Kathleen, additional, Newburger, Jane, additional, O'Leary, Patrick W., additional, Paridon, Stephen M., additional, Penny, Daniel J., additional, Qureshi, Shakeel A., additional, Rabinovitch, Marlene, additional, Redington, Andrew N., additional, Reid, Christopher J.D., additional, Reidy, John F., additional, Rigby, Michael L., additional, Rychik, Jack, additional, Salih, Caner, additional, Schulze-Neick, Ingram, additional, Sermer, Mathew, additional, Shaddy, Robert E., additional, Shekerdemian, Lara, additional, Shillingford, Amanda J., additional, Shirali, Girish S., additional, Silverman, Norman H., additional, Silversides, Candice K., additional, Sinha, Manish D., additional, Siu, Samuel C., additional, Smallhorn, Jeffrey F., additional, Srivastava, Deepak, additional, Stephens, Paul, additional, Stephenson, Elizabeth A., additional, Szwast, Anita L., additional, Taib, Rohayati, additional, Tulzer, Gerald, additional, Tweddell, James, additional, Uemura, Hideki, additional, Vanderwal, Patrick, additional, Vogel, Michael C., additional, Webb, Gary D., additional, Webber, Steven A., additional, Wernovsky, Gil, additional, Wilkinson, James L., additional, and Yoo, Shi-Joon, additional

Published
2010
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43. Predictors of cardiovascular health in teenagers (aged 13–14 years): a cross-sectional study linked with routine data

Author

James, Michaela, primary, Christian, Danielle, additional, Scott, Samantha, additional, Todd, Charlotte, additional, Stratton, Gareth, additional, Demmler, Joanne, additional, McCoubrey, Sarah, additional, Halcox, Julian P, additional, Audrey, Suzanne, additional, Ellins, Elizabeth Anne, additional, and Brophy, Sinead, additional

Published
2019
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46. Ultrasound-Versus Fluoroscopy-Guided Strategy for Transfemoral Transcatheter Aortic Valve Replacement Access: A Systematic Review and Meta-Analysis.

Author

Kotronias, Rafail A., Bray, Jonathan J. H., Rajasundaram, Skanda, Vincent, Flavien, Delhaye, Cedric, Scarsini, Roberto, Marin, Federico, Terentes-Printzios, Dimitrios, Halcox, Julian P. J., Mamas, Mamas A., Kharbanda, Rajesh, Van Belle, Eric, and Banning, Adrian P.

Abstract

BACKGROUND: Access site vascular and bleeding complications remain problematic for patients undergoing transcatheter aortic valve replacement (TAVR). Ultrasound-guided transfemoral access approach has been suggested as a technique to reduce access site complications, but there is wide variation in adoption in TAVR. We performed a systematic review and metaanalysis to compare access site vascular and bleeding complications according to the Valve Academic Research Consortium-2 classification following the use of either ultrasound- or conventional fluoroscopy-guided transfemoral TAVR access. METHODS: Medline, Embase, Web of Science, and The Cochrane Library were searched to November 2020 for studies comparing ultrasound- and fluoroscopy-guided access for transfemoral TAVR. A priori defined primary outcomes were extracted: (1) major, (2) minor, and (3) major and minor (total) access site vascular complications and (4) life-threatening/major, (5) minor, and (6) life-threatening, major, and minor (total) access site bleeding complications. RESULTS: Eight observational studies (n=3875) were included, with a mean participant age of 82.8 years, STS score 5.81, and peripheral vascular disease in 23.5%. An ultrasound-guided approach was significantly associated with a reduced risk of total (Mantel-Haenszel odds ratio [MH-OR], 0.50 [95% CI, 0.35-0.73]), major (MH-OR, 0.51 [95% CI, 0.35-0.74]), and minor (MH-OR, 0.59 [95% CI, 0.38-0.91]) access site vascular complications. Ultrasound guidance was also significantly associated with total access site bleeding complications (MH-OR, 0.59 [95% CI, 0.39-0.90]). The association remained significant in sensitivity analyses of maximally adjusted minor and total vascular access site complications (MH-OR, 0.51 [95% CI, 0.29-0.90]; MH-OR, 0.44 [95% CI, 0.20-0.99], respectively). CONCLUSIONS: In the absence of randomized studies, our data suggests a potential benefit for ultrasound guidance to obtain percutaneous femoral access in TAVR. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Carotid artery wave intensity in mid- to late-life predicts cognitive decline: the Whitehall II study

Author

Chiesa, Scott T, Masi, Stefano, Shipley, Martin J, Ellins, Elizabeth A, Fraser, Alan G, Hughes, Alun D, Patel, Riyaz S, Khir, Ashraf W, Halcox, Julian P, Singh-Manoux, Archana, Kivimaki, Mika, Celermajer, David S, and Deanfield, John E

Subjects
Male, cardiovascular risk factors, Prevention and Epidemiology, Carotid Artery, Common, Age Factors, Fast Track Clinical Research, Cognitive decline, Middle Aged, wave intensity, Prognosis, cognitive decline, Cohort Studies, Wave intensity, Cognition, Whitehall II study, Pulsatile Flow, Humans, Female, Cognitive Dysfunction, Cardiovascular risk factors, Aged
Abstract

© The Author(s) 2019. Aims: Excessive arterial pulsatility may contribute to cognitive decline and risk of dementia via damage to the fragile cerebral microcirculation. We hypothesized that the intensity of downstream-travelling pulsatile waves measured by wave intensity analysis in the common carotid artery during mid- to late-life would be associated with subsequent cognitive decline. ......................................................................................................................................................... Methods and results: Duplex Doppler ultrasound was used to calculate peak forward-travelling compression wave intensity (FCWI) within the common carotid artery in 3191 individuals [mean ± standard deviation (SD), age = 61 ± 6 years; 75% male] assessed as part of the Whitehall II study in 2003–05. Serial measures of cognitive function were taken between 2002–04 and 2015–16. The relationship between FCWI and cognitive decline was adjusted for sociodemographic variables, genetic and health-related risk factors, and health behaviours. Mean (SD) 10-year change in standardized global cognitive score was -0.39 (0.18). Higher FCWI at baseline was associated with accelerated cognitive decline during follow-up [difference in 10-year change of global cognitive score per 1 SD higher FCWI = -0.02 (95% confidence interval -0.04 to -0.00); P = 0.03]. This association was largely driven by cognitive changes in individuals with the highest FCWI [Q4 vs. Q1–Q3 = -0.05 (-0.09 to -0.01), P = 0.01], equivalent to an age effect of 1.9 years. Compared to other participants, this group was 50% more likely to exhibit cognitive decline (defined as the top 15% most rapid reductions in cognitive function during follow-up) even after adjustments for multiple potential confounding factors [odds ratio 1.49 (1.17–1.88)]. ............................................................................................................................................... Conclusion: Elevated carotid artery wave intensity in mid- to late-life predicts faster cognitive decline in long-term follow-up independent of other cardiovascular risk factors. Whitehall II study was supported by the UK Medical Research Council [MR/R024227/1]; the US National Institute on Aging [NIA, R01AG056477], the British Heart Foundation [32334]; and European Commission [LIFEPATH 633666]. S.T.C. receives research funding from the Brain Protection Company Ltd (Australia). M.K. was supported by the Medical Research Council, NIA, NordForsk, and Helsinki Institute of Life Sciences (Finland). J.E.D. was a BHF-funded Professor from 2003 to 2017. A.D.H. receives support from the British Heart Foundation [PG/15/75/31748, CS/15/6/31468, and CS/13/1/30327], the National Institute for Health Research University College London Hospitals Biomedical Research Centre, and works in a unit that receives support from the UK Medical Research Council [Programme Code MC_UU_12019/1].

Published
2019

50. Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years.

Author

Murray, Robert, Kitaba, Negusse, Antoun, Elie, Titcombe, Philip, Barton, Sheila, Cooper, Cyrus, Inskip, Hazel M., Burdge, Graham C., Mahon, Pamela A., Deanfield, John, Halcox, Julian P., Ellins, Elizabeth A., Bryant, Jennifer, Peebles, Charles, Lillycrop, Karen, Godfrey, Keith M., Hanson, Mark A., and EpiGen Consortium

Abstract

[Figure: see text]. [ABSTRACT FROM AUTHOR]

Published
2021
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