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512 results on '"Hallmans, Goran"'

1. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Author

Machiela, Mitchell J, Zhou, Weiyin, Karlins, Eric, Sampson, Joshua N, Freedman, Neal D, Yang, Qi, Hicks, Belynda, Dagnall, Casey, Hautman, Christopher, Jacobs, Kevin B, Abnet, Christian C, Aldrich, Melinda C, Amos, Christopher, Amundadottir, Laufey T, Arslan, Alan A, Beane-Freeman, Laura E, Berndt, Sonja I, Black, Amanda, Blot, William J, Bock, Cathryn H, Bracci, Paige M, Brinton, Louise A, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie E, Butler, Mary A, Canzian, Federico, Carreon, Tania, Chaffee, Kari G, Chang, I-Shou, Chatterjee, Nilanjan, Chen, Chu, Chen, Constance, Chen, Kexin, Chung, Charles C, Cook, Linda S, Bou, Marta Crous, Cullen, Michael, Davis, Faith G, De Vivo, Immaculata, Ding, Ti, Doherty, Jennifer, Duell, Eric J, Epstein, Caroline G, Fan, Jin-Hu, Figueroa, Jonine D, Fraumeni, Joseph F, Friedenreich, Christine M, Fuchs, Charles S, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, Gaudet, Mia M, Gaziano, J Michael, Giles, Graham G, Gillanders, Elizabeth M, Giovannucci, Edward L, Goldin, Lynn, Goldstein, Alisa M, Haiman, Christopher A, Hallmans, Goran, Hankinson, Susan E, Harris, Curtis C, Henriksson, Roger, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Hsiung, Chao A, Hu, Nan, Hu, Wei, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Johansen, Christoffer, Khaw, Kay-Tee, Kim, Hee Nam, Kim, Yeul Hong, Kim, Young Tae, Klein, Alison P, Klein, Robert, Koh, Woon-Puay, Kolonel, Laurence N, Kooperberg, Charles, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, LaCroix, Andrea, Lan, Qing, Landi, Maria Teresa, Le Marchand, Loic, Li, Donghui, Liang, Xiaolin, Liao, Linda M, Lin, Dongxin, Liu, Jianjun, Lissowska, Jolanta, Lu, Lingeng, Magliocco, Anthony M, and Malats, Nuria

Published
2016

2. New genetic loci link adipose and insulin biology to body fat distribution

Author

Shungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Mägi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph MW, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jian’an, Randall, Joshua C, Scherag, André, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M, Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L, Buyske, Steven, Demirkan, Ayse, Ehret, Georg B, Feitosa, Mary F, Goel, Anuj, Jackson, Anne U, Johnson, Toby, Kleber, Marcus E, Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J, Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V, Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M, Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B, Caspersen, Ida H, Clarke, Robert, Warwick Daw, E, Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex SF, Eklund, Niina, Erdos, Michael R, Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S, Golay, Alain, Grallert, Harald, Grammer, Tanja B, Gräßler, Jürgen, Grewal, Jagvir, Groves, Christopher J, Haller, Toomas, and Hallmans, Goran

Subjects
Genetics, Human Genome, Diabetes, Obesity, Nutrition, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Cardiovascular, Stroke, Adipocytes, Adipogenesis, Adipose Tissue, Age Factors, Body Fat Distribution, Body Mass Index, Epigenesis, Genetic, Europe, Female, Genome, Human, Genome-Wide Association Study, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Neovascularization, Physiologic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Racial Groups, Sex Characteristics, Transcription, Genetic, Waist-Hip Ratio, ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, GLGC, ICBP, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, General Science & Technology
Abstract

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P

Published
2015

3. Genome-wide association study of survival in patients with pancreatic adenocarcinoma

Author

Wu, Chen, Kraft, Peter, Stolzenberg-Solomon, Rachael, Steplowski, Emily, Brotzman, Michelle, Xu, Mousheng, Mudgal, Poorva, Amundadottir, Laufey, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, Kooperberg, Charles, Petersen, Gloria M, Zheng, Wei, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Buring, Julie E, Canzian, Federico, Cao, Guangwen, Duell, Eric J, Elena, Joanne W, Gaziano, J Michael, Giovannucci, Edward L, Hallmans, Goran, Hutchinson, Amy, Hunter, David J, Jenab, Mazda, Jiang, Guoliang, Khaw, Kay-Tee, LaCroix, Andrea, Li, Zhaoshen, Mendelsohn, Julie B, Panico, Salvatore, Patel, Alpa V, Qian, Zhi Rong, Riboli, Elio, Sesso, Howard, Shen, Hongbing, Shu, Xiao-Ou, Tjonneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chengfeng, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen, Hoover, Robert, Hartge, Patricia, Fuchs, Charles S, Lin, Dongxin, and Wolpin, Brian M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Prevention, Rare Diseases, Pancreatic Cancer, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Asian People, Biomarkers, Tumor, China, Europe, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Models, Genetic, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, Principal Component Analysis, Proportional Hazards Models, Protein Tyrosine Phosphatases, Non-Receptor, Survival Rate, White People, Cancer Genetics, Molecular Epidemiology, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background and objectiveSurvival of patients with pancreatic adenocarcinoma is limited and few prognostic factors are known. We conducted a two-stage genome-wide association study (GWAS) to identify germline variants associated with survival in patients with pancreatic adenocarcinoma.MethodsWe analysed overall survival in relation to single nucleotide polymorphisms (SNPs) among 1005 patients from two large GWAS datasets, PanScan I and ChinaPC. Cox proportional hazards regression was used in an additive genetic model with adjustment for age, sex, clinical stage and the top four principal components of population stratification. The first stage included 642 cases of European ancestry (PanScan), from which the top SNPs (p≤10(-5)) were advanced to a joint analysis with 363 additional patients from China (ChinaPC).ResultsIn the first stage of cases of European descent, the top-ranked loci were at chromosomes 11p15.4, 18p11.21 and 1p36.13, tagged by rs12362504 (p=1.63×10(-7)), rs981621 (p=1.65×10(-7)) and rs16861827 (p=3.75×10(-7)), respectively. 131 SNPs with p≤10(-5) were advanced to a joint analysis with cases from the ChinaPC study. In the joint analysis, the top-ranked SNP was rs10500715 (minor allele frequency, 0.37; p=1.72×10(-7)) on chromosome 11p15.4, which is intronic to the SET binding factor 2 (SBF2) gene. The HR (95% CI) for death was 0.74 (0.66 to 0.84) in PanScan I, 0.79 (0.65 to 0.97) in ChinaPC and 0.76 (0.68 to 0.84) in the joint analysis.ConclusionsGermline genetic variation in the SBF2 locus was associated with overall survival in patients with pancreatic adenocarcinoma of European and Asian ancestry. This association should be investigated in additional large patient cohorts.

Published
2014

4. Genome-wide association study of glioma and meta-analysis

Author

Rajaraman, Preetha, Melin, Beatrice S, Wang, Zhaoming, McKean-Cowdin, Roberta, Michaud, Dominique S, Wang, Sophia S, Bondy, Melissa, Houlston, Richard, Jenkins, Robert B, Wrensch, Margaret, Yeager, Meredith, Ahlbom, Anders, Albanes, Demetrius, Andersson, Ulrika, Freeman, Laura E Beane, Buring, Julie E, Butler, Mary Ann, Braganza, Melissa, Carreon, Tania, Feychting, Maria, Fleming, Sarah J, Gapstur, Susan M, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Henriksson, Roger, Hoffman-Bolton, Judith, Inskip, Peter D, Johansen, Christoffer, Kitahara, Cari M, Lathrop, Mark, Liu, Chenwei, Le Marchand, Loic, Linet, Martha S, Lonn, Stefan, Peters, Ulrike, Purdue, Mark P, Rothman, Nathaniel, Ruder, Avima M, Sanson, Marc, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Simon, Matthias, Stampfer, Meir, Stevens, Victoria L, Visvanathan, Kala, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Decker, Paul, Enciso-Mora, Victor, Fridley, Brooke, Gao, Yu-Tang, Kosel, Matthew, Lachance, Daniel H, Lau, Ching, Rice, Terri, Swerdlow, Anthony, Wiemels, Joseph L, Wiencke, John K, Shete, Sanjay, Xiang, Yong-Bing, Xiao, Yuanyuan, Hoover, Robert N, Fraumeni, Joseph F, Chatterjee, Nilanjan, Hartge, Patricia, and Chanock, Stephen J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Clinical Research, Brain Disorders, Prevention, Brain Cancer, Neurosciences, Cancer, Human Genome, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Aged, Brain Neoplasms, Case-Control Studies, Cohort Studies, Cyclin-Dependent Kinase Inhibitor p15, DNA Helicases, Female, Genome-Wide Association Study, Glioblastoma, Glioma, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Telomerase, Complementary and Alternative Medicine, Paediatrics and Reproductive Medicine, Genetics & Heredity, Reproductive medicine
Abstract

Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.

Published
2012

6. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

Author

Tanaka, Toshiko, Ngwa, Julius S, van Rooij, Frank JA, Zillikens, M Carola, Wojczynski, Mary K, Frazier-Wood, Alexis C, Houston, Denise K, Kanoni, Stavroula, Lemaitre, Rozenn N, Luan, Jian’an, Mikkilä, Vera, Renstrom, Frida, Sonestedt, Emily, Zhao, Jing Hua, Chu, Audrey Y, Qi, Lu, Chasman, Daniel I, de Oliveira Otto, Marcia C, Dhurandhar, Emily J, Feitosa, Mary F, Johansson, Ingegerd, Khaw, Kay-Tee, Lohman, Kurt K, Manichaikul, Ani, McKeown, Nicola M, Mozaffarian, Dariush, Singleton, Andrew, Stirrups, Kathleen, Viikari, Jorma, Ye, Zheng, Bandinelli, Stefania, Barroso, Inês, Deloukas, Panos, Forouhi, Nita G, Hofman, Albert, Liu, Yongmei, Lyytikäinen, Leo-Pekka, North, Kari E, Dimitriou, Maria, Hallmans, Goran, Kähönen, Mika, Langenberg, Claudia, Ordovas, Jose M, Uitterlinden, André G, Hu, Frank B, Kalafati, Ioanna-Panagiota, Raitakari, Olli, Franco, Oscar H, Johnson, Andrew, Emilsson, Valur, Schrack, Jennifer A, Semba, Richard D, Siscovick, David S, Arnett, Donna K, Borecki, Ingrid B, Franks, Paul W, Kritchevsky, Stephen B, Lehtimäki, Terho, Loos, Ruth JF, Orho-Melander, Marju, Rotter, Jerome I, Wareham, Nicholas J, Witteman, Jacqueline CM, Ferrucci, Luigi, Dedoussis, George, Cupples, L Adrienne, and Nettleton, Jennifer A

Published
2013
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7. Circulating prolactin levels and risk of epithelial ovarian cancer

Author

Clendenen, Tess V., Arslan, Alan A., Lokshin, Anna E., Liu, Mengling, Lundin, Eva, Koenig, Karen L., Berrino, Franco, Hallmans, Goran, Idahl, Annika, Krogh, Vittorio, Lukanova, Annekatrin, Marrangoni, Adele, Muti, Paola, Nolen, Brian M., Ohlson, Nina, Shore, Roy E., Sieri, Sabina, and Zeleniuch-Jacquotte, Anne

Published
2013

8. PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer's disease risk

Author

Lindman, Karin Lopatko, Jonsson, Caroline, Weidung, Bodil, Olsson, Jan, Pandey, Janardan P., Prokopenko, Dmitry, Tanzi, Rudolph E., Hallmans, Goran, Eriksson, Sture, Elgh, Fredrik, Lovheim, Hugo, Lindman, Karin Lopatko, Jonsson, Caroline, Weidung, Bodil, Olsson, Jan, Pandey, Janardan P., Prokopenko, Dmitry, Tanzi, Rudolph E., Hallmans, Goran, Eriksson, Sture, Elgh, Fredrik, and Lovheim, Hugo

Abstract

PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer's disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case-control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (epsilon 3/epsilon 4 or epsilon 4/epsilon 4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52-1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32-0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA x GM 17/17 was observed for the risk of developing AD (p .02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.

Published
2022
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9. Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study

Author

Travier, Noémie, Agudo, Antonio, May, Anne M., Gonzalez, Carlos, Luan, Jian'an, Wareham, Nick J., Bueno-de-Mesquita, H. Bas, van den Berg, Saskia W., Slimani, Nadia, Rinaldi, Sabina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Palli, Domenico, Sieri, Sabina, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Norat, Teresa, Romaguera, Dora, Rodriguez, Laudina, Sanchez, Maria-José, Dorronsoro, Miren, Barricarte, Aurelio, Huerta, José M., Key, Tim J., Orfanos, Philippos, Naska, Androniki, Trichopoulou, Antonia, Rohrmann, Sabina, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Hallmans, Goran, Johansson, Ingegerd, Manjer, Jonas, Lindkvist, Björn, Jakobsen, Mariane U., Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra H.

Published
2012
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10. Occupation and risk of lymphoma: a multicentre prospective cohort study (EPIC)

Author

Neasham, David, Sifi, Ahlem, Nielsen, Kaspar Rene, Overvad, Kim, Raaschou-Nielsen, Ole, Tjønneland, Anne, Barricarte, Aurelio, González, Carlos A, Navarro, Carmen, Suarez, Laudina Rodriguez, Travis, Ruth C, Key, Tim, Linseisen, Jakob, Kaaks, Rudolf, Crosignani, Paolo, Berrino, Franco, Rosso, Stefano, Mattiello, Amalia, Vermeulen, R C H, Bueno-de-Mesquita, H Bas, Berglund, Göran, Manjer, Jonas, Zackrisson, Sophia, Hallmans, Goran, Malmer, Beatrice, Bingham, Sheila, Khaw, Kay Tee, Bergmann, Manuela M, Boeing, Heiner, Trichopoulou, Antonia, Masala, Giovanna, Tumino, Rosario, Lund, Eiliv, Slimani, Nadia, Ferrari, Pietro, Boffetta, Paolo, Vineis, Paolo, and Riboli, Elio

Published
2011

12. Second-hand Smoke, Cotinine Levels, and Risk of Circulatory Mortality in a Large Cohort Study of Never-Smokers

Author

Gallo, Valentina, Neasham, David, Airoldi, Luisa, Ferrari, Pietro, Jenab, Mazda, Boffetta, Paolo, Overvad, Kim, Tjønneland, Anne, Clavel-Chapelon, Francoise, Boeing, Heiner, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Arriola, Larraitz, Lund, Eiliv, Bueno-De-Mesquita, Bas, Peeters, Petra H., Melander, Olle, Hallmans, Goran, Riboli, Elio, Saracci, Rodolfo, and Vineis, Paolo

Published
2010

14. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Published
2015
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16. Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data

Author

Wang, Zhaoming, Rajaraman, Preetha, Melin, Beatrice S., Chung, Charles C., Zhang, Weijia, McKean-Cowdin, Roberta, Michaud, Dominique, Yeager, Meredith, Ahlbom, Anders, Albanes, Demetrius, Andersson, Ulrika, Freeman, Laura Beane E., Buring, Julie E., Butler, Mary Ann, Carreón, Tania, Feychting, Maria, Gapstur, Susan M., Gaziano, Michael J., Giles, Graham G., Hallmans, Goran, Henriksson, Roger, Hoffman-Bolton, Judith, Inskip, Peter D., Kitahara, Cari M., Le Marchand, Loic, Linet, Martha S., Li, Shengchao, Peters, Ulrike, Purdue, Mark P., Rothman, Nathaniel, Ruder, Avima M., Sesso, Howard D., Severi, Gianluca, Stampfer, Meir, Stevens, Victoria L., Visvanathan, Kala, Wang, Sophia S., White, Emily, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Fraumeni, Joseph F., Chatterjee, Nilanjan, Hartge, Patricia, and Chanock, Stephen J.

Published
2015
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17. Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

Author

Shungin, Dmitry, Cornelis, Marilyn C, Divaris, Kimon, Holtfreter, Birte, Shaffer, John R, Yu, Yau-Hua, Barros, Silvana P, Beck, James D, Biffar, Reiner, Boerwinkle, Eric A, Crout, Richard J., Ganna, Andrea, Hallmans, Goran, Hindy, George, Hu, Frank B, Kraft, Peter, McNeil, Daniel W, Melander, Olle, Moss, Kevin L, North, Kari E, Orho-Melander, Marju, Pedersen, Nancy L, Ridker, Paul M, Rimm, Eric B, Rose, Lynda M, Rukh, Gull, Teumer, Alexander, Weyant, Robert J, Chasman, Daniel I, Joshipura, Kaumudi, Kocher, Thomas, Magnusson, Patrik KE, Marazita, Mary L, Nilsson, Peter, Offenbacher, Steve, Davey Smith, George, Lundberg, Pernilla, Palmer, Tom M, Timpson, Nicholas J, Johansson, Ingegerd, and Franks, Paul W

Published
2015
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18. Genetic studies of body mass index yield new insights for obesity biology

Author

Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jianʼan, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E., de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Sin Lo, Ken, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Vernon Smith, Albert, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, vanʼt Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Adrienne Cupples, L., Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Kees Hovingh, G., Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Wouter Jukema, J., Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Carola Zillikens, M., Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., OʼConnell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.

Published
2015
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19. Smoking and body fatness measurements: A cross-sectional analysis in the EPIC–PANACEA study

Author

Travier, Noémie, Agudo, Antonio, May, Anne M., Gonzalez, Carlos, Luan, Jian'an, Besson, Hervé, Wareham, Nick J., Slimani, Nadia, Rinaldi, Sabina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Vineis, Paolo, Rodriguez, Laudina, Sanchez, Maria-José, Dorronsoro, Miren, Barricarte, Aurelio, Tormo, Maria-José, Norat, Teresa, Mouw, Traci, Key, Tim J., Spencer, Elizabeth A., Bueno-de-Mesquita, H. Bas, Vrieling, Alina, Orfanos, Philippos, Naska, Ada, Trichopoulou, Antonia, Rohrmann, Sabina, Kaaks, Rudolf, M. Bergmann, Manuela, Boeing, Heiner, Hallmans, Goran, Johansson, Ingegerd, Manjer, Jonas, Lindkvist, Björn, Jakobsen, Mariane Uhre, Overvad, Kim, Tjonneland, Anne, Halkjaer, Jytte, Lund, Eiliv, Braaten, Toni, Odysseos, Andreani, Riboli, Elio, and Peeters, Petra H.

Published
2009
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20. Performance in omics analyses of Blood Samples in long-term storage: opportunities for the exploitation of existing Biobanks in environmental health research

Author

Hebels, Dennie G.A.J., Georgiadis, Panagiotis, Keun, Hector C., Athersuch, Toby J., Vineis, Paolo, Vermeulen, Roel, Portengen, Lutzen, Bergdahl, Ingvar A., Hallmans, Goran, Palli, Domenico, Bendinelli, Benedetta, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Kleinjans, Jos C.S., Kok, Theo M.C.M. de, Smith, Martyn T., and Kyrtopoulos, Soterios A.

Subjects
Environmental health -- Research, Medical sciences -- Methods -- Forecasts and trends, Blood -- Analysis and chemistry, Market trend/market analysis, Environmental issues, Health
Abstract

BACKGROUND: The suitability for omic analysis of biosamples collected in previous decades and currently stored in biobanks is unknown. OBJECTIVES: We evaluated the influence of handling and storage conditions of [...]

Published
2013

21. Plasma Amyloid-beta in Relation to Antibodies Against Herpes Simplex Virus, Cytomegalovirus, and Chlamydophila pneumoniae

Author

Lindman, Karin Lopatko, Weidung, Bodil, Olsson, Jan, Josefsson, Maria, Johansson, Anders, Eriksson, Sture, Hallmans, Goran, Elgh, Fredrik, Lovheim, Hugo, Lindman, Karin Lopatko, Weidung, Bodil, Olsson, Jan, Josefsson, Maria, Johansson, Anders, Eriksson, Sture, Hallmans, Goran, Elgh, Fredrik, and Lovheim, Hugo

Abstract

Background: Amyloid-beta (A beta), the key constituent of Alzheimer's disease (AD) plaques, has antimicrobial properties. Objective: To investigate the association between plasma A beta and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae. Methods: Plasma from 339 AD cases, obtained on average 9.4 years (+/- 4.00) before diagnosis, and their matched controls were analyzed for A beta(40) and A beta(42) oncentrations with Luminex xMAP technology and INNOBIA plasma A beta-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases. Results: Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of A beta 42 or A beta 40 in cases or controls. Conclusion: Levels of plasma A beta were not associated with antibodies against different AD-related pathogens.

Published
2021
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23. Rye whole grain and bran intake compared with refined wheat decreases urinary C-peptide, plasma insulin, and prostate specific antigen in men with prostate cancer

Author

Landberg, Rikard, Andersson, Swen-Olof, Zhang, Jie-Xian, Johansson, Jan-Erik, Stenman, Ulf-Hakan, Adlercreutz, Herman, Kamal-Eldin, Afar, Aman, Per, and Hallmans, Goran

Subjects
Rye -- Health aspects, Bran -- Health aspects, Prostate cancer -- Care and treatment, Cancer patients -- Food and nutrition, Food/cooking/nutrition
Abstract

Rye whole grain and bran intake has shown beneficial effects on prostate cancer progression in animal models, including lower tumor take rates, smaller tumor volumes, and reduced prostate specific antigen (PSA) concentrations. A human pilot study showed increased apoptosis after consumption of rye bran bread. In this study, we investigated the effect of high intake of rye whole grain and bran on prostate cancer progression as assessed by PSA concentration in men diagnosed with prostate cancer. Seventeen participants were provided with 485 g rye whole grain and bran products (RP) or refined wheat products with added cellulose (WP), corresponding to ~50% of daily energy intake, in a randomized controlled, crossover design. Blood samples were taken from fasting men before and after 2, 4, and 6 wk of treatment and 24-h urine samples were collected before the first intervention period and after treatment. Plasma total PSA concentrations were lower after treatment with RP compared with WP, with a mean treatment effect of -14% (P = 0.04). Additionally, fasting plasma insulin and 24-h urinary C-peptide excretion were lower after treatment with R P compared with WP (P < 0.01 and P = 0.01, respectively). Daily excretion of 5 lignans was higher after the RP treatment than after the WP treatment (P < 0.001). We conclude that whole grain and bran from rye resulted in significantly lower plasma PSA compared with a cellulose-supplemented refined wheat diet in patients with prostate cancer. The effect may be related to inhibition of prostate cancer progression caused by decreased exposure to insulin, as indicated by plasma insulin and urinary C-peptide excretion. J. Nutr. 140: 2180-2186, 2010. doi: 10.3945/jn.110.127688.

Published
2010

24. Serum B vitamin levels and risk of lung cancer

Author

Johansson, Mattias, Relton, Caroline, Ueland, Per Magne, Vollset, Stein Emil, Midttun, Oivind, Boffetta, Paolo, Jenab, Mazda, Clavel-Chapelon, Francoise, Nygard, Ottar, Slimani, Nadia, Boutron-Ruault, Marie-Christine, Rohrmann, Sabine, Boeing, Heiner, Weikert, Cornelia, Fagherazzi, Guy, Kaaks, Rudolf, Buenode-Mesquita, Bas, Agudo, Antonio, Barricarte, Aurelio, Navarro, Carmen, Ros, Martine M., van Gils,Carla H., Peeters, Petra H.M., Rodriguez, Laudina, Norat, Teresa, Krogh, Vittorio, Masala, Giovanna, Wareham, Nick, Allen, Naomi E., Crowe, Francesca, Gallo, Valentina, Sanchez, Maria-Jose, Larranaga, Nerea, Khaw, Kay-Tee, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Trichopoulou, Antonia, Lagiou, Pagona, Hallmans, Goran, Riboli, Elio, Vineis, Paolo, Brennan, Paul, Trichopoulos, Dimitrios, and Rasmuson, Torgny

Subjects
Lung cancer -- Risk factors, Serum -- Health aspects, Gene expression -- Analysis
Abstract

A study was conducted to evaluate the association, if any between serum B vitamin levels such as 1-carbon metabolism factors and the risk of lung cancer. Results indicated that such levels and methionine were inversely associated with the risk of lung cancer.

Published
2010

25. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C., Sampson, Joshua N., Hoskins, Jason W., Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S., Abnet, Christian C., Adjei, Andrew A., Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E., Ambrosone, Christine B., Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Jr, Andrulis, Irene L., Arici, Cecilia, Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Beane Freeman, Laura E., Berg, Christine D., Berndt, Sonja I., Bertazzi, Pier Alberto, Biritwum, Richard B., Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brennan, Paul, Brinton, Louise A., Brotzman, Michelle, Bueno-de-Mesquita, H. Bas, Buring, Julie E., Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E., Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P., Chu, Lisa W., Clavel-Chapelon, Francoise, Colditz, Graham A., Colt, Joanne S., Conti, David, Cook, Michael B., Cortessis, Victoria K., Crawford, E. David, Cussenot, Olivier, Davis, Faith G., De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P., Di Stefano, Anna Luisa, Diver, W. Ryan, Duell, Eric J., Elena, Joanne W., Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D., Flanagan, Adrienne M., Fraumeni, Joseph F., Jr, Freedman, Neal D., Fridley, Brooke L., Fuchs, Charles S., Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, Garcia-Closas, Reina, Gastier-Foster, Julie M., Gaziano, J. Michael, Gerhard, Daniela S., Giffen, Carol A., Giles, Graham G., Gillanders, Elizabeth M., Giovannucci, Edward L., Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gonzalez, Carlos, Gorlick, Richard, Greene, Mark H., Gross, Myron, Grossman, H. Barton, Grubb, Robert, III, Gu, Jian, Guan, Peng, Haiman, Christopher A., Hallmans, Goran, Hankinson, Susan E., Harris, Curtis C., Hartge, Patricia, Hattinger, Claudia, Hayes, Richard B., He, Qincheng, Helman, Lee, Henderson, Brian E., Henriksson, Roger, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hsing, Ann W., Hsiung, Chao Agnes, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Hunter, David J., Inskip, Peter D., Ito, Hidemi, Jacobs, Eric J., Jacobs, Kevin B., Jenab, Mazda, Ji, Bu-Tian, Johansen, Christoffer, Johansson, Mattias, Johnson, Alison, Kaaks, Rudolf, Kamat, Ashish M., Kamineni, Aruna, Karagas, Margaret, Khanna, Chand, Khaw, Kay-Tee, Kim, Christopher, Kim, In-Sam, Kim, Jin Hee, Kim, Yeul Hong, Kim, Young-Chul, Kim, Young Tae, Kang, Chang Hyun, Jung, Yoo Jin, Kitahara, Cari M., Klein, Alison P., Klein, Robert, Kogevinas, Manolis, Koh, Woon-Puay, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kratz, Christian P., Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kurucu, Nilgun, Lan, Qing, Lathrop, Mark, Lau, Ching C., Lecanda, Fernando, Lee, Kyoung-Mu, Lee, Maxwell P., Le Marchand, Loic, Lerner, Seth P., Li, Donghui, Liao, Linda M., Lim, Wei-Yen, Lin, Dongxin, Lin, Jie, Lindstrom, Sara, Linet, Martha S., Lissowska, Jolanta, Liu, Jianjun, Ljungberg, Börje, Lloreta, Josep, Lu, Daru, Ma, Jing, Malats, Nuria, Mannisto, Satu, Marina, Neyssa, Mastrangelo, Giuseppe, Matsuo, Keitaro, McGlynn, Katherine A., McKean-Cowdin, Roberta, McNeill, Lorna H., McWilliams, Robert R., Melin, Beatrice S., Meltzer, Paul S., Mensah, James E., Miao, Xiaoping, Michaud, Dominique S., Mondul, Alison M., Moore, Lee E., Muir, Kenneth, Niwa, Shelley, Olson, Sara H., Orr, Nick, Panico, Salvatore, Park, Jae Yong, Patel, Alpa V., Patino-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Peplonska, Beata, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Pu, Xia, Purdue, Mark P., Qiao, You-Lin, Rajaraman, Preetha, Riboli, Elio, Risch, Harvey A., Rodabough, Rebecca J., Rothman, Nathaniel, Ruder, Avima M., Ryu, Jeong-Seon, Sanson, Marc, Schned, Alan, Schumacher, Fredrick R., Schwartz, Ann G., Schwartz, Kendra L., Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Severi, Gianluca, Shen, Hongbing, Shen, Min, Shete, Sanjay, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesumaga, Luis, Sierri, Sabina, Loon Sihoe, Alan Dart, Silverman, Debra T., Simon, Matthias, Southey, Melissa C., Spector, Logan, Spitz, Margaret, Stampfer, Meir, Stattin, Par, Stern, Mariana C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael Z., Stram, Daniel O., Strom, Sara S., Su, Wu-Chou, Sund, Malin, Sung, Sook Whan, Swerdlow, Anthony, Tan, Wen, Tanaka, Hideo, Tang, Wei, Tang, Ze-Zhang, Tardon, Adonina, Tay, Evelyn, Taylor, Philip R., Tettey, Yao, Thomas, David M., Tirabosco, Roberto, Tjonneland, Anne, Tobias, Geoffrey S., Toro, Jorge R., Travis, Ruth C., Trichopoulos, Dimitrios, Troisi, Rebecca, Truelove, Ann, Tsai, Ying-Huang, Tucker, Margaret A., Tumino, Rosario, Van Den Berg, David, Van Den Eeden, Stephen K., Vermeulen, Roel, Vineis, Paolo, Visvanathan, Kala, Vogel, Ulla, Wang, Chaoyu, Wang, Chengfeng, Wang, Junwen, Wang, Sophia S., Weiderpass, Elisabete, Weinstein, Stephanie J., Wentzensen, Nicolas, Wheeler, William, White, Emily, Wiencke, John K., Wolk, Alicja, Wolpin, Brian M., Wong, Maria Pik, Wrensch, Margaret, Wu, Chen, Wu, Tangchun, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Yang, Hannah P., Yang, Pan-Chyr, Yatabe, Yasushi, Ye, Yuanqing, Yeboah, Edward D., Yin, Zhihua, Ying, Chen, Yu, Chong-Jen, Yu, Kai, Yuan, Jian-Min, Zanetti, Krista A., Zeleniuch-Jacquotte, Anne, Zheng, Wei, Zhou, Baosen, Mirabello, Lisa, Savage, Sharon A., Kraft, Peter, Chanock, Stephen J., Yeager, Meredith, Landi, Maria Terese, Shi, Jianxin, Chatterjee, Nilanjan, and Amundadottir, Laufey T.

Published
2014
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26. Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer

Author

Landberg, Rikard, Kamal-Eldin, Afaf, Andersson, Swen-Olof, Johansson, Jan-Erik, Zhang, Jie-Xian, Hallmans, Goran, and Aman, Per

Subjects
Prostate cancer -- Care and treatment, Tumor markers -- Research, High-fiber diet -- Management, Company business management, Food/cooking/nutrition
Abstract

Alkylresorcinols (AR), phenolic lipids exclusively present in the outer parts of wheat and rye grains, have been proposed as concentration biomarkers of whole-grain wheat and rye intake. A key feature of a good biomarker is high reproducibility, which indicates how accurately a single sample reflects the true mean biomarker concentration caused by a certain intake. In this study, the short- to medium-term reproducibility of plasma AR was determined using samples from a crossover intervention study, where men with prostate cancer (n = 17) were fed rye whole-grain/bran or refined wheat products for 6-wk periods. AR homologs C17:0 and C21:0 differed between the treatments (P< 0.001). The reproducibility determined by the intraclass correlation coefficient (ICC) was high (intervention period 1 : ICC = 0.90 [95% CI = 0.82-0.98], intervention period 2: ICC = 0.88 [95% CI = 0.78-0.98]). The results show that a single fasting plasma sample could be used to estimate the mean plasma AR concentration during a 6-wk intervention period with constant intake at a precision of [+ or -] 20% (80% CI). This suggests that the plasma AR concentration can be used as a reliable short- to medium-term biomarker for whole-grain wheat and rye under intervention conditions where intake is kept constant.

Published
2009

27. Genetic variation in glutathione-related genes and body burden of methylmercury

Author

Engstrom, Karin Schlawicke, Stromberg, Ulf, Lundh, Thomas, Johansson, Ingegerd, Vessby, Bengt, Hallmans, Goran, Skerfving, Staffan, and Broberg, Karin

Subjects
Glutathione -- Genetic aspects, Glutathione -- Health aspects, Methylmercury -- Health aspects, Methylmercury -- Research, Health risk assessment -- Methods
Abstract

BACKGROUND: Exposure to toxic methylmercury (MeHg) through fish consumption is a large problem worldwide, and it has led to governmental recommendations of reduced fish consumption and blacklisting of mercury-contaminated fish. [...]

Published
2008

28. Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic population

Author

Nothlings, Ute, Schulze, Matthias B., Weikert, Cornelia, Boeing, Heiner, van der Schouw, Yvonne T., Bamia, Christina, Benetou, Vasiliki, Lagiou, Pagona, Krogh, Vittorio, Beulens, Joline W.J., Peeters, Petra H.M., Halkjaer, Jytte, Tjonneland, Anne, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Clavel-Chapelon, Francoise, Lauzon, Blandine de, Boutron-Ruault, Marie-Christine, Vercambre, Marie-Noel, Kaaks, Rudolf, Linseisen, Jakob, Overvad, Kim, Arriola, Larraitz, Ardanaz, Eva, Gonzalez, Carlos A., Tormo, Marie-Jose, Bingham, Sheila, Khaw, Kay-Tee, Key, Tim J.A., Vineis, Paolo, Riboli, Elio, Ferrari, Pietro, Boffetta, Paolo, Bueno-de-Mesquita, H. Bas, van der A, Daphne L., Berglund, Goran, Wirfalt, Elisabet, Hallmans, Goran, Johansson, Ingegerd, Lund, Eiliv, and Trichopoulo, Antonia

Subjects
Vegetables -- Nutritional aspects, Vegetables -- Health aspects, Beans -- Health aspects, Beans -- Nutritional aspects, Legumes -- Health aspects, Legumes -- Nutritional aspects, Mimosaceae -- Health aspects, Mimosaceae -- Nutritional aspects, Fruit -- Nutritional aspects, Fruit -- Health aspects, Diabetics -- Food and nutrition, Cardiovascular diseases -- Prevention, Cancer -- Prevention, Cancer -- Nutritional aspects, Food/cooking/nutrition
Abstract

We examined the associations of intake of vegetables, legumes and fruit with all-cause and cause-specific morality in a population with prevalent diabetes in Europe. A cohort of 10,449 participants with self-reported diabetes within the European Prospective Investigation into Cancer and Nutrition study was followed for a mean of 9 y. Intakes of vegetables, legumes, and fruit were assessed at baseline between 1992 and 2000 using validated country-specific questionnaires. A total of 1346 deaths occurred. Multivariate relative risks (RR) for all-cause mortality were estimated in Cox regression models and RR for causespecific mortality were derived in a competing risk model. An increment in intake of total vegetables, legumes, and fruit of 80 g/d was associated with a RR of death from all causes of 0.94 [95% CI 0.9043.98]. Analyzed separately, vegetables and legumes were associated with a significantly reduced risk, whereas nonsignificant inverse associations for fruit intake were observed. Cardiovascular disease (CVD) mortality and mortality due to non-CVD/non-cancer causes were significantly inversely associated with intake of total vegetables, legumes, and fruit (RR 0.88 [95% CI 0.81-0.95] and 0.90 [0.82-0.99], respectively) but not cancer mortality (1.08 [0.99-1.17]). Intake of vegetables, legumes, and fruit was associated with reduced risks of allcause and CVD mortality in a diabetic population. The findings support the current state of evidence from general population studies that the protective potential of vegetable and fruit intake is larger for CVD than for cancer and suggest that diabetes patients may benefit from a diet high in vegetables and fruits.

Published
2008

29. Large-scale analysis of associating between LRP5 and LRP6 variants and osteoporosis

Author

van Meurs, Joyce B.J., Trikalinos, Thomas A., Ralston, Stuart H., Balcells, Susana, Brandi, Maria Luisa, Brixen, Kim, Kiel, Douglas P., Langdahl, Bente L., Lips, Paul, Ljunggren, Osten, Lorenc, Roman, Obermayer-Pietsch, Barbara, Ohlsson, Claes, Pettersson, Ulrika, Reid, David M., Rousseau, Francois, Scollen, Serena, Van Hul, Wim, Agueda, Lidia, Akesson, Kristina, Benevolenskaya, Lidia I., Ferrari, Serge L., Hallmans, Goran, Hofman, Albert, Husted, Lise Bjerre, Kruk, Marcin, Kaptoge, Stephen, Karasik, David, Karlsson, Magnus K., Lorentzon, Mattias, Masi, Laura, McGuigan, Fiona E.A., Mellstrom, Dan, Mosekilde, Leif, Nogues, Xavier, Pols, Huibert A.P., Reeve, Jonathan, Renner, Wilfried, Rivadeneira, Fernando, van Schoor, and Natasja M.

Subjects
Fractures -- Risk factors, Fractures -- Health aspects, Osteoporosis -- Genetic aspects, Low density lipoprotein receptors -- Research, Mutation (Biology) -- Research, Bones -- Density, Bones -- Genetic aspects
Abstract

A study to examine whether mutations to low-density lipoprotein receptor-related protein 5 (LRP5) and LRP6 affected bone mineral density (BMD) and increased the risk of fractures was conducted. Results revealed that LRP5 variants were commonly associated with BMD and increased risk of fractures.

Published
2008

30. Variations in Plasma Phytoestrogen Concentrations in European Adults

Author

Peeters, Petra H.M., Slimani, Nadia, van der Schouw, Yvonne T., Grace, Philip B., Navarro, Carmen, Tjonneland, Anne, Olsen, Anja, Clavel-Chapelon, Francoise, Touillaud, Marina, Boutron-Ruault, Marie-Christine, Jenab, Mazda, Kaaks, Rudolf, Linseisen, Jakob, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Dilis, Vardis, Boeing, Heiner, Weikert, Cornelia, Overvad, Kim, Pala, Valeria, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Bueno-de-Mesquita, H. Bas, van Gils, Carla H., Skeie, Guri, Jakszyn, Paula, Hallmans, Goran, Berglund, Goran, Key, Tim J., Travis, Ruth, Riboli, Elio, and Bingham, Sheila A.

Published
2007
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31. An Ig gamma Marker Genotype Is a Strong Risk Factor for Alzheimer Disease, Independent of Apolipoprotein E epsilon 4 Genotype

Author

Pandey, Janardan P., Olsson, Jan, Weidung, Bodil, Kothera, Ronald T., Johansson, Anders, Eriksson, Sture, Hallmans, Goran, Elgh, Fredrik, Lovheim, Hugo, Pandey, Janardan P., Olsson, Jan, Weidung, Bodil, Kothera, Ronald T., Johansson, Anders, Eriksson, Sture, Hallmans, Goran, Elgh, Fredrik, and Lovheim, Hugo

Abstract

Increasing evidence implicates HSV type 1 (HSV1) in the pathogenesis of late-onset Alzheimer disease (AD). HSV1 has evolved highly sophisticated strategies to evade host immunosurveillance. One strategy involves encoding a decoy Fc gamma receptor (Fc gamma R), which blocks Fc-mediated effector functions, such as Ab-dependent cellular cytotoxicity. Ig gamma marker (GM) allotypes, encoded by highly polymorphic IGHG genes on chromosome 14q32, modulate this immunoevasion strategy, and thus may act as effect modifiers of the HSV1-AD association. In this nested case-control human study, 365 closely matched case-control pairs-whose blood was drawn on average 9.6 y before AD diagnosis-were typed for GM alleles by a TagMan genotyping assay. APOE genotype and a genetic risk score based on nine additional previously known AD risk genes (ABCA7, BIN1, CD33, CLU, CR1, EPHA1, MS4A4E, NECTIN2, and PICALM) were extracted from a genome-wide association study analysis. Antiviral Abs were measured by ELISA. Conditional logistic regression models were applied. The distribution of GM 3/17 genotypes differed significantly between AD cases and controls, with higher frequency of GM 17/17 homozygotes in AD cases as compared with controls (19.8 versus 10.7%, p = 0.001). The GM 17/17 genotype was associated with a 4-fold increased risk of AD (odds ratio 4.142,p < 0.001). In conclusion, the results of this study demonstrate that Ig GM 17/17 genotype contributes to the risk of later AD development, independent of apolipoprotein epsilon 4 genotype and other AD risk genes, and explain, at least in part, why every HSV1-infected person is not equally likely to develop HSV1-associated AD.

Published
2020
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32. Prespecified 4-Kallikrein Marker Model at Age 50 or 60 for Early Detection of Lethal Prostate Cancer in a Large Population Based Cohort of Asymptomatic Men Followed for 20 Years

Author

Vertosick, Emily A., Häggström, Christel, Sjoberg, Daniel D., Hallmans, Goran, Johansson, Robert, Vickers, Andrew J., Stattin, Pär, Lilja, Hans, Vertosick, Emily A., Häggström, Christel, Sjoberg, Daniel D., Hallmans, Goran, Johansson, Robert, Vickers, Andrew J., Stattin, Pär, and Lilja, Hans

Abstract

Purpose: A prespecified statistical model based on 4 kallikrein markers in blood, commercially available as the 4Kscore (R), has been shown to accurately detect high grade (greater than Grade Group 2) prostate cancer in men with moderately elevated prostate specific antigen. We assessed whether the model predicted prostate cancer metastasis or death in men not subject to prostate specific antigen screening. Materials and Methods: The cohort includes 43,692 unscreened prostate cancerfree men from a Swedish population based cohort with low rates of prostate specific antigen screening (Vasterbotten Intervention Project). Using cryopreserved blood collected at ages 50 and 60 years from men in this cohort we analyzed the association between prostate specific antigen and other kallikrein marker levels in blood and risk of prostate cancer metastasis or death. Results: There were 308 with metastases and 172 prostate cancer deaths. Baseline prostate specific antigen was strongly associated with 20-year risk of prostate cancer death (c-index at age 50, 0.859, 95% CI 0.799-0.916; age 60, 0.840, 95% CI 0.799-0.878). Men 60 years old with prostate specific antigen below median (less than 1.2 ng/ml) had 0.4% risk of prostate cancer death at 20 years. Among men with moderately elevated prostate specific antigen (2.0 ng/ml or greater) the 4Kscore markedly improved discrimination (c-index 0.767 vs 0.828 and 0.774 vs 0.862 in men age 50 and 60, respectively). Long-term risk of prostate cancer death or metastasis in men with low 4Kscores was very low. Conclusions: Screening should focus on men in top prostate specific antigen quartile at age 60 years. Men with elevated prostate specific antigen but a low 4Kscore can safely be monitored with repeated blood markers in place of immediate biopsy.

Published
2020
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33. Consumption of vegetables and fruits and risk of breast cancer

Author

Gils, Carla H. van, Kesse, Emmanuelle, Thiebaut, Anne, Clavel-Chapelon, Francoise, Lahmann, Petra H., Boshuizen, Hendriek C., Bueno-dre-Mesquita, H. Bass, Peeters, Petra H.M., Sieri, Sabina, Ardanaz, Eva, Gonzalez, Carlos A., Vineis, Paolo, Panico, Salvatore, Tumino, rosario, Palli, domenico, Amiano, Pilar, Bingham, Sheila A., Psaltopoulou, Theodara, Allen, Naomi, Khaw, Kay-Tee, Key, tomothy J., Quiros, Jose R., Navarro, Carmen, Koliva, Maria, Wirfalt-Hallmans, Goran, Berglund, Goran, Boeing, Heiner, Linseisen, Jakob, Nagel, Gabriele, Trichopoulou, Antonia, Lenner, Per, Norat, Teresa, Alasker, Elin, Engeset, Dagrun, Lund, Eiliv, Olsen, Anja, Tjonneland, Anne, and Overvad, Kim

Subjects
Vegetables -- Nutritional aspects, Fruit -- Nutritional aspects, Breast cancer -- Risk factors
Abstract

Prospective study of women between the ages of 25 and 70 years is conducted to investigate the relation between total and specific vegetables and fruit intake as well as the incidence of breast cancer. The conclusion states that total or specific vegetable and fruit intake is not associated with risk for breast cancer.

Published
2005

34. Pregnancy-induced chromatin remodeling in the breast of postmenopausal women

Author

Russo, Jose, Santucci-Pereira, Julia, de Cicco, Ricardo López, Sheriff, Fathima, Russo, Patricia A., Peri, Suraj, Slifker, Michael, Ross, Eric, Mello, Maria Luiza S., Vidal, Benedicto C., Belitskaya-Lévy, Ilana, Arslan, Alan, Zeleniuch-Jacquotte, Anne, Bordas, Pal, Lenner, Per, Ahman, Janet, Afanasyeva, Yelena, Hallmans, Goran, Toniolo, Paolo, and Russo, Irma H.

Published
2012
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35. Association between adult height, genetic susceptibility and risk of glioma

Author

Kitahara, Cari M, Wang, Sophia S, Melin, Beatrice S, Wang, Zhaoming, Braganza, Melissa, Inskip, Peter D, Albanes, Demetrius, Andersson, Ulrika, Beane Freeman, Laura E, Buring, Julie E, Carreón, Tania, Feychting, Maria, Gapstur, Susan M, Gaziano, J Michael, Giles, Graham G, Hallmans, Goran, Hankinson, Susan E, Henriksson, Roger, Hsing, Ann W, Johansen, Christoffer, Linet, Martha S, McKean-Cowdin, Roberta, Michaud, Dominique S, Peters, Ulrike, Purdue, Mark P, Rothman, Nathaniel, Ruder, Avima M, Sesso, Howard D, Severi, Gianluca, Shu, Xiao-Ou, Stevens, Victoria L, Visvanathan, Kala, Waters, Martha A, White, Emily, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Zheng, Wei, Hoover, Robert, Fraumeni, Joseph F, Jr, Chatterjee, Nilanjan, Yeager, Meredith, Chanock, Stephen J, Hartge, Patricia, and Rajaraman, Preetha

Published
2012
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37. Educational level and risk of colorectal cancer in EPIC with specific reference to tumor location

Author

Leufkens, Anke M., Van Duijnhoven, Fränzel J.B., Boshuizen, Hendriek C., Siersema, Peter D., Kunst, Anton E., Mouw, Traci, Tjnneland, Anne, Olsen, Anja, Overvad, Kim, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Françoise, Morois, Sophie, Krogh, Vittorio, Tumino, Rosario, Panico, Salvatore, Polidoro, Silvia, Palli, Domenico, Kaaks, Rudolf, Teucher, Birgit, Pischon, Tobias, Trichopoulou, Antonia, Orfanos, Philippos, Goufa, Ioulia, Peeters, Petra H.M., Skeie, Guri, Braaten, Tonje, Rodríguez, Laudina, Lujan-Barroso, Leila, Sánchez-Pérez, Maria-José, Navarro, Carmen, Barricarte, Aurelio, Zackrisson, Sophia, Almquist, Martin, Hallmans, Goran, Palmqvist, Richard, Tsilidis, Konstantinos K., Khaw, Kay-Tee, Wareham, Nick, Gallo, Valentina, Jenab, Mazda, Riboli, Elio, and Bueno-de-Mesquita, Bas H.

Published
2012
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38. Human papillomavirus infection as a risk factor for squamous cell carcinoma of the head and neck

Author

Mork, Jon, Lie, A. Kathrine, Glattre, Eystein, Hallmans, Goran, Jellum, Egil, Koskela, Pentti, Moller, Bjorn, Pukkala, Eero, Schiller, John T., Youngman, Linda, Lehtinen, Matti, and Dillner, Joakim

Subjects
Papillomavirus infections -- Health aspects, Head and neck cancer -- Risk factors, Squamous cell carcinoma -- Risk factors
Abstract

Infection with human papillomavirus 16 appears to be a risk factor for squamous cell cancer of the head and neck. This was the conclusion of a study of 292 people with squamous cell head and neck cancer and 1,568 healthy volunteers. This virus has also been linked to cervical cancer.

Published
2001

40. Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis

Author

Kanoni, Stavroula, Nettleton, Jennifer A., Hivert, Marie-France, Ye, Zheng, van Rooij, Frank J.A., Shungin, Dmitry, Sonestedt, Emily, Ngwa, Julius S., Wojczynski, Mary K., Lemaitre, Rozenn N., Gustafsson, Stefan, Anderson, Jennifer S., Tanaka, Toshiko, Hindy, George, Saylor, Georgia, Renstrom, Frida, Bennett, Amanda J., van Duijn, Cornelia M., Florez, Jose C., Fox, Caroline S., Hofman, Albert, Hoogeveen, Ron C., Houston, Denise K., Hu, Frank B., Jacques, Paul F., Johansson, Ingegerd, Lind, Lars, Liu, Yongmei, McKeown, Nicola, Ordovas, Jose, Pankow, James S., Sijbrands, Eric J.G., Syvänen, Ann-Christine, Uitterlinden, André G., Yannakoulia, Mary, Zillikens, M. Carola, Wareham, Nick J., Prokopenko, Inga, Bandinelli, Stefania, Forouhi, Nita G., Cupples, L. Adrienne, Loos, Ruth J., Hallmans, Goran, Dupuis, Josée, Langenberg, Claudia, Ferrucci, Luigi, Kritchevsky, Stephen B., McCarthy, Mark I., Ingelsson, Erik, Borecki, Ingrid B., Witteman, Jacqueline C.M., Orho-Melander, Marju, Siscovick, David S., Meigs, James B., Franks, Paul W., and Dedoussis, George V.

Published
2011
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41. Cigar and pipe smoking and cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

McCormack, Valerie A., Agudo, Antonio, Dahm, Christina C., Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Boeing, Heiner, Manjer, Jonas, Almquist, Martin, Hallmans, Goran, Johansson, Ingegerd, Chirlaque, Maria Dolores, Barricarte, Aurelio, Dorronsoro, Miren, Rodriguez, Laudina, Redondo, Maria Luisa, Khaw, Kay-Tee, Wareham, Nick, Allen, Naomi, Key, Tim, Riboli, Elio, and Boffetta, Paolo

Published
2010
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42. Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: ten-year follow-up of the GLACIER Study

Author

Renstrom, Frida, Shungin, Dmitry, Johansson, Ingegerd, Florez, Jose C., Hallmans, Goran, Hu, Frank B., and Franks, Paul W.

Subjects
Genes -- Physiological aspects -- Research, Type 2 diabetes -- Genetic aspects -- Research, Hyperglycemia -- Genetic aspects -- Risk factors -- Research, Health
Abstract

OBJECTIVE--To assess whether recently discovered genetic loci associated with hyperglycemia also predict long-term changes in glycemic traits. RESEARCH DESIGN AND METHODS--Sixteen fasting glucose-raising loci were genotyped in middle-aged adults from the Gene x Lifestyle interactions And Complex traits Involved in Elevated disease Risk (GLACIER) Study, a population-based prospective cohort study from northern Sweden. Genotypes were tested for association with baseline fasting and 2-h post-challenge glycemia (N = 16,330), and for changes in these glycemic traits during a 10-year follow-up period (N = 4,059). RESULTS--Cross-sectional directionally consistent replication with fasting glucose concentrations was achieved for 12 of 16 variants; 10 variants were also associated with impaired fasting glucose (IFG) and 7 were independently associated with 2-h postchallenge glucose concentrations. In prospective analyses, the effect alleles at four loci (GCK rs4607517, ADRA2A rs10885122, DGKB-TMEM195 rs2191349, and G6PC2 rs560887) were nominally associated with worsening fasting glucose concentrations during 10-years of follow-up. MTNR1B rs10830963, which was predictive of elevated fasting glucose concentrations in cross-sectional analyses, was associated with a protective effect on postchallenge glucose concentrations during follow-up; however, this was only when baseline fasting and 2-h glucoses were adjusted for. An additive effect of multiple risk alleles on glycemic traits was observed: a weighted genetic risk score (80th vs. 20th centiles) was associated with a 0.16 mmol/l (P = 2.4 x [10.sup.-6]) greater elevation in fasting glucose and a 64% (95% CI: 33-201%) higher risk of developing IFG during 10 years of follow-up. CONCLUSIONS--Our findings imply that genetic profiling might facilitate the early detection of persons who are genetically susceptible to deteriorating glucose control; studies of incident type 2 diabetes and discrete cardiovascular end points will help establish whether the magnitude of these changes is clinically relevant., Glucose homeostasis in healthy individuals is tightly controlled through a complex pathway of regulatory mechanisms involving multiple organs and tissues. Chronic elevations in fasting and postchallenge blood glucose concentrations are [...]

Published
2011
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43. Type-specific persistence of human papillomavirus DNA before the development of invasive cervical cancer

Author

Wallin, Keng-Ling, Wiklund, Fredrik, Angstrom, Tord, Bergman, Frank, Stendahl, Ulf, Wadell, Goran, Hallmans, Goran, and Dillner, Joakim

Subjects
Papillomavirus infections -- Health aspects, Cervical cancer -- Risk factors
Abstract

Women whose Pap smear shows the presence of human papillomavirus have an increased risk of developing cervical cancer. Researchers analyzed Pap smears of 118 women who eventually developed cervical cancer and 118 women who did not. The healthy women had another Pap smear as did the women diagnosed with cervical cancer. At that time, 77% of the women with cervical cancer tested positive for papillomavirus but only 4% of the healthy women tested positive. The women with cervical cancer had the same virus type as they had on the previous Pap smear.

Published
1999

44. Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition

Author

Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Raaschou-Nielsen, Ole, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Chang-Claude, Jenny, Kaaks, Rudolf, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Vrieling, Alina, Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Engeset, Dagrun, Martinez, Carmen, Gonzalez, Carlos A., Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy A., Hallmans, Goran, Ljungberg, Borje, Allen, Naomi E., Roddam, Andrew W., Bingham, Sheila, Khaw, Kay-Tee, Slimani, Nadia, Boffetta, Paolo, Jenab, Mazda, Mouw, Traci, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio

Published
2009
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45. Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study

Author

Warensjo, Eva, Jansson, Jan-Hakan, Cederholm, Tommy, Boman, Kurt, Eliasson, Mats, Hallmans, Goran, Johansson, Ingegerd, and Sjorgren, Per

Subjects
Biological markers -- Research, Heart attack -- Risk factors, Heart attack -- Research, Milkfat -- Health aspects, Milkfat -- Research, Saturated fatty acids -- Health aspects, Saturated fatty acids -- Research, Food/cooking/nutrition, Health
Abstract

Background: High intakes of saturated fat have been associated with cardiovascular disease, and milk fat is rich in saturated fat. Objective: The objective of this study was to investigate the association between the serum milk fat biomarkers pentadecanoic acid (15:0), heptadecanoic acid (17:0), and their sum (15:0+17:0) and a first myocardial infarction (MI). Design: The study design was a prospective case-control study nested within a large population-based cohort in Sweden. Included in the study were 444 cases (307 men) and 556 controls (308 men) matched on sex, age, date of examination, and geographic region. Clinical, anthropometric, biomarker fatty acid, physical activity, and dietary data were collected. The odds of a first MI were investigated by using conditional logistic regression. Results: In women, proportions of milk fat biomarkers in plasma phospholipids were significantly higher (P < 0.05) in controls than in cases and were, in general, negatively, albeit weakly, correlated with risk factors for metabolic syndrome. The crude standardized odds ratios of becoming an MI case were 0.74 (95% CI: 0.58, 0.94) in women and 0.91 (95% CI: 0.77, 1.1) in men. After multivariable adjustment for confounders, the inverse association remained in both sexes and was significant in women. In agreement with biomarker data, quartiles of reported intake of cheese (men and women) and fermented milk products (men) were inversely related to a first MI (P for trend < 0.05 for all). Conclusions: Milk fat biomarkers were associated with a lower risk of developing a first MI, especially in women. This was partly confirmed in analysis of fermented milk and cheese intake. Components of metabolic syndrome were observed as potential intermediates for the risk relations. Am J Clin Nutr 2010;92:194-202. doi: 10.3945/ajcn.2009.29054.

Published
2010

46. Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk

Author

Fawcett, Katherine A., Wheeler, Eleanor, Morris, Andrew P., Ricketts, Sally L., Hallmans, Goran, Rolandsson, Olov, Daly, Allan, Wasson, Jon, Permutt, Alan, Hattersley, Andrew T., Glaser, Benjamin, Franks, Paul W., McCarthy, Mark I., Wareham, Nicholas J., Sandhu, Manjinder S., and Barroso, Ines

Subjects
Nucleotide sequencing -- Usage -- Research -- Genetic aspects, DNA sequencing -- Usage -- Research -- Genetic aspects, Single nucleotide polymorphisms -- Research -- Usage -- Genetic aspects, Type 2 diabetes -- Risk factors -- Genetic aspects -- Research
Abstract

OBJECTIVE--Wolfram syndrome 1 (WFS1) single nucleotide polymorphisms (SNPs) are associated with risk of type 2 diabetes. In this study we aimed to refine this association and investigate the role of low-frequency WFS1 variants in type 2 diabetes risk. RESEARCH DESIGN AND METHODS--For fine-mapping, we sequenced WFS1 exons, splice junctions, and conserved noncoding sequences in samples from 24 type 2 diabetic case and 68 control subjects, selected tagging SNPs, and genotyped these in 959 U.K. type 2 diabetic case and 1,386 control subjects. The same genomic regions were sequenced in samples from 1,235 type 2 diabetic case and 1,668 control subjects to compare the frequency of rarer variants between ease and control subjects. RESULTS--Of 31 tagging SNPs, the strongest associated was the previously untested 3' untranslated region rs1046320 (P = 0.008); odds ratio 0.84 and P = 6.59 x [10.sup.-7] on further replication in 3,753 case and 4,198 control subjects. High correlation between rs1046320 and the original strongest SNP (rs10010131) ([r.sup.2] = 0.92) meant that we could not differentiate between their effects in our samples. There was no difference in the cumulative frequency of 82 rare (minor allele frequency [MAF] CONCLUSIONS--We identified six highly correlated SNPs that show strong and comparable associations with risk of type 2 diabetes, but further refinement of these associations will require large sample sizes (>100,000) or studies in ethnically diverse populations. Low frequency variants in WFS1 are unlikely to have a large impact on type 2 diabetes risk in white U.K. populations, highlighting the complexities of undertaking association studies with low-frequency variants identified by resequencing. Diabetes 59:741-746, 2010, The post genome-wide association study era presents several challenges. These include fine-mapping association signals to genes and/or variants within the genomic regions of interest, assessing the impact of low frequency [...]

Published
2010
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47. Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition1–3

Author

Saadatian-Elahi, Mitra, Slimani, Nadia, Chajès, Véronique, Jenab, Mazda, Goudable, Joëlle, Biessy, Carine, Ferrari, Pietro, Byrnes, Graham, Autier, Philippe, Peeters, Petra HM, Ocké, Marga, de Mesquita, Bas Bueno, Johansson, Ingegerd, Hallmans, Goran, Manjer, Jonas, Wirfält, Elisabet, Gonzalez, Carlos A, Navarro, Carmen, Martinez, Carmen, Amiano, Pilar, Suárez, Laudina Rodriguez, Ardanaz, Eva, Tjønneland, Anne, Halkjaer, Jytte, Overvad, Kim, Jakobsen, Marianne Uhre, Berrino, Franco, Pala, Valeria, Palli, Domenico, Tumino, Rosario, Vineis, Paolo, de Magistris, Maria Santucci, Spencer, Elisabeth A, Crowe, Francesca L, Bingham, Sheila, Khaw, Kay-Tee, Linseisen, Jakob, Rohrmann, Sabine, Boeing, Heiner, Noethlings, Ute, Olsen, Karina Standahl, Skeie, Guri, Lund, Eiliv, Trichopoulou, Antonia, Oustoglou, Erifili, Clavel-Chapelon, Françoise, and Riboli, Elio

Published
2009
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48. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study

Author

Capellá, Gabriel, Pera, Guillem, Sala, Núria, Agudo, Antonio, Rico, Francisco, Del Giudicce, Giuseppe, Plebani, Mario, Palli, Domenico, Boeing, Heiner, Bueno-de-Mesquita, H Bas, Carneiro, Fátima, Berrino, Franco, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Berglund, Göran, Simán, Henrik, Nyrén, Olof, Hallmans, Goran, Martinez, Carmen, Dorronsoro, Miren, Barricarte, Aurelio, Navarro, Carmen, Quirós, José R, Allen, Naomi, Key, Tim, Bingham, Sheila, Caldas, Carlos, Linseisen, Jakob, Nagel, Gabriele, Overvad, Kim, Tjonneland, Anne, Boshuizen, Hendriek C, Peeters, Petra HM, Numans, Mattijs E, Clavel-Chapelon, Françoise, Trichopoulou, Antonia, Lund, Eiliv, Jenab, Mazda, Kaaks, Rudolf, Riboli, Elio, and González, Carlos A

Published
2008

49. Fruit, vegetables, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition

Author

van Duijnhoven, Franzel J.B., Bueno-De-Mesquita, H. Bas, Ferrari, Pietro, Jenab, Mazda, Boshuizen, Hendriek C., Ros, Martine M., Casagrande, Corinne, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Thorlacius-Ussing, Ole, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Morois, Sophie, Kaaks, Rudolf, Linseisen, Jakob, Boeing, Heiner, Nothlings, Ute, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Misirli, Gesthimani, Palli, Domenico, Sieri, Sabina, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, Peeters, Petra H.M., van Gils, Carla H., Ocke, Marga C., Lund, Eiliv, Engeset, Dagrun, Skeie, Guri, Suarez, Laudina Rodriguez, Gonzalez, Carlos A., Sanchez, Maria-Jose, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Berglund, Goran, Manjer, Jonas, Hallmans, Goran, Palmqvist, Richard, Bingham, Sheila A., Khaw, Kay-Tee, Key, Timothy J., Allen, Naomi E., Boffetta, Paolo, Slimani, Nadia, Rinaldi, Sabina, Gallo, Valentina, Norat, Teresa, and Riboli, Elio

Subjects
Vegetables -- Health aspects, Vegetables -- Research, Colorectal cancer -- Prevention, Colorectal cancer -- Research, Fruit -- Health aspects, Fruit -- Research, Food/cooking/nutrition, Health
Abstract

Background: A high consumption of fruit and vegetables is possibly associated with a decreased risk of colorectal cancer (CRC). However, the findings to date are inconsistent. Objective: We examined the relation between self-reported usual consumption of fruit and vegetables and the incidence of CRC. Design: In the European Prospective Investigation into Cancer and Nutrition (EPIC), 452,755 subjects (131,985 men and 320,770 women) completed a dietary questionnaire in 1992-2000 and were followed up for cancer incidence and mortality until 2006. A multivariate Cox proportional hazard model was used to estimate adjusted hazard ratios (HRs) and 95% CIs. Results: After an average follow-up of 8.8 y, 2,819 incident CRC cases were reported. Consumption of fruit and vegetables was inversely associated with CRC in a comparison of the highest with the lowest EPIC-wide quintile of consumption (HR: 0.86; 95% CI: 0.75, 1.00; P for trend = 0.04), particularly with colon cancer risk (HR: 0.76; 95% CI: 0.63, 0.91; P for trend < 0.0l). Only after exclusion of the first 2 y of follow-up were these findings corroborated by calibrated continuous analyses for a 100-g increase in consumption: HRs of 0.95 (95% CI: 0.91, 1.00; P = 0.04) and 0.94 (95% CI: 0.89, 0.99; P = 0.02), respectively. The association between fruit and vegetable consumption and CRC risk was inverse in never and former smokers, but positive in current smokers. This modifying effect was found for fruit and vegetables combined and for vegetables alone (P for interaction < 0.01 for both). Conclusions: These findings suggest that a high consumption of fruit and vegetables is associated with a reduced risk of CRC, especially of colon cancer. This effect may depend on smoking status.

Published
2009

50. Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies

Author

Jakobsen, Marianne U., O'Reilly, Eilis J., Heitmann, Berit L., Pereira, Mark A., Balter, Katarina, Fraser, Gary E., Goldbourt, Uri, Hallmans, Goran, Knekt, Paul, Liu, Simin, Pietinen, Pirjo, Spiegelman, Donna, Stevens, June, Virtamo, Jarmo, Willett, Walter C., and Ascherio, Alberto

Subjects
Coronary heart disease -- Risk factors, Coronary heart disease -- Prevention, Coronary heart disease -- Research, Dietary fat -- Health aspects, Dietary fat -- Research, Fatty acids -- Health aspects, Fatty acids -- Research, Food/cooking/nutrition, Health
Abstract

Background: Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations; therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance. Objective: We investigated associations between energy intake from monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and carbohydrates and risk of CHD while assessing the potential effect-modifying role of sex and age. Using substitution models, our aim was to clarify whether energy from unsaturated fatty acids or carbohydrates should replace energy from SFAs to prevent CHD. Design: This was a follow-up study in which data from 11 American and European cohort studies were pooled. The outcome measure was incident CHD. Results: During 4-10 y of follow-up, 5249 coronary events and 2155 coronary deaths occurred among 344,696 persons. For a 5% lower energy intake from SFAs and a concomitant higher energy intake from PUFAs, there was a significant inverse association between PUFAs and risk of coronary events (hazard ratio: 0.87; 95% CI: 0.77, 0.97); the hazard ratio for coronary deaths was 0.74 (95% CI: 0.61, 0.89). For a 5% lower energy intake from SFAs and a concomitant higher energy intake from carbohydrates, there was a modest significant direct association between carbohydrates and coronary events (hazard ratio: 1.07; 95% CI: 1.01, 1.14); the hazard ratio for coronary deaths was 0.96 (95% CI: 0.82, 1.13). MUFA intake was not associated with CHD. No effect modification by sex or age was found. Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.

Published
2009

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