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Rh-Catalyzed Alkylation and Alkynylation of 1 with -Diazo- -keto Esters, -Diazo Esters, -D... In general, all reactions were carried out employing 50 mg of B 1 b . Rh catalysis, C-H activation, cross dehydrogenative coupling, GBT-440, diazo ester, TIPS-EBX In the context of developing new analogues of the GBT-440, one of our initial objectives was replacing the hydroxymethyl ether (which connects the pyridine and salicylaldehyde cores) with an olefin or a keto ester by pyrazole-directed C-H activation on the pyridine ring (Scheme 1, eq. 1). Keywords: Rh catalysis; C-H activation; cross dehydrogenative coupling; GBT-440; diazo ester; TIPS-EBX EN Rh catalysis C-H activation cross dehydrogenative coupling GBT-440 diazo ester TIPS-EBX 3600 3609 10 10/19/23 20231102 NES 231102 Graph Heterocyclic scaffolds like pyridine and pyrazole are the most privileged scaffolds present in many drug molecules. [Extracted from the article]