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8 results on '"Halsema, L."'

4. Lindane-Induced Oxidative Stress. I. Time Course of Changes in Hepatic Microsomal Parameters, Antioxidant Enzymes, Lipid Peroxidative Indices and Morphological Characteristics

Author

Virgínia Berlanga Campos Junqueira, Osvaldo R. Koch, Van Halsema L, K Simizu, Silvia Berlanga de Moraes Barros, and Luis A. Videla

Subjects
Male, Lipid Peroxides, medicine.medical_specialty, Antioxidant, Thiobarbituric acid, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Toxicology, medicine.disease_cause, Biochemistry, Superoxide dismutase, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Stress, Physiological, Superoxides, Internal medicine, medicine, Animals, Pharmacology, biology, Superoxide Dismutase, Cytochrome P450, Rats, Inbred Strains, General Medicine, Catalase, Thiobarbiturates, Rats, Kinetics, Endocrinology, chemistry, Microsomes, Liver, Microsome, biology.protein, Lindane, Oxidation-Reduction, Hexachlorocyclohexane, Oxidative stress
Abstract

1. Lindane (60 mg/kg) administered orally to rats increased liver cytochrome P-450 content and superoxide radical (O2-.) generation 24 h after treatment, while formation of thiobarbituric acid reactants and NADPH/ADP-supported microsomal chemiluminescence were significantly increased 4 h after treatment. 2. Hepatic superoxide dismutase (SOD) and catalase decreased 6 h after lindane treatment and SOD/O2-. ratio progressively decreased during 4 to 24 h after lindane treatment. 3. Morphological evidence of hepatic cell injury after lindane treatment was seen at all times studied, and appeared to increase with time. 4. Lindane administration results in time-dependent oxidative stress in liver which involves an early component (4-6 h) related to the reductive metabolism of lindane, and a late component (24 h) associated with the induction of cytochrome P-450; the biochemical changes correlated with the observed morphological lesions.

Published
1988

5. Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status

Author

Van Halsema L, K Simizu, Luis A. Videla, Silvia Berlanga de Moraes Barros, and Virgínia Berlanga Campos Junqueira

Subjects
inorganic chemicals, Male, medicine.medical_specialty, Lipid Peroxides, Health, Toxicology and Mutagenesis, Toxicology, medicine.disease_cause, Biochemistry, Excretion, chemistry.chemical_compound, fluids and secretions, Stress, Physiological, Internal medicine, medicine, Animals, Bile, Pharmacology, Glutathione Disulfide, Hepatobiliary disease, Rats, Inbred Strains, General Medicine, Metabolism, Glutathione, Rats, Kinetics, Endocrinology, medicine.anatomical_structure, chemistry, Liver, Hepatocyte, Toxicity, Lindane, Oxidation-Reduction, Oxidative stress, Hexachlorocyclohexane
Abstract

1. Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22%) and GSSG was increased (20%), while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. These changes coincide with the onset of hepatic lipid peroxidation. 2. The changes induced by lindane at 4 h disappeared at 6 h after treatment, but liver GSSG content (91%), biliary GSSG excretion (133%) and bile flow (42%) were enhanced at 24 h. 3. The data indicate that lindane treatment elicits marked changes in hepatocyte glutathione status, with a decrease in the GSH/GSSG ratio at early (2-4 h) and late (24 h) periods of poisoning.

Published
1988

8. Lindane-induced oxidative stress. II. Time course of changes in hepatic glutathione status.

Author

Barros SB, Videla LA, Simizu K, Van Halsema L, and Junqueira VB

Subjects
Animals, Bile drug effects, Bile metabolism, Glutathione analogs & derivatives, Glutathione Disulfide, Hexachlorocyclohexane metabolism, Kinetics, Lipid Peroxides metabolism, Liver metabolism, Male, Oxidation-Reduction, Rats, Rats, Inbred Strains, Stress, Physiological metabolism, Glutathione metabolism, Hexachlorocyclohexane toxicity, Liver drug effects
Abstract

1. Four hours after treatment of rats with lindane (60 mg/kg), hepatic GSH content was decreased (22%) and GSSG was increased (20%), while biliary concentration and excretion of both GSH and GSSG and bile flow were diminished. These changes coincide with the onset of hepatic lipid peroxidation. 2. The changes induced by lindane at 4 h disappeared at 6 h after treatment, but liver GSSG content (91%), biliary GSSG excretion (133%) and bile flow (42%) were enhanced at 24 h. 3. The data indicate that lindane treatment elicits marked changes in hepatocyte glutathione status, with a decrease in the GSH/GSSG ratio at early (2-4 h) and late (24 h) periods of poisoning.

Published
1988
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