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7. Ultrastructure of human ovarian tissues and risk of cancer cells re-implantation after transplantation to chick embryo chorioallantois membrane (CAM) following vitrification or slow freezing

Author

Vatanparast, Mahboubeh, Karimizarchi, Mojgan, Halvaei, Iman, Palmerini, Maria Grazia, Macchiarelli, Guido, and Khalili, Mohammad Ali

Subjects
Ovarian tissue cryopreservation Cancer patients Slow freezing Vitrification CAM transplantation TEM, General Medicine, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology
Abstract

Ovarian follicle depletion and premature ovarian failure are significant challenges in cancer patients subjected to radio- or chemotherapy. Ovarian tissue (OT) cryopreservation would be an option when other fertility preservation methods are not accessible. This study aimed to analyze the structure and ultrastructure of human OTs transplanted onto chick embryo chorioallantois membrane (CAM) after cryopreservation by vitrification or slow freezing. OTs from 10 cancer patients underwent cryopreservation. CAM transplantation was done on fresh and cryopreserved OTs, to assign samples to nine study groups as follows: 1) FI-FIII = fresh, 5- and 10-days post-CAM transplantation groups; 2) VI-VIII = vitrified, 5- and 10-days post-transplantation vitrified groups; 3) SFI-SFIII: slow frozen, 5- and 10-days post-transplantation slow freezing groups. Proliferation ability, folliculogenesis, and structural and ultrastructure were analyzed. The density of primordial follicles did not change after both freezing methods, but reduced after 5 (P ≥ 0.05) and 10 days (P ≤ 0.05) post-CAM transplantation. The follicular grade significantly decreased in all transplanted tissues (P ≤ 0.0). The proliferation marker increased after cryopreservation, but reduced after transplantation (P ≤ 0.05). TEM evaluation showed better follicular ultrastructure in the fresh group, after transplantation. Stromal ultrastructure appeared more preserved after vitrification compared with slow freezing. There was no sign of malignant cell contamination after transplantation. Some follicular TEM abnormalities were found in both methods of freezing, with a better transplantation rate after vitrification. Also, enhanced follicular activation resulted in faster follicular depletion in this method. The information regarding post grafting events would improve our knowledge for longer OTs' lifespans.

Published
2023

9. Evaluating the role of silver nanoparticles on acrosomal reaction and spermatogenic cells in rat.

Author

Miresmaeili, Sayyed Mohsen, Halvaei, Iman, Fesahat, Farzaneh, Fallah, Asghar, Nikonahad, Narges, and Taherinejad, Mohaddeseh

Subjects
Medical Biotechnology, Reproductive Medicine, Biomedical and Clinical Sciences, Contraception/Reproduction, Nanoparticle, Spermatozoa, Spermatogenesis, Acrosome reaction, Reproductive medicine
Abstract

BackgroundNanoparticles have wide range of application while there are some reports regarding their probable effects on male reproductive system and spermatozoa.ObjectiveThe aim of this study was to evaluate the effect of different doses of silver nanoparticles (AgNPs) (70nm) on acrosome of rat spermatozoa and number of spermatogenic cells.Materials and methodsIn this experimental study, in experimental group, 32 male wistar rats (8 rats/group) received oral feeding AgNPs every 12 hr in one spermatogenesis period (48 days) by means of gavages in 25, 50 , 100 and 200 mg/kg concentration (experimental groups 1-4, respectively). The control group (8 rats) was treated on schedule with distilled water. Spermatozoa were stained by triple staining protocol for acrosome reaction. Histological evaluation on testis sections was performed using tissue processing and hematoxylin-eosin (H&E) staining.ResultsThere was significant difference between the control group and the experimental group 1 for acrosome reaction (11.00±0.00 and 24.25±3.68, respectively, p=0.01). There was only significant reduction in spermatogonia cells in experimental group 4. Experimental groups 2, 3 and 4 showed a significant reduction in the number of primary spermatocytes and spermatids as well as spermatozoa. But there were no significant differences between different groups for Sertoli cell number and seminiferous tubule diameter.ConclusionIt seems that Ag NPs have acute and significant effects on spermatogenesis and number of spermatogenic cells and also on acrosome reaction in sperm cells. More experimental investigations are necessary to elucidate better conclusion regarding the safety of nanoparticles on male reproduction system.

Published
2013

17. High-DNA integrity sperm selection using rheotaxis and boundary following behavior in a microfluidic chip.

Author

Zeaei, Soroush, Zabetian Targhi, Mohammad, Halvaei, Iman, and Nosrati, Reza

Subjects
SPERMATOZOA, REPRODUCTIVE technology, FERTILIZATION in vitro, MICROFLUIDICS
Abstract

Rheotaxis, as one of the main natural guidance mechanisms in vivo, has been used in microfluidics to separate motile sperm. However, the lack of DNA integrity assessment and the inability to separate the cells in a specific reservoir have been the main limitations for the practical application of most of the devices using rheotaxis for sperm separation. Here, we present a microfluidic chip that can separate highly motile sperm using their inherent rheotaxis and boundary-following behavior in a network of boomerang-shaped microchannels. The device design is informed by our FEM simulation results to predict sperm trajectories. Experimental results demonstrate the device's performance to separate over 16 000 motile sperm in under 20 min, sufficient for droplet-based IVF. Separated cells are classified into two motility groups, highly motile (swimming speed > 120 μm s−1) and motile (swimming speed < 120 μm s−1). The device selects sperm with over 45%, 20%, and 80% improvement in motility, the number of highly motile sperm, and DNA integrity, respectively, suggesting promising potential for applications in assisted reproduction. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Quality of Blastocysts Created by Embryo Splitting: A Time-Lapse Monitoring and Chromosomal Aneuploidy Study

Author

Omidi, Marjan, Khalili, Mohammad Ali, Halvaei, Iman, Montazeri, Fatemeh, and Kalantar, Seyed Mehdi

Subjects
Embryology, animal structures, mosaicism, blastocyst, time-lapse, embryonic structures, lcsh:R, Genetics, lcsh:Medicine, Original Article, lcsh:Q, aneuploidy, lcsh:Science
Abstract

Objective: The aim of this study was to screen the potential of human embryos to develop into expanding blastocysts following in vitro embryo splitting and then assess the quality of the generated blastocysts based on chromosomal characteristics and using morphokinetics. Materials and Methods: In this experimental study, a total of 82 good quality cleavage-stage donated embryos (8- 14 cells) were used (24 embryos were cultured to the blastocyst stage as controls and 58 embryos underwent in vitro splitting). After in vitro splitting, the blastomere donor and blastomere recipient embryos were named twin A and twin B, respectively. Morphokinetics and morphological parameters were evaluated using a time-lapse system in the blastocysts developed from twin embryos. Aneuploidy of chromosomes 13, 15, 16, 18, 21, 22, X and Y were analyzed in the twin blastocysts. Results: Following in vitro splitting, of the 116 resulting twin embryos, 80 (69%) developed to the expanded blastocyst (EBL) stage compared to 21 (87.5%) embryos in the control group (P>0.05). The morphokinetics analysis suggested that the developmental time-points were influenced by the in vitro splitting. Moreover, the blastocysts developed from A and B twins had impaired morphology compared to controls. Regarding chromosome abnormalities, there was no significant difference in the rate of aneuploidy or mosaicism between the different groups. Conclusion: This study showed that while no chromosomal abnormalities were seen, in vitro embryo splitting may affect the embryo morphokinetics.

Published
2020

22. Impairment of sperm efficiency in mice following short-term nano-titanium dioxide exposure: An experimental study

Author

Danafar, Amirhossein, primary, Khoradmehr, Arezoo, additional, Hosseini Bondarabadi, Mahya, additional, Mazaheri, Fahime, additional, Tamadon, Amin, additional, Pourmasoumi, Soheila, additional, Gholizadeh, Lida, additional, Moshref, Mojgan, additional, Halvaei, Iman, additional, Hosseini, Akram, additional, Golzadeh, Jalal, additional, Rahiminia, Tahereh, additional, and Anvari, Morteza, additional

Published
2022
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23. Alginate Effects on Human Sperm Parameters during Freezing and Thawing: A Prospective Study.

Author

Feyzmanesh, Somayeh, Halvaei, Iman, and Baheiraei, Nafiseh

Subjects
*ALGINIC acid, *SPERMATOZOA, *ALGINATES, *ACROSOME reaction, *THAWING, *FREEZING
Abstract

Objective: The main goal was to evaluate the effects of alginate on human sperm parameters during cryopreservation. Materials and Methods: In this prospective study, twenty-five normozoospermic samples were divided into two groups, encapsulated with 1% alginate and the control group. The samples were then frozen by rapid freezing. Different sperm parameters including motility, normal morphology, viability, acrosome reaction, and DNA integrity, were examined before freezing and after thawing. Results: All sperm parameters had a significant decrease after thawing compared to before freezing. Our data showed a significant decrease in sperm motility of the alginate group but sperm viability, normal morphology, and DNA fragmentation were similar between the two groups. However, the rates of intact acrosome and native DNA were significantly lower in the control group compared to the alginate group (45.12 ± 11.1 vs. 55.25 ± 10.69 and 52.2 ± 11.92 vs. 68.12 ± 10.15, respectively, P<0.05). Conclusion: It seems that alginate can prevent premature acrosome reaction and protect sperm DNA from denaturation during the rapid freezing process. [ABSTRACT FROM AUTHOR]

Published
2022
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26. Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Author

Kinyoki, Damaris K., Ross, Jennifer M., Lazzar-Atwood, Alice, Munro, Sandra B., Schaeffer, Lauren E., Abbasalizad-Farhangi, Mahdieh, Abbasi, Masoumeh, Abbastabar, Hedayat, Abdelalim, Ahmed, Abdoli, Amir, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Nebiyu Dereje, Abebo, Teshome Abuka, Abegaz, Kedir Hussein, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R. M., Abushouk, Abdelrahman I., Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adabi, Maryam, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Aduroja, Posi Emmanuel, Advani, Shailesh M., Afarideh, Mohsen, Aghaali, Mohammad, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Sepideh, Ahmed, Muktar Beshir, Ahmed, Rushdia, Ajumobi, Olufemi, Akal, Chalachew Genet, Akalu, Temesgen Yihunie, Akinyemiju, Tomi, Akombi, Blessing, Al-Aly, Ziyad, Alam, Samiah, Alamene, Genet Melak, Alanzi, Turki M., Rabanal, Jacqueline Elizabeth Alcalde, Alema, Niguse Meles, Ali, Beriwan Abdulqadir, Ali, Muhammad, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Almasi, Afshin, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M., Al-Raddadi, Rajaa M., Altirkawi, Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amare, Azmeraw T., Amegah, Adeladza Kofi, Amini, Saeed, Rarani, Mostafa Amini, Amiri, Fatemeh, Amit, Arianna Maever Loreche, Anber, Nahla Hamed, Andrei, Catalina Liliana, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Anteneh, Zelalem Alamrew, Antonio, Carl Abelardo T., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Araya, Ephrem Mebrahtu, Arefi, Zohreh, Aremu, Olatunde, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Asgari, Samaneh, Asghari, Babak, Ashagre, Alebachew Fasil, Asrat, Anemaw A., Ataeinia, Bahar, Atalay, Hagos Tasew, Atnafu, Desta Debalkie, Atout, Maha Moh’d Wahbi, Ausloos, Marcel, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Ayanore, Martin Amogre, Aynalem, Yared A. Asmare, Azadmehr, Abbas, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Babaee, Ebrahim, Badawi, Alaa, Badiye, Ashish D., Bahrami, Mohamad Amin, Baig, Atif Amin A., Bakhtiari, Ahad, Bakkannavar, Shankar M., Balakrishnan, Senthilkumar, Bali, Ayele Geleto, Banach, Maciej, Banik, Palash Chandra, Baradaran-Seyed, Zahra, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A., Bärnighausen, Till Winfried, Barua, Lingkan, Basaleem, Huda, Basu, Sanjay, Bayati, Mohsen, Bayih, Mulat Tirfie, Baynes, Habtamu Wondifraw, Bedi, Neeraj, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Yibeltal Alemu, Bennett, Derrick A., Berbada, Dessalegn Ajema, Berhe, Kidanemaryam, Berhe, Abadi Kidanemariam, Berman, Adam E., Bernstein, Robert S., Bhageerathy, Reshmi, Bhandari, Dinesh, Bharadwaj, Pankaj, Bhattacharjee, Natalia V., Bhattacharyya, Krittika, Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Sayeed, Muhammad Shahdaat Bin, Birara, Setognal, Birhane, Minuye Biniam Biniam, Birhanu, Minyichil, Biswas, Raaj Kishore, Bitew, Zebenay Workneh, Bogale, Kassawmar Angaw, Bohlouli, Somayeh, Bolla, Srinivasa Rao, Boloor, Archith, Borzì, Antonio M., Borzouei, Shiva, Brady, Oliver J., Bragazzi, Nicola Luigi, Braithwaite, Dejana, Briko, Nikolay Ivanovich, Britton, Gabrielle, Budhathoki, Shyam S., Nagaraja, Sharath Burugina, Busse, Reinhard, Butt, Zahid A., Cahuana-Hurtado, Lucero, Cámera, Luis Alberto, Campos-Nonato, Ismael R., Cano, Jorge, Car, Josip, Cárdenas, Rosario, Carrero, Juan J., Carvalho, Félix, Castaldelli-Maia, João Mauricio, Castañeda-Orjuela, Carlos A., Castro, Franz, Cerin, Ester, Chansa, Collins, Charan, Jaykaran, Chatterjee, Pranab, Chattu, Vijay Kumar, Chauhan, Bal Govind, Chavshin, Ali Reza, Chehrazi, Mohammad, Chichiabellu, Tesfaye Yitna, Chin, Ken Lee, Christopher, Devasahayam J., Chu, Dinh-Toi, Cicuttini, Flavia M., Collison, Michael L., Cork, Michael A., Cormier, Natalie, Cortesi, Paolo Angelo, Costa, Vera M., Dadi, Abel Fekadu Fekadu, Dagnew, Baye, Dahlawi, Saad M. A., Damiani, Giovanni, Darwish, Amira Hamed, Daryani, Ahmad, Das, Jai K., Gupta, Rajat Das, Dávila-Cervantes, Claudio, Davis Weaver, Nicole, Leo, Diego De, Neve, Jan-Walter De, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demissie, Dereje Bayissa, Demoz, Gebre Teklemariam, Denova-Gutiérrez, Edgar, Deribe, Kebede, Desai, Rupak, Desalegn, Beruk Berhanu, Desalew, Assefa, Deshpande, Aniruddha, Dey, Sagnik, Dharmaratne, Samath Dhamminda, Dhillon, Preeti, Dhimal, Meghnath, Dhungana, Govinda Prasad, Nasab, Mostafa Dianati, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Dinsa, Girmaye Deye, Dipeolu, Isaac Oluwafemi, Djalalinia, Shirin, Do, Hoa Thi, Do, Huyen Phuc, Doku, Paul Narh, Dorostkar, Fariba, Doshmangir, Leila, Dubey, Manisha, Adema, Bereket Duko, Dunachie, Susanna J., Duncan, Bruce B., Cousin, Ewerton, Durães, Andre R., Earl, Lucas, Leylabadlo, Hamed Ebrahimzadeh, Eftekhari, Aziz, El Sayed, Iman, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elbarazi, Iffat, Elemineh, Demelash Abewa, El-Jaafary, Shaimaa I., El-Khatib, Ziad, Elsharkawy, Aisha, El-Sherbiny, Yasser Mohamed, Elyazar, Iqbal R. F., Emamian, Mohammad Hassan, Enany, Shymaa, Endalew, Daniel Adane, Endalifer, Melese Linger, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Faraj, Anwar, Farashi, Sajjad, Fareed, Mohammad, Farioli, Andrea, Faro, Andre, Farzadfar, Farshad, Farzam, Hossein, Fatima, Syeda Sadia, Fattahi, Nazir, Fauk, Nelsensius Klau, Fazaeli, Ali Akbar, Fentahun, Netsanet, Ferede, Tomas Y., Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, João C., Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Foroutan, Masoud, Förster, Jana, Francis, Joel Msafiri, Fukumoto, Takeshi, Gayesa, Reta Tsegaye, Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Tsegaye Tewelde, Gebremariam, Hadush, Gebremariam, Kidane Tadesse, Gebremedhin, Ketema Bizuwork Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebreslassie, Assefa Ayalew Ayalew, Gebretsadik, Gebretsadkan G. G., Gedefaw, Getnet Azeze, Geramo, Yilma Chisha Dea, Gesesew, Hailay Abrha, Geta, Birhanu, Getenet, Agegnehu Bante, Gezae, Kebede Embaye, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghajar, Alireza, Ghajarzadeh, Mahsa, Ghashghaee, Ahmad, Ghiasvand, Hesam, Gholamian, Asadollah, Gilani, Syed Amir, Gill, Tiffany K., Ginawi, Ibrahim Abdelmageed, Goli, Srinivas, Gomes, Nelson G. M., Gopalani, Sameer Vali, Goudarzi, Houman, Goulart, Alessandra C., Govindakarnavar, Arunkumar, Grada, Ayman, Grivna, Michal, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Hafezi-Nejad, Nima, Haile, Michael Tamene, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Yadollah, Handiso, Demelash Woldeyohannes, Hankey, Graeme J., Haririan, Hamidreza, Hariyani, Ninuk, Hasaballah, Ahmed I., Hasan, Md. Mehedi, Hasankhani, Milad, Hasanpoor, Edris, Hasanzadeh, Amir, Hashemian, Maryam, Hassanipour, Soheil, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hawkes, Corinna, Hayat, Khezar, Hayelom, Desta Haftu, Heidari, Behnam, Heidari-Soureshjani, Reza, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J., Herrero, Mario, Herteliu, Claudiu, Heydarpour, Fatemeh, de Hidru, Hagos D., Hoang, Chi Linh, Hoek, Hans W., Hole, Michael K., Holla, Ramesh, Hollerich, Gillian, Rad, Enayatollah Homaie, Hong, Sung Hwi, Hoogar, Praveen, Horino, Masako, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hu, Guoqing, Huda, Tanvir M., Humayun, Ayesha, Hwang, Bing-Fang, Ibitoye, Segun Emmanuel, Ilesanmi, Olayinka Stephen, Ilic, Milena D., Imani-Nasab, Mohammad Hasan, Inbaraj, Leeberk Raja, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwu, Chidozie C. D., Iwu, Chinwe Juliana, Izadi, Neda, Jaafari, Jalil, Jaca, Anelisa, Jadidi-Niaragh, Farhad, Balalami, Nader Jafari, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalali, Amir, Jalilian, Farzad, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jehan, Fyezah, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, John, Oommen, John-Akinola, Yetunde O., Johnson, Kimberly B., Jonas, Jost B., Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kahsay, Amaha, Kahssay, Molla, Kalani, Hamed, Kalankesh, Leila L., Kalhor, Rohollah, Kamiab, Zahra, Kanchan, Tanuj, Kapil, Umesh, Kapoor, Neeti, Karami, Manoochehr, Matin, Behzad Karami, Karch, André, Karim, Mohd A., Karki, Surendra, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kasaye, Habtamu Kebebe, Kassa, Tesfaye Dessale, Kassaye, Hagazi Gebremedhin, Kassebaum, Nicholas J., Karyani, Ali Kazemi, Kengne, Andre Pascal, Ketema, Daniel Bekele, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khaksarian, Mojtaba, Khalid, Nauman, Khalil, Ibrahim A., Khalilov, Rovshan, Khan, Asad, Khan, Ejaz Ahmad, Khan, Md Nuruzzaman, Khan, Mohammad Saud, Khan, Muhammad Shahzeb, Khatab, Khaled, Khater, Amir, Khater, Mona M., Khatib, Mahalqua Nazli, Khayamzadeh, Maryam, Khazaei-Pool, Maryam, Khazaei, Mohammad, Khazaei, Salman, Khodayari, Mohammad Taghi, Khosravi, Mohammad Hossein, Khundkar, Roba, Kiadaliri, Ali, Kianipour, Neda, Kiirithio, Daniel N., Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kolola, Tufa, Komaki, Hamidreza, Kondlahalli, Shivakumar K. M., Koolivand, Ali, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U. G., Krishan, Kewal, Krohn, Kris J., Kugbey, Nuworza, Kumar, Manasi, Kumar, Pushpendra, Kumar, Vivek, Kurmi, Om P., Kuti, Oluwatosin, Vecchia, Carlo La, Lacey, Ben, Lad, Deepesh P., Lal, Aparna, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lamichhane, Prabhat, Lang, Justin J., Lansingh, Van C., Lasrado, Savita, Lebedev, Georgy, Lee, Paul H., Lee, Shaun Wen Huey, Leili, Mostafa, Letourneau, Ian D., Lewycka, Sonia, Li, Shanshan, Lim, Lee-Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Lodha, Rakesh, Longbottom, Joshua, Lopez, Jaifred Christian F., Lorkowski, Stefan, Macarayan, Erlyn Rachelle King, Madadin, Mohammed, El Razek, Hassan Magdy Abd, El Razek, Muhammed Magdy Abd, Maghavani, Dhaval P., Mahasha, Phetole Walter, Mahotra, Narayan Bahadur, Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malta, Deborah Carvalho, Manafi, Ali, Manafi, Farzad, Manafi, Navid, Manohar, Narendar Dawanu, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Marczak, Laurie B., Arnedo, Carlos Alberto Marrugo, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Massenburg, Benjamin Ballard, Maulik, Pallab K., Mayala, Benjamin K., Mazidi, Mohsen, Mehndiratta, Man Mohan, Mehri, Freshteh, Mehta, Kala M., Meitei, Wahengbam Bigyananda, Mekonnen, Fantahun Ayenew, Mekonnen, Teferi, Meles, Gebrekiros Gebremichael, Meles, Hagazi Gebre, Melese, Addisu, Mendoza, Walter, Menezes, Ritesh G., Mengesha, Meresa Berwo, Mensah, George A., Meretoja, Tuomo J., Miazgowski, Tomasz, Kostova, Neda Milevska, Miller, Ted R., Mills, Edward J., Mini, G. K., Mir, Seyed Mostafa, Miri, Mohammad, Mirjalali, Hamed, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Mithra, Prasanna, Moazen, Babak, Mohamadi, Efat, Mohamadi-Bolbanabad, Amjad, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammad, Dara K., Darwesh, Aso Mohammad, Mezerji, Naser Mohammad Gholi, Mohammadian-Hafshejani, Abdollah, Mohammadnia-Afrouzi, Mousa, Mohammadoo-Khorasani, Milad, Mohammadpourhodki, Reza, Mohammed, Salahuddin, Mohammed, Shafiu, Mohammed, Jemal Abdu, Mohammed, Ammas Siraj, Mohebi, Farnam, Mokari, Amin, Mokdad, Ali H., Montañez, Julio Cesar, Montero-Zamora, Pablo A., Moodley, Yoshan, Moossavi, Maryam, Moradi, Ghobad, Moradi, Masoud, Moradi, Yousef, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradpour, Farhad, Moradzadeh, Rahmatollah, Moraga, Paula, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Khaneghah, Amin Mousavi, Mozaffarian, Dariush, Mueller, Ulrich Otto, Murray, Christopher J. L., Murthy, G. V. S., Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nabavizadeh, Behnam, Naderi, Mehdi, Nadkarni, Girish N., Nagarajan, Ahamarshan Jayaraman, Naghavi, Mohsen, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Nansseu, Jobert Richie, Narayan, K. M. Venkat, Nascimento, Bruno Ramos, Nayak, Vinod, Nazari, Javad, Ndwandwe, Duduzile Edith, Negoi, Ionut, Negoi, Ruxandra Irina, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nigatu, Dabere, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A., Nong, Vuong Minh, Noubiap, Jean Jacques, Nowak, Christoph, Oancea, Bogdan, Ofori-Asenso, Richard, Oghenetega, Onome Bright, Oh, In-Hwan, Oladimeji, Olanrewaju, Oladnabi, Morteza, Olagunju, Andrew T., Olagunju, Tinuke O., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Oluwasanu, Mojisola Morenike, Omer, Muktar Omer, Onwujekwe, Obinna E., Asante, Kwaku Oppong, Oren, Eyal, Orisakwe, Orish Ebere, Ortiz, Alberto, Osarenotor, Osayomwanbo, Osgood-Zimmerman, Aaron E., Owolabi, Mayowa Ojo, P. A., Mahesh, Padubidri, Jagadish Rao, Pakshir, Keyvan, Pana, Adrian, Panda-Jonas, Songhomitra, Parsian, Hadi, Pashaei, Tahereh, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Ashish, Pathak, Mona, Pati, Sanghamitra, Patle, Ajay, Patton, George C., Paulos, Kebreab, Toroudi, Hamidreza Pazoki, Pepito, Veincent Christian Filipino, Perico, Norberto, Petri, William A., Pickering, Brandon V., Pigott, David M., Pirestani, Majid, Piroozi, Bakhtiar, Pirsaheb, Meghdad, Pokhrel, Khem Narayan, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Kalhori, Reza Pourmirza, Pourshams, Akram, Poustchi, Hossein, Prada, Sergio I., Preotescu, Liliana, Pribadi, Dimas Ria Angga, Syed, Zahiruddin Quazi, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Vafa, Rahman, Muhammad Aziz, Rahman, Sajjad ur, Rai, Rajesh Kumar, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Ramezanzadeh, Kiana, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Rao, Sowmya J., Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rathi, Priya, Rawaf, Salman, Rawaf, David Laith, Rawal, Lal, Ray, Sarah E., Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Nima, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Rezapour, Aziz, Riahi, Seyed Mohammad, Ribeiro, Ana Isabel, Rickard, Jennifer, Rodriguez, Alina, Roever, Leonardo, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Rubagotti, Enrico, Saad, Anas M., Saadatagah, Seyedmohammad, Sabde, Yogesh Damodar, Sabour, Siamak, Sadeghi, Ehsan, Sadeghi, Masoumeh, Safari, Saeed, Safari, Yahya, Safarpour, Hamid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Salehi, Farkhonde, Zahabi, Saleh Salehi, Salem, Hosni, Salem, Marwa R. Rashad, Salimi, Yahya, Salimzadeh, Hamideh, Kafil, Hossein Samadi, Sambala, Evanson Zondani, Samy, Abdallah M., Santos, Itamar S., Jose, Bruno Piassi Sao, Saraswathy, Sivan Yegnanarayana Iyer, Sarker, Abdur Razzaque, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Satpathy, Maheswar, Saxena, Sonia, Sayyah, Mehdi, Sbarra, Alyssa N., Schipp, Megan F., Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Schwebel, David C., Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Seyedmousavi, Seyedmojtaba, Shaahmadi, Faramarz, Shafaat, Omid, Shahabi, Saeed, Shaikh, Masood Ali, Shalash, Ali S., Shams-Beyranvand, Mehran, Shamshirian, Amir, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomars, Sharif, Mehdi, Sharma, Rajesh, Shehata, Hatem Samir, Sheikhtaheri, Abbas, Shibuya, Kenji, Shiferaw, Wondimeneh Shibabaw, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Shuval, Kerem, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Silva, Diego Augusto Santos, Simonetti, Biagio, Singh, Ambrish, Singh, Pushpendra, Singh, Virendra, Singh, Jasvinder A., Singh, Pankaj Kumar, Sinha, Dhirendra Narain, Sintayehu, Yitagesu, Sisay, Malede Mequanent M., Soheili, Amin, Soleymani, Bija, Soltani, Farzaneh, Soltani, Shahin, Soriano, Joan B., Sorrie, Muluken Bekele, Soshnikov, Sergey, Soyiri, Ireneous N., Spotin, Adel, Sreeramareddy, Chandrashekhar T., Srivastava, Rajni Kant Kant, Starodubova, Antonina, Sudaryanto, Agus, Sufiyan, Mu’awiyyah Babale, Suleria, Hafiz Ansar Rasul, Sulo, Gerhard, Sunguya, Bruno F., Sykes, Bryan L., Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadesse, Birkneh Tilahun, Taherkhani, Amir, Tamirat, Koku Sisay, Tassew, Segen Gebremeskel, Taveira, Nuno, Teklehaimanot, Berhane Fseha, Tekulu, Gebretsadkan Hintsa, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Tessema, Zemenu Tadesse, Thomas, Nihal, Titova, Mariya Vladimirovna, Tlaye, Kenean Getaneh, Tohidinik, Hamid Reza, Tonelli, Marcello, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Khanh Bao, Tripathi, Manjari, Uddin, Riaz, Ullah, Irfan, Unnikrishnan, Bhaskaran, Upadhyay, Era, Useh, Ushotanefe, Usman, Muhammad Shariq, Uthman, Olalekan A., Vacante, Marco, Vaezghasemi, Masoud, Valdez, Pascual R., VanderHeide, John, Varavikova, Elena, Varughese, Santosh, Vasankari, Tommi Juhani, Vasseghian, Yasser, Veisani, Yousef, Venkatesh, Srinivasaraghavan, Venketasubramanian, Narayanaswamy, Verma, Madhur, Vidale, Simone, Violante, Francesco S., Vlassov, Vasily, Vollmer, Sebastian, Vukovic, Rade, Waheed, Yasir, Wang, Haidong, Wang, Yafeng, Wang, Yuan-Pang, Weldesamuel, Girmay Teklay, Werdecker, Andrea, Wiangkham, Taweewat, Wiens, Kirsten E., Wijeratne, Tissa, Wolde, Haileab Fekadu, Wondafrash, Dawit Zewdu, Wonde, Tewodros Eshete, Wondmieneh, Adam Belay, Wu, Ai-Min, Xu, Gelin, Yadegar, Abbas, Yadollahpour, Ali, Jabbari, Seyed Hossein Yahyazadeh, Yamada, Tomohide, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yeshaneh, Alex, Yeshaw, Yigizie, Yeshitila, Yordanos Gizachew, Yilma, Mekdes Tigistu, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Youm, Yoosik, Younis, Mustafa Z., Yousefi, Zabihollah, Yousof, Hebat-Allah Salah A., Yu, Chuanhua, Yusefzadeh, Hasan, Moghadam, Telma Zahirian, Zaki, Leila, Zaman, Sojib Bin, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zarafshan, Hadi, Zepro, Nejimu Biza, Zerfu, Taddese Alemu, Zewale, Taye Abuhay, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Xiu-Ju, Zodpey, Sanjay, Zomorodian, Kamiar, Zotor, Francis Bruno, Afshin, Ashkan, Hay, Simon I., LBD Double Burden of Malnutrition Collaborator, Violante FS, Adema, Bereket Duko, Yeshaw, Yigizie, LBD Double Burden of Malnutrition Collaborators, Instituto de Saúde Pública da Universidade do Porto, 10922180 - Schutte, Aletta Elisabeth, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP), Veritati - Repositório Institucional da Universidade Católica Portuguesa, Biosciences, University of Helsinki, Clinicum, HUS Comprehensive Cancer Center, Institute for Molecular Medicine Finland, Department of Earth Observation Science, UT-I-ITC-ACQUAL, Faculty of Geo-Information Science and Earth Observation, Sálfræðideild (HR), Department of Psychology (RU), Samfélagssvið (HR), School of Social Sciences (RU), Háskólinn í Reykjavík, Reykjavik University, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD), Kinyoki, D, Ross, J, Lazzar-Atwood, A, Munro, S, Schaeffer, L, Abbasalizad-Farhangi, M, Abbasi, M, Abbastabar, H, Abdelalim, A, Abdoli, A, Abdollahi, M, Abdollahpour, I, Abdulkader, R, Abebe, N, Abebo, T, Abegaz, K, Abolhassani, H, Abreu, L, Abrigo, M, Abushouk, A, Accrombessi, M, 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A, Azari, S, Azarian, G, Azene, Z, Babaee, E, Badawi, A, Badiye, A, Bahrami, M, Baig, A, Bakhtiari, A, Bakkannavar, S, Balakrishnan, S, Bali, A, Banach, M, Banik, P, Baradaran-Seyed, Z, Baraki, A, Barboza, M, Barnighausen, T, Barua, L, Basaleem, H, Basu, S, Bayati, M, Bayih, M, Baynes, H, Bedi, N, Behzadifar, M, Bekele, Y, Bennett, D, Berbada, D, Berhe, K, Berhe, A, Berman, A, Bernstein, R, Bhageerathy, R, Bhandari, D, Bharadwaj, P, Bhattacharjee, N, Bhattacharyya, K, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Sayeed, M, Birara, S, Birhane, M, Birhanu, M, Biswas, R, Bitew, Z, Bogale, K, Bohlouli, S, Bolla, S, Boloor, A, Borzi, A, Borzouei, S, Brady, O, Bragazzi, N, Braithwaite, D, Briko, N, Britton, G, Budhathoki, S, Nagaraja, S, Busse, R, Butt, Z, Cahuana-Hurtado, L, Camera, L, Campos-Nonato, I, Cano, J, Car, J, Cardenas, R, Carrero, J, Carvalho, F, Castaldelli-Maia, J, Castaneda-Orjuela, C, Castro, F, Cerin, E, Chansa, C, Charan, J, Chatterjee, P, Chattu, V, Chauhan, B, Chavshin, A, Chehrazi, M, Chichiabellu, T, Chin, K, Christopher, D, Chu, D, Cicuttini, F, Collison, M, Cork, M, Cormier, N, Cortesi, P, Costa, V, Dadi, A, Dagnew, B, Dahlawi, S, Damiani, G, Darwish, A, Daryani, A, Das, J, Gupta, R, Davila-Cervantes, C, Davis Weaver, N, Leo, D, Neve, J, Demeke, F, Demis, A, Demissie, D, Demoz, G, Denova-Gutierrez, E, Deribe, K, Desai, R, Desalegn, B, Desalew, A, Deshpande, A, Dey, S, Dharmaratne, S, Dhillon, P, Dhimal, M, Dhungana, G, Nasab, M, Diaz, D, Forooshani, Z, Dinsa, G, Dipeolu, I, Djalalinia, S, Do, H, Doku, P, Dorostkar, F, Doshmangir, L, Dubey, M, Adema, B, Dunachie, S, Duncan, B, Duraes, A, Earl, L, Leylabadlo, H, Eftekhari, A, El Sayed, I, El Sayed Zaki, M, El Tantawi, M, Elbarazi, I, Elemineh, D, El-Jaafary, S, El-Khatib, Z, Elsharkawy, A, El-Sherbiny, Y, Elyazar, I, Emamian, M, Enany, S, Endalew, D, Endalifer, M, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Esteghamati, A, Etemadi, A, Etisso, A, Fanzo, J, Farahmand, M, Faraj, A, Farashi, S, Fareed, M, Farioli, A, Faro, A, Farzadfar, F, Farzam, H, Fatima, S, Fattahi, N, Fauk, N, Fazaeli, A, Fentahun, N, Ferede, T, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Feyissa, G, Filip, I, Fischer, F, Flohr, C, Foigt, N, Folayan, M, Fomenkov, A, Foroutan, M, Forster, J, Francis, J, Fukumoto, T, Gayesa, R, Geberemariyam, B, Gebrehiwot, T, Gebremariam, H, Gebremariam, K, Gebremedhin, K, Gebremeskel, G, Gebreslassie, A, Gebretsadik, G, Gedefaw, G, Geramo, Y, Gesesew, H, Geta, B, Getenet, A, Gezae, K, Ghaffarifar, F, Ghafourifard, M, Ghajar, A, Ghajarzadeh, M, Ghashghaee, A, Ghiasvand, H, Gholamian, A, Gilani, S, Gill, T, Ginawi, I, Goli, S, Gomes, N, Gopalani, S, Goudarzi, H, Goulart, A, Govindakarnavar, A, Grada, A, Grivna, M, Guimaraes, R, Guled, R, Guo, Y, Hafezi-Nejad, N, Haile, M, Haj-Mirzaian, A, Hall, B, Halvaei, I, Hamadeh, R, Hamidi, Y, Handiso, D, Hankey, G, Haririan, H, Hariyani, N, Hasaballah, A, Hasan, M, Hasankhani, M, Hasanpoor, E, Hasanzadeh, A, Hashemian, M, Hassanipour, S, Hassen, H, Havmoeller, R, Hawkes, C, Hayat, K, Hayelom, D, Heidari, B, Heidari-Soureshjani, R, Hendrie, D, Henok, A, Henry, N, Herrero, M, Herteliu, C, Heydarpour, F, de Hidru, H, Hoang, C, Hoek, H, Hole, M, Holla, R, Hollerich, G, Rad, E, Hong, S, Hoogar, P, Horino, M, Hossain, N, Hosseini, M, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Housseh, M, Hsairi, M, Hu, G, Huda, T, Humayun, A, Hwang, B, Ibitoye, S, Ilesanmi, O, Ilic, M, Imani-Nasab, M, Inbaraj, L, Iqbal, U, Irvani, S, Islam, S, Iwu, C, Izadi, N, Jaafari, J, Jaca, A, Jadidi-Niaragh, F, Balalami, N, Jafarinia, M, Jahani, M, Jakovljevic, M, Jalali, A, Jalilian, F, Jayatilleke, A, Jeemon, P, Jehan, F, Jenabi, E, Jha, R, Jha, V, Ji, J, Jia, P, John, O, John-Akinola, Y, Johnson, K, Jonas, J, Joseph, N, Joukar, F, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, A, Kabir, Z, Kahsay, A, Kahssay, M, Kalani, H, Kalankesh, L, Kalhor, R, Kamiab, Z, Kanchan, T, Kapil, U, Kapoor, N, Karami, M, Matin, B, Karch, A, Karim, M, Karki, S, Kasaeian, A, Kasahun, G, Kasaye, H, Kassa, T, Kassaye, H, Kassebaum, N, Karyani, A, Kengne, A, Ketema, D, Khader, Y, Khafaie, M, Khaksarian, M, Khalid, N, Khalil, I, Khalilov, R, Khan, A, Khan, E, Khan, M, Khatab, K, Khater, A, Khater, M, Khatib, M, Khayamzadeh, M, Khazaei-Pool, M, Khazaei, M, Khazaei, S, Khodayari, M, Khosravi, M, Khundkar, R, Kiadaliri, A, Kianipour, N, Kiirithio, D, Kim, Y, Kimokoti, R, Kisa, A, Kisa, S, Kolola, T, Komaki, H, Kondlahalli, S, Koolivand, A, Koul, P, Koyanagi, A, Kraemer, M, Krishan, K, Krohn, K, Kugbey, N, Kumar, M, Kumar, P, Kumar, V, Kurmi, O, Kuti, O, Vecchia, C, Lacey, B, Lad, D, Lal, A, Lal, D, Lami, F, Lamichhane, P, Lang, J, Lansingh, V, Lasrado, S, Lebedev, G, Lee, P, Lee, S, Leili, M, Letourneau, I, Lewycka, S, Li, S, Lim, L, Linn, S, Liu, S, Lodha, R, Longbottom, J, Lopez, J, Lorkowski, S, Macarayan, E, Madadin, M, El Razek, H, El Razek, M, Maghavani, D, Mahasha, P, Mahotra, N, Maled, V, Maleki, A, Maleki, S, Malta, D, Manafi, A, Manafi, F, Manafi, N, Manohar, N, Mansour-Ghanaei, F, Mansouri, B, Mansournia, M, Mapoma, C, Marami, D, Marczak, L, Arnedo, C, Martins-Melo, F, Masaka, A, Massenburg, B, Maulik, P, Mayala, B, Mazidi, M, Mehndiratta, M, Mehri, F, Mehta, K, Meitei, W, Mekonnen, F, Mekonnen, T, Meles, G, Meles, H, Melese, A, Mendoza, W, Menezes, R, Mengesha, M, Mensah, G, Meretoja, T, Miazgowski, T, Kostova, N, Miller, T, Mills, E, Mini, G, Mir, S, Miri, M, Mirjalali, H, Mirrakhimov, E, Mirzaei, H, Mirzaei, M, Mirzaei, R, Mirzaei-Alavijeh, M, Mithra, P, Moazen, B, Mohamadi, E, Mohamadi-Bolbanabad, A, Mohammad, K, Mohammad, Y, Mohammad, D, Darwesh, A, Mezerji, N, Mohammadian-Hafshejani, A, Mohammadnia-Afrouzi, M, Mohammadoo-Khorasani, M, Mohammadpourhodki, R, Mohammed, S, Mohammed, J, Mohammed, A, Mohebi, F, Mokari, A, Mokdad, A, Montanez, J, Montero-Zamora, P, Moodley, Y, Moossavi, M, Moradi, G, Moradi, M, Moradi, Y, Moradi-Joo, M, Moradi-Lakeh, M, Moradpour, F, Moradzadeh, R, Moraga, P, Morrison, S, Mosapour, A, Mosser, J, Mouodi, S, Khaneghah, A, Mozaffarian, D, Mueller, U, Murray, C, Murthy, G, Musa, K, Mustafa, G, Muthupandian, S, Nabavizadeh, B, Naderi, M, Nadkarni, G, Nagarajan, A, Naghavi, M, Naheed, A, Naik, G, Najafi, F, Nansseu, J, Narayan, K, Nascimento, B, Nayak, V, Nazari, J, Ndwandwe, D, Negoi, I, Negoi, R, Ngunjiri, J, Nguyen, C, Nguyen, H, Nigatu, D, Nigatu, Y, Nikbakhsh, R, Ningrum, D, Nnaji, C, Nong, V, Noubiap, J, Nowak, C, Oancea, B, Ofori-Asenso, R, Oghenetega, O, Oh, I, Oladimeji, O, Oladnabi, M, Olagunju, A, Olagunju, T, Olusanya, B, Olusanya, J, Oluwasanu, M, Omer, M, Onwujekwe, O, Asante, K, Oren, E, Orisakwe, O, Ortiz, A, Osarenotor, O, Osgood-Zimmerman, A, Owolabi, M, P. 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Subjects
Male, Local patterns, Double burden, Börn, Research & Experimental Medicine, Sjúkdómseinkenni, DOUBLE BURDEN, Childhood overweight, Lífefnafræði, Læknisfræði, 0302 clinical medicine, Syndemic, Child, 11 Medical and Health Sciences, under 5 years of age, General Medicine, 3. Good health, Geography, Medicine, Research & Experimental, Child, Preschool, Income, GROWTH, AFRICA, medicine.medical_specialty, Biochemistry & Molecular Biology, RJ, Medicina, Immunology, education, MODELS, wa_395, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Humans, Author Correction, Developing Countries, Poverty, Biology, LBD Double Burden of Malnutrition Collaborators, Demography, Science & Technology, Wasting Syndrome, Public health, MORTALITY, Infant, Næringarskortur, medicine.disease, Obesity, TRENDS, signs and symptoms, Social Class, Risk factors, Sameindalíffræði, ITC-ISI-JOURNAL-ARTICLE, UNDERNUTRITION, Human medicine, Clinical Medicine, 030217 neurology & neurosurgery, Pediatric Obesity, obesity, Offita, Áhættuþættir, Geographic Mapping, Overweight, RA0421, Global health, risk factors, 030212 general & internal medicine, Signs and symptoms, Wasting, Malnutrition, Global Burden of Diseases, Global Nutrition, low- and middle-income countries, 2. Zero hunger, 1. No poverty, Public Health, Global Health, Social Medicine and Epidemiology, A900 Others in Medicine and Dentistry, Childhood wasting, PREVALENCE, Chemistry, Mapping, Female, Lýðheilsa, medicine.symptom, Life Sciences & Biomedicine, GROWTH FAILURE, Nutritional Status, malnutrition, ITC-HYBRID, ws_115, children, Environmental health, medicine, Erfðafræði, wd_200, Malnutrition, Infant, Newborn, Klinisk medicin, Cell Biology, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, NA
Abstract

Artículo con numerosos autores, sólo se mencionan el primero, los de la UAM y grupo colectivo, A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of, This work was primarily supported by grant OPP1132415 from the Bill & Melinda Gates Foundation awarded to S.I.H.

Published
2020

27. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author

Wang, Haidong, primary, Abbas, Kaja M, additional, Abbasifard, Mitra, additional, Abbasi-Kangevari, Mohsen, additional, Abbastabar, Hedayat, additional, Abd-Allah, Foad, additional, Abdelalim, Ahmed, additional, Abolhassani, Hassan, additional, Abreu, Lucas Guimarães, additional, Abrigo, Michael R M, additional, Abushouk, Abdelrahman I, additional, Adabi, Maryam, additional, Adair, Tim, additional, Adebayo, Oladimeji M, additional, Adedeji, Isaac Akinkunmi, additional, Adekanmbi, Victor, additional, Adeoye, Abiodun Moshood, additional, Adetokunboh, Olatunji O, additional, Advani, Shailesh M, additional, Afshin, Ashkan, additional, Aghaali, Mohammad, additional, Agrawal, Anurag, additional, Ahmadi, Keivan, additional, Ahmadieh, Hamid, additional, Ahmed, Muktar Beshir, additional, Al-Aly, Ziyad, additional, Alam, Khurshid, additional, Alam, Tahiya, additional, Alanezi, Fahad Mashhour, additional, Alanzi, Turki M, additional, Alcalde-Rabanal, Jacqueline Elizabeth, additional, Ali, Muhammad, additional, Alicandro, Gianfranco, additional, Alijanzadeh, Mehran, additional, Alinia, Cyrus, additional, Alipour, Vahid, additional, Alizade, Hesam, additional, Aljunid, Syed Mohamed, additional, Allebeck, Peter, additional, Almadi, Majid Abdulrahman Hamad, additional, Almasi-Hashiani, Amir, additional, Al-Mekhlafi, Hesham M, additional, Altirkawi, Khalid A, additional, Alumran, Arwa Khalid, additional, Alvis-Guzman, Nelson, additional, Amini-Rarani, Mostafa, additional, Aminorroaya, Arya, additional, Amit, Arianna Maever L, additional, Ancuceanu, Robert, additional, Andrei, Catalina Liliana, additional, Androudi, Sofia, additional, Angus, Colin, additional, Anjomshoa, Mina, additional, Ansari, Fereshteh, additional, Ansari, Iman, additional, Ansari-Moghaddam, Alireza, additional, Antonio, Carl Abelardo T, additional, Antony, Catherine M, additional, Anvari, Davood, additional, Appiah, Seth Christopher Yaw, additional, Arabloo, Jalal, additional, Arab-Zozani, Morteza, additional, Aravkin, Aleksandr Y, additional, Aremu, Olatunde, additional, Ärnlöv, Johan, additional, Aryal, Krishna K, additional, Asadi-Pooya, Ali A, additional, Asgari, Samaneh, additional, Asghari Jafarabadi, Mohammad, additional, Atteraya, Madhu Sudhan, additional, Ausloos, Marcel, additional, Avila-Burgos, Leticia, additional, Avokpaho, Euripide Frinel Gbenato Arthur, additional, Ayala Quintanilla, Beatriz Paulina, additional, Ayano, Getinet, additional, Ayanore, Martin Amogre, additional, Azarian, Ghasem, additional, Babaee, Ebrahim, additional, Badiye, Ashish D, additional, Bagli, Eleni, additional, Bahrami, Mohammad Amin, additional, Bakhtiari, Ahad, additional, Balassyano, Shelly, additional, Banach, Maciej, additional, Banik, Palash Chandra, additional, Barker-Collo, Suzanne Lyn, additional, Bärnighausen, Till Winfried, additional, Barzegar, Akbar, additional, Basu, Sanjay, additional, Baune, Bernhard T, additional, Bayati, Mohsen, additional, Bazmandegan, Gholamreza, additional, Bedi, Neeraj, additional, Bell, Michellr L, additional, Bennett, Derrick A, additional, Bensenor, Isabela M, additional, Berhe, Kidanemaryam, additional, Berman, Adam E, additional, Bertolacci, Gregory J, additional, Bhageerathy, Reshmi, additional, Bhala, Neeraj, additional, Bhattacharyya, Krittika, additional, Bhutta, Zulfiqar A, additional, Bijani, Ali, additional, Biondi, Antonio, additional, Bisanzio, Donal, additional, Bisignano, Catherine, additional, Biswas, Raaj Kishore, additional, Bjørge, Tone, additional, Bohlouli, Somayeh, additional, Bohluli, Mehdi, additional, Bolla, Srinivasa Rao Rao, additional, Borzì, Antonio Maria, additional, Borzouei, Shiva, additional, Brady, Oliver J, additional, Braithwaite, Dejana, additional, Brauer, Michael, additional, Briko, Andrey Nikolaevich, additional, Briko, Nikolay Ivanovich, additional, Bumgarner, Blair R, additional, Burugina Nagaraja, Sharath, additional, Butt, Zahid A, additional, Caetano dos Santos, Florentino Luciano, additional, Cai, Tianji, additional, Callender, Charlton SKH, additional, Cámera, Luis LA Alberto, additional, Campos-Nonato, Ismael R, additional, Cárdenas, Rosario, additional, Carreras, Giulia, additional, Carrero, Juan J, additional, Carvalho, Felix, additional, Castaldelli-Maia, Joao Mauricio, additional, Castelpietra, Giulio, additional, Castro, Franz, additional, Catalá-López, Ferrán, additional, Cederroth, Christopher R, additional, Cerin, Ester, additional, Chattu, Vijay Kumar, additional, Chin, Ken Lee, additional, Chu, Dinh-Toi, additional, Ciobanu, Liliana G, additional, Cirillo, Massimo, additional, Comfort, Haley, additional, Costa, Vera Marisa, additional, Cowden, Richard G, additional, Cromwell, Elizabeth A, additional, Croneberger, Andrew J, additional, Cunningham, Matthew, additional, Dahlawi, Saad M A, additional, Damiani, Giovanni, additional, D'Amico, Emanuele, additional, Dandona, Lalit, additional, Dandona, Rakhi, additional, Dargan, Paul I, additional, Darwesh, Aso Mohammad, additional, Daryani, Ahmad, additional, Das Gupta, Rajat, additional, das Neves, José, additional, Davletov, Kairat, additional, De Leo, Diego, additional, Denova-Gutiérrez, Edgar, additional, Deribe, Kebede, additional, Dervenis, Nikolaos, additional, Desai, Rupak, additional, Dhungana, Govinda Prasad, additional, Dias da Silva, Diana, additional, Diaz, Daniel, additional, Dippenaar, Ilse N, additional, Djalalinia, Shirin, additional, Do, Hoa Thi, additional, Dokova, Klara, additional, Doku, David Teye, additional, Dorostkar, Fariba, additional, Doshi, Chirag P, additional, Doshmangir, Leila, additional, Doyle, Kerrie E, additional, Dubljanin, Eleonora, additional, Duraes, Andre Rodrigues, additional, Edvardsson, David, additional, Effiong, Andem, additional, El Sayed, Iman, additional, El Tantawi, Maha, additional, Elbarazi, Iffat, additional, El-Jaafary, Shaimaa I, additional, Emamian, Mohammad Hassan, additional, Eskandarieh, Sharareh, additional, Esmaeilzadeh, Firooz, additional, Estep, Kara, additional, Farahmand, Mohammad, additional, Faraj, Anwar, additional, Fareed, Mohammad, additional, Faridnia, Roghiyeh, additional, Faro, Andre, additional, Farzadfar, Farshad, additional, Fattahi, Nazir, additional, Fazaeli, Ali Akbar, additional, Fazlzadeh, Mehdi, additional, Feigin, Valery L, additional, Fereshtehnejad, Seyed-Mohammad, additional, Fernandes, Eduarda, additional, Ferreira, Manuela L, additional, Filip, Irina, additional, Fischer, Florian, additional, Flohr, Carsten, additional, Foigt, Nataliya A, additional, Folayan, Morenike Oluwatoyin, additional, Fomenkov, Artem Alekseevich, additional, Freitas, Marisa, additional, Fukumoto, Takeshi, additional, Fuller, John E, additional, Furtado, João M, additional, Gad, Mohamed M, additional, Gakidou, Emmanuela, additional, Gallus, Silvano, additional, Gebrehiwot, Abiyu Mekonnen, additional, Gebremedhin, Ketema Bizuwork, additional, Gething, Peter W, additional, Ghamari, Farhad, additional, Ghashghaee, Ahmad, additional, Gholamian, Asadollah, additional, Gilani, Syed Amir, additional, Gitimoghaddam, Mojgan, additional, Glushkova, Ekaterina Vladimirovna, additional, Gnedovskaya, Elena V, additional, Gopalani, Sameer Vali, additional, Goulart, Alessandra C, additional, Gugnani, Harish Chander, additional, Guo, Yuming, additional, Gupta, Rajeev, additional, Gupta, Subodh Sharan, additional, Haagsma, Juanita A, additional, Haj-Mirzaian, Arvin, additional, Haj-Mirzaian, Arya, additional, Halvaei, Iman, additional, Hamadeh, Randah R, additional, Hamagharib Abdullah, Kanaan, additional, Han, Chieh, additional, Handiso, Demelash Woldeyohannes, additional, Hankey, Graeme J, additional, Haririan, Hamidreza, additional, Haro, Josep Maria, additional, Hasaballah, Ahmed I, additional, Hassanipour, Soheil, additional, Hassankhani, Hadi, additional, Hay, Simon I, additional, Heibati, Behzad, additional, Heidari-Soureshjani, Reza, additional, Henny, Kiana, additional, Henry, Nathaniel J, additional, Herteliu, Claudiu, additional, Heydarpour, Fatemeh, additional, Hole, Michael K, additional, Hoogar, Praveen, additional, Hosgood, H Dean, additional, Hossain, Naznin, additional, Hosseinzadeh, Mehdi, additional, Hostiuc, Mihaela, additional, Hostiuc, Sorin, additional, Househ, Mowafa, additional, Hoy, Damian G, additional, Hu, Guoqing, additional, Huda, Tanvir M, additional, Ibitoye, Segun Emmanuel, additional, Ikuta, Kevin S, additional, Ilesanmi, Olayinka Stephen, additional, Ilic, Irena M, additional, Ilic, Milena D, additional, Imani-Nasab, Mohammad Hasan, additional, Islam, MdMohaimenul, additional, Iso, Hiroyasu, additional, Iwu, Chinwe Juliana, additional, Jaafari, Jalil, additional, Jacobsen, Kathryn H, additional, Jahagirdar, Deepa, additional, Jahanmehr, Nader, additional, Jalali, Amir, additional, Jalilian, Farzad, additional, James, Spencer L, additional, Janjani, Hosna, additional, Jenabi, Ensiyeh, additional, Jha, Ravi Prakash, additional, Jha, Vivekanand, additional, Ji, John S, additional, Jonas, Jost B, additional, Joukar, Farahnaz, additional, Jozwiak, Jacek Jerzy, additional, Jürisson, Mikk, additional, Kabir, Zubair, additional, Kalani, Hamed, additional, Kalankesh, Leila R, additional, Kamiab, Zahra, additional, Kanchan, Tanuj, additional, Kapoor, Neeti, additional, Karch, André, additional, Karimi, Salah Eddin, additional, Karimi, Seyed Asaad, additional, Kassebaum, Nicholas J, additional, Katikireddi, Srinivasa Vittal, additional, Kawakami, Norito, additional, Kayode, Gbenga A, additional, Keiyoro, Peter Njenga, additional, Keller, Cathleen, additional, Khader, Yousef Saleh, additional, Khalid, Nauman, additional, Khan, Ejaz Ahmad, additional, Khan, Maseer, additional, Khang, Young-Ho, additional, Khater, Amir M, additional, Khater, Mona M, additional, Khazaei, Salman, additional, Khazaie, Habibolah, additional, Khodayari, Mohammad Taghi, additional, Khubchandani, Jagdish, additional, Kianipour, Neda, additional, Kim, Cho-il, additional, Kim, Young-Eun, additional, Kim, Yun Jin, additional, Kinfu, Yohannes, additional, Kisa, Adnan, additional, Kisa, Sezer, additional, Kissimova-Skarbek, Katarzyna, additional, Kivimäki, Mika, additional, Komaki, Hamidreza, additional, Kopec, Jacek A, additional, Kosen, Soewarta, additional, Koul, Parvaiz A, additional, Koyanagi, Ai, additional, Kravchenko, Michael A, additional, Krishan, Kewal, additional, Krohn, Kris J, additional, Kuate Defo, Barthelemy, additional, Kumar, G Anil, additional, Kumar, Manasi, additional, Kumar, Pushpendra, additional, Kumar, Vivek, additional, Kusuma, Dian, additional, Kyu, Hmwe Hmwe, additional, La Vecchia, Carlo, additional, Lacey, Ben, additional, Lal, Dharmesh Kumar, additional, Lalloo, Ratilal, additional, Lami, Faris Hasan, additional, Lansky, Sonia, additional, Larson, Samantha Leigh, additional, Larsson, Anders O, additional, Lasrado, Savita, additional, Lassi, Zohra S, additional, Lazarus, Jeffrey V, additional, Lee, Paul H, additional, Lee, Shaun Wen Huey, additional, Leever, Andrew T, additional, LeGrand, Kate E, additional, Leonardi, Matilde, additional, Li, Shanshan, additional, Lim, Lee-Ling, additional, Lim, Stephen S, additional, Linn, Shai, additional, Lodha, Rakesh, additional, Logroscino, Giancarlo, additional, Lopez, Alan D, additional, Lopukhov, Platon D, additional, Lotufo, Paulo A, additional, Lozano, Rafael, additional, Lu, Alton, additional, Lunevicius, Raimundas, additional, Madadin, Mohammed, additional, Maddison, Emilie R, additional, Magdy Abd El Razek, Hassan, additional, Magdy Abd El Razek, Muhammed, additional, Mahasha, Phetole Walter, additional, Mahdavi, Mokhtar Mahdavi, additional, Malekzadeh, Reza, additional, Mamun, Abdullah A, additional, Manafi, Navid, additional, Mansour-Ghanaei, Fariborz, additional, Mansouri, Borhan, additional, Mansournia, Mohammad Ali, additional, Mapoma, Chabila Christopher, additional, Martini, Santi, additional, Martins-Melo, Francisco Rogerlândio, additional, Masaka, Anthony, additional, Mastrogiacomo, Claudia I, additional, Mathur, Manu Raj, additional, May, Erin A, additional, McAlinden, Colm, additional, McGrath, John J, additional, McKee, Martin, additional, Mehndiratta, Man Mohan, additional, Mehri, Fereshteh, additional, Mehta, Kala M, additional, Meitei, Wahengbam Bigyananda, additional, Memiah, Peter T N, additional, Mendoza, Walter, additional, Menezes, Ritesh G, additional, Mengesha, Endalkachew Worku, additional, Mensah, George A, additional, Meretoja, Atte, additional, Meretoja, Tuomo J, additional, Mestrovic, Tomislav, additional, Michalek, Irmina Maria, additional, Mihretie, Kebadnew Mulatu, additional, Miller, Ted R, additional, Mills, Edward J, additional, Milne, George J, additional, Mirrakhimov, Erkin M, additional, Mirzaei, Hamed, additional, Mirzaei, Maryam, additional, Mirzaei-Alavijeh, Mehdi, additional, Misganaw, Awoke Temesgen, additional, Moazen, Babak, additional, Moghadaszadeh, Masoud, additional, Mohamadi, Efat, additional, Mohammad, Dara K, additional, Mohammad, Yousef, additional, Mohammad Gholi Mezerji, Naser, additional, Mohammadbeigi, Abolfazl, additional, Mohammadian-Hafshejani, Abdollah, additional, Mohammadpourhodki, Reza, additional, Mohammed, Hussen, additional, Mohammed, Shafiu, additional, Mohebi, Farnam, additional, Mohseni Bandpei, Mohammad A, additional, Mokari, Amin, additional, Mokdad, Ali H, additional, Momen, Natalie C, additional, Monasta, Lorenzo, additional, Mooney, Meghan D, additional, Moradi, Ghobad, additional, Moradi, Masoud, additional, Moradi-Joo, Mohammad, additional, Moradi-Lakeh, Maziar, additional, Moradzadeh, Rahmatollah, additional, Moraga, Paula, additional, Moreno Velásquez, Ilais, additional, Morgado-da-Costa, Joana, additional, Morrison, Shane Douglas, additional, Mosser, Jonathan F, additional, Mouodi, Simin, additional, Mousavi, Seyyed Meysam, additional, Mousavi Khaneghah, Amin, additional, Mueller, Ulrich Otto, additional, Musa, Kamarul Imran, additional, Muthupandian, Saravanan, additional, Nabavizadeh, Behnam, additional, Naderi, Mehdi, additional, Nagarajan, Ahamarshan Jayaraman, additional, Naghavi, Mohsen, additional, Naghshtabrizi, Behshad, additional, Naik, Gurudatta, additional, Najafi, Farid, additional, Nangia, Vinay, additional, Nansseu, Jobert Richie, additional, Ndwandwe, Duduzile Edith, additional, Negoi, Ionut, additional, Negoi, Ruxandra Irina, additional, Ngunjiri, Josephine W, additional, Nguyen, Huong Lan Thi, additional, Nguyen, Trang Huyen, additional, Nigatu, Yeshambel T, additional, Nikbakhsh, Rajan, additional, Nikpoor, Amin Reza, additional, Nixon, Molly R, additional, Nnaji, Chukwudi A, additional, Nomura, Shuhei, additional, Noubiap, Jean Jacques, additional, Nouraei Motlagh, Soraya, additional, Nowak, Christoph, additional, Oţoiu, Adrian, additional, Odell, Christopher M, additional, Oh, In-Hwan, additional, Oladnabi, Morteza, additional, Olagunju, Andrew T, additional, Olusanya, Bolajoko Olubukunola, additional, Olusanya, Jacob Olusegun, additional, Omar Bali, Ahmed, additional, Ong, Kanyin L, additional, Onwujekwe, Obinna E, additional, Ortiz, Alberto, additional, Otstavnov, Nikita, additional, Otstavnov, Stanislav S, additional, Øverland, Simon, additional, Owolabi, Mayowa O, additional, P A, Mahesh, additional, Padubidri, Jagadish Rao, additional, Pakshir, Keyvan, additional, Palladino, Raffaele, additional, Pana, Adrian, additional, Panda-Jonas, Songhomitra, additional, Park, James, additional, Pasupula, Deepak Kumar, additional, Patel, Jenil R, additional, Patel, Sangram Kishor, additional, Patton, George C, additional, Paulson, Katherine R, additional, Pazoki Toroudi, Hamidreza, additional, Pease, Spencer A, additional, Peden, Amy E, additional, Pepito, Veincent Christian Filipino, additional, Peprah, Emmanuel K, additional, Pereira, Alexandre, additional, Pereira, David M, additional, Perico, Norberto, additional, Pigott, David M, additional, Pilgrim, Thomas, additional, Pilz, Tessa M, additional, Piradov, Michael A, additional, Pirsaheb, Meghdad, additional, Pokhrel, Khem Narayan, additional, Postma, Maarten J, additional, Pourjafar, Hadi, additional, Pourmalek, Farshad, additional, Pourshams, Akram, additional, Poznańska, Anna, additional, Prada, Sergio I, additional, Prakash, Sanjay, additional, Preotescu, Liliana, additional, Quazi Syed, Zahiruddin, additional, Rabiee, Mohammad, additional, Rabiee, Navid, additional, Radfar, Amir, additional, Rafiei, Alireza, additional, Raggi, Alberto, additional, Rahman, Muhammad Aziz, additional, Rajabpour-Sanati, Ali, additional, Ram, Pradhum, additional, Ranabhat, Chhabi Lal, additional, Rao, Sowmya J, additional, Rasella, Davide, additional, Rashedi, Vahid, additional, Rastogi, Prateek, additional, Rathi, Priya, additional, Rawal, Lal, additional, Remuzzi, Giuseppe, additional, Renjith, Vishnu, additional, Renzaho, Andre M N, additional, Resnikoff, Serge, additional, Rezaei, Nima, additional, Rezai, Mohammad sadegh, additional, Rezapour, Aziz, additional, Rickard, Jennifer, additional, Roever, Leonardo, additional, Ronfani, Luca, additional, Roshandel, Gholamreza, additional, Rostamian, Morteza, additional, Rubagotti, Enrico, additional, Rwegerera, Godfrey M, additional, Sabour, Siamak, additional, Saddik, Basema, additional, Sadeghi, Ehsan, additional, Sadeghi, Masoumeh, additional, Saeedi Moghaddam, Sahar, additional, Safari, Yahya, additional, Safi, Sare, additional, Safiri, Saeid, additional, Sagar, Rajesh, additional, Sahebkar, Amirhossein, additional, Sahraian, Mohammad Ali, additional, Sajadi, S Mohammad, additional, Salahshoor, Mohammad Reza, additional, Salama, Joseph S, additional, Salamati, Payman, additional, Salem, Marwa R Rashad, additional, Salimi, Yahya, additional, Salomon, Joshua A, additional, Salz, Inbal, additional, Samad, Zainab, additional, Samy, Abdallah M, additional, Sanabria, Juan, additional, Santric-Milicevic, Milena M, additional, Saraswathy, Sivan Yegnanarayana Iyer, additional, Sartorius, Benn, additional, Sarveazad, Arash, additional, Sathian, Brijesh, additional, Sathish, Thirunavukkarasu, additional, Sattin, Davide, additional, Saylan, Mete, additional, Schaeffer, Lauren E, additional, Schiavolin, Silvia, additional, Schwebel, David C, additional, Schwendicke, Falk, additional, Sekerija, Mario, additional, Senbeta, Anbissa Muleta, additional, Senthilkumaran, Subramanian, additional, Sepanlou, Sadaf G, additional, Serván-Mori, Edson, additional, Shabani, Mahsima, additional, Shahabi, Saeed, additional, Shahbaz, Mohammad, additional, Shaheen, Amira A, additional, Shaikh, Masood Ali, additional, Shalash, Ali S, additional, Shams-Beyranvand, Mehran, additional, Shamsi, MohammadBagher, additional, Shamsizadeh, Morteza, additional, Shannawaz, Mohammed, additional, Sharafi, Kiomars, additional, Sharafi, Zeinab, additional, Sharara, Fablina, additional, Sharma, Rajesh, additional, Shaw, David H, additional, Sheikh, 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additional, Vardavas, Constantine, additional, Vasankari, Tommi Juhani, additional, Vasconcelos, Ana Maria Nogales, additional, Vasseghian, Yasser, additional, Veisani, Yousef, additional, Venketasubramanian, Narayanaswamy, additional, Vidale, Simone, additional, Violante, Francesco S, additional, Vlassov, Vasily, additional, Vollset, Stein Emil, additional, Vos, Theo, additional, Vujcic, Isidora S, additional, Vukovic, Ana, additional, Vukovic, Rade, additional, Waheed, Yasir, additional, Wallin, Mitchell Taylor, additional, Walters, Magdalene K, additional, Wang, Hongbo, additional, Wang, Yuan-Pang, additional, Watson, Stefanie, additional, Wei, Jingkai, additional, Weiss, Jordan, additional, Weldesamuel, Girmay Teklay, additional, Werdecker, Andrea, additional, Westerman, Ronny, additional, Whiteford, Harvey A, additional, Wiangkham, Taweewat, additional, Wiens, Kirsten E, additional, Wijeratne, Tissa, additional, Wiysonge, Charles Shey, additional, Wojtyniak, Bogdan, additional, 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additional, Zhou, Maigeng, additional, Ziapour, Arash, additional, and Murray, Christopher J L, additional

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2020
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28. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Murray, Christopher J L, primary, Aravkin, Aleksandr Y, additional, Zheng, Peng, additional, Abbafati, Cristiana, additional, Abbas, Kaja M, additional, Abbasi-Kangevari, Mohsen, additional, Abd-Allah, Foad, additional, Abdelalim, Ahmed, additional, Abdollahi, Mohammad, additional, Abdollahpour, Ibrahim, additional, Abegaz, Kedir Hussein, additional, Abolhassani, Hassan, additional, Aboyans, Victor, additional, Abreu, Lucas Guimarães, additional, Abrigo, Michael R M, additional, Abualhasan, Ahmed, additional, Abu-Raddad, Laith Jamal, additional, Abushouk, Abdelrahman I, additional, Adabi, Maryam, additional, Adekanmbi, Victor, additional, Adeoye, Abiodun Moshood, additional, Adetokunboh, Olatunji O, additional, Adham, Davoud, additional, Advani, Shailesh M, additional, Agarwal, Gina, additional, Aghamir, Seyed Mohammad Kazem, additional, Agrawal, Anurag, additional, Ahmad, Tauseef, additional, Ahmadi, Keivan, additional, Ahmadi, Mehdi, additional, Ahmadieh, Hamid, additional, Ahmed, Muktar Beshir, additional, Akalu, Temesgen Yihunie, additional, Akinyemi, Rufus Olusola, additional, Akinyemiju, Tomi, additional, Akombi, Blessing, additional, Akunna, Chisom Joyqueenet, additional, Alahdab, Fares, additional, Al-Aly, Ziyad, additional, Alam, Khurshid, additional, Alam, Samiah, additional, Alam, Tahiya, additional, Alanezi, Fahad Mashhour, additional, Alanzi, Turki M, additional, Alemu, Biresaw wassihun, additional, Alhabib, Khalid F, additional, Ali, Muhammad, additional, Ali, Saqib, additional, Alicandro, Gianfranco, additional, Alinia, Cyrus, additional, Alipour, Vahid, additional, Alizade, Hesam, additional, Aljunid, Syed Mohamed, additional, Alla, François, additional, Allebeck, Peter, additional, Almasi-Hashiani, Amir, additional, Al-Mekhlafi, Hesham M, additional, Alonso, Jordi, additional, Altirkawi, Khalid A, additional, Amini-Rarani, Mostafa, additional, Amiri, Fatemeh, additional, Amugsi, Dickson A, additional, Ancuceanu, Robert, additional, Anderlini, Deanna, additional, Anderson, Jason A, additional, Andrei, Catalina Liliana, additional, Andrei, Tudorel, additional, Angus, Colin, additional, Anjomshoa, Mina, additional, Ansari, Fereshteh, additional, Ansari-Moghaddam, Alireza, additional, Antonazzo, Ippazio Cosimo, additional, Antonio, Carl Abelardo T, additional, Antony, Catherine M, additional, Antriyandarti, Ernoiz, additional, Anvari, Davood, additional, Anwer, Razique, additional, Appiah, Seth Christopher Yaw, additional, Arabloo, Jalal, additional, Arab-Zozani, Morteza, additional, Ariani, Filippo, additional, Armoon, Bahram, additional, Ärnlöv, Johan, additional, Arzani, Afsaneh, additional, Asadi-Aliabadi, Mehran, additional, Asadi-Pooya, Ali A, additional, Ashbaugh, Charlie, additional, Assmus, Michael, additional, Atafar, Zahra, additional, Atnafu, Desta Debalkie, additional, Atout, Maha Moh'd Wahbi, additional, Ausloos, Floriane, additional, Ausloos, Marcel, additional, Ayala Quintanilla, Beatriz Paulina, additional, Ayano, Getinet, additional, Ayanore, Martin Amogre, additional, Azari, Samad, additional, Azarian, Ghasem, additional, Azene, Zelalem Nigussie, additional, Badawi, Alaa, additional, Badiye, Ashish D, additional, Bahrami, Mohammad Amin, additional, Bakhshaei, Mohammad Hossein, additional, Bakhtiari, Ahad, additional, Bakkannavar, Shankar M, additional, Baldasseroni, Alberto, additional, Ball, Kylie, additional, Ballew, Shoshana H, additional, Balzi, Daniela, additional, Banach, Maciej, additional, Banerjee, Srikanta K, additional, Bante, Agegnehu Bante, additional, Baraki, Adhanom Gebreegziabher, additional, Barker-Collo, Suzanne Lyn, additional, Bärnighausen, Till Winfried, additional, Barrero, Lope H, additional, Barthelemy, Celine M, additional, Barua, Lingkan, additional, Basu, Sanjay, additional, Baune, Bernhard T, additional, Bayati, Mohsen, additional, Becker, Jacob S, additional, Bedi, Neeraj, additional, Beghi, Ettore, additional, Béjot, Yannick, additional, Bell, Michellr L, additional, Bennitt, Fiona B, additional, Bensenor, Isabela M, additional, Berhe, Kidanemaryam, additional, Berman, Adam E, additional, Bhagavathula, Akshaya Srikanth, additional, Bhageerathy, Reshmi, additional, Bhala, Neeraj, additional, Bhandari, Dinesh, additional, Bhattacharyya, Krittika, additional, Bhutta, Zulfiqar A, additional, Bijani, Ali, additional, Bikbov, Boris, additional, Bin Sayeed, Muhammad Shahdaat, additional, Biondi, Antonio, additional, Birihane, Binyam Minuye, additional, Bisignano, Catherine, additional, Biswas, Raaj Kishore, additional, Bitew, Helen, additional, Bohlouli, Somayeh, additional, Bohluli, Mehdi, additional, Boon-Dooley, Alexandra S, additional, Borges, Guilherme, additional, Borzì, Antonio Maria, additional, Borzouei, Shiva, additional, Bosetti, Cristina, additional, Boufous, Soufiane, additional, Braithwaite, Dejana, additional, Breitborde, Nicholas J K, additional, Breitner, Susanne, additional, Brenner, Hermann, additional, Briant, Paul Svitil, additional, Briko, Andrey Nikolaevich, additional, Briko, Nikolay Ivanovich, additional, Britton, Gabrielle B, additional, Bryazka, Dana, additional, Bumgarner, Blair R, additional, Burkart, Katrin, additional, Burnett, Richard Thomas, additional, Burugina Nagaraja, Sharath, additional, Butt, Zahid A, additional, Caetano dos Santos, Florentino Luciano, additional, Cahill, Leah E, additional, Cámera, Luis LA Alberto, additional, Campos-Nonato, Ismael R, additional, Cárdenas, Rosario, additional, Carreras, Giulia, additional, Carrero, Juan J, additional, Carvalho, Felix, additional, Castaldelli-Maia, Joao Mauricio, additional, Castañeda-Orjuela, Carlos A, additional, Castelpietra, Giulio, additional, Castro, Franz, additional, Causey, Kate, additional, Cederroth, Christopher R, additional, Cercy, Kelly M, additional, Cerin, Ester, additional, Chandan, Joht Singh, additional, Chang, Kai-Lan, additional, Charlson, Fiona J, additional, Chattu, Vijay Kumar, additional, Chaturvedi, Sarika, additional, Cherbuin, Nicolas, additional, Chimed-Ochir, Odgerel, additional, Cho, Daniel Youngwhan, additional, Choi, Jee-Young Jasmine, additional, Christensen, Hanne, additional, Chu, Dinh-Toi, additional, Chung, Michael T, additional, Chung, Sheng-Chia, additional, Cicuttini, Flavia M, additional, Ciobanu, Liliana G, additional, Cirillo, Massimo, additional, Classen, Thomas Khaled Dwayne, additional, Cohen, Aaron J, additional, Compton, Kelly, additional, Cooper, Owen R, additional, Costa, Vera Marisa, additional, Cousin, Ewerton, additional, Cowden, Richard G, additional, Cross, Di H, additional, Cruz, Jessica A, additional, Dahlawi, Saad M A, additional, Damasceno, Albertino Antonio Moura, additional, Damiani, Giovanni, additional, Dandona, Lalit, additional, Dandona, Rakhi, additional, Dangel, William James, additional, Danielsson, Anna-Karin, additional, Dargan, Paul I, additional, Darwesh, Aso Mohammad, additional, Daryani, Ahmad, additional, Das, Jai K, additional, Das Gupta, Rajat, additional, das Neves, José, additional, Dávila-Cervantes, Claudio Alberto, additional, Davitoiu, Dragos Virgil, additional, De Leo, Diego, additional, Degenhardt, Louisa, additional, DeLang, Marissa, additional, Dellavalle, Robert Paul, additional, Demeke, Feleke Mekonnen, additional, Demoz, Gebre Teklemariam, additional, Demsie, Desalegn Getnet, additional, Denova-Gutiérrez, Edgar, additional, Dervenis, Nikolaos, additional, Dhungana, Govinda Prasad, additional, Dianatinasab, Mostafa, additional, Dias da Silva, Diana, additional, Diaz, Daniel, additional, Dibaji Forooshani, Zahra Sadat, additional, Djalalinia, Shirin, additional, Do, Hoa Thi, additional, Dokova, Klara, additional, Dorostkar, Fariba, additional, Doshmangir, Leila, additional, Driscoll, Tim Robert, additional, Duncan, Bruce B, additional, Duraes, Andre Rodrigues, additional, Eagan, Arielle Wilder, additional, Edvardsson, David, additional, El Nahas, Nevine, additional, El Sayed, Iman, additional, El Tantawi, Maha, additional, Elbarazi, Iffat, additional, Elgendy, Islam Y, additional, El-Jaafary, Shaimaa I, additional, Elyazar, Iqbal RF, additional, Emmons-Bell, Sophia, additional, Erskine, Holly E, additional, Eskandarieh, Sharareh, additional, Esmaeilnejad, Saman, additional, Esteghamati, Alireza, additional, Estep, Kara, additional, Etemadi, Arash, additional, Etisso, Atkilt Esaiyas, additional, Fanzo, Jessica, additional, Farahmand, Mohammad, additional, Fareed, Mohammad, additional, Faridnia, Roghiyeh, additional, Farioli, Andrea, additional, Faro, Andre, additional, Faruque, Mithila, additional, Farzadfar, Farshad, additional, Fattahi, Nazir, additional, Fazlzadeh, Mehdi, additional, Feigin, Valery L, additional, Feldman, Rachel, additional, Fereshtehnejad, Seyed-Mohammad, additional, Fernandes, Eduarda, additional, Ferrara, Giannina, additional, Ferrari, Alize J, additional, Ferreira, Manuela L, additional, Filip, Irina, additional, Fischer, Florian, additional, Fisher, James L, additional, Flor, Luisa Sorio, additional, Foigt, Nataliya A, additional, Folayan, Morenike Oluwatoyin, additional, Fomenkov, Artem Alekseevich, additional, Force, Lisa M, additional, Foroutan, Masoud, additional, Franklin, Richard Charles, additional, Freitas, Marisa, additional, Fu, Weijia, additional, Fukumoto, Takeshi, additional, Furtado, João M, additional, Gad, Mohamed M, additional, Gakidou, Emmanuela, additional, Gallus, Silvano, additional, Garcia-Basteiro, Alberto L, additional, Gardner, William M, additional, Geberemariyam, Biniyam Sahiledengle, additional, Gebreslassie, Assefa Ayalew Ayalew Ayalew, additional, Geremew, Abraham, additional, Gershberg Hayoon, Anna, additional, Gething, Peter W, additional, Ghadimi, Maryam, additional, Ghadiri, Keyghobad, additional, Ghaffarifar, Fatemeh, additional, Ghafourifard, Mansour, additional, Ghamari, Farhad, additional, Ghashghaee, Ahmad, additional, Ghiasvand, Hesam, additional, Ghith, Nermin, additional, Gholamian, Asadollah, additional, Ghosh, Rakesh, additional, Gill, Paramjit Singh, additional, Ginindza, Themba G G, additional, Giussani, Giorgia, additional, Gnedovskaya, Elena V, additional, Goharinezhad, Salime, additional, Gopalani, Sameer Vali, additional, Gorini, Giuseppe, additional, Goudarzi, Houman, additional, Goulart, Alessandra C, additional, Greaves, Felix, additional, Grivna, Michal, additional, Grosso, Giuseppe, additional, Gubari, Mohammed Ibrahim Mohialdeen, additional, Gugnani, Harish Chander, additional, Guimarães, Rafael Alves, additional, Guled, Rashid Abdi, additional, Guo, Gaorui, additional, Guo, Yuming, additional, Gupta, Rajeev, additional, Gupta, Tarun, additional, Haddock, Beatrix, additional, Hafezi-Nejad, Nima, additional, Hafiz, Abdul, additional, Haj-Mirzaian, Arvin, additional, Haj-Mirzaian, Arya, additional, Hall, Brian J, additional, Halvaei, Iman, additional, Hamadeh, Randah R, additional, Hamidi, Samer, additional, Hammer, Melanie S, additional, Hankey, Graeme J, additional, Haririan, Hamidreza, additional, Haro, Josep Maria, additional, Hasaballah, Ahmed I, additional, Hasan, Md Mehedi, additional, Hasanpoor, Edris, additional, Hashi, Abdiwahab, additional, Hassanipour, Soheil, additional, Hassankhani, Hadi, additional, Havmoeller, Rasmus J, additional, Hay, Simon I, additional, Hayat, Khezar, additional, Heidari, Golnaz, additional, Heidari-Soureshjani, Reza, additional, Henrikson, Hannah J, additional, Herbert, Molly E, additional, Herteliu, Claudiu, additional, Heydarpour, Fatemeh, additional, Hird, Thomas R, additional, Hoek, Hans W, additional, Holla, Ramesh, additional, Hoogar, Praveen, additional, Hosgood, H Dean, additional, Hossain, Naznin, additional, Hosseini, Mostafa, additional, Hosseinzadeh, Mehdi, additional, Hostiuc, Mihaela, additional, Hostiuc, Sorin, additional, Househ, Mowafa, additional, Hsairi, Mohamed, additional, Hsieh, Vivian Chia-rong, additional, Hu, Guoqing, additional, Hu, Kejia, additional, Huda, Tanvir M, additional, Humayun, Ayesha, additional, Huynh, Chantal K, additional, Hwang, Bing-Fang, additional, Iannucci, Vincent C, additional, Ibitoye, Segun Emmanuel, additional, Ikeda, Nayu, additional, Ikuta, Kevin S, additional, Ilesanmi, Olayinka Stephen, additional, Ilic, Irena M, additional, Ilic, Milena D, additional, Inbaraj, Leeberk Raja, additional, Ippolito, Helen, additional, Iqbal, Usman, additional, Irvani, Seyed Sina Naghibi, additional, Irvine, Caleb Mackay Salpeter, additional, Islam, M Mofizul, additional, Islam, Sheikh Mohammed Shariful, additional, Iso, Hiroyasu, additional, Ivers, Rebecca Q, additional, Iwu, Chidozie C D, additional, Iwu, Chinwe Juliana, additional, Iyamu, Ihoghosa Osamuyi, additional, Jaafari, Jalil, additional, Jacobsen, Kathryn H, additional, Jafari, Hussain, additional, Jafarinia, Morteza, additional, Jahani, Mohammad Ali, additional, Jakovljevic, Mihajlo, additional, Jalilian, Farzad, additional, James, Spencer L, additional, Janjani, Hosna, additional, Javaheri, Tahereh, additional, Javidnia, Javad, additional, Jeemon, Panniyammakal, additional, Jenabi, Ensiyeh, additional, Jha, Ravi Prakash, additional, Jha, Vivekanand, additional, Ji, John S, additional, Johansson, Lars, additional, John, Oommen, additional, John-Akinola, Yetunde O, additional, Johnson, Catherine Owens, additional, Jonas, Jost B, additional, Joukar, Farahnaz, additional, Jozwiak, Jacek Jerzy, additional, Jürisson, Mikk, additional, Kabir, Ali, additional, Kabir, Zubair, additional, Kalani, Hamed, additional, Kalani, Rizwan, additional, Kalankesh, Leila R, additional, Kalhor, Rohollah, additional, Kanchan, Tanuj, additional, Kapoor, Neeti, additional, Karami Matin, Behzad, additional, Karch, André, additional, Karim, Mohd Anisul, additional, Kassa, Getachew Mullu, additional, Katikireddi, Srinivasa Vittal, additional, Kayode, Gbenga A, additional, Kazemi Karyani, Ali, additional, Keiyoro, Peter Njenga, additional, Keller, Cathleen, additional, Kemmer, Laura, additional, Kendrick, Parkes J, additional, Khalid, Nauman, additional, Khammarnia, Mohammad, additional, Khan, Ejaz Ahmad, additional, Khan, Maseer, additional, Khatab, Khaled, additional, Khater, Mona M, additional, Khatib, Mahalaqua Nazli, additional, Khayamzadeh, Maryam, additional, Khazaei, Salman, additional, Kieling, Christian, additional, Kim, Yun Jin, additional, Kimokoti, Ruth W, additional, Kisa, Adnan, additional, Kisa, Sezer, additional, Kivimäki, Mika, additional, Knibbs, Luke D, additional, Knudsen, Ann Kristin Skrindo, additional, Kocarnik, Jonathan M, additional, Kochhar, Sonali, additional, Kopec, Jacek A, additional, Korshunov, Vladimir Andreevich, additional, Koul, Parvaiz A, additional, Koyanagi, Ai, additional, Kraemer, Moritz U G, additional, Krishan, Kewal, additional, Krohn, Kris J, additional, Kromhout, Hans, additional, Kuate Defo, Barthelemy, additional, Kumar, G Anil, additional, Kumar, Vivek, additional, Kurmi, Om P, additional, Kusuma, Dian, 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2020
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29. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Vos, Theo, primary, Lim, Stephen S, additional, Abbafati, Cristiana, additional, Abbas, Kaja M, additional, Abbasi, Mohammad, additional, Abbasifard, Mitra, additional, Abbasi-Kangevari, Mohsen, additional, Abbastabar, Hedayat, additional, Abd-Allah, Foad, additional, Abdelalim, Ahmed, additional, Abdollahi, Mohammad, additional, Abdollahpour, Ibrahim, additional, Abolhassani, Hassan, additional, Aboyans, Victor, additional, Abrams, Elissa M, additional, Abreu, Lucas Guimarães, additional, Abrigo, Michael R M, additional, Abu-Raddad, Laith Jamal, additional, Abushouk, Abdelrahman I, additional, Acebedo, Alyssa, additional, Ackerman, Ilana N, additional, Adabi, Maryam, additional, Adamu, Abdu A, additional, Adebayo, Oladimeji M, additional, Adekanmbi, Victor, additional, Adelson, Jaimie D, additional, Adetokunboh, Olatunji O, additional, Adham, Davoud, additional, Afshari, Mahdi, additional, Afshin, Ashkan, additional, Agardh, Emilie E, additional, Agarwal, Gina, additional, Agesa, Kareha M, additional, Aghaali, Mohammad, additional, Aghamir, Seyed Mohammad Kazem, additional, Agrawal, Anurag, additional, Ahmad, Tauseef, additional, Ahmadi, Alireza, additional, Ahmadi, Mehdi, additional, Ahmadieh, Hamid, additional, Ahmadpour, Ehsan, additional, Akalu, Temesgen Yihunie, additional, Akinyemi, Rufus Olusola, additional, Akinyemiju, Tomi, additional, Akombi, Blessing, additional, Al-Aly, Ziyad, additional, Alam, Khurshid, additional, Alam, Noore, additional, Alam, Samiah, additional, Alam, Tahiya, additional, Alanzi, Turki M, additional, Albertson, Samuel B, additional, Alcalde-Rabanal, Jacqueline Elizabeth, additional, Alema, Niguse Meles, additional, Ali, Muhammad, additional, Ali, Saqib, additional, Alicandro, Gianfranco, additional, Alijanzadeh, Mehran, additional, Alinia, Cyrus, additional, Alipour, Vahid, additional, Aljunid, Syed Mohamed, additional, Alla, François, additional, Allebeck, Peter, additional, Almasi-Hashiani, Amir, additional, Alonso, Jordi, additional, Al-Raddadi, Rajaa M, additional, Altirkawi, Khalid A, additional, Alvis-Guzman, Nelson, additional, Alvis-Zakzuk, Nelson J, additional, Amini, Saeed, additional, Amini-Rarani, Mostafa, additional, Aminorroaya, Arya, additional, Amiri, Fatemeh, additional, Amit, Arianna Maever L, additional, Amugsi, Dickson A, additional, Amul, Gianna Gayle Herrera, additional, Anderlini, Deanna, additional, Andrei, Catalina Liliana, additional, Andrei, Tudorel, additional, Anjomshoa, Mina, additional, Ansari, Fereshteh, additional, Ansari, Iman, additional, Ansari-Moghaddam, Alireza, additional, Antonio, Carl Abelardo T, additional, Antony, Catherine M, additional, Antriyandarti, Ernoiz, additional, Anvari, Davood, additional, Anwer, Razique, additional, Arabloo, Jalal, additional, Arab-Zozani, Morteza, additional, Aravkin, Aleksandr Y, additional, Ariani, Filippo, additional, Ärnlöv, Johan, additional, Aryal, Krishna K, additional, Arzani, Afsaneh, additional, Asadi-Aliabadi, Mehran, additional, Asadi-Pooya, Ali A, additional, Asghari, Babak, additional, Ashbaugh, Charlie, additional, Atnafu, Desta Debalkie, additional, Atre, Sachin R, additional, Ausloos, Floriane, additional, Ausloos, Marcel, additional, Ayala Quintanilla, Beatriz Paulina, additional, Ayano, Getinet, additional, Ayanore, Martin Amogre, additional, Aynalem, Yared Asmare, additional, Azari, Samad, additional, Azarian, Ghasem, additional, Azene, Zelalem Nigussie, additional, Babaee, Ebrahim, additional, Badawi, Alaa, additional, Bagherzadeh, Mojtaba, additional, Bakhshaei, Mohammad Hossein, additional, Bakhtiari, Ahad, additional, Balakrishnan, Senthilkumar, additional, Balalla, Shivanthi, additional, Balassyano, Shelly, additional, Banach, Maciej, additional, Banik, Palash Chandra, additional, Bannick, Marlena S, additional, Bante, Agegnehu Bante, additional, Baraki, Adhanom Gebreegziabher, additional, Barboza, Miguel A, additional, Barker-Collo, Suzanne Lyn, additional, Barthelemy, Celine M, 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Published
2020
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30. Formation of organoid-like structures in the decellularized rat testis.

Author

Kiani, Mehrafarin, Movahedin, Mansoureh, Halvaei, Iman, and Soleimani, Masoud

Subjects
STAINS & staining (Microscopy), TESTIS, SODIUM dodecyl sulfate, SEMINIFEROUS tubules, TRITON X-100
Abstract

Objective(s): In testis, the extracellular matrix (ECM) in addition to the supportive role for cells in the seminiferous epithelium, is also essential for the accurate functioning of these cells. Thus, using a decellularized testicular ECM (DTECM), as a scaffold for three-dimensional (3D) culture of testicular cells can mimic native ECM for studying in vitro spermatogenesis. Materials and Methods: The rat testis was decellularized via perfusion of 0.5% sodium dodecyl sulfate (SDS) for 48 hr, followed by 1% Triton X-100 for 6 hr, and then 1% DNase I for 1 hr. The efficiency of decellularization was evaluated by histology, immunohistochemistry (IHC), scanning electron microscopy (SEM), and MTT test. The prepared scaffolds were recellularized with testicular cells and cultured and assessed with hematoxylin-eosin (H&E) staining after two weeks. Results: Based on the H&E image, no trace of cell components could be observed in DTECM. IHC images demonstrated collagen types I and IV, laminin, and fibronectin were preserved. Masson's trichrome and alcian blue staining revealed that collagen and glycosaminoglycans (GAGs) were retained, and the SEM image indicated that 3D testicular architecture remained after the decellularization process. Based on the results of the MTT test, DTECM was cytocompatible, and H&E images represented that DTECM supports testicular cell arrangements in seminiferous tubule-like structures (STLSs) and organoid-like structures (OLSs). Conclusion: The results showed that the applied protocol successfully decellularized the testis tissue of the rat. Therefore, these scaffolds may provide an appropriate vehicle for in vitro reconstruction of the seminiferous tubule. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Survival Assessment of Mouse Preimplantation Embryos After Exposure to Cell Phone Radiation

Author

Safian, Fereshteh, Khalili, Mohammad Ali, Khoradmehr, Arezoo, Anbari, Fatemeh, Soltani, Saeedeh, and Halvaei, Iman

Subjects
Mice, animal structures, Cell phone, In vitro, Viability, embryonic structures, Original Article, Preimplantation embryos, RF-EMF
Abstract

Background: Using cellular phone has rapidly increased all over the world. Also, the concern on the possible health hazards of electromagnetic fields (EMF) induced from cell phones to reproduction has been growing in many countries. The aim of this study was to assess the consequences and effects of exposure to the cell phone radiation on the quality and survival rates of preimplantation embryos in mice. Methods: A total of 40 mice (20 females and 20 males), 6 weeks old and sexually mature BALB/c, were used for control and experimental groups. The ovary burses were removed and the zygotes were dissected in the morning after mating. Next, 2-cell embryos were divided into two groups of control (n=150) and experimental (n=150). EMF (900–1800 MHz) was used for four days in experimental group for 30 min/day in culture at 37°C in a CO 2 incubator. The quality of embryos was recorded daily and the fluorescent staining was used for identification of viable blastocysts. All data were compared by Student’s t-test and Mann-Whitney test (p

Published
2016

35. Laser assisted zona hatching does not improve live birth rate in patients undergoing their first ICSI cycles

Author

Razi, Mohammad Hossein, Halvaei, Iman, and Razi, Yasamin

Subjects
lcsh:QH471-489, lcsh:Reproduction, Original Article, Delivery rate, Clinical pregnancy, ICSI, lcsh:Gynecology and obstetrics, Laser assisted hatching, lcsh:RG1-991
Abstract

Background: Routine use of assisted hatching (AH) following ICSI is a controversial issue in the literature. There are rare studies regarding the effect of laser assisted hatching (LAH) on live birth rate. Objective: Our main goal was to evaluate the effect of LAH on delivery rate as well as congenital anomaly in patients undergoing their first ICSI cycle. Materials and Methods: A total of 182 patients subjected to ICSI were randomly aliquot into two groups of experiment and control. In experiment group, the embryos were subjected to LAH to open a hole in ZP (about 10-12 µm) while in control group, the transferred embryos were intact with no AH. The patients were followed for clinical pregnancy and delivery rate as well as congenital anomaly. All the patients were infertile due to male factor infertility and LAH and embryo transfer were done on day 2. Results: Laboratory and clinical characteristics of two groups of experiment and control were the same. There were insignificant differences between two groups of experiment and control for clinical pregnancy rate (20% vs. 23.9%, respectively, p=0.3) and live birth rate (11.11% vs. 8.6%, respectively, p=0.6). Also no significant differences were observed between two groups of experiment and control for multiple pregnancy as well as congenital anomaly. Conclusion: Routine use of LAH in first ICSI cycle for male factor patients may have no beneficial effects on clinical pregnancy and live birth rate.

Published
2013

38. Acute Effects of Ruta graveolens L. on Sperm Parameters and DNA Integrity in Rats

Author

Halvaei, Iman, Roodsari, Hamid Reza Sadeghipour, and Harat, Zhila Naghibi

Subjects
Ruta graveolens L, Sperm function assay, Rat, Iranian traditional medicine, Original Article, Spermatozoa, Male contraception
Abstract

Background Increase in world population is one of the serious and threatening issues in this century. Therefore, it is vitally important to find safe and effective contraceptive methods, especially for men which already have few choices in this regard. Medicinal plants that were used for contraception in ancient times could be good sources of investigation in this filed. Ruta graveolens L. is one the plants introduced in the Iranian traditional medicine as an oral male contraception to be used before intercourse. In this study we tried to investigate the probable effects of the plant on the spermatozoa of male rats. Methods Ruta graveolens L. aqueous extract (5 g/kg) was administered orally to five groups of male rats and sperm motility was checked after half, one, two, four and six hours later. Moreover, one group of rats served as the control group. Subsequently, viability of cells (Eosin-Nigrosin staining), morphological changes (Diff-Quick staining), DNA status (acridine orange dye) and serum testosterone levels were assessed in the treated groups which had significant immotile spermatozoa. For statistical analysis, Student's t-test and one-way ANOVA with Tukey's post-hoc test were employed for comparison between groups. Results A significant reduction in sperm motility was seen one hour after administration of the extract in the case groups compared to the controls (36% vs. 68.15%, respectively, p

Published
2012

39. Evaluating the Role of First Polar Body Morphology on Rates of Fertilization and Embryo Development in ICSI Cycles

Author

Halvaei, Iman, Khalili, Mohammad Ali, Soleimani, Mehrdad, and Razi, Mohammad Hossein

Subjects
Embryology, lcsh:R5-920, fertilization rate, first polar body, Original Article, embryo development, icsi, oocyte morphology, lcsh:Medicine (General), Art
Abstract

Background: Recent studies have demonstrated that morphology of the first polar body (1st PB)is related to oocyte viability, which can be used as a prognostic tool to predict oocyte performanceand pregnancy outcomes in an intracytoplasmic sperm injection (ICSI) program. According to somestudies, there is a correlation between oocyte performance and 1st PB morphology, while others havenot reported any correlation. The objective of this study is to evaluate the role of 1st PB morphologyon rates of fertilization and embryo development in ICSI cases.Materials and Methods: In this prospective study morphological characteristics of 470 metaphaseII (MII) oocytes were assessed in 80 ICSI cycles. The women were ages 21-42 years (mean 32.6 ±0.2). Their oocytes were retrieved after a hyperstimulation protocol. After denudation, all oocyteswere evaluated for 1st PB morphology. The oocytes were divided into two groups of A (normal 1stPB) and B (abnormal fragmented 1st PB). In addition, other abnormalities, such as refractile bodies(RF), wide previtelline space (wPVS), central and general granulation, bull’s eye, vacuole, smoothendoplasmic reticulum cluster (SERc), debris in PVS, shape and dark oocyte were checked. Forverifying of fertilization, about 18-19 hours post-ICSI, oocytes were checked for two-pronuclear.Assessments of embryo quality, development and embryo transfer were done at day two. Chisquare,Fisher’s exact and independent sample t tests were chosen for statistical analysis.Results: Twenty-seven percent of oocytes had fragmented 1st PB, while the remainder was associatedwith other morphological abnormalities. A total of 46.1% and 26.9% of oocytes showed double andmultiple defects, respectively. RF was the most common abnormality observed in group B. Nosignificant differences in women’s’ ages between groups A and B were noted (p=0.3). A total of 179and 107 oocytes (61.5% vs. 59.8%) were fertilized in groups A and B, respectively (p=0.7). Therates of good embryo formation for A and B groups were 66.5% and 55.6% (p=0.07), and cleavagerates were 77.7% and 68.5%, respectively (p=0.09).Conclusion: The data demonstrated that 1st PB morphology does not appear to be a prognosticfactor for rates of fertilization and embryo development in ICSI cycles.

Published
2011

42. Ongoing Pregnancies following Cosmetic Micromanipulation of Preimplantation Embryos in Patients with Implantation Failure

Author

Halvaei, Iman, Khalili, Mohammad Ali, Safari, Somayyeh, and Esfandiari, Navid

Subjects
Article Subject
Abstract

Cosmetic micromanipulation is defined as fragment and coarse granulation removal from preimplantation embryos. We report two cases of pregnancies in patients with implantation failure following cosmetic micromanipulation.

Published
2015
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48. The quality of sperm preparation medium affects the motility, viability, and DNA integrity of human spermatozoa.

Author

Anbari, Fatemeh, Halvaei, Iman, Nabi, Ali, Ghazali, Shahin, Khalili, Mohammad Ali, and Johansson, Lars

Subjects
*SEMEN analysis, *CONCEPTION, *CELL survival, *SPERMATOZOA
Abstract

AIM: The goal was to compare the effects of three different sperm preparation media on sperm motility, viability, and DNA integrity of semen samples from normozoospermic men. METHODS: A total of 15 normozoospermic males were included in the study. The semen analysis (SA) was performed in accordance with the WHO guidelines (2010). After SA, each sample was divided into three aliquots, and swim-up was performed with three different sperm preparation media (Sperm Preparation Media, Origio, Denmark; Ham's F10, Biochrome, Berlin, Germany; and VitaSpermTM, Innovative Biotech, Iran). Sperm motility, viability, and DNA fragmentation were evaluated at 0, 1, 2, and 24 h after swim-up. RESULTS: There were no significant differences, at any time intervals, in the total sperm motility between the different sperm preparation media. However, the rate of progressive motility was significantly higher in spermatozoa prepared using the media from Origio in comparison with VitaSpermTM (P = 0.03), whereas no significant difference was found against Ham's F10 medium. No significant differences in sperm viability were seen between the media products. However, 1 h after swim-up, the extent of sperm DNA fragmentation was lower in the medium from Origio versus VitaSpermTM (P = 0.02). CONCLUSIONS: The data showed that the quality of medium for preparation of semen samples from normozoospermic men significantly affects the performance of spermatozoa in assisted conception programs. [ABSTRACT FROM AUTHOR]

Published
2016
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50. Assessment of spermicidal activity of the antimicrobial peptide sarcotoxin Pd: A potent contraceptive agent.

Author

Zare-Zardini, Hadi, Fesahat, Farzaneh, Anbari, Fatemeh, Halvaei, Iman, and Ebrahimi, Leila

Subjects
SPERMICIDES, ANTI-infective agents, SARCOTOXINS, MALE contraceptives, SEXUALLY transmitted diseases, ANTIBIOTICS, GLYCOSIDES, HYDROCARBONS, REFERENCE values, SPERMATOZOA, SPERM motility, PHARMACODYNAMICS
Abstract

ObjectivesIn searching for new spermicidal microbicides for use in the prevention of unplanned pregnancy and sexually transmitted infections (STIs) we investigated the spermicidal and cytotoxicity activities of the antimicrobial peptide sarcotoxin Pd. MethodsWashed sperm from 10 healthy, normal volunteers was treated with different concentrations of sarcotoxin Pd. Sperm motility and morphology were assessed at 0, 0.3, 5, 10 and 15 min. The cytotoxicity of sarcotoxin Pd in normal human cervical HeLa cells was measured. Percentage cell survival was expressed as the number of live cells in the test group. ResultsThe cytotoxic effect of sarcotoxin Pd was concentration-dependent. Significant cytotoxicity was observed at concentrations above 24 μg/ml. Sarcotoxin Pd immobilised 100% of spermatozoa at a dose of 90 and 80 μg/ml after 0.3 and 5 min, respectively, and immobilised 50% of spermatozoa after 15 min at lower doses. Sarcotoxin Pd inhibited sperm motility in a dose-dependent manner. The peptide immobilised sperm within 20 s at its maximal effective concentration of 90 μg/ml. ConclusionsSarcotoxin Pd appears to be a good candidate for a contraceptive agent in the prevention of unplanned pregnancy and STIs. 摘要 目的 为了寻找一种同时具有杀精子活性和抗菌活性的药物，既能防止非计划妊娠又能预防性传播疾病，我们对抗菌肽sarcotoxin Pd的杀精子活性和细胞毒性进行了研究。 方法 从10名健康的志愿者获得精液，洗涤后分别与不同浓度抗菌肽sarcotoxin Pd的液体进行混合。分别记录混合后0、0.3、5、10和15分钟时间间隔的精子形态和活动度。通过测定正常人宫颈HeLa细胞在含有不同浓度的抗菌肽sarcotoxin Pd培养基里进行培养后的活细胞数来反映其细胞毒性。 结果 抗菌肽sarcotoxin Pd的细胞毒性是浓度依赖性的。24ug/ml以上浓度的抗菌肽sarcotoxin Pd具有显著的细胞毒性。抗菌肽sarcotoxin Pd的杀精子活性在90ug/ml浓度0.3分钟以及80ug/ml浓度5分钟后可以使100%的精子失去活性，而较低的浓度则需要超过15分钟来使50%的精子失去活性。抗菌肽sarcotoxin Pd对精子活动度的影响也是剂量依赖性的。抗菌肽sarcotoxin Pd的最大有效浓度90ug/ml能够在20秒内让精子失去活性。 结论 抗菌肽sarcotoxin Pd看起来是既能防止非计划妊娠又能预防性传播疾病的避孕方法的一种不错的选择。 [ABSTRACT FROM PUBLISHER]

Published
2016
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