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24 results on '"Ham, Hyoungjun"'

1. GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Author

Park, Ann Y., Leney-Greene, Michael, Lynberg, Matthew, Gabrielski, Justin Q., Xu, Xijin, Schwarz, Benjamin, Zheng, Lixin, Balasubramaniyam, Arasu, Ham, Hyoungjun, Chao, Brittany, Zhang, Yu, Matthews, Helen F., Cui, Jing, Yao, Yikun, Kubo, Satoshi, Chanchu, Jean Michel, Morawski, Aaron R., Cook, Sarah A., Jiang, Ping, Ravell, Juan C., Cheng, Yan H., George, Alex, Faruqi, Aiman, Pagalilauan, Alison M., Bergerson, Jenna R. E., Ganesan, Sundar, Chauvin, Samuel D., Aluri, Jahnavi, Edwards-Hicks, Joy, Bohrnsen, Eric, Tippett, Caroline, Omar, Habib, Xu, Leilei, Butcher, Geoffrey W., Pascall, John, Karakoc-Aydiner, Elif, Kiykim, Ayca, Maecker, Holden, Tezcan, İlhan, Esenboga, Saliha, Heredia, Raul Jimenez, Akata, Deniz, Tekin, Saban, Kara, Altan, Kuloglu, Zarife, Unal, Emel, Kendirli, Tanıl, Dogu, Figen, Karabiber, Esra, Atkinson, T. Prescott, Cochet, Claude, Filhol, Odile, Bosio, Catherine M., Davis, Mark M., Lifton, Richard P., Pearce, Erika L., Daumke, Oliver, Aytekin, Caner, Şahin, Gülseren Evirgen, Aksu, Aysel Ünlüsoy, Uzel, Gulbu, Koneti Rao, V., Sari, Sinan, Dalgıç, Buket, Boztug, Kaan, Cagdas, Deniz, Haskologlu, Sule, Ikinciogullari, Aydan, Schwefel, David, Vilarinho, Silvia, Baris, Safa, Ozen, Ahmet, Su, Helen C., and Lenardo, Michael J.

Published
2024
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2. Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway

Author

Park, Ann Y., Leney-Greene, Michael, Lynberg, Matthew, Gabrielski, Justin Q., Xu, Xijin, Schwarz, Benjamin, Zheng, Lixin, Balasubramaniyam, Arasu, Ham, Hyoungjun, Chao, Brittany, Zhang, Yu, Matthews, Helen F., Cui, Jing, Yao, Yikun, Kubo, Satoshi, Chanchu, Jean Michel, Morawski, Aaron R., Cook, Sarah A., Jiang, Ping, Ravell, Juan C., Cheng, Yan H., George, Alex, Faruqi, Aiman, Pagalilauan, Alison M., Bergerson, Jenna R. E., Ganesan, Sundar, Chauvin, Samuel D., Aluri, Jahnavi, Edwards-Hicks, Joy, Bohrnsen, Eric, Tippett, Caroline, Omar, Habib, Xu, Leilei, Butcher, Geoffrey W., Pascall, John, Karakoc-Aydiner, Elif, Kiykim, Ayca, Maecker, Holden, Tezcan, İlhan, Esenboga, Saliha, Heredia, Raul Jimenez, Akata, Deniz, Tekin, Saban, Kara, Altan, Kuloglu, Zarife, Unal, Emel, Kendirli, Tanıl, Dogu, Figen, Karabiber, Esra, Atkinson, T. Prescott, Cochet, Claude, Filhol, Odile, Bosio, Catherine M., Davis, Mark M., Lifton, Richard P., Pearce, Erika L., Daumke, Oliver, Aytekin, Caner, Şahin, Gülseren Evirgen, Aksu, Aysel Ünlüsoy, Uzel, Gulbu, Koneti Rao, V., Sari, Sinan, Dalgıç, Buket, Boztug, Kaan, Cagdas, Deniz, Haskologlu, Sule, Ikinciogullari, Aydan, Schwefel, David, Vilarinho, Silvia, Baris, Safa, Ozen, Ahmet, Su, Helen C., and Lenardo, Michael J.

Published
2024
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5. Supplementary Figure from NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, primary, Li, Ying, primary, Zhang, Henan, primary, Gicobi, Joanina K., primary, Hirdler, Jacob B., primary, Liu, Xin, primary, Ham, Hyoungjun, primary, Peterson Martinez, Kodi E., primary, Lucien, Fabrice, primary, Lavoie, Roxane R., primary, Li, Hu, primary, Correia, Cristina, primary, Monie, Dileep D., primary, An, Zesheng, primary, Harrington, Susan M., primary, Wu, Xiaosheng, primary, Guo, Ruifeng, primary, Dronca, Roxana S., primary, Mansfield, Aaron S., primary, Yan, Yiyi, primary, Markovic, Svetomir N., primary, Park, Sean S., primary, Sun, Jie, primary, Qin, Hong, primary, Liu, Minetta C., primary, Vasmatzis, George, primary, Billadeau, Daniel D., primary, and Dong, Haidong, primary

Published
2024
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6. Supplementary Data from NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, primary, Li, Ying, primary, Zhang, Henan, primary, Gicobi, Joanina K., primary, Hirdler, Jacob B., primary, Liu, Xin, primary, Ham, Hyoungjun, primary, Peterson Martinez, Kodi E., primary, Lucien, Fabrice, primary, Lavoie, Roxane R., primary, Li, Hu, primary, Correia, Cristina, primary, Monie, Dileep D., primary, An, Zesheng, primary, Harrington, Susan M., primary, Wu, Xiaosheng, primary, Guo, Ruifeng, primary, Dronca, Roxana S., primary, Mansfield, Aaron S., primary, Yan, Yiyi, primary, Markovic, Svetomir N., primary, Park, Sean S., primary, Sun, Jie, primary, Qin, Hong, primary, Liu, Minetta C., primary, Vasmatzis, George, primary, Billadeau, Daniel D., primary, and Dong, Haidong, primary

Published
2024
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7. Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNα expression by human plasmacytoid dendritic cells

Author

Wiest, Matthew J., primary, Baert, Laurie, additional, Gu, Chao, additional, Gayler, Kevin M., additional, Ham, Hyoungjun, additional, Gorvel, Laurent, additional, Keddis, Mira T., additional, Griffing, Leroy W., additional, Joo, HyeMee, additional, Gorvel, Jean-Pierre, additional, Billadeau, Daniel D., additional, Kane, Robert R., additional, and Oh, SangKon, additional

Published
2023
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8. HkRP3 Is a Microtubule-Binding Protein Regulating Lytic Granule Clustering and NK Cell Killing

Author

Ham, Hyoungjun, Huynh, Walter, Schoon, Renee A, Vale, Ronald D, and Billadeau, Daniel D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Prevention, Vaccine Related, Biodefense, Underpinning research, 1.1 Normal biological development and functioning, Cell Line, Dyneins, Guanine Nucleotide Exchange Factors, Humans, Immunity, Cellular, Killer Cells, Natural, Microtubule-Associated Proteins, Microtubule-Organizing Center, Secretory Vesicles, Immunology, Biochemistry and cell biology
Abstract

NK cells provide host defense by killing viral-infected and cancerous cells through the secretion of preformed lytic granules. Polarization of the lytic granules toward the target cell is dependent on an intact microtubule (MT) network as well as MT motors. We have recently shown that DOCK8, a gene mutated in a primary immunodeficiency syndrome, is involved in NK cell killing in part through its effects on MT organizing center (MTOC) polarization. In this study, we identified Hook-related protein 3 (HkRP3) as a novel DOCK8- and MT-binding protein. We further show that HkRP3 is present in lytic granule fractions and interacts with the dynein motor complex and MTs. Significantly, depletion of HkPR3 impaired NK cell cytotoxicity, which could be attributed to a defect in not only MTOC polarity, but also impaired clustering of lytic granules around the MTOC. Our results demonstrate an important role for HkRP3 in regulating the clustering of lytic granules and MTOC repositioning during the development of NK cell-mediated killing.

Published
2015

9. Data from NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, primary, Li, Ying, primary, Zhang, Henan, primary, Gicobi, Joanina K., primary, Hirdler, Jacob B., primary, Liu, Xin, primary, Ham, Hyoungjun, primary, Peterson Martinez, Kodi E., primary, Lucien, Fabrice, primary, Lavoie, Roxane R., primary, Li, Hu, primary, Correia, Cristina, primary, Monie, Dileep D., primary, An, Zesheng, primary, Harrington, Susan M., primary, Wu, Xiaosheng, primary, Guo, Ruifeng, primary, Dronca, Roxana S., primary, Mansfield, Aaron S., primary, Yan, Yiyi, primary, Markovic, Svetomir N., primary, Park, Sean S., primary, Sun, Jie, primary, Qin, Hong, primary, Liu, Minetta C., primary, Vasmatzis, George, primary, Billadeau, Daniel D., primary, and Dong, Haidong, primary

Published
2023
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10. Supplementary Figure from NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, primary, Li, Ying, primary, Zhang, Henan, primary, Gicobi, Joanina K., primary, Hirdler, Jacob B., primary, Liu, Xin, primary, Ham, Hyoungjun, primary, Peterson Martinez, Kodi E., primary, Lucien, Fabrice, primary, Lavoie, Roxane R., primary, Li, Hu, primary, Correia, Cristina, primary, Monie, Dileep D., primary, An, Zesheng, primary, Harrington, Susan M., primary, Wu, Xiaosheng, primary, Guo, Ruifeng, primary, Dronca, Roxana S., primary, Mansfield, Aaron S., primary, Yan, Yiyi, primary, Markovic, Svetomir N., primary, Park, Sean S., primary, Sun, Jie, primary, Qin, Hong, primary, Liu, Minetta C., primary, Vasmatzis, George, primary, Billadeau, Daniel D., primary, and Dong, Haidong, primary

Published
2023
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11. Supplementary Data from NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, primary, Li, Ying, primary, Zhang, Henan, primary, Gicobi, Joanina K., primary, Hirdler, Jacob B., primary, Liu, Xin, primary, Ham, Hyoungjun, primary, Peterson Martinez, Kodi E., primary, Lucien, Fabrice, primary, Lavoie, Roxane R., primary, Li, Hu, primary, Correia, Cristina, primary, Monie, Dileep D., primary, An, Zesheng, primary, Harrington, Susan M., primary, Wu, Xiaosheng, primary, Guo, Ruifeng, primary, Dronca, Roxana S., primary, Mansfield, Aaron S., primary, Yan, Yiyi, primary, Markovic, Svetomir N., primary, Park, Sean S., primary, Sun, Jie, primary, Qin, Hong, primary, Liu, Minetta C., primary, Vasmatzis, George, primary, Billadeau, Daniel D., primary, and Dong, Haidong, primary

Published
2023
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14. NKG7 Is a T-cell–Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy

Author

Wen, Ti, primary, Barham, Whitney, additional, Li, Ying, additional, Zhang, Henan, additional, Gicobi, Joanina K., additional, Hirdler, Jacob B., additional, Liu, Xin, additional, Ham, Hyoungjun, additional, Peterson Martinez, Kodi E., additional, Lucien, Fabrice, additional, Lavoie, Roxane R., additional, Li, Hu, additional, Correia, Cristina, additional, Monie, Dileep D., additional, An, Zesheng, additional, Harrington, Susan M., additional, Wu, Xiaosheng, additional, Guo, Ruifeng, additional, Dronca, Roxana S., additional, Mansfield, Aaron S., additional, Yan, Yiyi, additional, Markovic, Svetomir N., additional, Park, Sean S., additional, Sun, Jie, additional, Qin, Hong, additional, Liu, Minetta C., additional, Vasmatzis, George, additional, Billadeau, Daniel D., additional, and Dong, Haidong, additional

Published
2021
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16. DOCK7 protects against replication stress by promoting RPA stability on chromatin

Author

Gao, Ming, primary, Guo, Guijie, additional, Huang, Jinzhou, additional, Hou, Xiaonan, additional, Ham, Hyoungjun, additional, Kim, Wootae, additional, Zhao, Fei, additional, Tu, Xinyi, additional, Zhou, Qin, additional, Zhang, Chao, additional, Zhu, Qian, additional, Liu, Jiaqi, additional, Yan, Yuanliang, additional, Xu, Zhijie, additional, Yin, Ping, additional, Luo, Kuntian, additional, Weroha, John, additional, Deng, Min, additional, Billadeau, Daniel D, additional, and Lou, Zhenkun, additional

Published
2021
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18. Dominant-activating Gαi2 mutations cause human immunodeficiency and autoimmunity by causing defective leukocyte migration and altered T cell activation

Author

Ham, Hyoungjun, primary, Lamborn, Ian, additional, Zhang, Yu, additional, Berchiche, Yamina, additional, Koval, Alexey, additional, Jing, Huie, additional, Mandl, Judith N., additional, Happel, Corinne, additional, murdock, Heardley M, additional, Masutani, Evan, additional, McElwee, Joshua J, additional, Matthews, Helen F, additional, Druey, Kirk M, additional, Mustillo, Peter J, additional, Germain, Ronald N, additional, Sakmar, Thomas, additional, Katanaev, Vladimir, additional, and Su, Helen, additional

Published
2017
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20. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1

Author

Lee, Seung Baek, primary, Kim, Jung Jin, additional, Nam, Hyun-Ja, additional, Gao, Bowen, additional, Yin, Ping, additional, Qin, Bo, additional, Yi, Sang-Yeop, additional, Ham, Hyoungjun, additional, Evans, Debra, additional, Kim, Sun-Hyun, additional, Zhang, Jun, additional, Deng, Min, additional, Liu, Tongzheng, additional, Zhang, Haoxing, additional, Billadeau, Daniel D., additional, Wang, Liewei, additional, Giaime, Emilie, additional, Shen, Jie, additional, Pang, Yuan-Ping, additional, Jen, Jin, additional, van Deursen, Jan M., additional, and Lou, Zhenkun, additional

Published
2015
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23. Germline mutations in a G protein identify signaling cross-talk in T cells.

Author

Ham H, Jing H, Lamborn IT, Kober MM, Koval A, Berchiche YA, Anderson DE, Druey KM, Mandl JN, Isidor B, Ferreira CR, Freeman AF, Ganesan S, Karsak M, Mustillo PJ, Teo J, Zolkipli-Cunningham Z, Chatron N, Lecoquierre F, Oler AJ, Schmid JP, Kuhns DB, Xu X, Hauck F, Al-Herz W, Wagner M, Terhal PA, Muurinen M, Barlogis V, Cruz P, Danielson J, Stewart H, Loid P, Rading S, Keren B, Pfundt R, Zarember KA, Vill K, Potocki L, Olivier KN, Lesca G, Faivre L, Wong M, Puel A, Chou J, Tusseau M, Moutsopoulos NM, Matthews HF, Simons C, Taft RJ, Soldatos A, Masle-Farquhar E, Pittaluga S, Brink R, Fink DL, Kong HH, Kabat J, Kim WS, Bierhals T, Meguro K, Hsu AP, Gu J, Stoddard J, Banos-Pinero B, Slack M, Trivellin G, Mazel B, Soomann M, Li S, Watts VJ, Stratakis CA, Rodriguez-Quevedo MF, Bruel AL, Lipsanen-Nyman M, Saultier P, Jain R, Lehalle D, Torres D, Sullivan KE, Barbarot S, Neu A, Duffourd Y, Similuk M, McWalter K, Blanc P, Bézieau S, Jin T, Geha RS, Casanova JL, Makitie OM, Kubisch C, Edery P, Christodoulou J, Germain RN, Goodnow CC, Sakmar TP, Billadeau DD, Küry S, Katanaev VL, Zhang Y, Lenardo MJ, and Su HC

Subjects
Humans, Cell Movement genetics, Cell Proliferation, Immunity genetics, MAP Kinase Signaling System, Phosphatidylinositol 3-Kinases metabolism, Phosphatidylinositol 3-Kinases genetics, Proto-Oncogene Proteins c-akt metabolism, ras Proteins metabolism, ras Proteins genetics, Signal Transduction, Pedigree, Germ-Line Mutation, GTP-Binding Protein alpha Subunit, Gi2 genetics, ras GTPase-Activating Proteins genetics, Receptors, Antigen, T-Cell metabolism, T-Lymphocytes immunology, T-Lymphocytes metabolism
Abstract

Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2 , which encodes G αi2 , a key component in heterotrimeric G protein signal transduction usually thought to regulate adenylyl cyclase-mediated cyclic adenosine monophosphate (cAMP) production. Patients with activating G αi2 mutations had clinical presentations that included impaired immunity. Mutant G αi2 impaired cell migration and augmented responses to T cell receptor (TCR) stimulation. We found that mutant G αi2 influenced TCR signaling by sequestering the guanosine triphosphatase (GTPase)-activating protein RASA2, thereby promoting RAS activation and increasing downstream extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)-AKT S6 signaling to drive cellular growth and proliferation.

Published
2024
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24. NKG7 Is a T-cell-Intrinsic Therapeutic Target for Improving Antitumor Cytotoxicity and Cancer Immunotherapy.

Author

Wen T, Barham W, Li Y, Zhang H, Gicobi JK, Hirdler JB, Liu X, Ham H, Peterson Martinez KE, Lucien F, Lavoie RR, Li H, Correia C, Monie DD, An Z, Harrington SM, Wu X, Guo R, Dronca RS, Mansfield AS, Yan Y, Markovic SN, Park SS, Sun J, Qin H, Liu MC, Vasmatzis G, Billadeau DD, and Dong H

Subjects
Animals, Humans, Mice, T-Lymphocytes, Cytotoxic, CD8-Positive T-Lymphocytes immunology, Immunotherapy, Membrane Proteins metabolism, Neoplasms immunology, Neoplasms therapy, RNA, Messenger therapeutic use
Abstract

Cytotoxic CD8 + T cells (CTL) are a crucial component of the immune system notable for their ability to eliminate rapidly proliferating malignant cells. However, the T-cell intrinsic factors required for human CTLs to accomplish highly efficient antitumor cytotoxicity are not well defined. By evaluating human CD8 + T cells from responders versus nonresponders to treatment with immune checkpoint inhibitors, we sought to identify key factors associated with effective CTL function. Single-cell RNA-sequencing analysis of peripheral CD8 + T cells from patients treated with anti-PD-1 therapy showed that cells from nonresponders exhibited decreased expression of the cytolytic granule-associated molecule natural killer cell granule protein-7 ( NKG7 ). Functional assays revealed that reduced NKG7 expression altered cytolytic granule number, trafficking, and calcium release, resulting in decreased CD8 + T-cell-mediated killing of tumor cells. Transfection of T cells with NKG7 mRNA was sufficient to improve the tumor-cell killing ability of human T cells isolated from nonresponders and increase their response to anti-PD-1 or anti-PD-L1 therapy in vitro . NKG7 mRNA therapy also improved the antitumor activity of murine tumor antigen-specific CD8 + T cells in an in vivo model of adoptive cell therapy. Finally, we showed that the transcription factor ETS1 played a role in regulating NKG7 expression. Together, our results identify NKG7 as a necessary component for the cytotoxic function of CD8 + T cells and establish NKG7 as a T-cell-intrinsic therapeutic target for enhancing cancer immunotherapy. See related article by Li et al., p. 154., (©2021 The Authors; Published by the American Association for Cancer Research.)

Published
2022
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