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307 results on '"Hamada, Yoshinori"'

13. Pancreatobiliary reflux in individuals with a normal pancreaticobiliary junction: a prospective multicenter study

Author

Horaguchi, Jun, Fujita, Naotaka, Kamisawa, Terumi, Honda, Goro, Chijiiwa, Kazuo, Maguchi, Hiroyuki, Tanaka, Masao, Shimada, Mitsuo, Igarashi, Yoshinori, Inui, Kazuo, Hanada, Keiji, Itoi, Takao, Hamada, Yoshinori, Koshinaga, Tsugumichi, Fujii, Hideki, Urushihara, Naoto, Ando, Hisami, and The committee of Diagnostic Criteria of The Japanese Study Group on Pancreaticobiliary Maljunction

Published
2014
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15. Exploring the length of the common channel of pancreaticobiliary maljunction on magnetic resonance cholangiopancreatography

Author

Itokawa, Fumihide, Kamisawa, Terumi, Nakano, Toshiaki, Itoi, Takao, Hamada, Yoshinori, Ando, Hisami, Fujii, Hideki, Koshinaga, Tsugumichi, Yoshida, Hitoshi, Tamoto, Eiji, Noda, Takuo, Kimura, Yasutoshi, Maguchi, Hiroyuki, Urushihara, Naoto, Horaguchi, Jun, Morotomi, Yoshiki, Sato, Masahito, Hanada, Keiji, Tanaka, Masao, Takahashi, Astushi, Yamaguchi, Taketo, Arai, Yuuki, Horiguchi, Akihiko, Igarashi, Yoshinori, and Inui, Kazuo

Published
2015
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27. Epidermal growth factor and interleukin-1[beta] synergistically stimulate the production of nitric oxide in rat intestinal epithelial cells

Author

Kitagawa, Katsuhiko, Hamada, Yoshinori, Kato, Yasunori, Nakai, Koji, Nishizawa, Mikio, Ito, Seiji, and Okumura, Tadayoshi

Subjects
Epidermal growth factor -- Research, Biological sciences
Abstract

Epidermal growth factor (EGF) is one of the trophic factors for intestinal adaptation after small bowel transplantation (SBT). A recent report indicates that nitric oxide (NO) has cytoprotective effects on bacterial translocation (BT) after SBT. We hypothesized that EGF stimulates the expression of the inducible NO synthase (iNOS) gene in the graft after SBT, followed by increased production of NO, resulting in the decrease of BT. Intestinal epithelial cells (IEC)-6 were treated with EGF and/or IL-1[beta] in the presence and absence of phosphatidylinositol 3-kinase (P13-kinase) and EGF receptor kinase inhibitors (LY-294002 and tyrphostin A25). The induction of NO production and iNOS and its signal molecules, including the inhibitory protein of NF-[kappa]B (I[kappa]B), NF-[kappa]B, and Akt, were analyzed. IL-1[beta] stimulated the degradation of I[kappa]B and the activation of NF-[kappa]B but had no effect on iNOS induction. EGF, which had no effect on the NF-[kappa]B activation and iNOS induction, stimulated the upregulation of type 1 IL-1 receptor (IL-1R1) through P13-kinase/Akt. Simultaneous addition of EGF and IL-1[beta] stimulated synergistically the induction of iNOS, leading to the increased production of NO. Our results indicate that EGF and IL-1[beta] stimulate two essential signals for iNOS induction in IEC-6 cells: the upregulation of IL-1R1 through P13-kinase/Akt and the activation of NF-[kappa]B through I[kappa]B kinase, respectively. Simultaneous addition of EGF and IL-I[beta] can enhance the production of NO, which may contribute to the cytoprotective effect of EGF against intestinal injury. inducible nitric oxide synthase; nuclear factor-[kappa]B; phosphatidylinositol 3-kinase; Akt; type 1 interleukin-1 receptor.

Published
2004

47. Simultaneous development of adenocarcinoma and gastrointestinal stromal tumor (GIST) in the stomach: case report

Author

Yamamoto Daigo, Hamada Yoshinori, Tsubota Yu, Kawakami Katsuhiro, Yamamoto Chizuko, and Yamamoto Mitsuo

Subjects
gastric cancer, GIST, stomach, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. Case presentation We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvature of the proximal stomach and a submucosal nodule that measured about 3 cm in diameter in the lower part of the stomach body. Their pathological examination showed gastric cancer (poorly differentiated diffuse adenocarcinoma) and GIST (low-risk category). Further, immunohistochemical staining for C-kit and CD34 was positive, while that for SMA and S-100 was negative. Conclusion Although it is not easy to speculate on the coexistence of adenocarcinoma and GIST, pre-and post-operative diagnoses may be essential, and such cancer development is not considered to be unusual.

Published
2012
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