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24 results on '"Hamahira, Kiyoshi"'

1. Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan

Author

Matsuzaki, Satoshi, Yamazaki, Shoko, Ikeda, Kazuyuki, Hara, Takuma, Kanetaka, Taichi, Kizawa, Toshitaka, Kikuchi, Masako, Hara, Ryoki, Fujii, Kentaro, Takahashi, Mayu, Sonoda, Kaori, Yoshihashi, Tomokuni, Imagawa, Tomoyuki, Yamazaki, Kazuko, Ebato, Takasuke, Oana, Shinji, Murase, Ayako, Sakaki, Shinichiro, Fujimoto, Takeshi, Saito, Yoshihiko, Shirai, Ryota, Takeuchi, Ichiro, Naoi, Kazuyuki, Kenmotsu, Yasushi, Goto, Chiaki, Kise, Hiroaki, Okada, Seigo, Kishimoto, Sayuri, Oba, Utako, Ozawa, Sayaka, Seki, Mitsuru, Odagiri, Tesshu, Shiono, Junko, Nagumo, Kiyoshi, Kimura, Mitsuaki, Yoshibayashi, Muneo, Horita, Norihisa, Tsuboi, Tatsuo, Matsubara, Tomoyo, Hara, Satoshi, Ishii, Taku, Hosokawa, Susumu, Kishi, Takayuki, Fukazawa, Ryuji, Ogawa, Shunichi, Ohshima, Miho, Fukunaga, Hideo, Kouzan, Hiroko, Ichihara, Tomoko, Hashimoto, Kunio, Tokunaga, Hirohide, Suzuki, Hiroshi, Iwashima, Satoru, Hamahira, Kiyoshi, Ishiguchi, Yukiko, Kajino, Mayumi, Kishi, Kanta, Nagai, Noriko, Ito, Shigeru, Ogino, Hirotaro, Amaya, Eriko, Doi, Hiraku, Waki, Kenji, Shiraishi, Taisuke, Iwai, Takashi, Sato, Tetsuji, Akimoto, Katsumi, Soga, Takashi, Naito, Hiroyuki, Aihara, Makiko, Fukuda, Yutaka, Imagawa, Kazuo, Shiba, Takeshi, Matsuki, Shigenobu, Miura, Masaru, Araki, Tooru, Furuyama, Hideto, Naito, Takeshi, Miyamoto, Tomoyuki, Masuda, Hiroshi, Kobayashi, Tohru, Hachiya, Akira, Nakashima, Yasutaka, Shimizu, Hiroyuki, Nozawa, Tomo, Ogihara, Yoshihito, Ito, Shuichi, Takatsuki, Shinichi, Katsumata, Nobuyuki, Suzuki, Yasuo, Takenaka, Satoshi, Hirono, Keiichi, Kobayashi, Tomio, Suganuma, Eisuke, Takahashi, Kei, and Saji, Tsutomu

Published
2018
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2. Renal biopsy criterion in idiopathic nephrotic syndrome with microscopic hematuria at onset

Author

Hama, Taketsugu, Nakanishi, Koichi, Shima, Yuko, Sato, Masashi, Mukaiyama, Hironobu, Togawa, Hiroko, Hamahira, Kiyoshi, Tanaka, Ryojiro, Kaito, Hiroshi, Nozu, Kandai, Iijima, Kazumoto, and Yoshikawa, Norishige

Subjects
Nephrotic syndrome -- Diagnosis -- Care and treatment, Kidney biopsy -- Health aspects, Health
Abstract

Background The criterion for performing a renal biopsy in children with idiopathic nephrotic syndrome (NS) showing microscopic hematuria at onset remains controversial. Methods To determine an adequate renal biopsy criterion in children with NS showing hematuria, the optimal cutoff for the maximum red blood cell (RBC) range in urine sediment to separate minimal change disease (MCD) from other glomerular changes was obtained by receiver operating characteristic analysis. We studied 29 children with NS showing hematuria who were screened from 1,320 patients who underwent renal biopsies between January 2001 and September 2011. Patients were divided into two groups according to the cutoff value to verify its validity. Results The optimal maximum RBC range was 30-49/high-power field (HPF). In group 1 (RBC [less than or equal to] 29/HPF, n = 14), 3 patients showed nephritis and the other 11 patients showed MCD. In group 2 (RBC [greater than or equal to] 30/HPF, n = 15), 1 patient showed focal segmental glomerulosclerosis, 12 showed nephritis, and the other 2 showed MCD. These findings indicated that the ratio of non-MCD/MCD was significantly higher in group 2 than in group 1 (P < 0.01). Conclusions The use of maximum RBC range (30-49/HPF) for a criterion of renal biopsy in patients with NS showing hematuria may be reasonable for clinical practice. Keywords Minimal change disease * Focal segmental glomerulosclerosis * IgA nephropathy * Membranoproliferative glomerulonephritis * Receiver operating characteristic analysis, Introduction Idiopathic nephrotic syndrome (NS) is defined as NS in the absence of systemic disease. This category is divided into two types of entities according to histopathological findings: minimal change [...]

Published
2015
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11. Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment

Author

Ashraf, Shazia, primary, Kudo, Hiroki, additional, Rao, Jia, additional, Kikuchi, Atsuo, additional, Widmeier, Eugen, additional, Lawson, Jennifer A., additional, Tan, Weizhen, additional, Hermle, Tobias, additional, Warejko, Jillian K., additional, Shril, Shirlee, additional, Airik, Merlin, additional, Jobst-Schwan, Tilman, additional, Lovric, Svjetlana, additional, Braun, Daniela A., additional, Gee, Heon Yung, additional, Schapiro, David, additional, Majmundar, Amar J., additional, Sadowski, Carolin E., additional, Pabst, Werner L., additional, Daga, Ankana, additional, van der Ven, Amelie T., additional, Schmidt, Johanna M., additional, Low, Boon Chuan, additional, Gupta, Anjali Bansal, additional, Tripathi, Brajendra K., additional, Wong, Jenny, additional, Campbell, Kirk, additional, Metcalfe, Kay, additional, Schanze, Denny, additional, Niihori, Tetsuya, additional, Kaito, Hiroshi, additional, Nozu, Kandai, additional, Tsukaguchi, Hiroyasu, additional, Tanaka, Ryojiro, additional, Hamahira, Kiyoshi, additional, Kobayashi, Yasuko, additional, Takizawa, Takumi, additional, Funayama, Ryo, additional, Nakayama, Keiko, additional, Aoki, Yoko, additional, Kumagai, Naonori, additional, Iijima, Kazumoto, additional, Fehrenbach, Henry, additional, Kari, Jameela A., additional, El Desoky, Sherif, additional, Jalalah, Sawsan, additional, Bogdanovic, Radovan, additional, Stajić, Nataša, additional, Zappel, Hildegard, additional, Rakhmetova, Assel, additional, Wassmer, Sharon-Rose, additional, Jungraithmayr, Therese, additional, Strehlau, Juergen, additional, Kumar, Aravind Selvin, additional, Bagga, Arvind, additional, Soliman, Neveen A., additional, Mane, Shrikant M., additional, Kaufman, Lewis, additional, Lowy, Douglas R., additional, Jairajpuri, Mohamad A., additional, Lifton, Richard P., additional, Pei, York, additional, Zenker, Martin, additional, Kure, Shigeo, additional, and Hildebrandt, Friedhelm, additional

Published
2018
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12. Infliximab for the Treatment of Refractory Kawasaki Disease: A Nationwide Survey in Japan

Author

Masuda, Hiroshi, primary, Kobayashi, Tohru, additional, Hachiya, Akira, additional, Nakashima, Yasutaka, additional, Shimizu, Hiroyuki, additional, Nozawa, Tomo, additional, Ogihara, Yoshihito, additional, Ito, Shuichi, additional, Takatsuki, Shinichi, additional, Katsumata, Nobuyuki, additional, Suzuki, Yasuo, additional, Takenaka, Satoshi, additional, Hirono, Keiichi, additional, Kobayashi, Tomio, additional, Suzuki, Hiroshi, additional, Suganuma, Eisuke, additional, Takahashi, Kei, additional, Saji, Tsutomu, additional, Matsuzaki, Satoshi, additional, Yamazaki, Shoko, additional, Ikeda, Kazuyuki, additional, Hara, Takuma, additional, Kanetaka, Taichi, additional, Kizawa, Toshitaka, additional, Kikuchi, Masako, additional, Hara, Ryoki, additional, Fujii, Kentaro, additional, Takahashi, Mayu, additional, Sonoda, Kaori, additional, Yoshihashi, Tomokuni, additional, Imagawa, Tomoyuki, additional, Yamazaki, Kazuko, additional, Ebato, Takasuke, additional, Oana, Shinji, additional, Murase, Ayako, additional, Sakaki, Shinichiro, additional, Fujimoto, Takeshi, additional, Saito, Yoshihiko, additional, Shirai, Ryota, additional, Takeuchi, Ichiro, additional, Naoi, Kazuyuki, additional, Kenmotsu, Yasushi, additional, Goto, Chiaki, additional, Kise, Hiroaki, additional, Okada, Seigo, additional, Kishimoto, Sayuri, additional, Oba, Utako, additional, Ozawa, Sayaka, additional, Seki, Mitsuru, additional, Odagiri, Tesshu, additional, Shiono, Junko, additional, Nagumo, Kiyoshi, additional, Kimura, Mitsuaki, additional, Yoshibayashi, Muneo, additional, Horita, Norihisa, additional, Tsuboi, Tatsuo, additional, Matsubara, Tomoyo, additional, Hara, Satoshi, additional, Ishii, Taku, additional, Hosokawa, Susumu, additional, Kishi, Takayuki, additional, Fukazawa, Ryuji, additional, Ogawa, Shunichi, additional, Ohshima, Miho, additional, Fukunaga, Hideo, additional, Kouzan, Hiroko, additional, Ichihara, Tomoko, additional, Hashimoto, Kunio, additional, Tokunaga, Hirohide, additional, Iwashima, Satoru, additional, Hamahira, Kiyoshi, additional, Ishiguchi, Yukiko, additional, Kajino, Mayumi, additional, Kishi, Kanta, additional, Nagai, Noriko, additional, Ito, Shigeru, additional, Ogino, Hirotaro, additional, Amaya, Eriko, additional, Doi, Hiraku, additional, Waki, Kenji, additional, Shiraishi, Taisuke, additional, Iwai, Takashi, additional, Sato, Tetsuji, additional, Akimoto, Katsumi, additional, Soga, Takashi, additional, Naito, Hiroyuki, additional, Aihara, Makiko, additional, Fukuda, Yutaka, additional, Imagawa, Kazuo, additional, Shiba, Takeshi, additional, Matsuki, Shigenobu, additional, Miura, Masaru, additional, Araki, Tooru, additional, Furuyama, Hideto, additional, Naito, Takeshi, additional, and Miyamoto, Tomoyuki, additional

Published
2018
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16. Renal blood flow with ultrasonography and vesicoureteral reflux in childhood upper urinary tract infection

Author

Hamahira, Kiyoshi, primary, Horinouchi, Tomoko, additional, Inoue, Michio, additional, Okamoto, Mitsuhiro, additional, Sakata, Reiko, additional, Onishi, Noriko, additional, Kurokawa, Daisuke, additional, Hayano, Katsunori, additional, Fujiwara, Azumi, additional, Ban, Hirofumi, additional, Takami, Yuichi, additional, Takahashi, Hironobu, additional, Ioroi, Tomoaki, additional, Kugo, Masaaki, additional, and Watanuki, Yutaka, additional

Published
2014
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19. Yersinia pseudotuberculosis infection in Kawasaki disease and its clinical characteristics.

Author

Tomoko Horinouchi, Kandai Nozu, Kiyoshi Hamahira, Yosuke Inaguma, Jun Abe, Hiroshi Nakajima, Masaaki Kugo, Kazumoto Iijima, Horinouchi, Tomoko, Nozu, Kandai, Hamahira, Kiyoshi, Inaguma, Yosuke, Abe, Jun, Nakajima, Hiroshi, Kugo, Masaaki, and Iijima, Kazumoto

Subjects
YERSINIA diseases, YERSINIA pseudotuberculosis, MUCOCUTANEOUS lymph node syndrome diagnosis, ETIOLOGY of diseases, STEROID drugs, HEART disease complications, INTRAVENOUS immunoglobulins, DIAGNOSIS, COMBINATION drug therapy, COMPARATIVE studies, DOSE-effect relationship in pharmacology, GLUCOCORTICOIDS, GRAM-negative bacteria, IMMUNOGLOBULINS, IMMUNOLOGICAL adjuvants, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, MUCOCUTANEOUS lymph node syndrome, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, TREATMENT effectiveness, BACTERIAL antibodies, METHYLPREDNISOLONE, DISEASE complications
Abstract

Background: The etiology of Kawasaki disease (KD) is unknown. Reportedly, there is an association between KD and Yersinia pseudotuberculosis (YPT). Steroid therapy for KD patients with high risk of cardiac sequelae (CS) has been reported; however, the number of reports is limited.Methods: We conducted a prospective study of 108 patients with newly diagnosed KD in one year to determine how many KD patients have positive anti-YPT antibody titers and/or positive anti-YPT-derived mitogen (YPM) antibody titers. In addition, we tried to identify clinical differences between KD patients in whom YPT infection was or not a contributing factor. We also compared clinical characteristics of patients treated with the protocol of the Randomized controlled trial to Assess Immunoglobulin plus Steroid Efficacy for Kawasaki disease (RAISE) study (RAISE group) and with the conventional Intravenous immunoglobulin (IVIG) protocol (conventional group).Results: Eleven patients (10%) were positive for anti-YPT and/or anti-YPM antibodies (positive group) and 97 (90%) were negative (negative group). Cardiac sequelae (CS) occurred significantly more frequently in the positive than the negative group (two patients, 18% vs one patient, 1%, p = 0.027). Forty patients were in the RAISE group. Two of 40 (5%) in the RAISE group and one of 68 (1.47%) in the conventional group had CS (p = 0.55).Conclusions: KD patients with YPT infection had CS significantly more frequently and treatment with RAISE protocol did not decrease the frequency of CS in our cohort, nor did YPT infection affect risk scores of no response to IVIG. However, our sample size was overly small to draw such conclusions. Further investigation in a larger cohort is necessary to confirm our findings. Additionally, further research is needed to determine whether early diagnosis of YPT can prevent KD from developing and reduce the incidence of CS. [ABSTRACT FROM AUTHOR]

Published
2015
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20. Nihon Shoni Jinzobyo Gakkai Zasshi

Author

Kaito, Hiroshi, primary, Nozu, Kandai, additional, Kanda, Kyoko, additional, Tanaka, Ryojiro, additional, Yoshiya, Kunihiko, additional, Hamahira, Kiyoshi, additional, Sekine, Takashi, additional, Igarashi, Takashi, additional, and Matsuo, Masafumi, additional

Published
2007
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24. Clinicopathological characteristics and renal outcomes of childhood-onset lupus nephritis with acute kidney injury: A multicenter study.

Author

Ishimori S, Kaito H, Shima Y, Kamioka I, Hamahira K, Nozu K, Nakanishi K, Tanaka R, Yoshikawa N, and Iijima K

Subjects
Adolescent, Adult, Child, Female, Humans, Kidney Failure, Chronic epidemiology, Lupus Nephritis complications, Lupus Nephritis therapy, Male, Risk Factors, Survival Rate, Kidney Failure, Chronic etiology, Lupus Nephritis pathology
Abstract

Objectives: Acute kidney injury (AKI) at onset of adult systemic lupus erythematosus (SLE) is a risk factor for end stage kidney disease (ESKD). However, data on childhood-onset lupus nephritis (LN) with AKI are scarce. Methods: We retrospectively reviewed the complete files of pediatric SLE patients from 1995 to 2010. All patients underwent kidney biopsy promptly after diagnosis. Results: Thirty-six patients (10 males and 26 females) were enrolled. Mean age at diagnosis and observation period were 11.6 ± 2.4 and 8.1 ± 4.4 years, respectively. Seven patients had AKI at onset of SLE. Compared with those without AKI, patients with AKI had significantly higher proportions of pathologically proliferative LN. Only one patient with AKI progressed to ESKD without complete recovery of renal function. Overall and renal survival rates were 100and 97.2%, respectively. There was no significant difference in estimated glomerular filtration rate at the final visit (85ml/min/1.73 m 2 in the AKI group vs. 103.2 ml/min/1.73 m 2 in the non-AKI group; p  = .11). Conclusion: Our study demonstrated favorable renal outcomes in childhood-onset LN with AKI in the near to midterm period. Inducing complete remission may be important for preserving renal function.

Published
2019
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