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Although the influenza virus usually causes a self-limiting disease, deaths are reported even in children without risk factors. We aimed to identify clinical features, mortality associated with severe Influenza A and B virus infections of children admitted PICU. We conducted a retrospective study in children with confirmed influenza infection between 2012-2019 who were admitted to PICU. Demographic features, risk factors, clinical data, microbiological data, complications and outcomes were collected. During 7 influenza seasons (2012-2011 to 2015-2016) 713 children diagnosed with laboratory-confirmed influenza related lower respiratory tract infection, and pediatric intensive care unit admission was needed in 6% (46/713) of the patients. Thirty-one patients (67.4%) were diagnosed with Influenza A and 15 patients were diagnosed with Influenza B. Epidemiologic and clinical characteristics were similar in both Influenza types, lactate dehydrogenase levels were significantly higher for Influenza A than for Influenza B infections. Although the Influenza A to B ratio among the patients admitted to the PICU was 2.06, the percentage of cases requiring PICU admission was nearly two times higher in Influenza B cases. There was no statistically significant difference in disease severity and complications in patients with Influenza A and Influenza B. This article is protected by copyright. All rights reserved.

Background Renoprotective effects of vitamin D analogues have been shown in several experimental and clinical studies, the exact mechanism of the therapeutic effectiveness of these analogues in Nephrotic syndrome remains unclear, and these are relatively few studies on potential treatment roles for vitamin D analogues in nephrotic-range proteinuria. ?ndicate similar efficacy of the vitamin D analogues calcitriol and paricalcitol in time-limited amelioration of proteinuria in nephrotic syndrome, yet suggest the likelihood of mechanisms other than direct upregulation of nephrin and podocin in podocytes underlie the renoprotective effects of vitamin D analogues. Objective To investigate the effect of vitamin D (Vit D) analogues calcitriol and paricalcitol on urinary protein/creatinine ratio (UPCR) and renal podocin and nephrin expression in a rat model of puromycin aminonucleoside (PAN)-induced nephrotic syndrome (NS). Methods A total of 28 male Wistar Albino rats were separated into 4 groups (n=7 for each) including CON [control; intraperitoneal (IP) saline injection], PAN (NS + IP saline injection), PAN-C (NS + IP 0.4 µg/kg/day calcitriol injection), and PAN-P (NS + IP 240 ng/kg/day paricalcitol injection). Nephrotic syndrome was induced via intravenous (IV) administration of 10mg/100gr PAN. The UPCR as well as histopathological, immuno-histochemical, and real time PCR analyses of kidney tissue specimens were recorded and analyzed among the 4 groups. Results Median UPCR (Day 4) was significantly lower in both the PAN-C [1.45 (range 1.20-1.80)] and PAN-P [1.40 (range 1.10-1.80)] groups than in the PAN group [2.15 (range 2.00-2.40)] (P

Left ventricular assist devices have become an important therapeutic option as a mechanical circulatory support system in the treatment of end -stage heart failure. Organ transplants from brain dead donors on mechanical circulatory support are rare. In the literature, many successful solid-organ transplants have been reported using these donors. However, to our knowledge, this is the first report of successful solid-organ transplant from a child donor with a nonpulsatile ventricular assist device.