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2. Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium

Author

Ahmadi, Matthew N., Blodgett, Joanna M., Atkin, Andrew J., Chan, Hsiu-Wen, del Pozo Cruz, Borja, Suorsa, Kristin, Bakker, Esmee A., Pulsford, Richard M., Mielke, Gregore I., Johansson, Peter J., Hettiarachchi, Pasan, Thijssen, Dick H. J., Stenholm, Sari, Mishra, Gita D., Teixeira-Pinot, Armando, Rangul, Vegar, Sherar, Lauren B., Ekelund, Ulf, Hughes, Alun D., Lee, I.-Min, Holtermann, Andreas, Koster, Annemarie, Hamer, Mark, and Stamatakis, Emmanuel

Published
2024
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9. The impact of selected methodological factors on data collection outcomes in observational studies of device-measured physical behaviour in adults: A systematic review

Author

Pulsford, Richard M., Brocklebank, Laura, Fenton, Sally A. M., Bakker, Esmée, Mielke, Gregore I., Tsai, Li-Tang, Atkin, Andrew J., Harvey, Danielle L., Blodgett, Joanna M., Ahmadi, Matthew, Wei, Le, Rowlands, Alex, Doherty, Aiden, Rangul, Vegar, Koster, Annemarie, Sherar, Lauren B., Holtermann, Andreas, Hamer, Mark, and Stamatakis, Emmanuel

Published
2023
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11. Sedentary Behaviour and Depression

Author

Hamer, Mark, Smith, Lee, Ahrens, Wolfgang, Series Editor, Pigeot, Iris, Series Editor, Leitzmann, Michael F., editor, Jochem, Carmen, editor, and Schmid, Daniela, editor

Published
2023
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29. Associations Between Adolescent Sport and Exercise Participation and Device-Assessed Physical Activity in Adulthood: Evidence From the 1970 British Cohort Study.

Author

Scicluna, Nicholas, Hamer, Mark, and Blodgett, Joanna M.

Subjects
SPORTS participation, PHYSICAL activity, ADULTS, COHORT analysis, TEENAGERS, MEDICAL examinations of athletes, TREADMILL exercise
Abstract

Background: Adolescence is a critical period filled with life changes. Early implementation of effective health promotion strategies could help alleviate the morbidity and mortality associated with inactivity. This study investigated whether adolescent participation in exercise and sport is associated with device-assessed physical activity (PA) levels in midlife. Methods: A total of 2984 participants (41.2% male) from the 1970 British Cohort Study were included. Participants were surveyed at age 16 years on 5 indicators of exercise and sport participation. Total daily PA and moderate to vigorous PA (MVPA) at age 46 years were measured using a thigh-worn accelerometer, worn for 7 days. Associations between each adolescent exercise or sport indicator and adulthood total daily PA and MVPA were examined using linear regressions, adjusting for sex, wear time, body mass index, smoking, disability, malaise, alcohol consumption, social class, education, and self-rated health. Results: In fully adjusted models, adolescents who reported exercising "much more" than others (8.6 min/d; 95% confidence interval, −0.1 to 17.1), who played sports at the park/playground more than once a week (8.5 [3.0–14.0] min/d), and who exercised on the most recent Saturday (3.8 [0.7–6.9] min/d) had higher adult total PA levels than those who reported the lowest activity levels. There was no evidence of an association between greater sport and exercise participation at age 16 y and MVPA at age 46 y. There was no association between sports at school and either measure of adult PA. Conclusion: Active adolescents, particularly those who engaged in out-of-school exercise, had higher total daily PA levels, but not MVPA levels, in midlife. This highlights the potential of early PA interventions to improve PA levels in adulthood. [ABSTRACT FROM AUTHOR]

Published
2023
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33. The Effect of Using Anchored Wake Time to Derive 24‐h Device Measured Circadian Physical Behavior Patterns.

Author

Granat, Malcolm H., Ahmadi, Matthew N., Stamatakis, Emmanuel, and Hamer, Mark

Subjects
EXERCISE, ACCELEROMETRY, ACCELERATION (Mechanics), BEHAVIOR, DESCRIPTIVE statistics, WALKING, LONGITUDINAL method, CIRCADIAN rhythms, HEALTH behavior, COMPARATIVE studies, PHYSICAL activity, TIME, PHYSIOLOGICAL effects of acceleration
Abstract

Introduction: Tailoring physical activity interventions to individual chronotypes and preferences by time of day could promote more effective and sustainable behavior change; however, our understanding of circadian physical behavior patterns is very limited. Objective: To characterize and compare 24‐h physical behavior patterns expressed relative to clock time (the standard measurement of time‐based on a 24‐h day) versus wake‐up time in a large British cohort age 46. Methods: Data were analyzed from 4979 participants in the age 46 sweep of the 1970 British Cohort Study who had valid activPAL accelerometer data across ≥4 days. Average steps and upright time (time standing plus time stepping) per 30‐min interval were determined for weekdays and weekends, both in clock time and synchronized to individual wake‐up times. Results: The mean weekday steps were 9588, and the mean weekend steps were 9354. The mean weekday upright time was 6.6 h, and the mean weekend upright time was 6.4 h. When synchronized to wake‐up time, steps peaked 1 h after waking on weekdays and 2.5 h after waking on weekends. Upright time peaked immediately, in the first 30‐min window, after waking on both weekdays and weekends. Conclusions: Aligning accelerometer data to wake‐up times revealed distinct peaks in stepping and upright times shortly after waking. Activity built up more gradually across clock time in the mornings, especially on weekends. Synchronizing against wake‐up times highlighted the importance of circadian rhythms and personal schedules in understanding population 24‐h physical behavior patterns, and this may have important implications for promoting more effective and sustainable behavior change. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential

Author

Judson, Robert N, Quarta, Marco, Oudhoff, Menno J, Soliman, Hesham, Yi, Lin, Chang, Chih Kai, Loi, Gloria, Vander Werff, Ryan, Cait, Alissa, Hamer, Mark, Blonigan, Justin, Paine, Patrick, Doan, Linda TN, Groppa, Elena, He, WenJun, Su, Le, Zhang, Regan H, Xu, Peter, Eisner, Christine, Low, Marcela, Barta, Ingrid, Lewis, Coral-Ann B, Zaph, Colby, Karimi, Mohammad M, Rando, Thomas A, and Rossi, Fabio M

Subjects
Medical Biotechnology, Medical Physiology, Biomedical and Clinical Sciences, Regenerative Medicine, Stem Cell Research - Nonembryonic - Human, Biotechnology, Muscular Dystrophy, Stem Cell Research, Transplantation, Rare Diseases, Stem Cell Research - Nonembryonic - Non-Human, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Musculoskeletal, Active Transport, Cell Nucleus, Animals, Cell Differentiation, Cell Line, Cell Lineage, Cell Nucleus, Cell Proliferation, Cell Self Renewal, Cells, Cultured, Gene Deletion, Histone-Lysine N-Methyltransferase, Mice, Muscle Development, Muscle, Skeletal, MyoD Protein, Protein Binding, Protein Methyltransferases, Pyrrolidines, Regeneration, Stem Cell Transplantation, Stem Cells, Sulfonamides, Tetrahydroisoquinolines, beta Catenin, SET domain, WNT, differentiation, methylation, methyltransferase, muscle stem cells, myogenesis, satellite cells, skeletal muscle, β-catenin, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

The development of cell therapy for repairing damaged or diseased skeletal muscle has been hindered by the inability to significantly expand immature, transplantable myogenic stem cells (MuSCs) in culture. To overcome this limitation, a deeper understanding of the mechanisms regulating the transition between activated, proliferating MuSCs and differentiation-primed, poorly engrafting progenitors is needed. Here, we show that methyltransferase Setd7 facilitates such transition by regulating the nuclear accumulation of β-catenin in proliferating MuSCs. Genetic or pharmacological inhibition of Setd7 promotes in vitro expansion of MuSCs and increases the yield of primary myogenic cell cultures. Upon transplantation, both mouse and human MuSCs expanded with a Setd7 small-molecule inhibitor are better able to repopulate the satellite cell niche, and treated mouse MuSCs show enhanced therapeutic potential in preclinical models of muscular dystrophy. Thus, Setd7 inhibition may help bypass a key obstacle in the translation of cell therapy for muscle disease.

Published
2018

38. Mechanisms underlying exercise intolerance in long COVID: An accumulation of multisystem dysfunction

Author

Jamieson, Alexandra, primary, Al Saikhan, Lamia, additional, Alghamdi, Lamis, additional, Hamill Howes, Lee, additional, Purcell, Helen, additional, Hillman, Toby, additional, Heightman, Melissa, additional, Treibel, Thomas, additional, Orini, Michele, additional, Bell, Robert, additional, Scully, Marie, additional, Hamer, Mark, additional, Chaturvedi, Nishi, additional, Montgomery, Hugh, additional, Hughes, Alun D., additional, Astin, Ronan, additional, and Jones, Siana, additional

Published
2024
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39. Cardiovascular Disease Events in Adults with a History of State Care in Childhood: Pooling of Unpublished Results from 9 Cohort Studies

Author

Batty, G. David, primary, Kivimäki, Mika, additional, Almquist, Ylva Brännström, additional, Eriksson, Johan G., additional, Gissler, Mika, additional, Gnanamanickam, Emmanuel, additional, Hamer, Mark, additional, Jackisch, Josephine, additional, Juon, Hee-Soon, additional, Keski-Säntti, Markus, additional, Li, Chaiquan, additional, Mikkola, Tuija, additional, Murray, Emily, additional, Sacker, Amanda, additional, Segal, Leonie, additional, and Frank, Philipp, additional

Published
2024
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