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2. Simultaneous Visualization of R-Loops/RNA:DNA Hybrids and Replication Forks in a DNA Combing Assay.

Author

Ivanov, Miroslav Penchev, Zecchini, Heather, and Hamerlik, Petra

Subjects
GENE expression, GEL electrophoresis, ELECTRON microscopy, CELL physiology, NEURODEGENERATION, DNA replication
Abstract

R-loops, structures that play a crucial role in various biological processes, are integral to gene expression, the maintenance of genome stability, and the formation of epigenomic signatures. When these R-loops are deregulated, they can contribute to the development of serious health conditions, including cancer and neurodegenerative diseases. The detection of R-loops is a complex process that involves several approaches. These include S9.6 antibody- or RNAse H-based immunoprecipitation, non-denaturing bisulfite footprinting, gel electrophoresis, and electron microscopy. Each of these methods offers unique insights into the nature and behavior of R-loops. In our study, we introduce a novel protocol that has been developed based on a single-molecule DNA combing assay. This innovative approach allows for the direct and simultaneous visualization of RNA:DNA hybrids and replication forks, providing a more comprehensive understanding of these structures. Our findings confirm the transcriptional origin of the hybrids, adding to the body of knowledge about their formation. Furthermore, we demonstrate that these hybrids have an inhibitory effect on the progression of replication forks, highlighting their potential impact on DNA replication and cellular function. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Adult brain tumour research in 2024: Status, challenges and recommendations

Author

Purshouse, Karin, primary, Bulbeck, Helen J., additional, Rooney, Alasdair G., additional, Noble, Karen E., additional, Carruthers, Ross D., additional, Thompson, Gerard, additional, Hamerlik, Petra, additional, Yap, Christina, additional, Kurian, Kathreena M., additional, Jefferies, Sarah J., additional, Lopez, Juanita S., additional, Jenkinson, Michael D., additional, Hanemann, C. Oliver, additional, and Stead, Lucy F., additional

Published
2024
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5. Data from Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1

Author

Staniszewska, Anna D., primary, Pilger, Domenic, primary, Gill, Sonja J., primary, Jamal, Kunzah, primary, Bohin, Natacha, primary, Guzzetti, Sofia, primary, Gordon, Jacob, primary, Hamm, Gregory, primary, Mundin, Gill, primary, Illuzzi, Giuditta, primary, Pike, Andy, primary, McWilliams, Lisa, primary, Maglennon, Gareth, primary, Rose, Jonathan, primary, Hawthorne, Glen, primary, Cortes Gonzalez, Miguel, primary, Halldin, Christer, primary, Johnström, Peter, primary, Schou, Magnus, primary, Critchlow, Susan E., primary, Fawell, Stephen, primary, Johannes, Jeffrey W., primary, Leo, Elisabetta, primary, Davies, Barry R., primary, Cosulich, Sabina, primary, Sarkaria, Jann N., primary, O'Connor, Mark J., primary, and Hamerlik, Petra, primary

Published
2024
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6. Supplementary Data 1 from Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1

Author

Staniszewska, Anna D., primary, Pilger, Domenic, primary, Gill, Sonja J., primary, Jamal, Kunzah, primary, Bohin, Natacha, primary, Guzzetti, Sofia, primary, Gordon, Jacob, primary, Hamm, Gregory, primary, Mundin, Gill, primary, Illuzzi, Giuditta, primary, Pike, Andy, primary, McWilliams, Lisa, primary, Maglennon, Gareth, primary, Rose, Jonathan, primary, Hawthorne, Glen, primary, Cortes Gonzalez, Miguel, primary, Halldin, Christer, primary, Johnström, Peter, primary, Schou, Magnus, primary, Critchlow, Susan E., primary, Fawell, Stephen, primary, Johannes, Jeffrey W., primary, Leo, Elisabetta, primary, Davies, Barry R., primary, Cosulich, Sabina, primary, Sarkaria, Jann N., primary, O'Connor, Mark J., primary, and Hamerlik, Petra, primary

Published
2024
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7. AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity

Author

Maiani, Emiliano, Milletti, Giacomo, Nazio, Francesca, Holdgaard, Søs Grønbæk, Bartkova, Jirina, Rizza, Salvatore, Cianfanelli, Valentina, Lorente, Mar, Simoneschi, Daniele, Di Marco, Miriam, D’Acunzo, Pasquale, Di Leo, Luca, Rasmussen, Rikke, Montagna, Costanza, Raciti, Marilena, De Stefanis, Cristiano, Gabicagogeascoa, Estibaliz, Rona, Gergely, Salvador, Nélida, Pupo, Emanuela, Merchut-Maya, Joanna Maria, Daniel, Colin J., Carinci, Marianna, Cesarini, Valeriana, O’sullivan, Alfie, Jeong, Yeon-Tae, Bordi, Matteo, Russo, Francesco, Campello, Silvia, Gallo, Angela, Filomeni, Giuseppe, Lanzetti, Letizia, Sears, Rosalie C., Hamerlik, Petra, Bartolazzi, Armando, Hynds, Robert E., Pearce, David R., Swanton, Charles, Pagano, Michele, Velasco, Guillermo, Papaleo, Elena, De Zio, Daniela, Maya-Mendoza, Apolinar, Locatelli, Franco, Bartek, Jiri, and Cecconi, Francesco

Published
2021
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10. Preclinical Characterization of AZD9574, a Blood–Brain Barrier Penetrant Inhibitor of PARP1

Author

Staniszewska, Anna D., primary, Pilger, Domenic, additional, Gill, Sonja J., additional, Jamal, Kunzah, additional, Bohin, Natacha, additional, Guzzetti, Sofia, additional, Gordon, Jacob, additional, Hamm, Gregory, additional, Mundin, Gill, additional, Illuzzi, Giuditta, additional, Pike, Andy, additional, McWilliams, Lisa, additional, Maglennon, Gareth, additional, Rose, Jonathan, additional, Hawthorne, Glen, additional, Cortes Gonzalez, Miguel, additional, Halldin, Christer, additional, Johnström, Peter, additional, Schou, Magnus, additional, Critchlow, Susan E., additional, Fawell, Stephen, additional, Johannes, Jeffrey W., additional, Leo, Elisabetta, additional, Davies, Barry R., additional, Cosulich, Sabina, additional, Sarkaria, Jann N., additional, O'Connor, Mark J., additional, and Hamerlik, Petra, additional

Published
2023
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13. Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

Author

Wang, Xiuxing, Prager, Briana C., Wu, Qiulian, Kim, Leo J.Y., Gimple, Ryan C., Shi, Yu, Yang, Kailin, Morton, Andrew R., Zhou, Wenchao, Zhu, Zhe, Obara, Elisabeth Anne Adanma, Miller, Tyler E., Song, Anne, Lai, Sisi, Hubert, Christopher G., Jin, Xun, Huang, Zhi, Fang, Xiaoguang, Dixit, Deobrat, Tao, Weiwei, Zhai, Kui, Chen, Cong, Dong, Zhen, Zhang, Guoxin, Dombrowski, Stephen M., Hamerlik, Petra, Mack, Stephen C., Bao, Shideng, and Rich, Jeremy N.

Published
2018
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17. SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Author

Obara, Elisabeth Anne Adanma, Aguilar-Morante, Diana, Rasmussen, Rikke Darling, Frias, Alex, Vitting-Serup, Kristoffer, Lim, Yi Chieh, Elbæk, Kirstine Juul, Pedersen, Henriette, Vardouli, Lina, Jensen, Kamilla Ellermann, Skjoth-Rasmussen, Jane, Brennum, Jannick, Tuckova, Lucie, Strauss, Robert, Dinant, Christoffel, Bartek, Jiri, and Hamerlik, Petra

Published
2020
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18. Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.

Author

Chen, Jiajia, Laverty, Daniel J., Talele, Surabhi, Bale, Ashwin, Carlson, Brett L., Porath, Kendra A., Bakken, Katrina K., Burgenske, Danielle M., Decker, Paul A., Vaubel, Rachael A., Eckel-Passow, Jeanette E., Bhargava, Rohit, Lou, Zhenkun, Hamerlik, Petra, Harley, Brendan, Elmquist, William F., Nagel, Zachary D., Gupta, Shiv K., and Sarkaria, Jann N.

Subjects
DNA repair, GLIOBLASTOMA multiforme, HOMOLOGOUS recombination, AUTOMATED teller machines, RADIATION-sensitizing agents, GENE targeting, TUMOR suppressor proteins
Abstract

ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a potent radiosensitizer. This study evaluated the spectrum of radiosensitizing effects and the impact of TP53 mutation status in a panel of IDH1 wild-type (WT) glioblastoma (GBM) patient-derived xenografts (PDXs). AZD1390 suppressed radiation-induced ATM signaling, abrogated G0-G1 arrest, and promoted a proapoptotic response specifically in p53-mutant GBM in vitro. In a preclinical trial using 10 orthotopic GBM models, AZD1390/RT afforded benefit in a cohort of TP53-mutant tumors but not in TP53-WT PDXs. In mechanistic studies, increased endogenous DNA damage and constitutive ATM signaling were observed in TP53-mutant, but not in TP53-WT, PDXs. In plasmid-based reporter assays, GBM43 (TP53-mutant) showed elevated DNA repair capacity compared with that in GBM14 (p53-WT), whereas treatment with AZD1390 specifically suppressed homologous recombination (HR) efficiency, in part, by stalling RAD51 unloading. Furthermore, overexpression of a dominant-negative TP53 (p53DD) construct resulted in enhanced basal ATM signaling, HR activity, and AZD1390-mediated radiosensitization in GBM14. Analyzing RNA-seq data from TCGA showed up-regulation of HR pathway genes in TP53-mutant human GBM. Together, our results imply that increased basal ATM signaling and enhanced dependence on HR represent a unique susceptibility of TP53-mutant cells to ATM inhibitor–mediated radiosensitization. Editor's summary: Standard of care for glioblastoma (GBM) includes treatment with radiation therapy (RT) and temozolomide; however, long-term survival remains rare. To improve RT, Chen et al. investigated the use of AZD1390, a brain-penetrant ATM inhibitor and radiosensitizer in combination with RT in mouse models. They saw that this combination was beneficial for a cohort of patient-derived xenografts that were TP53-mutant, suppressing homologous recombination efficiency and extending survival. This represents a potential therapy that could benefit patients with TP53-mutant GBM and warrants further study. —Dorothy Hallberg [ABSTRACT FROM AUTHOR]

Published
2024
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20. Immunostaining protocol for infiltrating brain cancer spheroids for light-sheet imaging

Author

Bjorknes, Benedicte, Neye, Oliver Emil, Hamerlik, Petra, Jauffred, Liselotte, Bjorknes, Benedicte, Neye, Oliver Emil, Hamerlik, Petra, and Jauffred, Liselotte

Abstract

Glioblastoma tumors form in brains' white matter and are fast-growing and aggressive. Poor prognosis is the result of therapeutic resistance and infiltrating growth into the surrounding brain. Here we present a protocol for the detection of the cytoskeleton intermediate filament, vimentin, in cells at the proliferating spheroid surface. By combining a classical invasion assay with immunofluorescence and light-sheet imaging, we find that it is exactly these cytoskeleton-reinforcing cells on the spheroid's surface that will start the infiltration. We anticipate our results to be the starting point of more sophisticated investigation of anti-cancer drug effects on cytoskeleton reorganisation.

Published
2023

21. Non-metabolic functions of phosphofructokinase-1 orchestrate tumor cellular invasion and genome maintenance under bevacizumab therapy

Author

Lim, Yi Chieh, Jensen, Kamilla E., Aguilar-Morante, Diana, Vardouli, Lina, Vitting-Seerup, Kristoffer, Gimple, Ryan C., Wu, Qiulian, Pedersen, Henriette, Elbaek, Kirstine J., Gromova, Irina, Ihnatko, Robert, Kristensen, Bjarne W., Petersen, Jeanette K., Skjoth-Rasmussen, Jane, Flavahan, William, Rich, Jeremy N., Hamerlik, Petra, Lim, Yi Chieh, Jensen, Kamilla E., Aguilar-Morante, Diana, Vardouli, Lina, Vitting-Seerup, Kristoffer, Gimple, Ryan C., Wu, Qiulian, Pedersen, Henriette, Elbaek, Kirstine J., Gromova, Irina, Ihnatko, Robert, Kristensen, Bjarne W., Petersen, Jeanette K., Skjoth-Rasmussen, Jane, Flavahan, William, Rich, Jeremy N., and Hamerlik, Petra

Abstract

Background Glioblastoma (GBM) is a highly lethal malignancy for which neoangiogenesis serves as a defining hallmark. The anti-VEGF antibody, bevacizumab, has been approved for the treatment of recurrent GBM, but resistance is universal. Methods We analyzed expression data of GBM patients treated with bevacizumab to discover potential resistance mechanisms. Patient-derived xenografts (PDXs) and cultures were interrogated for effects of phosphofructokinase-1, muscle isoform (PFKM) loss on tumor cell motility, migration, and invasion through genetic and pharmacologic targeting. Results We identified PFKM as a driver of bevacizumab resistance. PFKM functions dichotomize based on subcellular location: cytosolic PFKM interacted with KIF11, a tubular motor protein, to promote tumor invasion, whereas nuclear PFKM safeguarded genomic stability of tumor cells through interaction with NBS1. Leveraging differential transcriptional profiling, bupivacaine phenocopied genetic targeting of PFKM, and enhanced efficacy of bevacizumab in preclinical GBM models in vivo. Conclusion PFKM drives novel molecular pathways in GBM, offering a translational path to a novel therapeutic paradigm.

Published
2023

22. Abstract 234: ITCC-P4: Genomic profiling and analyses of pediatric patient tumor and patient-derived xenograft (PDX) models for high throughput in vivo testing

Author

Gopisetty, Apurva, primary, Federico, Aniello, additional, Surdez, Didier, additional, Iddir, Yasmine, additional, Zaidi, Sakina, additional, Saint-Charles, Alexandra, additional, Waterfall, Joshua, additional, Saberi-Ansari, Elnaz, additional, Wierzbinska, Justyna, additional, Schlicker, Andreas, additional, Mack, Norman, additional, Schwalm, Benjamin, additional, Previti, Christopher, additional, Weiser, Lena, additional, Buchhalter, Ivo, additional, Böttcher, Anna-Lisa, additional, Sill, Martin, additional, Autry, Robert, additional, Estermann, Frank, additional, Jones, David, additional, Volckmann, Richard, additional, Zwijnenburg, Danny, additional, Eggert, Angelika, additional, Heidenreich, Olaf, additional, Iradier, Fatima, additional, Jeremias, Irmela, additional, Kovar, Heinrich, additional, Klusmann, Jan-Henning, additional, Debatin, Klaus-Michael, additional, Bomken, Simon, additional, Hamerlik, Petra, additional, Hattersley, Maureen, additional, Witt, Olaf, additional, Chesler, Louis, additional, Mackay, Alan, additional, Gojo, Johannes, additional, Cairo, Stefano, additional, Schueler, Julia, additional, Schulte, Johannes, additional, Geoerger, Birgit, additional, Molenaar, Jan J., additional, Shields, David J., additional, Caron, Hubert N., additional, Vassal, Gilles, additional, Stancato, Louis F., additional, Pfister, Stefan M., additional, Jaeger, Natalie, additional, Koster, Jan, additional, Kool, Marcel, additional, and Schleiermacher, Gudrun, additional

Published
2023
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23. Supplementary Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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24. Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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25. Supplementary Table 2 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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26. Supplementary Table 1 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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27. Supplementary Table 3 from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Author

Dixit, Deobrat, primary, Prager, Briana C., primary, Gimple, Ryan C., primary, Poh, Hui Xian, primary, Wang, Yang, primary, Wu, Qiulian, primary, Qiu, Zhixin, primary, Kidwell, Reilly L., primary, Kim, Leo J.Y., primary, Xie, Qi, primary, Vitting-Seerup, Kristoffer, primary, Bhargava, Shruti, primary, Dong, Zhen, primary, Jiang, Li, primary, Zhu, Zhe, primary, Hamerlik, Petra, primary, Jaffrey, Samie R., primary, Zhao, Jing Crystal, primary, Wang, Xiuxing, primary, and Rich, Jeremy N., primary

Published
2023
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28. Supplemental Methods from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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29. SFigure 5 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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30. SFigure 6 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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31. SFigure 1 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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32. SFigure 7 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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33. SFigure 4 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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34. SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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35. SFigure 2 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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45. Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Author

Schonberg, David L., Miller, Tyler E., Wu, Qiulian, Flavahan, William A., Das, Nupur K., Hale, James S., Hubert, Christopher G., Mack, Stephen C., Jarrar, Awad M., Karl, Robert T., Rosager, Ann Mari, Nixon, Anne M., Tesar, Paul J., Hamerlik, Petra, Kristensen, Bjarne W., Horbinski, Craig, Connor, James R., Fox, Paul L., Lathia, Justin D., and Rich, Jeremy N.

Published
2015
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50. DDDR-01. AZD9574 IS A NOVEL, BRAIN PENETRANT PARP-1 SELECTIVE INHIBITOR WITH ACTIVITY IN AN INTRACRANIAL XENOGRAFT MODEL OF TRIPLE NEGATIVE BREAST CARCINOMA WITH HOMOLOGOUS RECOMBINATION REPAIR DEFICIENCY

Author

Jamal, Kunzah, primary, Staniszewska, Anna, additional, Gordon, Jacob, additional, Pilger, Domenic, additional, Illuzzi, Giuditta, additional, Wilson, Joanne, additional, Smith, Aaron, additional, Gosselin, Eric, additional, McWilliams, Lisa, additional, Wen, Shenghua, additional, McGrath, Frank, additional, Dowdell, Gregory, additional, Kabbabe, Dominic, additional, Griffin, Matthew, additional, Davies, Barry, additional, Hamerlik, Petra, additional, Schou, Magnus, additional, Pike, Andy, additional, and Johannes, Jeffrey, additional

Published
2022
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