23 results on '"Hamidizadeh, Nasrin"'
Search Results
2. The host mTOR pathway and parasitic diseases pathogenesis
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Rashidi, Sajad, Mansouri, Reza, Ali-Hassanzadeh, Mohammad, Mojtahedi, Zahra, Shafiei, Reza, Savardashtaki, Amir, Hamidizadeh, Nasrin, Karimazar, Mohammadreza, Nguewa, Paul, and Manzano-Román, Raúl
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- 2021
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3. Evaluating prevalence of depression, anxiety and hopelessness in patients with Vitiligo on an Iranian population
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Hamidizadeh, Nasrin, Ranjbar, Sara, Ghanizadeh, Ahmad, Parvizi, Mohammad Mahdi, Jafari, Peyman, and Handjani, Farhad
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- 2020
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4. Evaluation of Lipid Profile and Serum Adiponectin Levels in Patients with Lichen Planus
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Dastgheib, Ladan, primary, Hamidizadeh, Nasrin, additional, Mardani, Maryam, additional, Ranjbar, Sara, additional, Jafari, Peyman, additional, and Nozari, Farnoosh, additional
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- 2023
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5. Comparison of Post-Hospital Il-6, Il-10, and Tnf-Α Levels with Pre-Death Levels of These Cytokines in Deceased Burn Patients
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Hamidizadeh, Nasrin, primary, Fotoohi, Maryam, additional, Jafari, Peyman, additional, Pirbonyeh, Neda, additional, Ranjbar, Sara, additional, Zardosht, Mitra, additional, and Mohamdi, Ali Akbar, additional
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- 2023
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6. Association of Personality Traits with Treatment Adherence in Vitiligo.
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Hedayati, Arvin, Mani, Arash, Hamidizadeh, Nasrin, Chohedri, Elnaz, Khalaj, Hossein Moradi, Moshfeghinia, Reza, and Oji, Bahare
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PERSONALITY ,MEDICAL radiology ,CROSS-sectional method ,MULTIPLE regression analysis ,INTERVIEWING ,REGRESSION analysis ,T-test (Statistics) ,DESCRIPTIVE statistics ,HOSPITAL wards ,QUESTIONNAIRES ,PATIENT compliance ,DATA analysis software ,VITILIGO ,ULTRAVIOLET radiation - Abstract
Background: Vitiligo is an acquired, auto-immune chronic skin disorder with different treatment modalities. Insufficient adherence to treatment is closely related to the efficacy of a prescribed treatment, and also, there are some associations between adherence behaviour and personality. Therefore, the study aimed to assess a relationship between five-factor personality traits and treatment adherence in patients with vitiligo. Methods: In this cross-sectional study, patients with vitiligo who received Ultraviolet B (UVB) phototherapy were recruited. The Morisky Medication Adherence Scale (MMAS-8) assessed treatment adherence, and personality factors were evaluated by NEO Five-Factor Personality Inventory (NEO-FFI). Data were analysed using t-tests, correlations, and multiple regression. Results: Among 70 participants, 62.9% had low adherence, 24.3% had medium adherence, and 12.9 % had high adherence. There was a positive correlation between neuroticism (p<0.001) and adherence score. Furthermore, a negative correlation between Agreeableness (p=0.13), Conscientiousness (p<0.001), Openness to experiences (p=005), Extraversion (p<0.001), and adherence score was obtained. In the regression analysis method, only the factors of neuroticism (p<0.001) and openness (p=0.001), and conscientiousness (p=0.016) predicted the dependent variable (adherence score) at the significance level. Conclusion: This study demonstrated that openness to experience and conscientiousness positively affected adherence, while Neuroticism negatively affected adherence. Considering these personality factors can effectively screen poor adherence and improve treatment adherence. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Serum Levels of IL-22 in Patients with Oral Lichen Planus and Cutaneous Lichen Planus
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Mardani, Maryam, Torabi Ardakani, Shiva, Dastgheib, Ladan, and Hamidizadeh, Nasrin
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Serum ,integumentary system ,lcsh:R ,lcsh:Medicine ,lcsh:RK1-715 ,stomatognathic diseases ,stomatognathic system ,il-22 ,oral lichen planus ,cutaneous lichen planus ,serum ,lcsh:Dentistry ,Oral lichen planus ,IL-22 ,Original Article ,Cutaneous lichen planus ,skin and connective tissue diseases - Abstract
Statement of the Problem: Lichen planus disease is a chronic inflammatory disorder of mucosal and cutaneous tissues with yet unclear etiology and pathogenesis. Cytokines play an important role in the initiation, maintenance of inflammatory and intercellular crosstalk. Purpose: We assessed serum levels of IL-22 in patients with oral and cutaneous lichen planus and made comparison with healthy individuals. Materials and Method: In this case-control study, peripheral blood samples of 40 patients with lichen planus disease, included two groups of oral lichen planus (n=20) and cutaneous lichen planus (n=20) were compared with 32 healthy individuals in this case-control study. Serum samples were prepared from patients with lichen planus and IL-22 concentration was measured in each serum sample by using a commercial ELISA Kit. The obtained data were then analyzed using the Kruskal-Wallis (one-way ANOVA) test. Results: The IL-22 serum levels were significantly higher in patients with oral lichen planus compared to the healthy control group (p< 0.001). No statistically significant differences were observed in serum levels of IL-22 in cutaneous lichen planus patients compared to the controls (p= 0.183). Conclusion: Increased IL-22 serum levels in patients with oral lichen planus may play an important role in the pathogenesis of oral lichen planus. The administration of the recombinant or antagonist of IL-22 could be a new therapeutic opportunity in the treatment of oral lichen planus.
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- 2020
8. The Effects of Different Classes of Antihypertensive Drugs on Patients with COVID-19 and Hypertension: A Mini-Review
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Nozari, Farnoosh and Hamidizadeh, Nasrin
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Article Subject - Abstract
Hypertension is a major risk factor for cardiovascular disease. Previous studies showed that patients with hypertension are at an increased risk of developing severe COVID-19 infection. Therefore, proper blood pressure control in hypertensive patients with COVID-19 is of great importance. In this review, we discussed the effects of different classes of antihypertensive drugs on patients with hypertension and COVID-19.
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- 2022
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9. Mutagenesis in DYRK1B by Overlap Extension-PCR (OE-PCR) Technique and Synthesis of Recombinant Lentivirus Carrying DYRKB R102C
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daneshparvar, afrooz, primary, razban, vahid, additional, jamhiri, iman, additional, fallahi, jafar, additional, moghtaderi, behnam, additional, hamidizadeh, nasrin, additional, and dianatpour, mehdi, additional
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- 2022
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10. Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus
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Mardani, Maryam, primary, Mofidi, Hossein, additional, Dastgheib, Ladan, additional, Ranjbar, Sara, additional, and Hamidizadeh, Nasrin, additional
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- 2021
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11. Primary tonsillar lymphomas according to the new World Health Organization classification: to report 87 cases and literature review and analysis
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Mohammadianpanah, Mohammad, Daneshbod, Yahya, Ramzi, Mani, Hamidizadeh, Nasrin, Dehghani, Seyed Javad, Bidouei, Farzad, Khademi, Bijan, Ahmadloo, Niloofar, Ansari, Mansour, Omidvari, Shapour, Mosalaei, Ahmad, and Dehghani, Mehdi
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- 2010
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12. Efficacy of cryotherapy plus topical Juniperus excelsa M. Bieb cream versus cryotherapy plus placebo in the treatment of Old World cutaneous leishmaniasis: A triple-blind randomized controlled clinical trial
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Parvizi, Mohammad Mahdi, primary, Handjani, Farhad, additional, Moein, Mahmoodreza, additional, Hatam, Gholamreza, additional, Nimrouzi, Majid, additional, Hassanzadeh, Jafar, additional, Hamidizadeh, Nasrin, additional, Khorrami, Hamid Reza, additional, and Zarshenas, Mohammad Mehdi, additional
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- 2017
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13. Leech therapy in treatment of cutaneous leishmaniasis: a case report
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Hamidizadeh, Nasrin, primary, Azizi, Amir, additional, Zarshenas, Mohammad M., additional, and Ranjbar, Sara, additional
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- 2017
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14. World Congress Integrative Medicine & Health 2017: part three
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Ortiz, Miriam, primary, Schnabel, Katharina, additional, Teut, Michael, additional, Rotter, Gabriele, additional, Binting, Sylvia, additional, Cree, Margit, additional, Lotz, Fabian, additional, Suhr, Ralf, additional, Brinkhaus, Benno, additional, Parvizi, Mohammad M., additional, Handjani, Farhad, additional, Zarshenas, Mohammad M., additional, Moein, Mahmood R., additional, Nimrouzi, Majid, additional, Hatam, Gholamreza, additional, Hasanzadeh, Jafar, additional, Hamidizadeh, Nasrin, additional, Heydari, Mojtaba, additional, Namazi, Mohammad R., additional, Parvizi, Zahra, additional, Pasalar, Mehdi, additional, Mosaffa-Jahromi, Maryam, additional, Bagheri-Lankarani, Kamran, additional, Afsharypuor, Suleiman, additional, Tamaddon, Ali M., additional, Ostovar, Mohadeseh, additional, Peloni, Giuseppe, additional, Bolliger, Ingo, additional, Faria, Rui M. Da Cunha, additional, Quadri, Pierluigi, additional, Sanzeni, Wilma, additional, Zemp, Damiano, additional, Risvoll, Hilde, additional, Giverhaug, Trude, additional, Halvorsen, Kjell H., additional, Waaseth, Marit, additional, Musial, Frauke, additional, Rossi, Elio, additional, Baccetti, Sonia, additional, Picchi, Marco, additional, Conti, Tommaso, additional, Firenzuoli, Fabio, additional, Guido, Carmelo, additional, Bosco, Filippo, additional, Panozzo, Marialessandra, additional, Cervino, Chiara, additional, Nurra, Linda, additional, Traversi, Antonella, additional, Vuono, Katia, additional, Sabatini, Federica, additional, Bellandi, Tommaso, additional, Rutert, Britta, additional, Eggert, Angelika, additional, Seifert, Georg, additional, Stritter, Wiebke, additional, Holmberg, Christine, additional, Längler, Alfred, additional, Salamonsen, Anita, additional, Wiesener, Solveig, additional, Schad, Friedemann, additional, Steele, Megan, additional, Kröz, Matthias, additional, Matthes, Harald, additional, Herbstreit, Cornelia, additional, Thronicke, Anja, additional, Schlingensiepen, Irene, additional, von Schoen-Angerer, Tido, additional, Schneider, Romy, additional, Waeber, Livia, additional, Vagedes, Jan, additional, Kaczala, Gregor, additional, Pharisa, Cosette, additional, Wildhaber, Johannes, additional, Huber, Benedikt, additional, Sidorov, Pavel, additional, Sovershaeva, Evgeniya, additional, Simões-Wüst, Ana P., additional, Nietlispach, Anna, additional, Mennet, Mónica, additional, Schnelle, Martin, additional, von Mandach, Ursula, additional, Wang, Xia, additional, Woo, Hye L., additional, Lee, Jin M., additional, Wu, Yuhao, additional, Cho, Yumin, additional, Yun, Younghee, additional, Kim, Hyunho, additional, Jung, Wonmo, additional, Jang, Bo-Hyung, additional, Ziea, Eric, additional, Hui, Henny, additional, Li, Mia, additional, Tsui, Dora, additional, Lam, Christine, additional, Hsieh, Joyce, additional, Chan, Edith, additional, Balneaves, Lynda, additional, Burnside, Sandra, additional, Doyle, Ethel, additional, Dorazio, Shelley, additional, Chan, Pak K., additional, Bhagra, Anjali, additional, Chen, Po-Hsu, additional, Chung, Vincent C. H., additional, Wu, Justin C. Y., additional, Lin, Zhi X., additional, Wong, Wendy, additional, Wu, Xin Y., additional, Ho, Robin S. T., additional, Wong, Charlene H. L., additional, Chan, Lily, additional, Ziea, Eric T. C., additional, Elder, William, additional, Cardarelli, Roberto, additional, Kaspar, Cornelia, additional, Kempenich, Robert, additional, Kopferschmitt, Jacques, additional, Marinko, Zulj, additional, Damir, Sebo, additional, Vcev, Aleksandar, additional, Monezi, Ricardo, additional, Ruggerini, Eny Márcia, additional, Fuchigami, Ivna M., additional, Mazini, Ana C. Moreno, additional, Oliveira, Maria Waldenez, additional, Papuga, Petar, additional, Schloss, Janet, additional, Steel, Amie, additional, Jacobsen, Márcia da Silva, additional, Jacobsen, Miranda Rodrigo, additional, Mangini, Maria T., additional, Trapani, Gianfranco, additional, Di Giampietro, Tiziana, additional, Zanino, Luisella, additional, Ciullo, Luigi, additional, Lanaro, Diego, additional, Cerritelli, Francesco, additional, Macrì, Francesco, additional, Tsai, Andre, additional, Lin, Chin, additional, Wu, Tu-Hsing, additional, D’Alessandro, Eduardo, additional, Watts, Sam, additional, Zhang, Ying, additional, Wu, Xufang, additional, Li, Xun, additional, Fei, Yutong, additional, Liu, Jianping, additional, Zhao, Nanqi, additional, Jia, Liyan, additional, Yan, Xiaoyi, additional, Zhen, Fei, additional, Liu, Zhaolan, additional, Ahn, Jinhyang, additional, AlEidi, Sulaiman, additional, Mohamed, Ashry Gad, additional, Al-Beda, Abdullah M., additional, Abutalib, Raid A., additional, Khalil, Mohemmed K. M., additional, Amri, Hakima, additional, Badekila, Sathyanarayana, additional, Behmanesh, Elham, additional, Mozaffarpour, Seyyedali, additional, Shirooye, Pantea, additional, Meybodi, Razie N., additional, Mokaberinejad, Roshanak, additional, Tansaz, Mojgan, additional, Daneshfard, Babak, additional, Hosseinkhani, Ayda, additional, Tafazoli, Vahid, additional, Jaladat, Amir M., additional, Sadeghi, Hasan, additional, Zhou, Li, additional, Zhao, Meng, additional, Li, Weiwei, additional, Larsen, Anette L., additional, Kristoffersen, Agnete E., additional, Hamran, Torunn, additional, Evjen, Bjørg, additional, Stub, Trine, additional, Li, Meiling, additional, Cai, Jianxiong, additional, Lu, Taoying, additional, Yin, Lingjia, additional, Wu, Darong, additional, Wang, Lixin, additional, Liew, Siaw M., additional, Liu, Tiegang, additional, Bai, Chen, additional, Zheng, Zian, additional, Wan, Yuxiang, additional, Xu, Jingnan, additional, Wang, Xuan, additional, Yu, He, additional, Gu, Xiaohong, additional, Yang, Guoyan, additional, Ostrowski, Deja, additional, Fox, Kealoha, additional, Tabatabei, Fatemeh, additional, Amini, Fatemeh, additional, Sathasivampillai, Saravanan, additional, Rajamanoharan, Pholtan, additional, Munday, Michael, additional, Heinrich, Michael, additional, Scherrer, Yvonne M., additional, Szuter, Carolyn, additional, Tabatabaei, Fatemeh, additional, Tavakoli, Ali, additional, Tavakoli, Fatemeh, additional, rostami, Mahsa, additional, Torri, Maria C., additional, Walach, Harald, additional, Warner, Faith, additional, Majumdar, Anne, additional, Serasingh, Palitha, additional, Abbing, Annemarie, additional, Ponstein, Anne, additional, Baars, Erik, additional, Croke, Sarah, additional, Hanser, Suzanne, additional, Heckel, Viola, additional, Krüerke, Daniel, additional, Weiss, Sebastian, additional, Metzner, Susanne, additional, Lee, Jang W., additional, Hyun, Min K., additional, Masetti, Morgana, additional, Oepen, Renate, additional, Gruber, Harald, additional, Heusser, Peter, additional, Pelz, Holger, additional, Perlitz, Volker, additional, Robinson, Nicola, additional, Ronan, Patricia, additional, Mian, Awais, additional, Madge, Su, additional, Lorenc, Ava, additional, Agent, Penny, additional, Carr, Siobhan, additional, Winnubst, Monica E., additional, Abolghasemi, Jafar, additional, Fedi, Paolo, additional, Di Stefano, Mariella, additional, Belvedere, Katia, additional, Beaven, Katherine, additional, Rose, Anita, additional, Florschutz, Gerhard, additional, Phil, Nicola Brough, additional, Parsons, Helen, additional, Stewart-Brown, Sarah, additional, Burke, Katherine, additional, Busch, Martine, additional, Heyning, Fenna, additional, Smit, Jan, additional, Jeekel, Hans, additional, de Goeij, Hans, additional, Guido, Paulo Caceres, additional, Barraza, Norma, additional, Balbarrey, Ziomara, additional, Ribas, Alejandra, additional, Jimenez, Beatriz, additional, Iachino, Claudia, additional, Quattrone, Fabiana, additional, Gaioli, Marisa, additional, Dell’Orso, Marta, additional, Villanueva, Silvia, additional, Rocha, Carmen, additional, Macchi, Adriana, additional, Chen, Lina, additional, Wang, Sicheng, additional, Choi, Eunji, additional, Go, Namgyeong, additional, Lee, Yongho, additional, Dahal, Gokarna, additional, Frauenknecht, Xaver, additional, Gerhardt, Heike, additional, Galanti, Mónica, additional, Cerda, Carmen J., additional, Heckersdorf, Daniela Navarrete, additional, Jorquera, Héctor, additional, Saldivia, María L. Alcázar, additional, Jakubonienė, Daiva, additional, McEwen, Bradley, additional, Melo, Francislete, additional, Fontana, Fernanda Mulinari, additional, Valle, Ana C. Viana, additional, Neres, Maria T. Borges, additional, Mohagheghzadeh, Abolali, additional, Zohalinezhad, Mohammad E., additional, Njaradi, Olja, additional, Dunjic, Momir, additional, Pokladnikova, Jitka, additional, Selke-Krulichova, Iva, additional, Seo, Jinsoon, additional, Jang, Hyunchul, additional, Moltó-Puigmartí, Carolina, additional, van Dongen, Martien, additional, Dagnelie, Pieter, additional, Thijs, Carel, additional, Tihanyi, Eva, additional, Hegyi, Gabriella, additional, and Tong, Xiaolin, additional
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- 2017
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15. Composition of minerals and trace elements at Mamasani thermal source: A possible preventive treatment for some skin diseases
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Hamidizadeh, Nasrin, primary, Simaeetabar, Shima, additional, Handjani, Farhad, additional, Ranjbar, Sara, additional, Moghadam, MohammadGohari, additional, and Parvizi, MohammadMahdi, additional
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- 2017
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16. The evaluation of quercetin and luteolin efficacy on cutaneous leishmaniasis in mice infected with Leishmania major
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Hatam, Gholamreza, primary, Hamidizadeh, Nasrin, additional, Ranjbar, Sara, additional, and Asgari, Qasem, additional
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- 2017
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17. Generation of danger signals by small molecular weight environmental compounds
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Hamidizadeh, Nasrin
- Abstract
The allergic contact dermatitis (ACD) to small molecular weight compounds is a common inflammatory skin reaction. ACD is restricted to industrialized countries, has an enormous sociomedical and socioeconomic impact. About 2,800 compounds from the six million chemicals known in our environment are believed to have allergic, and to a lesser degree also contact-sensitizing or immunogenic properties causing allergic contact dermatitis. ACD results from T cell responses to harmless, low molecular weight chemicals (haptens) applied to the skin. Haptens are not directly recognized by the cells of the immune system. They need to be presented by subsets of antigen presenting cells to the cells of the immune system. In this regard, epidermal Langerhans cells (LC) and the cells into which they mature (dendritic cells) are believed to play a pivotal role in the sensitization process for ACD. LC are able to bind the haptens, internalize them, and present them to naive T cells and induce thereby the development of effector T cells. They are so-called professional antigen presenting cells. This process is initiated and maintained by the release of several mediators, which are released by various cells after their contact with the haptens. One of the first proteins secreted into the environment is interleukin (IL)-1ß. This cytokine is produced and secreted minutes after an antigen enters the cell. It is commonly believed that the large amounts of this protein and other cytokines such as granulocyte-colony stimulation factor (GM-CSF) and tumor necrosis factor alpha (TNF-ï¡) needed for the initiation and activation of ACD are coming first from other cells residing in the skin, e.g., keratinocytes, monocytes and macrophages. These cytokines provide the danger signals needed for the activation of the Langerhans cell (LC), which then produce via a positive feedback loop various cytokines themselves. In addition, other proteins such as chemokines influence the generation of danger signals, migration, homing of T cells in the local lymph nodes as well as the recruitment of T cells into the skin. Thus, a small molecular compounds or hapten needs to be able to induce danger signals in order to become immunogenic. In this study, we investigated whether para-phenylenediamine (PPD), an arylamine and common contact allergen, is able to induce danger signals and likely provide the signals needed for an initiation of an immune response[162, 163]. PPD is used as an antioxidant, an ingredient of hair dyes, intermediate of dyestuff, and PPD is found in chemicals used for photographic processing. But up to date, it has not been clearly demonstrated if PPD itself is a sensitizing agent. Thus, this study aimed on the potential of PPD to provide the danger signals by studying IL-1β, TNF-ï¡, and monocyte chemoattractant proteins (MCP-1) in human monocytes, peripheral blood mononuclear cells (PBMC) from healthy volunteers, and also in two human monocyte cell lines namely U937, and THP-1. This study found that PPD decreased dose- and time-dependently the expression and release of three relevant mediators involved in the generation of danger signals. Namely, PPD reduced the mRNA and protein levels for IL-1ß, TNF-ï¡, and MCP-1 in primary human monocytes from various donors. These findings were extended and validated by investigations using the cell line U937. The data were highly specific for PPD, and no such results were gained for its known auto oxidation product called Bandrowski- base or for meta-phenylenediamine (MPD), and ortho-phenylenediamine (OPD). Therefore, we can speculate that this effect is likely to be dependent on the para-substitution. Based on these results we conclude that PPD itself is not able to mount a cascade for the induction of danger signals. It should be mentioned that it is still possible that PPD induces danger signals for sensitization by other unknown processes. Therefore, more research is still needed focusing on this subject especially in professional antigen presenting cells in order to solve the still open question whether PPD itself sensitizes naive T cells or if PPD is solely an allergen. Independently we found unexpectedly that PPD as well as other haptens such as 2, 4-Dinitrochlorobenzene, nickelsulfate, as well as some terpenoide increased clearly the expression of CC chemokin receptor 2 (CCR2), the receptor for the chemokine MCP-1. Up to date, the main importance for the CCR2 receptor comes from results demonstrating that CCR2 is critical for the migration of monocytes after encounter with bacterial lipopolysaccharides. Under these circumstances the receptor disappears from the cell surface and is down regulated. An up regulation of CCR2 has not been reported for haptens, and deserves further investigations., Die allergische Kontaktdermatitis (ACD) durch kleinmolekulare Umweltsubstanzen "sogenannte Haptene - ist sehr häufig in den westlichen Industrieländern. Man geht davon aus, dass von den ca. 8000 bekannten Umweltchemikalien annährend 2800 Allergene oder eventuell sogar immunogene Wirkungen hervorrufen können. Trotz intensiver Forschungsaktivitäten während der letzten 20 Jahre ist für viele Umweltchemikalien noch unklar, welche Molekülbestandteile oder Seitengruppen die immunogenen und/oder allergenen Effekte hervorrufen. Dies trifft sowohl für die Sensibilisierungsphase als auch für die Auslösephase der ACD zu. Beide Phasen werden durch eine Anzahl von Mediatoren wie verschiedene Zytokine und Chemokine ausgelöst und unterstützt. So ist bekannt, dass die notwendigen Interleukine (IL) wie beispielsweise IL-1ß, der Granulozyten-Makrophagen koloniestimulierende Faktor (GM"CSF), Tumor-Nekrose-Faktor Alpha (TNF-alpha) und Chemokine wie das Monozyten-chemotaktische Protein 1 (MCP-1) nach einem Antigenkontakt von Hautzellen wie Keratinozyten sowie Monozyten und Makrophagen ausgeschüttet werden. Diese Zytokine bilden die notwendigen Signale-danger signals- für die Aktivierung der beteiligten Zellen. Für die weitaus meisten Chemikalien ist bisher nicht bekannt, ob und inwieweit sie die erforderlichen Signale -danger signals- selbst auslösen können. Im Rahmen dieser Arbeit wurde dieser Frage anhand der Modellsubstanz para-Phenylendiamin (PPD), einem Arylamin, nachgegangen. PPD ist ein bekanntes und häufiges Kontaktallergen. Die Substanz wird vornehmlich als Koppler bei der Farbpigmentherstellung eingesetzt. Voruntersuchungen legten nahe, dass PPD die Signalwege für die Bildung von danger signals stimuliert und möglicherweise naive T-Zellen sensibilisieren kann. Die Induktion der Genexpression und Sekretion von IL-1β, TNF-alpha, und MCP-1 durch PPD wurde in vitro an primären humanen Monozyten verschiedener Spender untersucht. Die IL-1ß Sekretion wurde in Monozyten durch PPD bereits nach 30 Minuten gehemmt, während eine Hemmung der TNF-alpha Sekretion erst nach einer Stunde signifikant meßbar war. Des weiteren wurde eine signifikante Verringerung der IL-1ß und TNF-alpha mRNA Spiegel und der Proteinmenge nach zweistündigem PPD-Kontakt in peripheren mononukleären Zellen des Blutes verschiedener Spender nachgewiesen. Die MCP-1 mRNA Spiegel zeigten nach 45 Minuten eine eindeutige Verringerung, während die verminderte MCP-1 Ausschüttung nach zwei Stunden nachgewiesen wurde. Neben MCP-1 verringerte sich auch die Sekretion von MCP-3. Das Ausmaß der PPD-induzierten Effekte varierte zwischen den verschiedenen Zellspendern, sie konnten jedoch bei jedem Zelldonor signifikant nachgewiesen werden. Zur detaillierten Analyse der Wirkungen auf die Chemokine wurden Untersuchungen in zwei Monozytenzelllinien (U937, THP-1) durchgeführt. Zur Erfassung des Einflusses von PPD auf die Chemokin-induzierte Wanderung der Zellen wurde seine Wirkung auf den MCP-1 Rezeptor CCR2 (CC-Chemokinrezeptor 2) auf der Zelloberfläche ebenfalls analysiert. PPD hemmte in U937 Zellen, die den CCR2 Rezeptor nicht an der Zelloberfläche exprimieren, die MCP-1 mRNA Spiegel und die Sekretion von MCP-1 in die Umgebung. Somit waren die Effekte unabhängig von der Signalkette des CCR2 Rezeptors. In THP-1 Zellen, die den CCR2 Rezeptor an der Zelloberfläche exprimieren, regulierte PPD die Rezeptorexpression auf der Zelloberfläche dosis-und zeitabhängig hoch. Diese Untersuchungen deuten auf eine aktive Hochregulation des Rezeptors durch PPD hin. Zur Spezifitätsanalyse der gewonnenen Ergebnisse wurde neben PPD sein bekanntes Autooxidationsprodukt, die Bandrowski- Base, meta-Phenylendiamin und ortho-Phenylendiamin in die Untersuchungen einbezogen. Nur PPD konnte die bekannten Signalwege für die Induktion von danger signals hemmen. Aus diesen Analysen wurde ersichtlich, dass die para-Stellung der beiden NH2-Gruppen für die Effekte essentiell ist. Aufgrund der Ergebnisse kann geschlossen werden, dass PPD die Signalwege für die Induktion der danger signals nicht eigenständig induzieren kann.
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- 2006
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18. The evaluation of quercetin and luteolin efficacy on cutaneous leishmaniasis in mice infected with Leishmania major.
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Hamidizadeh, Nasrin, Ranjbar, Sara, Asgari, Qasem, and Hatam, Gholamreza
- Subjects
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QUERCETIN , *CUTANEOUS leishmaniasis , *LUTEOLIN , *DRUG efficacy , *LABORATORY mice , *THERAPEUTICS - Abstract
Introduction: Almost 1.5-2 million people are infected with leishmaniasis and 60,000 die due to the disease every year. The treatment of cutaneous leishmaniasis with the existing medications is not effective and accompanied with various side effects. Expensiveness and not being available in different forms are other limitations associated with these drugs. In addition to, parasite resistance restricts the use of these medications; therefore, identification of new treatment methods is highly essential. Humans have always used medicinal plants for the treatment of diseases. This study aimed to assess the impact of quercetin and luteolin on leishmaniasis wounds created on mice's tails. Materials and Methods: A total of 56 infected Balb/C mice were divided into eight groups, each containing seven animals. The first three groups received 3.5 mg/kg luteolin through oral, intradermal, and intraperitoneal routes. The other three groups received 14 mg/kg quercetin through oral, intradermal, and intraperitoneal routes. The treatments were administered twice a week for 4 weeks in comparison to meglumine antimonite as control groups. Results: The results showed that there was no statistically significant difference between the recovery of mice in the luteolin and quercetin groups and those in the meglumine antimonite group. However, the ratio of recovered Balb/C mice in the luteolin and quercetin group is 1.75-2 times more than meglumine group, respectively. Conclusion: Quercetin and luteolin seems to be candidate medications with fewer side effects for recovery from cutaneous leishmaniasis. They can also be used as complementary medications together with other standard drugs, such as meglumine, antimonite, and cryotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
19. Decreased glucose-6-phosphate dehydrogenase levels in vitiligo patients: Further evidence of oxidative stress
- Author
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Namazi, MohammadReza, primary, Farahi-Jahromy, Amir, additional, Fallahzadeh, MohammadKazem, additional, Ashkani-Esfahani, Soheil, additional, Hamidizadeh, Nasrin, additional, and Ghavipisheh, Mahsa, additional
- Published
- 2014
- Full Text
- View/download PDF
20. FS01.8 Substance-specific modulation of TNF-Alpha and IL-1Beta in human monocytes by para-Phenylenediamine and not by its autoxidation product Bandrowski’s Base
- Author
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Hamidizadeh, Nasrin, primary, Breuer, S, additional, Merk, HF, additional, and Bloemeke, B, additional
- Published
- 2008
- Full Text
- View/download PDF
21. Octopirox 1% shampoo versus ketoconazole 2% shampoo in the treatment of pityriasis versicolor: A randomized, controlled, double-blind clinical trial.
- Author
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Hamidizadeh, Nasrin, Dastgheib, Ladan, Ranjbar, Sara, Handjani, Farhad, and Jafari, Peyman
- Abstract
Background and Aim: Pityriasis versicolor (PV) is a fungal infection of the skin that is caused by Malassezia species in tropical and subtropical areas. Various treatments such as ketoconazole 2% shampoo are effective in the treatment of PV. In this study, the therapeutic effects of ketoconazole 2% shampoo and Octopirox 1% shampoo on PV were compared. Methods: Fourty-two patients participated in the study. Twenty-five patients were treated using Octopirox 1% shampoo and 17 patients were treated by ketoconazole 2% shampoo. Each shampoo was administered for 5 minutes after daily showers for three weeks. At the end of the treatment period, patients were evaluated on the basis of the results KOH test and clinical examinations. Results: At the end of the treatment period in ketoconazole 2% shampoo group, 64.7% of patients were cured. In Octopirox 1% shampoo group, 44% of patients were cured. The detected difference was not statistically significant (P=0.187). Conclusion: Both shampoos were effective in eliminating the symptoms, but ketoconazole 2% shampoo was more effective in improving the associated hyperpigmentation and erythema than Octopirox 2% shampoo. No side effects were observed in either group. [ABSTRACT FROM AUTHOR]
- Published
- 2014
22. Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy.
- Author
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Handjani, Farhad, Yousef, Saeed Reza, Saki, Nasrin, and Hamidizadeh, Nasrin
- Subjects
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LEISHMANIASIS treatment , *COLD therapy , *CYTOKINES , *ENZYME-linked immunosorbent assay , *INTERFERONS , *INTERLEUKINS , *VEINS , *IMMUNOLOGIC receptors - Abstract
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy. [ABSTRACT FROM AUTHOR]
- Published
- 2017
23. Decreased glucose-6-phosphate dehydrogenase levels in vitiligo patients: Further evidence of oxidative stress.
- Author
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Farahi-Jahromy A, Fallahzadeh MK, Ashkani-Esfahani S, Hamidizadeh N, Ghavipisheh M, and Namazi MR
- Published
- 2014
- Full Text
- View/download PDF
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