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Background: Psychological health affects numerous physiological processes of the body. The psychological well-being of pregnant women is a global concern. Aim: To compare the blood glucose level (random) in normal versus stress, depression and anxiety among pregnant women (Trimester wise) in district Hyderabad. Methods: A cross-sectional study (survey-based) was conducted in a fixed time frame. The pregnant women were randomly selected and segregated into three groups (trimester wise). The sample size (n) was 123. Random blood glucose level was measured by using the check UC-1001. Stress, anxiety and depression were analyzed by using a valid questionnaire DASS-21. Student t-test was employed as appropriate. Data is shown as mean±standard deviation. Results: Blood glucose level was observed significantly higher (P-value: 0.0004, 0.009 and 0.046) in stressed women (137.82 ±28.94, 142.60 ±40.34 and 126.82 ±35.92) as compared to normal (107.6 ±18.01, 115.05 ± 18.68 and 105.53 ±21.56). Similarly, the blood glucose level was observed higher (P- values: 0.043, 0.065 and 0.078 in depressed women (128.62 ±29.85, 136.79 ±37.10 and 122.44 ±33.41) as compared to normal (105.62 ±13.71, 112.22 ±24.60 and 101.22 ±18.66). An elevated blood glucose level (P-value in First, Second and Third trimester was 0.230, 0.065 and 0.900 respectively) was observed in those who were suffering from Anxiety (125.63 ±29.27, 136.79 ±37.10 and 121.81 ±32.36) as compared to those whose blood glucose level is normal (107.25 ±17.85, 112.22 ±24.61 and 123.66 ±37.04). Conclusion: An elevated blood glucose level was observed in all three trimesters in stressed, depressed and anxious pregnant women. Keywords: Anxiety, Depression, Stress, Blood Glucose. Trimester

Objectives: To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS). Methods: A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT). Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p-value of ≤0.05 regarded as significant. Results: Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65±5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570. Conclusion: It is concluded from the study that cortisol responses of VVS and POTS were positive. doi: https://doi.org/10.12669/pjms.38.1.4122 How to cite this:Khan HF, Ambreen S, Raziq H, Hayat A. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):185-189. doi: https://doi.org/10.12669/pjms.38.1.4122 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Objective: To determine the level of serotonin in patients of vasovagal syncope and postural tachycardia syndrome after head-up tilt test. Method: The cross-sectional analytical study was conducted at the Islamic International Medical College and the Department of Electrophysiology, Armed Forces Institute of Cardiology, Rawalpindi, from April 2017 to March 2018. Group A comprised cases of vasovagal syncope, group B had patients of postural tachycardia syndrome, and group C had healthy controls. Cases were chosen on the basis of history, episodes of syncope and findings of head-up tilt test. After the test, blood samples were taken for hormonal analysis of serotonin using enzyme-linked immunosorbent assay. Data was analysed using SPSS 21. Results: Of the 80 subjects, 35(43.8%) were in group A, 35(43.8%) in group B and 10(12.4%) in group C. Mean serotonin value in group A was 918.39±380.16nM, in group B it was 1188.70±449.55nM., while in control group C the mean value was 771.40±376.14nM (p

Syncope occurs as a result of cerebral hypoperfusion. Various neuroendocrine hormones have some role in the pathogenesis of Syncope. Current study was conducted to determine the role of Angiotensin II in pathophysiology of vasovagal syncope (VVS) and Postural tachycardia syndrome (POTS). Study Design: Cross sectional analytical study. Setting: Islamic International Medical College, Rawalpindi and in Electrophysiology department (AFIC). Period: April 2017 to April 2018. Material and Methods: Sample size of this study was comprises of 80 subjects, having 35 cases of VVS and POTS each and 10 controls were also taken. Cases were collected on the basis of Head up tilt test (HUT) result and on their previous history of syncope, then their blood samples were collected and stored. Hormonal analysis of Angiotensin II was performed by ELISA technique. SPSS statistics 21 was used to evaluate result by applying ANOVA test. p value of < 0.05 was considered significant. Result: Analysis of Angiotensin II concentration in Postural tachycardia syndrome, Vasovagal and control group was found 170.93 ± 118.59 pg/ml, 152.16 ± 91.40 pg/ml and 136.93 ± 43.18 pg/ml respectively. In statistical analysis p value was 0.570 which is insignificant. Conclusion: It is concluded that Angiotensin II exerts role in the pathophysiology of VVS and POTS as shown by the difference in the value of Angiotensin II in VVS, POTS and in control group.