Author: "Hammenfors, D." - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Hammenfors, D."' showing total 79 results

Start Over Author "Hammenfors, D."

79 results on '"Hammenfors, D."'

1. OP0113 GENOME-WIDE ASSOCIATION STUDY OF Ro/SSA+ AND Ro/SSA-SJÖGREN’S CASES IN THE SJÖGREN’S GENETIC NETWORK (SGENE) DEMONSTRATES DIVERGENT GENETIC ARCHITECTURE IN PATIENT SUBPHENOTYPES

Author: Rasmussen, A., primary, Radziszewski, M., additional, Khatri, B., additional, Tessneer, K. L., additional, Pontarini, E., additional, Bombardieri, M., additional, Rischmueller, M., additional, Wahren-Herlenius, M., additional, Kvarnström, M., additional, Witte, T., additional, Bootsma, H., additional, Verstappen, G. M., additional, Kroese, F. G. M., additional, Vissink, A., additional, Pringle, S., additional, Tzioufas, A., additional, Mavragani, C., additional, Baer, A., additional, Alarcon-Riquelme, M., additional, Martin, J., additional, Mariette, X., additional, Nocturne, G., additional, Pers, J. O., additional, Gottenberg, J. E., additional, Ng, W. F., additional, Shiboski, C., additional, Taylor, K. E., additional, Criswell, L., additional, Warner, B. M., additional, Farris, A. D., additional, James, J. A., additional, Scofield, R. H., additional, Guthridge, J. M., additional, Wallace, D. J., additional, Venuturupali, S., additional, Brennan, M. T., additional, Imgenberg-Kreuz, J., additional, Ronnblom, L., additional, Baecklund, E., additional, Eloranta, M. L., additional, Aqrawi, L. A., additional, Palm, Ø., additional, Brun, J. G., additional, Hammenfors, D., additional, Jonsson, M. V., additional, Appel, S., additional, Bucher, S. M., additional, Forsblad-D’elia, H., additional, Mandl, T., additional, Eriksson, P., additional, Nordmark, G., additional, and Lessard, C. J., additional
Published: 2024
Full Text: View/download PDF

2. POS1454 ARE ULTRASOUND SALIVARY PARENCHYMAL ABNORMALITIES MORE SEVERE IN PRIMARY SJÖGREN PATIENTS WITH A HIGHER DISEASE DURATION? A TRANSVERSAL INTERNATIONAL STUDY

Author: Tison, A., primary, Jousse-Joulin, S., additional, Consigny, M., additional, Moog, P., additional, Hofauer, B., additional, Hachulla, E., additional, Lamotte, C., additional, Morel, J., additional, Mouterde, G., additional, Milic, V., additional, Bootsma, H., additional, Stel, A. J., additional, Fisher, B. A., additional, Maybury, M., additional, Baer, A., additional, Direnzo, D., additional, Kim, H. R., additional, Min, H. K., additional, Lee, S. S., additional, Choi, S. E., additional, Carvajal Alegria, G., additional, Boisramé, S., additional, Guellec, D., additional, Cornec, D., additional, Jonsson, M., additional, Hammenfors, D., additional, Saraux, A., additional, and Devauchelle-Pensec, V., additional
Published: 2023
Full Text: View/download PDF

3. Patients with Primary Sjögrenʼs Syndrome Have Alterations in Absolute Quantities of Specific Peripheral Leucocyte Populations

Author: Davies, R., Hammenfors, D., Bergum, B., Jakobsen, K., Solheim, M., Vogelsang, P., Brun, J. G., Bryceson, Y., Jonsson, R., and Appel, S.
Published: 2017
Full Text: View/download PDF

4. Childhood-onset of primary Sjögren’s syndrome: phenotypic characterization at diagnosis of 158 children

Author: Ramos-Casals, M., Acar-Denizli, N., Vissink, A., Brito-Zeron, P., Li, X., Carubbi, F., Priori, R., Toplak, N., Baldini, C., Faugier-Fuentes, E., Kruize, A. A., Mandl, T., Tomiita, M., Gandolfo, S., Hashimoto, K., Hernandez-Molina, G., Hofauer, B., Mendieta-Zeron, S., Rasmussen, A., Sandhya, P., Sene, D., Trevisani, V. F. M., Isenberg, D., Sundberg, E., Pasoto, S. G., Sebastian, A., Suzuki, Y., Retamozo, S., Xu, B., Giacomelli, R., Gattamelata, A., Bizjak, M., Bombardieri, S., Loor-Chavez, R. -E., Hinrichs, A., Olsson, P., Bootsma, H., Lieberman, S. M., Kostov, B., Horvath, I. -F., Szanto, A., Seror, R., Mariette, X., Kvarnstrom, M., Wahren-Herlenius, M., Praprotnik, S., Solans, R., Nordmark, G., Hammenfors, D., Brun, J. G., Gheita, T. A., Atzeni, F., Armagan, B., Kilic, L., Kalyoncu, U., Nakamura, T., Takagi, Y., Consani, S., Solorzano, F. O., Translational Immunology Groningen (TRIGR), Personalized Healthcare Technology (PHT), Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Universitat Politècnica de Catalunya. ADBD - Anàlisi de Dades Complexes per a les Decisions Empresarials
Subjects: Male, Systemic disease, Anti-nuclear antibody, Epidemiology, Autoimmune diseases, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Disease, Severity of Illness Index, Parotid Gland, Medicine, CLASSIFICATION CRITERIA, Pharmacology (medical), Registries, Age of Onset, biology, 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS], Dry eyes, Phenotype, Sjogren's syndrome, Female, epidemiology, Antibody, medicine.symptom, PAROTITIS, medicine.medical_specialty, Biomatemàtica, Adolescent, 62 Statistics::62D05 Sampling theory, sample surveys [Classificació AMS], Childhood, Paediatrics, Humans, Sjogren's Syndrome, paediatrics, AGE, Rheumatology, Peripheral nerve, Rheumatoid factor, autoimmune diseases, Sampling (Statistics), Primary Sjögren Syndrome, childhood, Biomathematics, Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària [Àrees temàtiques de la UPC], business.industry, CLINICAL-FEATURES, medicine.disease, Dry mouth, Dermatology, stomatognathic diseases, biology.protein, Sjogren’s syndrome, CONSENSUS, business, Mostreig (Estadística), Parotitis
Abstract: Objectives To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed below the age of 19 years according to the fulfilment of the 2002/2016 classification criteria. Results Among the 12 083 patients included in the Sjögren Big Data Registry, 158 (1.3%) patients had a childhood-onset diagnosis (136 girls, mean age of 14.2 years): 126 (80%) reported dry mouth, 111 (70%) dry eyes, 52 (33%) parotid enlargement, 118/122 (97%) positive minor salivary gland biopsy and 60/64 (94%) abnormal salivary US study, 140/155 (90%) positive ANA, 138/156 (89%) anti-Ro/La antibodies and 86/142 (68%) positive RF. The systemic EULAR Sjögren’s syndrome disease activity index (ESSDAI) domains containing the highest frequencies of active patients included the glandular (47%), articular (26%) and lymphadenopathy (25%) domains. Patients with childhood-onset primary SS showed the highest mean ESSDAI score and the highest frequencies of systemic disease in 5 (constitutional, lymphadenopathy, glandular, cutaneous and haematological) of the 12 ESSDAI domains, and the lowest frequencies in 4 (articular, pulmonary, peripheral nerve and CNS) in comparison with patients with adult-onset disease. Conclusions Childhood-onset primary SS involves around 1% of patients with primary SS, with a clinical phenotype dominated by sicca features, parotid enlargement and systemic disease. Age at diagnosis plays a key role in modulating the phenotypic expression of the disease.
Published: 2021
Full Text: View/download PDF

5. Expression of Toll‐Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögrenʼs Syndrome

Author: Karlsen, M., Jakobsen, K., Jonsson, R., Hammenfors, D., Hansen, T., and Appel, S.
Published: 2017
Full Text: View/download PDF

6. Influence of the age at diagnosis in the disease expression of primary Sjögren's syndrome: Analysis of 12,753 patients from the Sjögren Big Data Consortium

Author: Retamozo, S., Acar-Denizli, N., Horváth, I. F., Ng, W. -F, Rasmussen, A., Dong, X., Li, X., Baldini, C., Olsson, P., Priori, R., Seror, R., Gottenberg, J. -E, Kruize, A. A., Hernandez-Molina, G., Vissink, A., Sandhya, P., Armagan, B., Quartuccio, L., Sebastian, A., Praprotnik, S., Bartoloni, E., Kwok, S. -K, Kvarnstrom, M., Rischmueller, M., Soláns-Laqué, R., Sene, D., Pasoto, S. G., Suzuki, Y., Isenberg, D. A., Valim, V., Nordmark, G., Nakamura, H., Virginia Trevisani, Hofauer, B., Sisó-Almirall, A., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Atzeni, F., Hammenfors, D., Maure, B., Carsons, S. E., Gheita, T., Sánchez-Berná, I., López-Dupla, M., Morel, J., Inanç, N., Fonseca-Aizpuru, E., Morcillo, C., Vollenweider, C., Melchor, S., Vázquez, M., Díaz-Cuiza, E., Consani-Fernández, S., De-Miguel-Campo, B., Szántó, A., Bombardieri, S., Gattamelata, A., Hinrichs, A., Sánchez-Guerrero, J., Danda, D., Kilic, L., Vita, S., Wiland, P., Gerli, R., Park, S. -H, Wahren-Herlenius, M., Bootsma, H., Mariette, X., Ramos-Casals, M., Brito-Zerón, P., Translational Immunology Groningen (TRIGR), and Personalized Healthcare Technology (PHT)
Subjects: immunological markers, MANIFESTATIONS, age, Sjogren's syndrome, ONSET, YOUNG, MANAGEMENT, LYMPHOMA, disease phenotype, CLASSIFICATION CRITERIA, CONSENSUS, PROJECT, SALIVARY FLOW
Abstract: Objective. To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjogren's syndrome (pSS). Methods. By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression. Results. There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of 95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R-2 0.87) and the frequency of abnormal oral tests (adjusted R-2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase). Conclusion. The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.
Published: 2021

7. Influence of the age at diagnosis in the disease expression of primary Sjögren's syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium

Author: Universitat Rovira i Virgili, Retamozo S; Acar-Denizli N; Horváth IF; Ng WF; Rasmussen A; Dong X; Li X; Baldini C; Olsson P; Priori R; Seror R; Gottenberg JE; Kruize AA; Hernandez-Molina G; Vissink A; Sandhya P; Armagan B; Quartuccio L; Sebastian A; Praprotnik S; Bartoloni E; Kwok SK; Kvarnstrom M; Rischmueller M; Soláns-Laqué R; Sene D; Pasoto SG; Suzuki Y; Isenberg DA; Valim V; Nordmark G; Nakamura H; Trevisani VFM; Hofauer B; Sisó-Almirall A; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Atzeni F; Hammenfors D; Maure B; Carsons SE; Gheita T; Sánchez-Berná I; López-Dupla M; Morel J; Inanç N; Fonseca-Aizpuru E; Morcillo C; Vollenweider C; Melchor S; Vázquez M; Díaz-Cuiza E; Consani-Fernández S; De-Miguel-Campo B; Szántó A; Bombardieri S; Gattamelata A; Hinrichs A; Sánchez-Guerrero J; Danda D; Kilic L; De Vita S; Wiland P; Gerli R; Park SH; Wahren-Herlenius M; Bootsma H; Mariette X; Ramos-Casals M; Brito-Zerón P, Universitat Rovira i Virgili, and Retamozo S; Acar-Denizli N; Horváth IF; Ng WF; Rasmussen A; Dong X; Li X; Baldini C; Olsson P; Priori R; Seror R; Gottenberg JE; Kruize AA; Hernandez-Molina G; Vissink A; Sandhya P; Armagan B; Quartuccio L; Sebastian A; Praprotnik S; Bartoloni E; Kwok SK; Kvarnstrom M; Rischmueller M; Soláns-Laqué R; Sene D; Pasoto SG; Suzuki Y; Isenberg DA; Valim V; Nordmark G; Nakamura H; Trevisani VFM; Hofauer B; Sisó-Almirall A; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Atzeni F; Hammenfors D; Maure B; Carsons SE; Gheita T; Sánchez-Berná I; López-Dupla M; Morel J; Inanç N; Fonseca-Aizpuru E; Morcillo C; Vollenweider C; Melchor S; Vázquez M; Díaz-Cuiza E; Consani-Fernández S; De-Miguel-Campo B; Szántó A; Bombardieri S; Gattamelata A; Hinrichs A; Sánchez-Guerrero J; Danda D; Kilic L; De Vita S; Wiland P; Gerli R; Park SH; Wahren-Herlenius M; Bootsma H; Mariette X; Ramos-Casals M; Brito-Zerón P
Abstract: Objective. To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjögren's syndrome (pSS). Methods. By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression. Results. There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of <90% in patients diagnosed at the youngest ages and >95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R2 0.87) and the frequency of abnormal oral tests (adjusted R2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.
Published: 2021

8. Salivary Gland Ultrasonography in Sjögren's Syndrome: A European Multicenter Reliability Exercise for the HarmonicSS Project

Author: Zabotti, A. Zandonella Callegher, S. Tullio, A. Vukicevic, A. Hocevar, A. Milic, V. Cafaro, G. Carotti, M. Delli, K. De Lucia, O. Ernst, D. Ferro, F. Gattamelata, A. Germanò, G. Giovannini, I. Hammenfors, D. Jonsson, M.V. Jousse-Joulin, S. Macchioni, P. Parisi, S. Perricone, C. Stradner, M.H. Filipovic, N. Tzioufas, A.G. Valent, F. De Vita, S.
Abstract: Objectives: Salivary gland ultrasonography (SGUS) is increasingly applied for the management of primary Sjögren's syndrome (pSS). This study aims to: (i) compare the reliability between two SGUS scores; (ii) test the reliability among sonographers with different levels of experience. Methods: In the reliability exercise, two four-grade semi-quantitative SGUS scoring systems, namely De Vita et al. and OMERACT, were tested. The sonographers involved in work-package 7 of the HarmonicSS project from nine countries in Europe were invited to participate. Different levels of sonographers were identified on the basis of their SGUS experience and of the knowledge of the tested scores. A dedicated atlas was used as support for SGUS scoring. Results: Twenty sonographers participated in the two rounds of the reliability exercise. The intra-rater reliability for both scores was almost perfect, with a Light's kappa of 0.86 for the De Vita et al. score and 0.87 for the OMERACT score. The inter-rater reliability for the De Vita et al. and the OMERACT score was substantial with Light's Kappa of 0.75 and 0.77, respectively. Furthermore, no significant difference was noticed among sonographers with different levels of experience. Conclusion: The two tested SGUS scores are reliable for the evaluation of major salivary glands in pSS, and even less-expert sonographers could be reliable if adequately instructed. © Copyright © 2020 Zabotti, Zandonella Callegher, Tullio, Vukicevic, Hocevar, Milic, Cafaro, Carotti, Delli, De Lucia, Ernst, Ferro, Gattamelata, Germanò, Giovannini, Hammenfors, Jonsson, Jousse-Joulin, Macchioni, Parisi, Perricone, Stradner, Filipovic, Tzioufas, Valent and De Vita.
Published: 2020

9. EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies

Author: Ramos-Casals, M., Brito-Zeron, P., Bombardieri, S., Bootsma, H., De Vita, S., Dorner, T., Fisher, B. A., Gottenberg, J. -E., Hernandez-Molina, G., Kocher, A., Kostov, B., Kruize, A. A., Mandl, T., W. -F., Ng, Retamozo, S., Seror, R., Shoenfeld, Y., Siso-Almirall, A., Tzioufas, A. G., Vitali, C., Bowman, S., EULAR-Sjögren Syndrome Task Force Group: Sebastian A, Mariette X., Saraux, A, Vissink, A, Rasmussen, A, Hofauer, B, Armagan, B, Feijoo-Massó, C, Shiboski, Ch, Baldini, C, Vollenweider, C, Sene, D, Hammenfors, D, Isenberg, D, Danda, D, Bartoloni, E, Hospital Clinic i Provincial de Barcelona (SCReN), CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, H. CIMA-Sanitas, Barcelona, University of Pisa - Università di Pisa, University of Groningen [Groningen], Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Birmingham [Birmingham], Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], University Hospital Basel [Basel], Bern University Hospital [Berne] (Inselspital), Transverse group for research in primary care [Barcelona], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat Politècnica de Catalunya [Barcelona] (UPC), University Medical Center [Utrecht], Skane University Hospital [Malmo], Lund University [Lund], Newcastle University [Newcastle], Newcastle Upon Tyne Hospitals NHS Foundation Trust, Universidad de Córdoba = University of Córdoba [Córdoba], Universidad Nacional de Córdoba [Argentina], Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Saint Petersburg University (SPBU), CAP Les Corts (CAPSBE), National and Kapodistrian University of Athens (NKUA), Santo Stefano Riabilitazione, University Hospitals Birmingham [Birmingham, Royaume-Uni], Centre National de la Recherche Scientifique (CNRS)-Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa, and Salvy-Córdoba, Nathalie
Subjects: MESH: Antirheumatic Agents, Autoimmune diseases, MESH: Hydroxychloroquine, Matemàtiques i estadística::Matemàtica aplicada a les ciències [Àrees temàtiques de la UPC], Azathioprine, Administration, Ophthalmic, MESH: Cyclosporine, 0302 clinical medicine, Adrenal Cortex Hormones, MESH: Muscarinic Agonists, Epidemiology, Immunology and Allergy, 030212 general & internal medicine, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, treatment, Anti-Inflammatory Agents, Non-Steroidal, 92 Biology and other natural sciences::92B Mathematical biology in general [Classificació AMS], [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, MESH: Anti-Inflammatory Agents, Non-Steroidal, MESH: Administration, Ophthalmic, 3. Good health, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Sjogren's Syndrome, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antirheumatic Agents, Cyclosporine, Rituximab, MESH: Immunosuppressive Agents, MESH: Lubricant Eye Drops, sjøgren's syndrome, MESH: Saliva, Artificial, autoimmune diseases, Immunosuppressive Agents, medicine.drug, Hydroxychloroquine, medicine.medical_specialty, Biomatemàtica, Immunology, Muscarinic Agonists, General Biochemistry, Genetics and Molecular Biology, Lubricant Eye Drops, MESH: Adrenal Cortex Hormones, 03 medical and health sciences, Therapeutic approach, Rheumatology, medicine, Humans, Intensive care medicine, Glucocorticoids, Sjøgren's syndrome, Biomathematics, 030203 arthritis & rheumatology, MESH: Humans, business.industry, Abatacept, Saliva, Artificial, Evidence-based medicine, medicine.disease, Belimumab, Treatment, stomatognathic diseases, MESH: Sjogren's Syndrome, MESH: Glucocorticoids, business, Rheumatism
Abstract: International audience; The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR SS Task Force) aimed at developing the first EULAR evidence and consensus-based recommendations for the management of patients with SjS with topical and systemic medications. The aim was to develop a rational therapeutic approach to SjS patients useful for healthcare professionals, physicians undergoing specialist training, medical students, the pharmaceutical industry and drug regulatory organisations following the 2014 EULAR standardised operating procedures. The Task Force (TF) included specialists in rheumatology, internal medicine, oral health, ophthalmology, gynaecology, dermatology and epidemiology, statisticians, general practitioners, nurses and patient representatives from 30 countries of the 5 continents. Evidence was collected from studies including primary SjS patients fulfilling the 2002/2016 criteria; when no evidence was available, evidence from studies including associated SjS or patients fulfilling previous sets of criteria was considered and extrapolated. The TF endorsed the presentation of general principles for the management of patients with SjS as three overarching, general consensus-based recommendations and 12 specific recommendations that form a logical sequence, starting with the management of the central triplet of symptoms (dryness, fatigue and pain) followed by the management of systemic disease. The recommendations address the use of topical oral (saliva substitutes) and ocular (artificial tear drops, topical non-steroidal anti-inflammatory drugs, topical corticosteroids, topical CyA, serum tear drops) therapies, oral muscarinic agonists (pilocarpine, cevimeline), hydroxychloroquine, oral glucocorticoids, synthetic immunosuppressive agents (cyclophosphamide, azathioprine, methotrexate, leflunomide and mycophenolate), and biological therapies (rituximab, abatacept and belimumab). For each recommendation, levels of evidence (mostly modest) and TF agreement (mostly very high) are provided. The 2019 EULAR recommendations are based on the evidence collected in the last 16 years in the management of primary 2002 SjS patients and on discussions between a large and broadly international TF. The recommendations synthesise current thinking on SjS treatment in a set of overarching principles and recommendations. We hope that the current recommendations will be broadly applied in clinical practice and/or serve as a template for national societies to develop local recommendations.
Published: 2019
Full Text: View/download PDF

10. How the age at diagnosis modifies the phenotype of primary Sjögren syndrome: analysis in 11.420 patients (Big data Sjögren project

Author: Retamozo, S, Acar-Denizli, N, Ng, WF, Horvath, I., Rasmussen, A., Seror, R., Li, X, Baldini, C, Gottenberg, J., Sandhya, P, Quartuccio L, R, Priori, Roberta, Hernandez-Molina, G, Armagan, B, Kruize, A, Kwok, S, Kvarnstrom, M, Praprotnik, S, Sene, D, Bartoloni Bocci, E, Solans-Laqué, R, Rischmueller, M, Mandl, T, Suzuki, Y, Isenberg, D, Valim, V, Sebastián, A., Nordmark, G, Bootsma, H, Nakamura, H, Giacomelli, R, Devauchelle-Pensec, V., Hofauer, B, Bombardieri, M, Fernandes Moça Trevisani, V, Hammenfors, D, Pasoto, S, Gheita, T, Atzeni, F, Morel, J., Vollenveider, C, Consani-Fernández, S, Mariette, X., Ramos-Casals, M, Brito-Zerón, P, Michel, Geneviève, INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University (UNITED KINGDOM), University of Debrecen, OMRF Oklahoma, University of Oklahoma (OU), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Department of Clinical Immunology and Rheumatology, Vellore (Christian Medical College & Hospital), Department of Medical Area, University Hospital Santa Maria della Misericordia, Udine, Ospedale 'Santa Maria della Misericordia' = University Hospital 'Santa Maria della Misericordia', Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Karolinska Institutet [Stockholm], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Université Paris Diderot - Paris 7 (UPD7), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa University (KU), University College of London [London] (UCL), Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Queen Mary University of London (QMUL), Federal University of Sao Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, Cairo University, Messina and Milan Univ, Milan, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), German Hospital, Buenos Aires, Facultad de Ciencias (UDELAR), Hosp Maciel montevideo, Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., and H. CIMA-Sanitas, Barcelona
Subjects: [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

11. LYMPHOMA ARISING AT THE TIME OF DIAGNOSIS OF PRIMARY SJOGREN SYNDROME: A HIGHLY-ACTIVE SYSTEMIC SUBSET OF THE DISEASE

Author: Retamozo, S, Acar-Denizli, N, Ng, Wf, Szanto, A, Rasmussen, A., Seror, R., Li, X, Baldini, C, Gottenberg, J., Sandhya, P, Quartuccio, L, Priori, R, Hernandez-Molina, G, Armagan, B, Kruize, A, Kwok, S, Kvarnstrom, M, Praprotnik, S, Sene, D, Solans-Laque, R, Rischmueller, M, Mandl, T, Suzuki, Y, Isenberg, D, Valim, V, Sebastián, A., Nordmark, G, Bootsma, H, Nakamura, H, Giacomelli, R, Devauchelle-Pensec, V., Hofauer, B, Bombardieri, M, Fernandes Mocatrevisani, V, Hammenfors, D, Pasoto, S, Gheita, T, Atzeni, F, Morel, J., Vollenveider, C, Consani-Fernandez, S, Mariette, X., Ramos-Casals, M, Brito-Zeron, P, Bartoloni Bocci, E, INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University (UNITED KINGDOM), University of Debrecen, OMRF Oklahoma, University of Oklahoma (OU), INSERM UMR972, SFR André Lwoff, Université Paris Sud, APHP Paul Brousse, Anhui Provincial Hosp, University of Pisa - Università di Pisa, Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Christian Medical College & Hospital, Azienda Ospedaliera Universitaria Santa Maria della Misericordia, Udine, Italy., Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Karolinska Institutet [Stockholm], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Université Paris Diderot - Paris 7 (UPD7), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Kanazawa University (KU), University College of London [London] (UCL), Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), Lymphocytes B, Autoimmunité et Immunothérapies (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-LabEX IGO Immunothérapie Grand Ouest-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Queen Mary University of London (QMUL), Federal University of Sao Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, Cairo University, Univ Messina, Dipartimento Sci Matemat & Informat Sci Fis & Sci, Viale Ferdinando Stagno dAlcontres 31, I-98166 Messina S Agata, Italy, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), German Hospital, Buenos Aires, Hospital Maciel, Immunologie antivirale systémique et cérébrale, Université Paris-Sud - Paris 11 (UP11)-IFR93-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain., H. CIMA-Sanitas, Barcelona, Università degli Studi di Perugia (UNIPG), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), and Michel, Geneviève
Subjects: [SDV.IMM] Life Sciences [q-bio]/Immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

12. Influence of epidemiology and ethnicity on systemic expression of primary Sjögren syndrome in 9974 patients

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaèle, Li, X, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, R, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Fernandes Moça Trevisani, Virginia, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zerón, Pilar, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Université Paris Sud (Paris 11), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Les Hôpitaux Universitaires de Strasbourg (HUS), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Department of Rheumatology and Clinical Immunology Groningen (Dep Rheum - GRONINGEN), University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Université Fédérale de São Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, German Hosp, Buenos Aires, H. CIMA-Sanitas, Barcelona, and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

13. Sjögren big data project, the first example of data sharing in autoimmune diseases: analysis of 10475 worldwide patients

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Mandl, T, Seror, Raphaèle, Li, X, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, A, Minniti, Hernandez-Molina, Gabriela, Kalyoncu, Umut, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, Damien, Bartolini, E, Solans, R., Rischmueller, Maureen, Suzuki, Y, Isenberg, David, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michèle, Fernandes Moça Trevisani, Virginia, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, Jacques, Vollenveider, Cristina, Brito-Zerón, Pilar, Ramos-Casals, Manuel, Hospital Clinic (IDIBAPS), Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Lund University, Malmö University Hospital, Université Paris Sud (Paris 11), Anhui Provincial Hosp, University of Pisa - Università di Pisa, Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université dePerugia, Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Kanazawa University (KU), Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Department of Medical Sciences, Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), Department of Rheumatology and Clinical Immunology Groningen (Dep Rheum - GRONINGEN), University Medical Center Groningen [Groningen] (UMCG), Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London (QMUL), Université Fédérale de São Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UiB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Service de Rhumatologie [CHU de Montpellier], CHU Montpellier, German Hosp, Buenos Aires, H. CIMA-Sanitas, Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

14. A north-south worldwide gradient in systemic activity of primary Sjögren syndrome: increased severe disease in patients from southern countries

Author: Retamozo, Soledad, Acar-Denizli, Nihan, Fai Ng, W, Zeher, M, Rasmussen, A, Seror, Raphaele, LI, Xiaogai, Baldini, C, Gottenberg, Jacques-Eric, Danda, D, Quartuccio, Luca, Priori, Roberta, Hernandez-Molina, G, Armagan, B, Kruize, Aike A, Kwok, S-K, Wahren-Herlenius, Marie, Praprotnik, Sonja, Sene, D, Bartoloni, Elena, Solans, R., Rischmueller, Maureen, Mandl, T, Suzuki, Y, Isenberg, David A, Valim, V, Wiland, Piotr, Nordmark, Gunnel, Fraile, G, Bootsma, Hendrika, Nakamura, T, Giacomelli, R., Devauchelle-Pensec, Valérie, Hofauer, Benedikt, Bombardieri, Michele, Trevisani, Virginia Fernandes Moça, Hammenfors, D, S.G., Pasoto, Gheita, Tamer A, Atzeni, Fabiola, Morel, J, Vollenveider, Cristina, Ramos-Casals, Manel, Rheumatology Unit, Cordoba (Institute University of Biomedical Sciences University of Cordoba (IUCBC), Hospital Clinic (IDIBAPS), INICSA, UNC, CONICED, Cordoba, Mimar Sinan Üniversitesi, Newcastle University [Newcastle], University of Debrecen [Hungary], Oklahoma Medical Research Foundation, Oklahoma Medical Research Foundation (OMRF), Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicêtre, Anhui Provincial Hosp, University of Pisa - Università di Pisa, Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Christian Medical College & Hospital, Rheumatology Clinic, Udine (DSMB), UO Complessa Reumatologia, Rome, INCMNSS, Mexico, Hacettepe University = Hacettepe Üniversitesi, University Medical Center [Utrecht], Catholic University of Korea, Unit of Experimental Rheumatology, Stockhom (Department of Medicine), Department of Rheumatology, University Medical Centre, Université Paris Diderot - Paris 7 (UPD7), Università degli Studi di Perugia (UNIPG), Vall d'Hebron University Hospital [Barcelona], The University of Western Australia (UWA), Lund University, Malmö University Hospital, Kanazawa Medical University, Centre for Rheumatology - London, Federal University of Espírito Santo, Wroclaw Medical University, Uppsala Universitet [Uppsala], Hospital Universitario Ramón y Cajal [Madrid], Universidad de Alcalá - University of Alcalá (UAH), University of Groningen [Groningen], Nagasaki University, University of L'Aquila [Italy] (UNIVAQ), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Lymphocyte B et Auto-immunité (LBAI), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Hals-Nasen-Ohrenklinik und Poliklinik, Munchen, Queen Mary University London, Federal University of Sao Paulo (Unifesp), Haukeland University Hospital, University of Bergen (UIB), Hospital das Clinicas, University of Sao Paulo School of Medicine, Cairo University - Faculty of Medicine, Messina and Milan Univ, Milan, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), German Hosp, Buenos Aires, Laboratory of Autoimmune Diseases Josep Font Barcelona, CELLEX-IDIBAPS Department of Autoimmune Diseases, Barcelona, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), University of Bergen (UiB), and Michel, Geneviève
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

15. Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren’s syndrome

Author: Jousse‐Joulin, S., primary, Gatineau, F., additional, Baldini, C., additional, Baer, A., additional, Barone, F., additional, Bootsma, H., additional, Bowman, S., additional, Brito‐Zerón, P., additional, Cornec, D., additional, Dorner, T., additional, Vita, S., additional, Fisher, B., additional, Hammenfors, D., additional, Jonsson, M., additional, Mariette, X., additional, Milic, V., additional, Nakamura, H., additional, Ng, W.‐F., additional, Nowak, E., additional, Ramos‐Casals, M., additional, Rasmussen, A., additional, Seror, R., additional, Shiboski, C.H., additional, Nakamura, T., additional, Vissink, A., additional, Saraux, A., additional, and Devauchelle‐Pensec, V., additional
Published: 2019
Full Text: View/download PDF

16. Video clip assessment of a salivary gland ultrasound scoring system in Sjögren's syndrome using consensual definitions: An OMERACT ultrasound working group reliability exercise

Author: Jousse-Joulin, S., D'Agostino, Maria Antonietta, Nicolas, C., Naredo, E., Ohrndorf, S., Backhaus, M., Tamborrini, G., Chary-Valckenaere, I., Terslev, L., Iagnocco, A., Collado, P., Hernandez-Diaz, C., Gandjbakhch, F., Schmidt, W. A., Filippou, G., Dejaco, Christian, Stradner, M. H., Mortada, M. A., Hoa Evar, A., Chrysidis, S., El Mardenly, G., De Agustin, J. J., Thiele, R., Maccarter, D. K., Finzel, S., Hanova, P., Zabotti, A., Glaser, C., Alavi, Z., Hammenfors, D. S., Gatineau, F., Bruyn, G. A. W., D'Agostino M. A. (ORCID:0000-0002-5347-0060), Dejaco C., Jousse-Joulin, S., D'Agostino, Maria Antonietta, Nicolas, C., Naredo, E., Ohrndorf, S., Backhaus, M., Tamborrini, G., Chary-Valckenaere, I., Terslev, L., Iagnocco, A., Collado, P., Hernandez-Diaz, C., Gandjbakhch, F., Schmidt, W. A., Filippou, G., Dejaco, Christian, Stradner, M. H., Mortada, M. A., Hoa Evar, A., Chrysidis, S., El Mardenly, G., De Agustin, J. J., Thiele, R., Maccarter, D. K., Finzel, S., Hanova, P., Zabotti, A., Glaser, C., Alavi, Z., Hammenfors, D. S., Gatineau, F., Bruyn, G. A. W., D'Agostino M. A. (ORCID:0000-0002-5347-0060), and Dejaco C.
Abstract: Objective To develop ultrasound (US) definitions and a US novel scoring system for major salivary gland (SG) lesions in patients with primary Sjögren's syndrome (pSS) and to test their intrareader and inter-reader reliability using US video clips. Methods Twenty-five rheumatologists were subjected to a three-round, web-based Delphi process in order to agree on (1) definitions and scanning procedure of salivary gland ultrasonography (SGUS): parotid, submandibular and sublingual glands (PG, SMG and SLG); (2) definitions for the elementary SGUS lesions in patients with Sjögren's syndrome; (3) scoring system for grading changes. The experts rated the statements on a 1-5 Likert scale. In the second step, SGUS video clips of patients with pSS and non-pSS sicca cases were collected containing various spectrums of disease severity followed by an intrareader and inter-reader reliability exercise. Each video clip was evaluated according to the agreed definitions. Results Consensual definitions were developed after three Delphi rounds. Among the three selected SGs, US assessment of PGs and SMGs was agreed on. Agreement was reached to score only greyscale lesions and to focus on anechoic/hypoechoic foci in a semiquantitative matter or, if not possible on a qualitatively (present/absent) evaluation of fatty or fibrous lesions. Intrareader reliability for detecting and scoring these lesions was excellent (Cohen's kappa 0.81) and inter-reader reliability was good (Light's kappa 0.66). Conclusion New definitions for developing a novel semiquantitative US score in patients with pSS were developed and tested on video clips. Inter-reader and intrareader reliabilities were good and excellent, respectively.
Published: 2019

17. How the different systemic organ involvements are overlapped in patients with primary Sjogren syndrome: analysis using a mathematical model

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheite, (Gheite, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

18. How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project)

Author: Brito-Zerón, P., Acar-Denizli, N., Ng, Wf, Zeher, M., Rasmussen, A., Mandl, T., Seror, R., Li, X., Baldini, C., Gottenberg, Je, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, Aa, Kwok, Sk, Marika Kvarnström, Praprotnik, S., Sène, D., Bartoloni, E., Solans, R., Rischmueller, M., Suzuki, Y., Isenberg, Da, Valim, V., Wiland, P., Nordmark, G., Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Knopf, A., Bombardieri, M., Trevisani, Vf, Hammenfors, D., Pasoto, Sg, Retamozo, S., Gheita, Ta, Atzeni, F., Morel, J., Vollenveider, C., Horvath, If, Sivils, Kl, Olsson, P., Vita, S., Sánchez-Guerrero, J., Kilic, L., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Sjögren Big Data Consortium, Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHRU Brest - Service de Rhumatologie (CHU - BREST - Rhumato), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11), Herrada, Anthony, and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Complement C4, Complement C3, Middle Aged, Aged, Antibodies, Antinuclear, Autoantibodies, Biomarkers, Cryoglobulins, Female, Humans, Phenotype, Prognosis, Registries, Rheumatoid Factor, Sjogren's Syndrome, Antibodies, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Antinuclear
Abstract: International audience; OBJECTIVES:To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).METHODS:The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. The centres shared a harmonised data architecture and conducted cooperative online efforts in order to refine collected data under the coordination of a big data statistical team. Inclusion criteria were the fulfillment of the 2002 classification criteria. Immunological tests were carried out using standard commercial assays.RESULTS:By January 2018, the participant centres had included 10,500 valid patients from 22 countries. The cohort included 9,806 (93%) women and 694 (7%) men, with a mean age at diagnosis of primary SjS of 53 years, mainly White (78%) and included from European countries (71%). The frequency of positive immunological markers at diagnosis was 79.3% for ANA, 73.2% for anti-Ro, 48.6% for RF, 45.1% for anti- La, 13.4% for low C3 levels, 14.5% for low C4 levels and 7.3% for cryoglobulins. Positive autoantibodies (ANA, Ro, La) correlated with a positive result in salivary gland biopsy, while hypocomplementaemia and especially cryoglo-bulinaemia correlated with systemic activity (mean ESSDAI score of 17.7 for cryoglobulins, 11.3 for low C3 and 9.2 for low C4, in comparison with 3.8 for negative markers). The immunological markers with a great number of statistically-significant associations (p
Published: 2018

19. Systemic Sjogren presenting without sicca syndrome: characterization of 240 patients according to the new 2017 ACR/EULAR Classification Criteria

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Acar-Denizli, (Acar-Denizli, N, 4 ), Nihan), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

20. How ethnicity modifies systemic activity of primary Sjogren syndrome: analysis of baseline ESSDAI scores in a multi-ethnic international cohort

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, X, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

21. Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis

Author: Retamozo, (Retamozo, S, Soledad)(, 1, 2 3 ), Kostov, (Kostov, B, 4 ), Belchin), Zeher, (Zeher, M, 5 ), Margit), Sivils, (Sivils, K, 6 ), Kathy), Mandl, (Mandl, T, 7 ), Thomas), Seror, (Seror, R, Raphaele)(, 8, Li, 9, (Li, Xm, Xiaomei)( 10, ), Baldini, (Baldini, C, Chiara)( 11, ), Mariette, (Mariette, X, Xavier)(, 8, Gottenberg, 9, (Gottenberg, Je, Jacques-Eric)( 12, ), Danda, (Danda, D, Debashish)( 13, ), Priori, (Priori, R, Roberta)( 14, ), Quartuccio, (Quartuccio, L, Luca)( 15, ), Hernandez-Molina, (Hernandez-Molina, G, Gabriela)( 16, ), Armagan, (Armagan, B, Berkan)( 17, ), Kruize, (Kruize, Aa, ( 18 ), Aike A., Kwok, (Kwok, Sk, Seung-Ki)( 19, ), Wahren-Herlenius, (Wahren-Herlenius, M, Marie)(, 20, 21, ), Praprotnik, (Praprotnik, S, Sonja)( 22, ), Sene, (Sene, D, Damien)( 23, ), Bartoloni, (Bartoloni, E, Elena)( 24, ), Rischmueller, (Rischmueller, M, Maureen)( 25, ), Solans, (Solans, R, Roser)( 26, ), Suzuki, (Suzuki, Y, Yasunori)( 27, ), Isenberg, (Isenberg, D, David)( 28, ), Valim, (Valim, V, Valeria)( 29, ), Wiland, (Wiland, P, Piotr)( 30, ), Nordmark, (Nordmark, G, Gunnel)( 31, ), Fraile, (Fraile, G, Guadalupe)( 32, ), Bootsma, (Bootsma, H, Hendrika)( 33, ), Nakamura, (Nakamura, T, Takashi)( 34, ), Giacomelli, Roberto, (Giacomelli, R, Roberto)( 35, ), Devauchelle-Pensec, (Devauchelle-Pensec, V, Valerie)( 36, ), Hofauer, (Hofauer, B, Benedikt)( 37, ), Bombardieri, (Bombardieri, M, Michele)( 38, ), Trevisani, VFM (Moca Trevisani, Virginia Fernandes)( 39, ), Hammenfors, (Hammenfors, D, Daniel)(, 40, 41, ), Pasoto, (Pasoto, Sg, ( 42 ), Sandra G., Carsons, (Carsons, Se, ( 43 ), Steven E., Gheita, (Gheita, Ta, ( 44 ), Tamer A., Atzeni, (Atzeni, F, Fabiola)( 45, ), Morel, (Morel, J, Jacques)(, 46, 47, ), Vollenveider, (Vollenveider, C, Cristina)( 48, ), Brito-Zeron, (Brito-Zeron, P, Pilar)(, 1, 49, ), Ramos-Casals, (Ramos-Casals, M, and Manuel)
Published: 2018

22. SAT0457 SjÖgren big data project, the first example of data sharing in autoimmune diseases: analysis of 10475 worldwide patients

Author: Retamozo, S., primary, Acar-Denizli, N., additional, Fai Ng, W., additional, Zeher, M., additional, Rasmussen, A., additional, Mandl, T., additional, Seror, R., additional, Li, X., additional, Baldini, C., additional, Gottenberg, J.-E., additional, Danda, D., additional, Quartuccio, L., additional, Minniti, A., additional, Hernandez-Molina, G., additional, Kalyoncu, U., additional, Kruize, A.A., additional, Kwok, S.-K., additional, Wahren-Herlenius, M., additional, Praprotnik, S., additional, Sene, D., additional, Bartoloni, E., additional, Solans, R., additional, Rischmueller, M., additional, Suzuki, Y., additional, Isenberg, D., additional, Valim, V., additional, Wiland, P., additional, Nordmark, G., additional, Fraile, G., additional, Bootsma, H., additional, Nakamura, T., additional, Giacomelli, R., additional, Devauchelle-Pensec, V., additional, Hofauer, B., additional, Bombardieri, M., additional, Fernandes Moça Trevisani, V., additional, Hammenfors, D., additional, Pasoto, S.G., additional, Gheita, T.A., additional, Atzeni, F., additional, Morel, J., additional, Vollenveider, C., additional, Brito-Zerón, P., additional, and Ramos-Casals, M., additional
Published: 2018
Full Text: View/download PDF

23. A North-South Worldwide Gradient in Systemic Activity of Primary Sjögren Syndrome : Increased Severe Disease in Patients from Southern Countries

Author: Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandi, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., Ramos-Casals, M., Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandi, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., and Ramos-Casals, M.
Published: 2018
Full Text: View/download PDF

24. Influence of epidemiology and ethnicity on systemic expression of primary Sjögren syndrome in 9974 patients

Author: Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandl, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensee, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., Ramos-Casals, M., Retamozo, S., Acar-Denizli, N., Ng, W. Fai, Zeher, M., Rasmussen, A., Seror, R., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Armagan, B., Kruize, A. A., Kwok, S. -K, Wahren-Herlenius, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Rischmueller, M., Mandl, T., Suzuki, Y., Isenberg, D., Valim, V., Wiland, P., Nordmark, Gunnel, Fraile, G., Bootsma, H., Nakamura, T., Giacomelli, R., Devauchelle-Pensee, V., Hofauer, B., Bombardieri, M., Fernandes Moca Trevisani, V., Hammenfors, D., Pasoto, S. G., Gheita, T. A., Atzeni, F., Morel, J., Vollenveider, C., Brito-Zeron, P., and Ramos-Casals, M.
Published: 2018
Full Text: View/download PDF

25. Baseline ESSDAI/DAS scores in 8061 patients with primary sjÖgren syndrome: characterization of systemic disease

Author: Brito-Zerόn, P, Acar-Denizli, N, Zeher, M, Rasmussen, A, Li, X, Baldini, C, Gottenberg, J-E, Danda, D, Quartuccio, L, Hernandez-Molina, G, Kruize, Aa, Park, S-H, Kvarnström, M, Praprotnik, S, Sene, D, Alunno, A, Solans, R, Mandl, T, Suzuki, Y, Rischmueller, M, Nordmark, G, Fraile, G, Wiland, P, Bootsma, H, Nakamura, T, Valim, V, Giacomelli, R, Seror, R, Devauchelle-Pensec, V, Hofauer, B, Bombardieri, M, Trevisani, V, Hammenfors, D, Minniti, A, Pasoto, Sg, Morel, J, Retamozo, S, Gheita, Ta, Atzeni, F, Vollenveider, C, Mariette, X, and Ramos-Casals, M
Published: 2017

26. OP0040 Integration of salivary-gland ultrasonography in classification criteria for primary sjÖgren's syndrome: an international vignette-based study

Author: Jousse-Joulin, S, primary, Gatineau, F, additional, Baldini, C, additional, Arends, S, additional, Barone, F, additional, Baer, A, additional, Bootsma, H, additional, Bowman, S, additional, Brito-Zeron, P, additional, Cornec, D, additional, Dorner, T, additional, Vita, S De, additional, Fisher, B, additional, Hammenfors, D, additional, Jonsson, M, additional, Mariette, X, additional, Milic, V, additional, Nakamura, T, additional, Ng, W-F, additional, Nowak, E, additional, Rasmussen, A, additional, Seror, R, additional, Shiboski, C, additional, Ramos-Casals, M, additional, Vissink, A, additional, Saraux, A, additional, and Devauchelle-Pensec, V, additional
Published: 2017
Full Text: View/download PDF

27. Weight of salivary gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren's syndrome.

Author: Jousse‐Joulin, S., Gatineau, F., Baldini, C., Baer, A., Barone, F., Bootsma, H., Bowman, S., Brito‐Zerón, P., Cornec, D., Dorner, T., Vita, S., Fisher, B., Hammenfors, D., Jonsson, M., Mariette, X., Milic, V., Nakamura, H., Ng, W.‐F., Nowak, E., and Ramos‐Casals, M.
Subjects: SALIVARY glands, ULTRASONIC imaging, RELATIONAL databases, CLASSIFICATION, SYNDROMES, RESEARCH, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, RESEARCH funding, SJOGREN'S syndrome, ALGORITHMS
Abstract: Objective: Major salivary gland ultrasonography (SGUS) is widely used for the diagnosis of primary Sjögren's syndrome (pSS). Our objective was to assess the contribution of SGUS compared to other items of the 2016 ACR/EULAR pSS classification criteria, based on expert opinion.Methods: A secure web-based relational database was used by 24 experts from 14 countries to assess 512 realistic vignettes developed from data of patients with suspected pSS. Each vignette provided classification criteria items and information on history, clinical symptoms and SGUS findings. Each expert assessed 64 vignettes, and each vignette was assessed by 3 experts. A diagnosis of pSS was defined according to at least 2 of 3 experts. Validation was performed in the independent French DiapSS cohort of patients with suspected pSS.Results: A criteria-based pSS diagnosis and SGUS findings were independently associated with an expert diagnosis of pSS (P < 0.001). The derived diagnostic weights of individual items in the 2016 ACR/EULAR criteria including SGUS were as follows: anti-SSA, 3; focus score ≥ 1, 3; SGUS score ≥ 2, 1; positive Schirmer's test, 1; dry mouth, 1; and salivary flow rate < 0.1 mL/min, 1. The corrected C statistic area under the curve for the new weighted score was 0.96. Adding SGUS improves the sensitivity from 90.2 % to 95.6% with a quite similar specificity 84.1% versus 82.6%. Results were similar in the DiapSS cohort: adding SGUS improves the sensitivity from 87% to 93%.Conclusion: SGUS had similar weight compared to minor items, and its addition improves the performance of the 2016 ACR/EULAR classification criteria. [ABSTRACT FROM AUTHOR]
Published: 2020
Full Text: View/download PDF

28. Analysis Of 9302 Patients From The Big Data International Primary Sjogren Syndrome Cohort : Clinical Presentation At Diagnosis Of European Vs Non-European Patients

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Priori, R., Quartuccio, L., Hernandez-Molina, G., Kruize, A., Park, S. -H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Suzuki, Y., Isenberg, D., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Vissink, A., Nakamura, T., Valim, V., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Carsons, S. E., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Priori, R., Quartuccio, L., Hernandez-Molina, G., Kruize, A., Park, S. -H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Suzuki, Y., Isenberg, D., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Vissink, A., Nakamura, T., Valim, V., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Carsons, S. E., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
Full Text: View/download PDF

29. Baseline Essdai/ Das Scores In 8061 Patients With Primary Sjögren Syndrome : Characterization Of Systemic Disease

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Alunno, A., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Wiland, P., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Minniti, A., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Alunno, A., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Wiland, P., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Minniti, A., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
Full Text: View/download PDF

30. Predicting Survival In 6240 Patients With Primary Sjögren' Syndrome (Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombaidieri, M., Trevisani, V., Hammenfors, D., Priori, R., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Li, X., Baldini, C., Gottenberg, J-E, Danda, D., Quartuccio, L., Hernandez-Molina, G., Kruize, A. A., Park, S-H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Mandl, T., Suzuki, Y., Rischmueller, M., Nordmark, Gunnel, Fraile, G., Sebastian, A., Bootsma, H., Nakamura, T., Valim, V., Giacomelli, R., Seror, R., Devauchelle-Pensec, V., Hofauer, B., Bombaidieri, M., Trevisani, V., Hammenfors, D., Priori, R., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., and Ramos-Casals, M.
Published: 2017
Full Text: View/download PDF

31. Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren : Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Gerli, R., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Park, S. -H, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Saraux, A., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Gerli, R., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Park, S. -H, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Saraux, A., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., and Ramos-Casals, M.
Published: 2016
Full Text: View/download PDF

32. Worldwide Heterogeneous Diagnostic Approach To Primary Sjögren Syndrome in 8315 Patients (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Bartoloni, E., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Kwok, S. -K, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E, Danda, D., Quartuccio, L., Priori, R., Hernandez-Molina, G., Kruize, A., Valim, V., Kvarnstrom, M., Sene, D., Bartoloni, E., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Kwok, S. -K, Nordmark, Gunnel, Suzuki, Y., Giacomelli, R., Devauchelle-Pensec, V., Bombardieri, M., Hofauer, B., Bootsma, H., Hammenfors, D., Fraile, G., Carsons, S., Gheita, T., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Horvath, I. -F, Sivils, K., Theander, E., Sandhya, P., De Vita, S., Sanchez-Guerrero, J., van der Heijden, E., Moca-Trevisano, V., Wahren-Herlenius, M., Mariette, X., and Ramos-Casals, M.
Published: 2016
Full Text: View/download PDF

33. SAT0287 Ethnic Differences Strongly Influence The Phenotypic Expression of Primary Sjögren: Study of 7887 Patients from 20 Countries on 5 Continents (EULAR-SS Task Force Big Data Sjögren Project)

Author: Brito-Zerόn, P., primary, Acar-Denizli, N., additional, Zeher, M., additional, Rasmussen, A., additional, Seror, R., additional, Mandl, T., additional, Li, X., additional, Baldini, C., additional, Gottenberg, J.-E., additional, Danda, D., additional, Quartuccio, L., additional, Priori, R., additional, Hernández-Molina, G., additional, Kruize, A., additional, Valim, V., additional, Kvarnstrom, M., additional, Sene, D., additional, Gerli, R., additional, Praprotnik, S., additional, Isenberg, D., additional, Solans, R., additional, Rischmueller, M., additional, Park, S.-H., additional, Nordmark, G., additional, Suzuki, Y., additional, Giacomelli, R., additional, Saraux, A., additional, Bombardieri, M., additional, Hofauer, B., additional, Bootsma, H., additional, Hammenfors, D., additional, Fraile, G., additional, Carsons, S., additional, Gheita, T., additional, Morel, J., additional, Vollenveider, C., additional, Atzeni, F., additional, Retamozo, S., additional, Horvath, I.-F., additional, Sivils, K., additional, Theander, E., additional, Sandhya, P., additional, De Vita, S., additional, Sanchez-Guerrero, J., additional, van der Heijden, E., additional, Moça-Trevisano, V., additional, Wahren-Herlenius, M., additional, Mariette, X., additional, and Ramos-Casals, M., additional
Published: 2016
Full Text: View/download PDF

34. OP0089 Big Data Sjögren Project (Eular-SS Task Force International Network): Characterization at Diagnosis of 5027 Patients with Primary Sjögren Syndrome

Author: Brito Zeron, P., primary, Kostov, B.A., additional, Zeher, M., additional, Theander, E., additional, Gottenberg, J.-E., additional, Baldini, C., additional, Quartuccio, L., additional, Priori, R., additional, Kvarnstrom, M., additional, Kruize, A., additional, Hernández Molina, G., additional, Praprotnik, S., additional, Isenberg, D., additional, Bartoloni, E., additional, Rasmussen, A., additional, Solans, R., additional, Valim, V., additional, Giacomelli, R., additional, Carsons, S., additional, Hammenfors, D., additional, Vollenweider, C., additional, Atzeni, F., additional, Mandl, T., additional, De Vita, S., additional, Wahren-Herlenius, M., additional, Sanchez-Guerrero, J., additional, Gerli, R., additional, Sivils, K., additional, Mowa, S., additional, Brun, J.G., additional, Mariette, X., additional, and Ramos-Casals, M., additional
Published: 2015
Full Text: View/download PDF

35. FRI0419 Big Data Sjogren Project (Eular-SS Task Force International Network): Systemic Involvement at Diagnosis Evaluated by the Essdai in 3314 Patients with Primary Sjögren Syndrome

Author: Brito Zeron, P., primary, Kostov, B.A., additional, Seror, R., additional, Baldini, C., additional, Quartuccio, L., additional, Kvarnstrom, M., additional, Kruize, A., additional, Hernández Molina, G., additional, Praprotnik, S., additional, Bartoloni, E., additional, Solans, R., additional, Theander, E., additional, Valim, V., additional, Priori, R., additional, Zeher, M., additional, Isenberg, D., additional, Rasmussen, A., additional, Giacomelli, R., additional, Carsons, S., additional, Hammenfors, D., additional, Vollenweider, C., additional, Atzeni, F., additional, Mandl, T., additional, De Vita, S., additional, Wahren-Herlenius, M., additional, Sanchez-Guerrero, J., additional, Gerli, R., additional, Sivils, K., additional, Mowa, S., additional, Brun, J.G., additional, Mariette, X., additional, and Ramos-Casals, M., additional
Published: 2015
Full Text: View/download PDF

36. OP0236 Ultrasonography of major salivary glands in primary sjÖgren’s syndrome – correlation with glandular function and minor gland inflammation

Author: Hammenfors, D., primary, Jonsson, R., additional, Brun, J.G., additional, and Jonsson, M.V., additional
Published: 2013
Full Text: View/download PDF

37. INTEGRATION OF SALIVARY-GLAND ULTRASONOGRAPHY IN CLASSIFICATION CRITERIA FOR PRIMARY SJOGREN'S SYNDROME: AN INTERNATIONAL VIGNETTE-BASED STUDY

Author: Jousse-Joulin, S., Gatineau, F., Baldini, C., Arends, S., Barone, F., Baer, A., Bootsma, H., Bowman, S., Brito-Zeron, P., Cornec, D., Dorner, T., De Vita, S., Fisher, B., Hammenfors, D., Jonsson, M., Mariette, X., Milic, V., Nakamura, T., Ng, W. -F., Nowak, E., Rasmussen, A., Seror, R., Shiboski, C., Ramos-Casals, M., Vissink, A., Saraux, A., Devauchelle-Pensec, V., Translational Immunology Groningen (TRIGR), and Personalized Healthcare Technology (PHT)

38. The Big Data Sjögren consortium: A project for a new data science era

Author: Acar-Denizli, N., Kostov, B., Ramos-Casals, M., Brito-Zerón, P., Morcillo, C., Flores-Chávez, A., Ng, F., Horvath, I. -F, Szántó, A., Rasmussen, A., Sivils, K., Scofeld, H., Seror, R., Mariette, X., Mandl, T., Olsson, P., Li, X., Xu, B., Baldini, C., Bombardieri, S., Gottenberg, J. E., Danda, D., Sandhya, P., Quartuccio, L., Corazza, L., Vita, S., Priori, R., Minniti, A., Hernandez-Molina, G., Sánchez-Guerrero, J., Kruize, A. A., Heijden, E., Valim, V., Kvarnstrom, M., Wahren-Herlenius, M., Sene, D., Gerli, R., Bartoloni, E., Praprotnik, S., Isenberg, D., Solans, R., Rischmueller, M., Downie-Doyle, S., Kwok, S-K, Park, S-H, Nordmark, G., Suzuki, Y., Kawano, M., Giacomelli, R., Carubbi, F., Devauchelle-Pensec, V., Saraux, A., Bombardieri, M., Astorri, E., Hofauer, B., Knopf, A., Bootsma, H., Vissink, A., Hammenfors, D., Brun, J. G., Fraile, G., Carsons, S. E., Gheita, T. A., Abd El-Latif, E. M., Khalil, H. M., Morel, J., Vollenveider, C., Atzeni, F., Retamozo, S., Moça Trevisano, V., Armagan, B., Kilic, L., Kalyoncu, U., Nakamura, H., Shimizu, T., Takatani, A., Nakamura, T., Takagi, Y., Sebastian, A., Wiland, P., Pasoto, S. G., Sisó-Almirall, A., Consani-Fernández, S., Sibilia, J., Miceli-Richard, C., Nocturne, G., Benessiano, J., Dieude, P., Dubost, J-J, Fauchais, A-L, Goeb, V., Hachulla, E., Larroche, C., Le Guern, V., Puéchal, X., Perdriger, A., Rist, S., Vittecoq, O., Ravaud, P., Díaz-López, B., Feijoo, C., Pallarés, L., López-Dupla, M., Pérez-Alvarez, R., Ripoll, M., Pinilla, B., Akasbi, M., Maure, B., Fonseca, E., JESUS CANORA, La Red, G., Chamorro, A. J., Jiménez-Heredia, I., Fanlo, P., Guisado-Vasco, P., and Zamora, M.

39. Automating evaluation of salivary gland ultrasound images in PSS patients using the scattered transform algorithm - a pilot study

Author: Hammenfors, D. S., Nes, P. G., Milic, V., Delli, K., Hofauer, B., Baldini, C., Devauchelle-Pensec, V., Theander, E., Brun, J. G., and Jonsson, M. V.

40. ANALYSIS OF 9302 PATIENTS FROM THE BIG DATA INTERNATIONAL PRIMARY SJOGREN SYNDROME COHORT: CLINICAL PRESENTATION AT DIAGNOSIS OF EUROPEAN VS NON-EUROPEAN PATIENTS

Author: Brito-Zeron, P., Acar-Denizli, N., Zeher, M., Rasmussen, A., Seror, R., Mandl, T., Li, X., Baldini, C., Gottenberg, J. -E., Danda, D., Priori, R., Quartuccio, L., Hernandez-Molina, G., Kruize, A.A., Park, S. -H, Kvarnstrom, M., Praprotnik, S., Sene, D., Bartoloni, E., Solans, R., Suzuki, Y., Isenberg, D., Rischmueller, M., Nordmark, G., Fraile, G., Sebastian, A., Vissink, A., Nakamura, T., Valim, V., Giacomelli, R., Devauchelle-Pensec, V., Hofauer, B., Bombardieri, M., Trevisani, V., Hammenfors, D., Carsons, S. E., Pasoto, S. G., Morel, J., Retamozo, S., Gheita, T. A., Atzeni, F., Vollenveider, C., Mariette, X., Ramos-Casals, M., Personalized Healthcare Technology (PHT), and Translational Immunology Groningen (TRIGR)

41. Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: Prevalence and clinical relevance in a large international, multi-ethnic cohort of patients

Author: Retamozo, S., Acar-Denizli, N., Rasmussen, A., Horváth, I. F., Baldini, C., roberta priori, Sandhya, P., Hernandez-Molina, G., Armagan, B., Praprotnik, S., Kvarnstrom, M., Gerli, R., Sebastian, A., Solans, R., Rischmueller, M., Pasoto, S. G., Valim, V., Nordmark, G., Kruize, A., Nakamura, H., Hofauer, B., Giacomelli, R., Trevisani, V. F. M., Devauchelle-Pensec, V., Atzeni, F., Gheita, T. A., Consani-Fernández, S., Szántó, A., Sivils, K., Gattamelata, A., Danda, D., Kilic, L., Bartoloni, E., Bombardieri, S., Sánchez-Guerrero, J., Wahren-Herlenius, M., Mariette, X., Ramos-Casals, M., Brito-Zerón, P., Morcillo, C., Flores-Chávez, A., Ng, F., Zeher, M., Scofield, H., Seror, R., Mandl, T., Olsson, P., Li, X., Xu, B., Gottenberg, J. E., Quartuccio, L., Corazza, L., Vita, S., Colafrancesco, S., Heijden, E., Sene, D., Isenberg, D., Downie-Doyle, S., Kwok, S. -K, Park, S. -H, Suzuki, Y., Kawano, M., Carubbi, F., Saraux, A., Bombardieri, M., Astorri, E., Knopf, A., Bootsma, H., Vissink, A., Hammenfors, D., Brun, J. G., Fraile, G., Carsons, S. E., Abd El-Latif, E. M., Khalil, H. M., Morel, J., Vollenveider, C., Moça Trevisano, V., Kalyoncu, U., Shimizu, T., Takatani, A., Nakamura, T., Takagi, Y., Wiland, P., Kostov, B., Sisó-Almirall, A., Sibilia, J., Miceli-Richard, C., Nocturne, G., Benessiano, J., Dieude, P., Dubost, J. -J, Fauchais, A. -L, Goeb, V., Hachulla, E., Larroche, C., Le Guern, V., Puéchal, X., Perdriger, A., Rist, S., Vittecoq, O., Ravaud, P., Díaz-López, B., Casanovas, A., Pallarés, L., López-Dupla, M., Pérez-Alvarez, R., Ripoll, M., Pinilla, B., Akasbi, M., Maure, B., Fonseca, E., Canora, J., La Red, G., Chamorro, A. J., Jiménez-Heredia, I., Fanlo, P., Guisado-Vasco, P., and Zamora, M.

42. Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases.

Author: Bianchi M, Kozyrev SV, Notarnicola A, Sandling JK, Pettersson M, Leonard D, Sjöwall C, Gunnarsson I, Rantapää-Dahlqvist S, Bengtsson AA, Jönsen A, Svenungsson E, Enocsson H, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Baecklund E, Jonsson R, Hammenfors D, Eriksson P, Mandl T, Omdal R, Padyukov L, Andersson H, Molberg Ø, Diederichsen LP, Syvänen AC, Wahren-Herlenius M, Nordmark G, Lundberg IE, Rönnblom L, and Lindblad-Toh K
Subjects: Humans, Case-Control Studies, Female, Male, Adult, Middle Aged, Autoimmune Diseases genetics, Autoimmune Diseases immunology, Autoantibodies immunology, Autoantibodies blood, Antibodies, Antinuclear immunology, Antibodies, Antinuclear blood, Myositis genetics, Myositis immunology, Sjogren's Syndrome genetics, Sjogren's Syndrome immunology, Lupus Erythematosus, Systemic genetics, Lupus Erythematosus, Systemic immunology
Abstract: Objective: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common features., Methods: We performed targeted DNA sequencing of coding and regulatory regions from approximately 1,900 immune-related genes in a large cohort of 2,292 well-characterized Scandinavian patients with SIADs with SLE, pSS, and myositis as well as 1,252 controls. A gene-based functionally weighted genetic score for aggregate testing of all genetic variants, including rare variants, was complemented by in silico functional analyses and in vitro reporter experiments., Results: Case-control association analysis detected known and potentially novel genetic loci in agreement with previous genetic and transcriptomics findings linked to the SIAD autoimmune background. Intriguingly, case-case comparisons between patient subgroups with and without specific autoantibodies revealed that the subgroups defined by antinuclear antibodies and anti-double-stranded DNA antibodies have unique genetic profiles reflecting their heterogeneity. When focusing on clinical features, we overall showed that dual-specificity phosphatase 1 (DUSP1) protective genetic variants lead to increased gene expression and potentially to anti-inflammatory effects on the SIAD-associated skin phenotype. This is consistent with recent genetic findings on eczema and with the previously reported down-regulation of the MAPK signaling-related gene DUSP1 in other skin disorders., Conclusion: Together, this suggests common molecular mechanisms potentially underlying overlapping clinical manifestations shared among different disorders and informs clinical heterogeneity, which could be translated to improve disease diagnostic and treatment, also in more generalized disease frameworks., (© 2024 The Author(s). Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
Published: 2025
Full Text: View/download PDF

43. Are ultrasound salivary parenchymal lesions more severe in primary Sjögren patients with a longer disease duration? A cross-sectional study.

Author: Tison A, Jousse-Joulin S, Consigny M, Moog P, Hofauer B, Hachulla E, Lamotte C, Morel J, Mouterde G, Milic V, Bootsma H, Stel A, Fisher BA, Maybury M, Baer A, DiRenzo D, Kim HR, Min HK, Lee SS, Choi SE, Alegria GC, Boisramé S, Guellec D, Cornec D, Quéré B, Jonsson M, Hammenfors D, Saraux A, and Devauchelle-Pensec V
Abstract: Objectives: Salivary gland ultrasound (SGUS) has an interest in primary Sjögren's disease (pSD) for diagnosis, but the evolution of parenchymal lesions over time is unknown. The objective of this study was to assess the severity of ultrasound abnormalities in relation to pSD duration from the time of buccal dryness onset., Methods: In this cross-sectional international multicentre study, patients with pSD according to the 2002 or 2016 ACR/EULAR classification criteria were included. Parenchymal abnormalities were classified according to the semiquantitative score as defined by OMERACT. Patients were separated into 4 groups (Group A: < 5 years, Group B: 5-9 years, Group C: 10-20 years, and Group D: > 20 years from the onset of buccal dryness). The association between disease duration groups and SGUS lesions was quantified in terms of odds ratios and 95% confidence intervals., Results: A total of 247 patients were consecutively included between May 2019 and February 2022. Eighty-nine percent of patients had a focus score ≥1/4 mm2, and 85% had positive anti-Ro/SSA. pSD duration was associated with a pathological OMERACT score (score 2 or 3): OR for 5-year duration: 1.23 [95% CI 1.04; 1.47], p= 0.0383). Considering each US item, the only statistical association with pSD duration was found regarding the presence of hyperechoic bands (25% or more): OR for five-year duration 1.18 [95% CI 1.03; 1.36], p= 0.038), independent of an older age., Conclusion: pSD duration was associated with the presence of hyperechoic bands, but not with hypoechoic areas, suggesting a progressive fibro-adipose evolution., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Published: 2024
Full Text: View/download PDF

44. A high polygenic risk score is associated with SSA/SSB antibody positivity and early onset in primary Sjögren's disease.

Author: Fugmann C, Reid S, Pucholt P, Kvarnström M, Björk A, Mofors J, Sjöwall C, Eriksson P, Olsson P, Mandl T, Forsblad-d'Elia H, Magnusson Bucher S, Johnsen SJ, Norheim KB, Appel S, Hammenfors D, Jensen JL, Palm Ø, Omdal R, Jonsson R, Baecklund E, Wahren-Herlenius M, Leonard D, Imgenberg-Kreuz J, and Nordmark G
Abstract: Objectives: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis., Methods: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were available (n = 7742). Two PRSs were constructed, one including HLA gene variants (n = 21 SNVs), and one without HLA (n = 18 SNVs). High PRS quartile (Q4) individuals were compared with low PRS (Q1-3)., Results: A high PRS was associated with SSA antibody positive SjD (OR 9.16, 95% CI 7.75-10.85, p= 3.7x10-146), and strengthened in SjD positive for both SSA/SSB antibodies (OR 13.67, 95% CI 10.88-17.32, p= 4.6x10-108). High PRS classified SSA/SSB antibody positive SjD with very good accuracy (AUC 0.86). PRS without HLA showed a weaker association with SSA/SSB positive SjD (OR 2.09, 95% CI 1.71-2.55, p= 6.4x10-13). Antibody negative SjD displayed a PRS similar to controls. Patients in the high PRS quartile were significantly younger at diagnosis, 48.9 ± 14.9 vs 53.4 ± 13.4 years in the low PRS quartiles (Q1-3), p= 2.2x10-6, and presented higher frequencies of ANA, SSA and SSA/SSB antibodies, p < 1x10-5., Conclusion: A high PRS is associated with SSA/SSB antibody positivity and early disease onset, both largely attributed to the weight of the HLA alleles. Integration of PRS with other biomarkers applied to clinical phenotypes, could be a useful tool for disease risk stratification and treatment decisions., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
Published: 2024
Full Text: View/download PDF

45. Reliability Exercise of Ultrasound Salivary Glands in Sjögren's Disease: An International Web Training Initiative.

Author: Quéré B, Saraux A, Carvajal-Alegria G, Guellec D, Mouterde G, Lamotte C, Hammenfors D, Jonsson M, Choi SE, Hong-Ki M, Stel A, Fisher BA, Maybury M, Hofauer B, Ferro F, Milic V, Direnzo D, Devauchelle-Pensec V, and Jousse-Joulin S
Abstract: Introduction: Major salivary gland ultrasonography (SGUS) demonstrated its good metric properties as an outcome measure for diagnosing primary Sjögren's disease (SD). The objective was to assess SGUS reliability among sonographers with different levels of experience, using web training., Methods: Sonographers from expert centers participated in the reliability exercise. Before exercises, training was done by videoconferencing. Reliability of the two most experienced sonographers (MES) was assessed and then compared to other sonographers. Intra-reader and inter-reader reliability of SGUS items were assessed by computing Cohen's κ coefficients., Results: All sets were read twice by all 14 sonographers within a 4-month interval. Intra-reader reliability of MES was almost perfect for homogeneity, substantial for Outcome Measures in Rheumatology (OMERACT) scoring system (OMERACTss). Among LES (less experienced sonographers), reliability was moderate to almost perfect for homogeneity, fair to moderate for OMERACTss, and fair to almost perfect for binary OMERACTss. Inter-reader reliability between MES was almost perfect for homogeneity, substantial for diagnosis, moderate for OMERACTss, and substantial for binary OMERACTss. Compared to MES, reliabilities of LES were moderate to almost perfect for both homogeneity and diagnosis, only fair to moderate for OMERACTss, but increased in binary OMERACTss., Conclusions: Videoconferencing training sessions in an international reliability exercise could be an excellent tool to train experienced and less-experienced sonographers. SGUS homogeneity items is useful to distinguish normal from abnormal salivary glands parenchyma independently of diagnosis. Structural damage evaluations by OMERACT scoring system is a new comprehensive score to diagnose patients with SD and could be easily used by sonographers in a binary method., (© 2024. The Author(s).)
Published: 2024
Full Text: View/download PDF

46. Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland.

Author: Wiley MM, Khatri B, Joachims ML, Tessneer KL, Stolarczyk AM, Rasmussen A, Anaya JM, Aqrawi LA, Bae SC, Baecklund E, Björk A, Brun JG, Bucher SM, Dand N, Eloranta ML, Engelke F, Forsblad-d'Elia H, Fugmann C, Glenn SB, Gong C, Gottenberg JE, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kelly JA, Khanam S, Kim K, Kvarnström M, Mandl T, Martín J, Morris DL, Nocturne G, Norheim KB, Olsson P, Palm Ø, Pers JO, Rhodus NL, Sjöwall C, Skarstein K, Taylor KE, Tombleson P, Thorlacius GE, Venuturupalli S, Vital EM, Wallace DJ, Grundahl KM, Radfar L, Brennan MT, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Appel S, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner BM, Rischmueller M, Witte T, Farris AD, Mariette X, Shiboski CH, Wahren-Herlenius M, Alarcón-Riquelme ME, Ng WF, Sivils KL, Guthridge JM, Adrianto I, Vyse TJ, Tsao BP, Nordmark G, and Lessard CJ
Abstract: Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chromatin interactions in immune, salivary gland epithelial, and kidney epithelial cells revealed cell type-specific allelic effects for all five SNPs that expanded regulation beyond effects on DDX6 and CXCR5 expression. Mapping the local chromatin regulatory network revealed several additional genes of interest, including lnc-PHLDB1-1 . Collectively, functional characterization implicated the risk alleles of these SNPs as modulators of promoter and/or enhancer activities that regulate cell type-specific expression of DDX6 , CXCR5 , and lnc-PHLDB1-1 , among others. Further, these findings emphasize the importance of exploring the functional significance of SNPs in the context of complex chromatin architecture in disease-relevant cell types and tissues., Competing Interests: Competing Interests C.J.L.* and A.D.F. have an active collaborative research agreement with Janssen. E.B. has an active research collaboration with Pfizer. T.M. is employed as medical solutions lead in rheumatology at UCB. R.H.S. is a consultant for Jansen Pharmaceuticals. S.J.B. provided consultancy services for Abbvie, BMS, Galapagos, Iqvia, J&J, Kiniksa, and Novartis in 2020–2021. L.R. provided consultancy services for AstraZeneca. B.M.W. has active collaborative research agreements with Astellas Bio and Pfizer, Inc. M.R. received grants from Amgen, AstraZeneca, Bristol Myers-Squibb, Novartis, and Servier for clinical trials in Sjögren’s Syndrome and SLE. All other authors have reported that they have no competing interests to report.
Published: 2023
Full Text: View/download PDF

47. Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.

Author: Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, Shiboski CH, Wahren-Herlenius M, Ng WF, Sivils KL, Adrianto I, Nordmark G, and Lessard CJ
Published: 2023
Full Text: View/download PDF

48. Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome.

Author: Lundtoft C, Sjöwall C, Rantapää-Dahlqvist S, Bengtsson AA, Jönsen A, Pucholt P, Wu YL, Lundström E, Eloranta ML, Gunnarsson I, Baecklund E, Jonsson R, Hammenfors D, Forsblad-d'Elia H, Eriksson P, Mandl T, Bucher S, Norheim KB, Auglaend Johnsen SJ, Omdal R, Kvarnström M, Wahren-Herlenius M, Truedsson L, Nilsson B, Kozyrev SV, Bianchi M, Lindblad-Toh K, Yu CY, Nordmark G, Sandling JK, Svenungsson E, Leonard D, and Rönnblom L
Subjects: Humans, Complement Pathway, Classical, DNA Copy Number Variations, Complement System Proteins genetics, Hereditary Complement Deficiency Diseases, Complement C4 genetics, Sjogren's Syndrome genetics, Lupus Erythematosus, Systemic
Abstract: Objective: Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary Sjögren's syndrome (SS) has not been studied systematically. This study was undertaken to investigate potential associations of heterozygous C2 deficiency and C4 copy number variation with clinical manifestations in patients with SLE and patients with primary SS., Methods: The presence of the common 28-bp C2 deletion rs9332736 and C4 copy number variation was examined in Scandinavian patients who had received a diagnosis of SLE (n = 958) or primary SS (n = 911) and in 2,262 healthy controls through the use of DNA sequencing. The concentration of complement proteins in plasma and classical complement function were analyzed in a subgroup of SLE patients., Results: Heterozygous C2 deficiency-when present in combination with a low C4A copy number-substantially increased the risk of SLE (odds ratio [OR] 10.2 [95% confidence interval (95% CI) 3.5-37.0]) and the risk of primary SS (OR 13.0 [95% CI 4.5-48.4]) when compared to individuals with 2 C4A copies and normal C2. For patients heterozygous for rs9332736 with 1 C4A copy, the median age at diagnosis was 7 years earlier in patients with SLE and 12 years earlier in patients with primary SS when compared to patients with normal C2. Reduced C2 levels in plasma (P = 2 × 10 -9 ) and impaired function of the classical complement pathway (P = 0.03) were detected in SLE patients with heterozygous C2 deficiency. Finally, in a primary SS patient homozygous for C2 deficiency, we observed low levels of anti-Scl-70, which suggests a risk of developing systemic sclerosis or potential overlap between primary SS and other systemic autoimmune diseases., Conclusion: We demonstrate that a genetic pattern involving partial deficiencies of C2 and C4A in the classical complement pathway is a strong risk factor for SLE and for primary SS. Our results emphasize the central role of the complement system in the pathogenesis of both SLE and primary SS., (© 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.)
Published: 2022
Full Text: View/download PDF

49. Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.

Author: Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, Shiboski CH, Wahren-Herlenius M, Ng WF, Sivils KL, Adrianto I, Nordmark G, and Lessard CJ
Published: 2022
Full Text: View/download PDF

50. Aberrant signaling of immune cells in Sjögren's syndrome patient subgroups upon interferon stimulation.

Author: Sarkar I, Davies R, Aarebrot AK, Solberg SM, Petrovic A, Joshi AM, Bergum B, Brun JG, Hammenfors D, Jonsson R, and Appel S
Subjects: Female, Humans, Interferon-alpha metabolism, Signal Transduction physiology, T-Lymphocytes metabolism, Leukocytes, Mononuclear metabolism, Sjogren's Syndrome
Abstract: Background: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity and lack of knowledge regarding its pathogenesis makes pSS a difficult disease to manage., Methods: An exploratory analysis using mass cytometry was conducted of MAPK/ERK and JAK/STAT signaling pathways in peripheral blood mononuclear cells (PBMC) from 16 female medication free pSS patients (8 anti-Sjögren's syndrome-related antigen A negative/SSA- and 8 SSA+) and 8 female age-matched healthy donors after stimulation with interferons (IFNs)., Results: We found significant differences in the frequencies of memory B cells, CD8+ T central and effector memory cells and terminally differentiated CD4+ T cells among the healthy donors and patient subgroups. In addition, we observed an upregulation of HLA-DR and CD38 in many cell subsets in the patients. Upon IFNα2b stimulation, slightly increased signaling through pSTAT1 Y701 was observed in most cell types in pSS patients compared to controls, while phosphorylation of STAT3 Y705 and STAT5 Y694 were slightly reduced. IFNγ stimulation resulted in significantly increased pSTAT1 Y701 induction in conventional dendritic cells (cDCs) and classical and non-classical monocytes in the patients. Most of the observed differences were more prominent in the SSA+ subgroup, indicating greater disease severity in them., Conclusions: Augmented activation status of certain cell types along with potentiated pSTAT1 Y701 signaling and reduced pSTAT3 Y705 and pSTAT5 Y694 induction may predispose pSS patients, especially the SSA+ subgroup, to upregulated expression of IFN-induced genes and production of autoantibodies. These patients may benefit from therapies targeting these pathways., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sarkar, Davies, Aarebrot, Solberg, Petrovic, Joshi, Bergum, Brun, Hammenfors, Jonsson and Appel.)
Published: 2022
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

79 results on '"Hammenfors, D."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources