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For a malaria elimination strategy, Haiti’s National Malaria Control Program piloted a mass drug administration (MDA) with indoor residual spraying (IRS) in 12 high-transmission areas across five communes after implementing community case management and strengthened surveillance. The MDA distributed sulfadoxine–pyrimethamine and single low-dose primaquine to eligible residents during house visits. The IRS campaign applied pirimiphos–methyl insecticide on walls of eligible houses. Pre- and post-campaign cross-sectional surveys were conducted to assess acceptability, feasibility, drug safety, and effectiveness of the combined interventions. Stated acceptability for MDA before the campaign was 99.2%; MDA coverage estimated at 10 weeks post-campaign was 89.6%. Similarly, stated acceptability of IRS at baseline was 99.9%; however, household IRS coverage was 48.9% because of the high number of ineligible houses. Effectiveness measured by Plasmodium falciparum prevalence at baseline and 10 weeks post-campaign were similar: 1.31% versus 1.43%, respectively. Prevalence of serological markers were similar at 10 weeks post-campaign compared with baseline, and increased at 6 months. No severe adverse events associated with the MDA were identified in the pilot; there were severe adverse events in a separate, subsequent campaign. Both MDA and IRS are acceptable and feasible interventions in Haiti. Although a significant impact of a single round of MDA/IRS on malaria transmission was not found using a standard pre- and post-intervention comparison, it is possible there was blunting of the peak transmission. Seasonal malaria transmission patterns, suboptimal IRS coverage, and low baseline parasitemia may have limited the effectiveness or the ability to measure effectiveness.

Additional file 3. Bivariate association between exposure to tMDA in 2018 and fourfold increases (or fourfold decreases) in MFI in 2018 compared to 2017.

Additional file 1. Changes in individuals’ normalized antibody concentration level for five P. falciparum antigens (2018 vs. 2017, by exposure group). Antibody concentration level is expressed by the median fluorescence intensity (MFI) after log-transformation and standardization between years for titre concentration. Mean individual changes between 2017 (pre-MDA) and 2018 (post-MDA) are displayed by the linear regression coefficients.

Additional file 2. Effects of tMDA on antibody concentration levels using logistic regression models with fixed effects at the individual level.

Trabajo presentado en el World Aquaculture 2012, celebrado en Praga del 1 al 5 de septiembre de 2012.

Skeletogenesis is a continuous process occurring during fish larval development that is influenced by vitamin K VK, an essential factor for the correct formation of coagulation factors and skeletal matrix proteins. High levels of skeletal deformities are recorded in most commonly cultured species like the sparids, sea bass and flatfish like the Senegalese sole. The appearance of malformations takes place during the larval stages, when skeletal structures are forming. This work was funded by project PDTC-MAR-105152-2008 (SPECIAL K) from the Foundation of Science and Technology.

Reliable juvenile production or recruitment requires high numbers of healthy fish larvae. Despite considerable progress in marine fish farming in the past 20 years, juvenile fish production is still fraught with problems which arise during the larval phase. In fisheries, juvenile recruitment in some populations has not recovered despite long-term moratoria on captures and protection of the broodstock. These issues highlight the growing importance of multidisciplinary fish larval research.