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11 results on '"Hamzaoğlu, Kübra"'

1. Evaluation of serum levels of soluble vascular endothelial (sVE)-Cadherin in early- and late-onset preeclampsia serum sVE-Cadherin levels in preeclampsia.

Author

Acikgöz, Abdullah Serdar, Gök, Koray, Tüten, Abdullah, Kaya, Barış, Hamzaoğlu, Kübra, Kolomuç Gayretli, Tuğba, Malik, Eduard, and Güralp, Onur

Subjects
DIASTOLIC blood pressure, PREGNANT women, SYSTOLIC blood pressure, ENDOTHELIUM diseases, PREECLAMPSIA
Abstract

Objective: Endothelial dysfunction is a major feature of preeclampsia. sVE-cadherin plays a role in the preservation and regulation of the endothelial barrier. For that reason, to evaluation of sVE-cadherin may help elucidate the disease pathophysiology of preeclampsia. Methods: The sample size was calculated as a minimum of 46 pregnant women for each group based on serum sVE-Cadherin levels in a pilot study of 10 preeclamptic and 10 control groups. Hundred-twenty pregnancies complicated with early-onset (n = 60) and late-onset (n = 60) preeclampsia were compared with 120 gestational-age (GA)-matched (±1 week) uncomplicated pregnancies. The venous blood sampling was performed upon preeclampsia diagnosis prior to the onset of the labor in the preeclampsia group and the matching (±1 week) pregnancy week in the control group. Demographic and biochemical parameters were evaluated. Results: Mean serum sVE-Cadherin was significantly higher in women with EOPE compared to that of the GA-matched control group (5.86 ± 1.57 ng/mL vs. 2.28 ± 0.80 ng/mL, p < 0.001), in women with LOPE compared to that of the GA-matched control group (3.11 ± 0.97 ng/mL vs. 1.69 ± 0.87 ng/mL, p < 0.001), and in women with EOPE compared to that of LOPE group (5.86 ± 1.57 ng/mL vs. 3.11 ± 0.97 ng/mL, p < 0.001) after correction for GA. Serum sVE-Cadherin positively correlated with systolic and diastolic blood pressure and a negative correlation with gestational age at sampling. Conclusion: The serum level of sVE-Cadherin was higher in women with preeclampsia than that of GA-matched healthy pregnant women, in women with EOPE compared to that of LOPE. sVE-Cadherin is an important marker in early-onset pre-eclampsia with severe clinical findings. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Incidence and Risk Factors of Venous Thromboembolism in Patients Undergoing Surgery for Gynecologic Malignancies.

Author

Turan, Hasan, Kahramanoğlu, İlker, Alakbarova, Ulviyya, Hamzaoğlu, Kübra, Beşe, Tugan, Arvas, Macit, and Demirkıran, Fuat

Subjects
THROMBOEMBOLISM, GYNECOLOGIC surgery, LYMPHADENECTOMY, LOW-molecular-weight heparin, SURGICAL complications, CHRONIC kidney failure, GYNECOLOGIC oncology
Abstract

Introduction: A potentially fatal complication of gynecological cancer surgery is venous thromboembolism (VTE). Low-molecular-weight heparin prophylaxis does not reduce the risk of VTE. This research determined the incidence of VTE and to identify the risk factors in patients having surgery for gynecological malignancy with extended dual prophylaxis. Methods: In this retrospective cohort study, all patients with gynecological cancer undergone surgery at the Division of Gynecologic Oncology of İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine were identified between January 2008 and April 2018. Age, body mass index (BMI), menopausal status, comorbidities, the primary site of the neoplasm in gynecology, surgical details, and operative time, the need for intensive care unit admission, perioperative complications, the patient's smoking habits, the diagnosis of VTE, and follow-up assessments up to one month after surgery were among the data collected. Results: With a 2.4% incidence rate, 29 of 1,201 analyzed patients experienced postoperative VTE events. BMI >30, operation duration >180 min, paraaortic and/or pelvic lymphadenectomy, neoadjuvant chemotherapy, smoking, and chronic renal failure were revealed to be significant variables [odds ratio (OR): 5.357; 95% confidence interval (CI): 1.833-15.654; p=0.002; OR: 5.698; 95% CI: 1.971-16.474; p=0.001; OR: 0.252; 95% CI: 0.068-0.933; p=0.039; OR: 0.002; 95% CI: 0.001-0.025; p=0.001; OR: 0.217; 95% CI: 0.082-0.577; p=0.002; OR: 0.033; 95% CI: 0.003-0.379; p=0.006, respectively]. Conclusion: We suggest that every patient undergoing gynecological oncology surgery should have preoperative pharmacological and postoperative extended dual prophylaxis to achieve the lowest incidence of VTE in this group. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Conservative management of 11 weeks old cervical ectopic pregnancy with transvaginal ultrasound-guided combined methotrexate injection: Case Report and Literature Review

Author

Özçivit, İpek Betül, Cepni, İsmail, Hamzaoğlu, Kübra, Erenel, Hakan, Madazlı, Rıza, and İÜC, Cerrahpaşa Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü

Subjects
Combined methotrexate, Transvaginal ultrasound guided aspiration, Cervical ectopic pregnancy
Abstract

OZCIVIT, IPEK BETUL/0000-0002-5645-7064; HAMZAOGLU, KUBRA/0000-0002-7965-8301 WOS:000519990600054 PubMed ID: 32066111 INTRODUCTION: The ultimate treatment approach for cervical ectopic pregnancy remains controversial. Gestational age, serum p-hCG levels, fetal cardiac activity presence and the patient's claim for fertility preservation are the major challenges for method of choice in each individual case. Medical treatment may be a favorable option for the treatment of late diagnosed cases, as well as the early ones. PRESENTATION OF CASE: In this case report, we aim to present a case of 10 4/7 weeks of cervical ectopic pregnancy successfully treated with transvaginal ultrasound-guided local and systemic methotrexate injection. DISCUSSION: The case presented here is exceptional because even though the advanced gestational age, presence of fetal cardiac activity and high serum p-hCG values, the abortion has occurred successfully. Conservative treatment without any need of further surgical intervention was sufficient for full recovery with the preservation of reproductive capacity. CONCLUSION: In conclusion, transvaginal ultrasound guided local and systemic methotrexate injection may be performed successfully for the cases of advanced gestational age with fetal cardiac activity and high serum p-hCG levels. (C) 2020 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.

Published
2020

9. Pregnancy Outcomes of 115 Cases With Maternal Heart Disease

Author

Özel, Ayşegül, Hamzaoğlu, Kübra, Durmaz, Eser, Madazlı, Rıza, and İÜC

Subjects
Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Mikrobiyoloji, Kalp ve Kalp Damar Sistemi, Endokrinoloji ve Metabolizma, Nörolojik Bilimler, Anestezi, Biyofizik, Klinik Nöroloji, Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme, Üroloji ve Nefroloji, Solunum Sistemi, Transplantasyon, Acil Tıp, Androloji, Kulak, Burun, Boğaz, Halk ve Çevre Sağlığı, Anatomi ve Morfoloji, Sağlık Bilimleri ve Hizmetleri, Enfeksiyon Hastalıkları, Patoloji, Geriatri ve Gerontoloji, Genel ve Dahili Tıp, Dermatoloji, Cerrahi, Fizyoloji, Göz Hastalıkları, Alerji, Odyoloji ve Konuşma-Dil Patolojisi, Hücre Biyolojisi, İmmünoloji, Tıbbi Araştırmalar Deneysel, Kadın Hastalıkları ve Doğum, Onkoloji, Periferik Damar Hastalıkları, Psikiyatri, Adli Tıp, Pediatri, Ortopedi, Gastroenteroloji ve Hepatoloji, Hematoloji, Rehabilitasyon, Biyokimya ve Moleküler Biyoloji, Yoğun Bakım, Tıp, Romatoloji, Biyoloji
Abstract

Objective: To evaluate the outcomes of pregnancies with maternal heart disease. Material and Method: the results of 115 patients in our clinic between 2013 and 2018 were retrospectively analyzed. the type of heart disease and functional classification of the New York Heart Association were taken into consideration when evaluating the cases. Results: According to the New York Heart Association classification, the distribution of patients was 67.1% for stage I, 18.2% for stage II, and 14.7% for stage III–IV. There was no maternal or perinatal mortality. the incidence of rheumatic and congenital heart diseases was 51.3% and 27.8%, respectively. Maternal morbidity was observed in 18 cases (15.6%). Mean gestational age and birth weight were significantly higher in the stage I–II functional capacity group (p0.05). Conclusion: It is possible to obtain satisfactory results for both mother and fetus in the majority of pregnant women with heart disease when managed with a multidisciplinary approach. Amaç: Maternal kalp hastalığı bulunan gebeliklerin sonuçlarını değerlendirmek. Gereç ve Yöntem: 2013-2018 yılları arasında bir kliniğimizdeki 115 maternal kalp hastalığı olan olgunun sonuçları retrospektif olarak incelenmiştir. Olgular değerlendirilirken kalp hastalıklarının türü ve New York Kalp Derneği’nin fonksiyonel sınıflaması göz önünde bulundurulmuştur. Bulgular: New York Kalp Derneği sınıflamasına göre hastaların dağılımı evre I için %67,1, evre II için %18,2, evre III–IV için ise %14,7 idi. Maternal ya da perinatal mortalite saptanmadı. Romatizmal ve konjenital kalp hastalıklarının görülme oranı sırasıyla %51,3 ve %27,8 olarak bulundu. Maternal morbidite 18 olguda (%15,6) gözlendi. Ortalama doğum haftası ve doğum kilosu evre I–II fonksiyonel kapasiteli grupta belirgin yüksekti (p0,05). Sonuç: Multidisipliner bir yaklaşımla yönetildiğinde kalp hastalığı bulunan gebelerin çoğunluğunda hem anne hem fetüs için memnun edici sonuçların alınması mümkündür.

Published
2020
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10. Biyokimyasal (sıcam soluble interselüler adezyon molekülü-sıvam (intra vasküler adezyon molekülü) - se- selectin (soluble E-selektin)- pentraxin -3) ve biyofiziksel (collum uzunluğu, uteroservikal açı,myometrium kalınlığı) parametrelerin erken doğum öngörüsündeki yeri

Author

Hamzaoğlu, Kübra, Madazlı, Rıza, and Kadın Hastalıkları ve Doğum Anabilim Dalı

Subjects
Obstetrics and Gynecology, Kadın Hastalıkları ve Doğum
Abstract

AMAÇ: Erken doğum tehdidi (EDT) olan gebelerde sVCAM-1, sICAM-1, sE-Selektin, pentraxin-3, myometriyal kalınlık, uteroservikal açı ve servikal uzunluğunun erken doğum öngörüsündeki yerini belirlemek.MATERYAL-METOD: 2018-2019 tarihleri arasında erken doğum tehditi nedeniyle yatırılan 46 gebe çalışma grubunu, EDT bulguları olmayan 47 gebe ise kontrol grubunu oluşturdu. Erken doğum tehdidi tanısı alan gebeler sonuçlarına göre iki gruba ayrıldı: 34.gebelik haftasından önce doğuran 16 gebe 'gerçek erken doğum tehdidi grubu', 34.gebelik haftasından sonra doğuran 30 gebe ise 'yalancı erken doğum tehdidi grubu' olarak adlandırıldı. Belirtilen biyokimyasal ve biyofiziksel özelliklerin erken doğum öngörüsündeki etkinlikleri değerlendirildi.BULGULAR: Gerçek EDT ve yalancı EDT gruplarının servikal uzunluk ölçümleri arasında anlamlı fark gözlenmedi (20.6 ±4.2 mm ve 17.3±6.0 mm sırasıyla, p>0.05). Ortalama myometrial kalınlık ölçümü gerçek EDT grubunda (9.3 ±1.7 mm), yalancı EDT (8.5 ±1.9 mm) ve kontrol grubuna göre (7.8 ±2.1 mm) anlamlı olarak daha yüksek saptandı (p= 0.029). s ICAM-1 ve sVCAM-1 ' in ortalama median değerileri EDT grubunda kontrol grubuna göre anlamlı olarak daha yüksek bulundu ( p 0.05). The mean myometrial thickness was significantly higher in the true-PTL group (9.3 ± 1.7 mm) than the false-PTL (8.5 ± 1.9 mm) and control groups (7.8 ± 2.1 mm) (p = 0.029). The mean median values of sICAM1 and sVCAM1 were notably higher in PTL group than in control group (p

Published
2019

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