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147 results on '"Han, Jian-Feng"'

2. Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses

Author

Jiang, Tao, Jiang, Jia-Fu, Deng, Yong-Qiang, Jiang, Bao-Gui, Fan, Hang, Han, Jian-Feng, Hu, Yi, Zhuang, Dao-Min, Kargbo, David, An, Xiao-Ping, Mi, Zhi-Qiang, Zhao, Guang-Yu, Xin, Wen-Wen, Tan, Ya-Fang, He, Jun, Gao, Rong-Bao, Wang, Hong, Chen, Cao, Wang, Feng, Li, Chun-Xiao, Zhao, Jian-Jun, Cui, Yu-Jun, Bei, Zhu-Chun, Zhang, Ke, Shang, Xue-Yi, Zhang, Wen-Hui, Pei, Guang-Qian, Wang, Yun-Fei, Wang, Wei, Shu, Peng, Liu, Wen-Li, Cheng, Shi, Zhu, Shun-Ya, Kanu, Alex, Kargbo, Brima, Gao, Bo, Tong, Yi-Gang, Fang, Tong-Yu, and Cao, Wu-Chun

Published
2017

13. A new DOA estimation algorithm based on compressed sensing

Author

Han Jian-Feng, Zhang Liyi, Ban Zhe, Yang Yi, and Zhang Yong

Subjects
Matrix (mathematics), Compressed sensing, Redundancy (information theory), Computer Networks and Communications, Direction finding, Computer science, 0202 electrical engineering, electronic engineering, information engineering, 020206 networking & telecommunications, 020201 artificial intelligence & image processing, 02 engineering and technology, Algorithm, Software
Abstract

Considering the computational complexity and redundancy of traditional array signal arrival angle (DOA) estimation algorithms, the compressed sensing technology was used to improve the real-time and accurate performance of the DOA estimation algorithm, in which, the space sparse signals were reconstructed from the array data by means of array manifold matrix. Compared with the classical MUSIC algorithm, the compressed sensing DOA estimation method could effectively improve the direction finding accuracy and angle resolution with low SNR and snapshot deficiency. Moreover, the proposed algorithm could achieve the coherent signal estimation correctly, and the simulation results show that its performance was superior to that of traditional algorithm.

Published
2018

14. An indoor gas leakage source localization algorithm using distributed maximum likelihood estimation in sensor networks

Author

Ban Zhe, Zhang Liyi, Yang Yi, Zhang Yong, and Han Jian-Feng

Subjects
Pollution, Turbulent diffusion, General Computer Science, Computer science, Maximum likelihood, media_common.quotation_subject, 020206 networking & telecommunications, Computational intelligence, 02 engineering and technology, 010501 environmental sciences, 01 natural sciences, Environmental monitoring, 0202 electrical engineering, electronic engineering, information engineering, Motion planning, Likelihood function, Algorithm, Wireless sensor network, 0105 earth and related environmental sciences, Leakage (electronics), media_common
Abstract

Gas leakage source localization based on sensor networks has an important practical significance in many fields such as environmental monitoring, security protection and pollution control. This paper proposed a gas leakage source localization algorithm using distributed maximum likelihood estimation method for mobile sensor network to improve the lower performance with static sensor network. Firstly, the likelihood function of gas leakage source parameters was deduced based on the gas turbulent diffusion model. Then, the parameters of gas leakage source were estimated based on the likelihood function with the gas concentration measurement in environment. Finally, the gas leakage source location would be achieved through the iterative optimization of the likelihood function. The preliminary experimental results show that the proposed distributed Maximum Likelihood Estimation method could be achieved an acutely gas leakage source location in an indoor environment. And the reasonable path planning and dynamic topology changing could improve the positioning performance.

Published
2017

17. Recombination of human coxsackievirus B5 in hand, foot, and mouth disease patients, China

Author

Han, Jian-Feng, Jiang, Tao, Fan, Xing-Liang, Yang, Li-Ming, Yu, Man, Cao, Rui-Yuan, Wang, Jun-Zhi, Qin, E.-De, and Qin, Cheng-Feng

Subjects
Coxsackievirus infections -- Risk factors -- Diagnosis -- Research, Genetic recombination -- Research, Health
Abstract

To the Editor: Hand, foot, and mouth disease (HFMD) is an acute viral infectious disease in infants and young children. However, since 2008, HFMD has emerged as a major public [...]

Published
2012
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19. Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo

Author

Qin E-De, Jiang Tao, Tian Xue, Deng Yong-Qiang, Cao Rui-Yuan, Han Jian-Feng, and Qin Cheng-Feng

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Human enterovirus 71 (EV71) has emerged as a significant cause of acute encephalitis and deaths in young children. The clinical manifestations caused by EV71 varied from mild hand, foot and mouth disease to severe neurological complications and deaths, but its pathogenesis remains elusive. Antibody dependent enhancement (ADE) infection has been reported in various viruses and has been shown to contribute to disease severity. Results In this study, the presence of sub-neutralizing antibody was demonstrated to enhance EV71 infection in THP-1 cells and increase the mortality of EV71 infection in a suckling mouse model. Further, a secondary infection model was established to characterize the correlation between ADE and disease severity, and primary asymptomatic EV71 infection was shown to increase the mortality of the secondary EV71 infection in suckling mice. Conclusions Together, these in vitro and in vivo experiments strongly supported the hypothesis of ADE infection of EV71. The present findings indicate ADE might contribute to the pathogenesis of severe EV71 infection, and raise practical issues of vaccine development and antibody-based therapy.

Published
2011
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20. Producing infectious enterovirus type 71 in a rapid strategy

Author

Qin E-De, Yu Man, Tian Xue, Cao Rui-Yuan, Han Jian-Feng, and Qin Cheng-Feng

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Enterovirus 71 (EV71) is an etiologic agent of hand-foot-and-mouth disease (HFMD), and recent HFMD epidemics worldwide have been associated with a severe form of brainstem encephalitis associated with pulmonary edema and high case-fatality rates. EV71 contains a positive-sense single-stranded genome RNA of approximately 7400 bp in length which encodes a polyprotein with a single open reading frame (ORF), which is flanked by untranslated regions at both the 5' and 3' ends. Results A long distance RT-PCR assay was developed to amplify the full length genome cDNA of EV71 by using specific primes carrying a SP6 promoter. Then the in vitro synthesized RNA transcripts from the RT-PCR amplicons were then transfected into RD cells to produce the rescued virus. The rescued virus was further characterized by RT-PCR and indirect fluorescent-antibody (IFA) assay in comparison with the wild type virus. The rescued viruses were infectious on RD cells and neurovirulent when intracerebrally injected into suckling mice. Conclusions Thus, we established a rapid method to produce the infectious full length cDNA of EV71 directly from RNA preparations and specific mutations can be easily engineered into the rescued enterovirus genome by this method.

Published
2010
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21. Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis

Author

Gao,Fan, Chen,Chen, Lyu,Jun, Zheng,Jie, Ma,Xian-Cang, Yuan,Xing-Yun, Huo,Kang, Han,Jian-Feng, Gao,Fan, Chen,Chen, Lyu,Jun, Zheng,Jie, Ma,Xian-Cang, Yuan,Xing-Yun, Huo,Kang, and Han,Jian-Feng

Abstract

Fan Gao,1 Chen Chen,2 Jun Lyu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Purpose: The platelet distribution width (PDW) reflects the status of platelet activity and may be useful for early predictions of the clinical outcome of stroke patients. The purpose of the study was to determine the associations between PDW and clinical outcomes after intravenous thrombolysis in stroke patients. Patients and methods: Acute ischemic stroke patients who received intravenous treatment with recombinant tissue-type plasminogen activator were selected for inclusion in the retrospective cohort of this study. The relations between PDW at admission and clinical outcomes were analyzed, including a poor outcome as assessed using the modified Rankin Scale at 3 months, early neurological improvement, and any hemorrhage. The effect of PDW at admission on a poor outcome at 3 months was analyzed using a multivariable logistic regression model with adjustment for potential confounders. The optimal PDW cutoff for predicting poor outcome at 3 months was determined by analyzing the receiver operating characteristics curve. Results: PDW was significantly higher for a good outcome than a poor outcome (p=0.005), with median (interquartile range) values of 16.2 (13.2–17.2) and 13.6 (12.5–15.9), respectively. PDW was also higher in patients with early neurological improvement than in patients without improvement (p=0.020) and did not differ between hemorrhage and nonhemorrhage pa

Published
2018

23. Characterization of cis -Acting RNA Elements of Zika Virus by Using a Self-Splicing Ribozyme-Dependent Infectious Clone

Author

Liu, Zhong-Yu, primary, Yu, Jiu-Yang, additional, Huang, Xing-Yao, additional, Fan, Hang, additional, Li, Xiao-Feng, additional, Deng, Yong-Qiang, additional, Ji, Xue, additional, Cheng, Meng-Li, additional, Ye, Qing, additional, Zhao, Hui, additional, Han, Jian-Feng, additional, An, Xiao-Ping, additional, Jiang, Tao, additional, Zhang, Bo, additional, Tong, Yi-Gang, additional, and Qin, Cheng-Feng, additional

Published
2017
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24. De Ritis ratio (AST/ALT) as an independent predictor of poor outcome in patients with acute ischemic stroke

Author

Gao,Fan, Chen,Chen, Lu,Jun, Zheng,Jie, Ma,Xian-Cang, Yuan,Xing-Yun, Huo,Kang, Han,Jian-Feng, Gao,Fan, Chen,Chen, Lu,Jun, Zheng,Jie, Ma,Xian-Cang, Yuan,Xing-Yun, Huo,Kang, and Han,Jian-Feng

Abstract

Fan Gao,1 Chen Chen,2 Jun Lu,1 Jie Zheng,1 Xian-Cang Ma,1,3 Xing-Yun Yuan,2 Kang Huo,2 Jian-Feng Han2 1Clinical Research Center, 2Department of Neurology, 3Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Purpose: The aspartate transaminase/alanine transaminase ratio (De Ritis ratio, AAR) was reported to be associated with patients’ prognosis in certain diseases recently. The objective of the current study was to determine the association between the AAR at admission and poor outcome at 3 months in acute ischemic stroke (AIS) patients.Patients and methods: This retrospective cohort study included patients who experienced their first-ever AIS between June 2015 and March 2016. The primary outcome measure was a poor outcome at 3 months (modified Rankin Scale score >2). Multivariate logistic regression models were used to assess the relationship between AAR quartiles and clinical outcomes among the AIS patients. Receiver operating characteristic curve analysis was applied to identify the optimal cutoff for AAR in predicting the prognosis of AIS.Results: In terms of the relationship between poor outcome and AAR, the adjusted odds ratio comparing the highest and lowest AAR quartiles was 2.15 (95% confidence interval =1.14–4.05). An AAR of 1.53 was identified as the optimal cutoff. In a prespecified subgroup analysis according to the time from symptom onset to treatment (>24 vs ≤24 hours), there was no significant difference in the effect of AAR >1.53 between the two groups.Conclusion: An increased AAR at admission is significantly associated with a poor outcome at 3 months in AIS patients. Keywords: De Ritis ratio, stroke, prognosis, aspartate transaminase, alanine transaminase, modified Rankin scale, poor outcome

Published
2017

31. Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice

Author

Zhao, Hui, primary, Li, Hao-Yang, additional, Han, Jian-Feng, additional, Deng, Yong-Qiang, additional, Zhu, Shun-Ya, additional, Li, Xiao-Feng, additional, Yang, Hui-Qin, additional, Li, Yue-Xiang, additional, Zhang, Yu, additional, Qin, E-De, additional, Chen, Rong, additional, and Qin, Cheng-Feng, additional

Published
2015
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35. Parallel mRNA and MicroRNA Profiling of HEV71-Infected Human Neuroblastoma Cells Reveal the Up-Regulation of miR-1246 in Association with DLG3 Repression

Author

Xu, Li-Juan, primary, Jiang, Tao, additional, Zhao, Wei, additional, Han, Jian-Feng, additional, Liu, Juan, additional, Deng, Yong-Qiang, additional, Zhu, Shun-Ya, additional, Li, Yue-Xiang, additional, Nian, Qing-Gong, additional, Zhang, Yu, additional, Wu, Xiao-Yan, additional, Qin, E-De, additional, and Qin, Cheng-Feng, additional

Published
2014
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39. Human IgG Subclasses against Enterovirus Type 71: Neutralization versus Antibody Dependent Enhancement of Infection

Author

Cao, Rui-Yuan, primary, Dong, Da-Yong, additional, Liu, Rui-Ju, additional, Han, Jian-Feng, additional, Wang, Guang-Chuan, additional, Zhao, Hui, additional, Li, Xiao-Feng, additional, Deng, Yong-Qiang, additional, Zhu, Shun-Ya, additional, Wang, Xiao-Yu, additional, Lin, Fang, additional, Zhang, Fu-Jun, additional, Chen, Wei, additional, Qin, E-De, additional, and Qin, Cheng-Feng, additional

Published
2013
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49. Parallel mRNA and MicroRNA Profiling of HEV71-Infected Human Neuroblastoma Cells Reveal the Up-Regulation of miR-1246 in Association with DLG3 Repression.

Author

Xu, Li-Juan, Jiang, Tao, Zhao, Wei, Han, Jian-Feng, Liu, Juan, Deng, Yong-Qiang, Zhu, Shun-Ya, Li, Yue-Xiang, Nian, Qing-Gong, Zhang, Yu, Wu, Xiao-Yan, Qin, E-De, and Qin, Cheng-Feng

Subjects
MESSENGER RNA, MICRORNA, NEUROBLASTOMA, GENETIC regulation, ETIOLOGY of diseases, GENE expression
Abstract

Human enterovirus 71 (HEV71) has emerged as the leading cause of viral encephalitis in children in most Asian countries. The roles of host miRNAs in the neurological pathogenesis of HEV71 infection remain unknown. In the present study, comprehensive miRNA expression profiling in HEV71-infected human neuroblastoma SH-SY5Y cells was performed using the Affymetrix Gene Chip microarray assay and was validated using real-time RT-PCR. Among the 69 differentially expressed miRNAs, miR-1246 was specifically induced by HEV71 infection in human neuroblastoma cells, but inhibition of miR-1246 failed to affect HEV71 replication. Parallel mRNA and microRNA profiling based on the 35 K Human Genome Array identified 182 differentially regulated genes. Target prediction of miR-1246 and network modeling revealed 14 potential target genes involved in cell death and cell signaling. Finally, a combined analysis of the results from mRNA profiling and miR-1246 target predication led to the identification of disc-large homolog 3 (DLG3), which is associated with neurological disorders, for further validation. Sequence alignment and luciferase reporter assay showed that miR-1246 directly bound with the 3′-UTR of DLG3 gene. Down-regulation of miR-1246 induced significant changes in DLG3 expression levels in HEV71-infected SHSY5Y cells. Together, these results suggested that miR-1246 might play a role in neurological pathogenesis of HEV71 by regulating DLG3 gene in infected cells. These findings provide new information on the miRNA and mRNA profiles of HEV71-infected neuroblastoma cells. The biological significance of miR-1246 and DLG3 during the course of HEV71 infection deserves further investigation. [ABSTRACT FROM AUTHOR]

Published
2014
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