1. Aging and acupuncture effects on hippocampal gene expression profile of SAMP10
- Author
-
Han, Jing-xian, Ding, Xiao-rong, Yu, Jian-chun, Yu, Tao, Lu, Ming-xia, and Wang, Shu
- Subjects
- *
PATHOGENIC microorganisms , *BRAIN , *AGING , *GENE expression - Abstract
In order to explore the pathogenic mechanisms of cerebral senescence and its possible effective acupuncture therapy, we applied cDNA array technique to study expression of the aging-related genes in hippocampus and acupuncture effect on them. SAMP10 and SAMR1 were selected and randomly divided into four groups: R1 control group, P10 control group, P10 acupuncture group and P10 pseudo-acupuncture group. The results showed that acupuncture not only could partly or completely reverse the effect of aging on hippocampal gene expression, but also influence some gene expression which were unrelated to aging. However, pseudo-acupuncture had some effect on aging-unrelated gene expression and little or no effect on aging-related genes. Therefore, we suspect that acupuncture points may have both therapeutic effect and “stress-inducing reaction”. Pseudo-acupuncture has only “responsiveness” without therapeutic effect. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF