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Objective To observe the clinical effect of external application of Traditional Chinese Medicine(TCM) in the treatment of acute gouty arthritis. Methods Totally 61 patients with acute gouty arthritis who met the inclusion criteria were included as research subjects. They were treated with TCM external application which designed to promote blood circulation and remove blood stasis within 2 hours after admission. The changes of Visual Analogue Scale of pain and TCM symptom score before and after treatment were observed. Results After treatment, VAS score and TCM symptom score of patients were significantly decreased, with a significant difference(P< 0. 05). Conclusion The external application of Traditional Chinese Medicine in the treatment of gouty arthritis has definite curative effect, simple operation and low price, which is worth promoting. (目的 观察中药外敷治疗急性痛风性关节炎的临床疗效。方法 选取符合纳入标准的61例急性痛风性关节炎患者为研究对象, 在入院2 h内采用自拟活血化瘀中药局部外敷, 观察其治疗前后疼痛视觉模拟评分(VAS)及中医症候积分的变化。结果 治疗后, 患者VAS评分及中医症候分均较治疗前降低, 差异有统计学意义(P＜0. 05)。结论 采用中药外敷治疗痛风性关节炎疗效确切, 且操作简单。)

Objective To explore the association between DLL3 expression and chemosensitivity of advanced SCLC patients to cis-platinum/etoposide therapy, and to evaluate the prognostic value of DLL3. Methods We selected 64 patients diagnosed as stage Ⅲ/Ⅳ SCLC. Protein levels of DLL3 were examined by immunohistochemistry. χ2 test was used to analyze the relation between DLL3 expression and chemotherapy efficacy. Kaplan-Meier and Cox multivariate analysis were used to investigate the impacts of DLL3 and other factors on PFS and OS of advanced SCLC patients. Results DLL3 was detected in 84.1% (54/64) of the samples and not associated with gender, age, smoking history or stage (P > 0.05). The response rate(RR) and disease control rate in DLL3-high group were lower than those in DLL3-low group (P < 0.05); PFS of patients with low DLL3 expression were better than those with high DLL3 expression (P < 0.05). DLL3 expression, tumor stage and tumor diameter were independent prognostic factors for PFS, and tumor stage was an independent prognostic factor for OS of advanced SCLC patients. Conclusion DLL3 is related to the response rate of EP chemotherapy and PFS. It may become a biomarker for predicting chemosensitivity. DLL3 has no predictive value for long-term prognosis of patients with advanced SCLC.

Seminaphthorhodafluor (SNARF) Schiff base (SNARF-SB) bridged periodic mesoporous organosilicas (SSPMOs) with "turn-on" fluorescence enhancement for sensing Cu2+ were synthesized via a template-directed co-condensation method. Small-angle x-ray scattering (SAXS) patterns, high resolution transmission electron microscope (HRTEM) images, and N2 adsorption–desorption isotherms indicated the presence of mesoporous structure in the SSPMOs. FT-IR spectra and 29Si MAS NMR data confirmed the successful incorporation of bridged organic groups in the framework of SSPMOs. The luminous properties that SSPMOs had a selective response to Cu2+ were investigated by UV–Vis absorption spectroscopy and fluorescence spectroscopy. The limit of detection (LOD) was 5.1 × 10–7 M and binding stoichiometry was determined 1:1 between SNARF-SB and Cu2+. The fluorescence enhancement of SSPMOs towards Cu2+ was induced by ring-opening of the spirolactam in SNARF-SB in framework of SSPMOs, which was confirmed by FT-IR spectra of SNARF-SB with Cu2+. Moreover, SSPMOs have improved fluorescence lifetimes compared with that of SNARF-SB. Therefore, SSPMOs can be a progressive chemical sensor for Cu2+ due to its high selectivity, recyclability, and stability. [ABSTRACT FROM AUTHOR]

Seminaphthorhodafluor (SNARF) Schiff base (SNARF-SB) bridged periodic mesoporous organosilicas (SSPMOs) with "turn-on" fluorescence enhancement for sensing Cu2+ were synthesized via a template-directed co-condensation method. Small-angle x-ray scattering (SAXS) patterns, high resolution transmission electron microscope (HRTEM) images, and N2 adsorption–desorption isotherms indicated the presence of mesoporous structure in the SSPMOs. FT-IR spectra and 29Si MAS NMR data confirmed the successful incorporation of bridged organic groups in the framework of SSPMOs. The luminous properties that SSPMOs had a selective response to Cu2+ were investigated by UV–Vis absorption spectroscopy and fluorescence spectroscopy. The limit of detection (LOD) was 5.1 × 10–7 M and binding stoichiometry was determined 1:1 between SNARF-SB and Cu2+. The fluorescence enhancement of SSPMOs towards Cu2+ was induced by ring-opening of the spirolactam in SNARF-SB in framework of SSPMOs, which was confirmed by FT-IR spectra of SNARF-SB with Cu2+. Moreover, SSPMOs have improved fluorescence lifetimes compared with that of SNARF-SB. Therefore, SSPMOs can be a progressive chemical sensor for Cu2+ due to its high selectivity, recyclability, and stability. [ABSTRACT FROM AUTHOR]