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Additional file 1. Fig. S1. TEM corresponding size distribution histogram of ZIF67/Ola/Lapa. Fig. S2. SEM image and corresponding size distribution histogram of ZIF67/Ola/Lapa nanoparticles. Fig. S3. Hydrodynamic diameters of ZIF67/Ola/Lapa dispersed in saline and DMEM. Fig. S4. XPS high-resolution spectrum of Co 2p and F1s. Fig. S5. UV–vis absorption spectra of the solutions containing ZIF67, ZIF67/Ola, ZIF67/Lapa and ZIF67/Ola/Lapa. Fig. S6. UV–vis absorption spectra of the solutions containing different concentrations of Ola and its standard curve. Fig. S7. UV–vis absorption spectra of the solutions containing different concentrations of Lapa and its standard curve. Fig. S8. UV-vis absorbance spectra of Ola, and Lapa before and after loading. Fig. S9. Drug release behavior of Lapa and Ola at different pH. Fig. S10. CLSM images of MDA-MB-231 cells incubated with ZIF67/Ola/Lapa for different time periods. Fig. S11. Flow cytometry of MDA-MB-231 cells incubated with ZIF67/Ola/Lapa for different time periods. Fig. S12. CLSM images of intracellular ROS generation treated with ZIF67/Ola/Lapa in HBL-100 normal cells. Fig. S13. PCR analysis of NQO1 expression level of HBL-100 normal cells and MDA-MB-231 breast cancer cells. Fig. S14. The cytotoxicity of ZIF67, Ola and ZIF67/Ola towards MDA-MB-231 cells. Fig. S15. The cytotoxicity of ZIF67/Ola/Lapa towards A549 cells or A549 cells pretreated with Dicoumarol. Fig. S16. The cytotoxicity of ZIF67/Ola/Lapa towards HBL-100 normal cells. Fig. S17. Body weight of MDA-MB-231 tumor-bearing mice under different treatments. Fig. S18. H&E stained images of major organs obtained from different groups. Fig. S19. Blood biochemistry data including numbers of ALT, CREA, WBC, and HGB. Table S1: The detailed data of drug loading capacity.