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5. Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Lim, Meikuang, Wang, Weiqiang, Liang, Lu, Han, Zhi-bo, Li, Zongjin, Geng, Jie, Zhao, Meng, Jia, Honghong, Feng, Jie, Wei, Zhe, Song, Baoquan, Zhang, Jiemin, Li, Jun, Liu, Tianwen, Wang, Fan, Li, Ting, Li, Jianming, Fang, Yihu, Gao, Jianhua, and Han, Zhongchao

Published
2018
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17. Safety and Efficacy of Placenta-Derived Mesenchymal Stem Cell Treatment for Diabetic Patients with Critical Limb Ischemia: A Pilot Study.

Author

Wang, Jiao, Zeng, Xiang-Xia, Cai, Wei, Han, Zhi-Bo, Zhu, Ling-Yan, Liu, Jian-Ying, and Xu, Ji-Xiong

Subjects
STEM cell treatment, MESENCHYMAL stem cells, INTERMITTENT claudication, PEOPLE with diabetes, MAGNETIC resonance angiography, ANKLE brachial index
Abstract

Aim Diabetic foot has become the main cause of non-traumatic amputation. Stem cell therapy, especially mesenchymal stem cells (MSCs), holds a great promise as a therapy for diabetic foot with ischemia limb arterial disease. The aim of this pilot study is to evaluate the safety and efficacy of placenta-derived MSCs (P-MSCs) treatment for diabetic patients with critical limb ischemia (CLI). Methods Four eligible diabetic patients with CLI were consecutively enrolled in this pilot study. On the base of the standard-of-care treatment, these patients accepted P-MSCs treatment by intramuscular injection for successive 3 times at an interval of 4 weeks, and the safety and efficacy of placenta-derived MSCs (P-MSCs) treatment were evaluated. Results There were no serious adverse events during the period of P-MSCs injection and the 24-weeks follow-up period. The clinical ischemic features of patients were improved 24 weeks after P-MSCs treatment. The scores of resting pain and limb coldness significantly decreased, and pain-free walking distance significantly increased from baseline to 24 weeks after P-MSCs therapy. The resting ankle brachial index increased, but no statistically significant difference was found. The findings of magnetic resonance angiography showed the increase of collateral vessel formation in one patient, but there were no significant changes observed in the other patients. Conclusions The data in this pilot study indicated that multiple intramuscular P-MSCs injections may be a safe and effective alternative therapy for diabetic patients with CLI, and larger, placebo-controlled, perspective studies are needed to prove these results. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Additional file 4: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Meikuang Lim, Weiqiang Wang, Liang, Lu, Han, Zhi-Bo, Zongjin Li, Geng, Jie, Zhao, Meng, Honghong Jia, Feng, Jie, Wei, Zhe, Baoquan Song, Jiemin Zhang, Li, Jun, Tianwen Liu, Wang, Fan, Li, Ting, Jianming Li, Yihu Fang, Jianhua Gao, and Zhongchao Han

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Figure S3. Histological images of left ventricular basal, middle, and apex cross-sections after TTC staining in the three groups PBS (n = 3), low-dose group (n = 4), and high-dose group (n = 4) at 8 weeks follow-up. Schematic infarct distribution shows that the infarction (white color) is located in the anterior and anteroseptal segments of the heart. (PPTX 6390 kb)

Published
2018
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19. Additional file 7: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Meikuang Lim, Weiqiang Wang, Liang, Lu, Han, Zhi-Bo, Zongjin Li, Geng, Jie, Zhao, Meng, Honghong Jia, Feng, Jie, Wei, Zhe, Baoquan Song, Jiemin Zhang, Li, Jun, Tianwen Liu, Wang, Fan, Li, Ting, Jianming Li, Yihu Fang, Jianhua Gao, and Zhongchao Han

Subjects
cardiovascular diseases
Abstract

Figure S6. Intravenous injection of allogeneic UC-MSCs did not affect mRNA expression of the chemotaxis factors SDF1-alpha and its receptor CXCR4 in the infarct area (A,D), border area (B,E), or remote area (C,F) of LV myocardium at week 8 after AMI. (PPTX 151Â kb)

Published
2018
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20. Additional file 2: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Meikuang Lim, Weiqiang Wang, Liang, Lu, Han, Zhi-Bo, Zongjin Li, Geng, Jie, Zhao, Meng, Honghong Jia, Feng, Jie, Wei, Zhe, Baoquan Song, Jiemin Zhang, Li, Jun, Tianwen Liu, Wang, Fan, Li, Ting, Jianming Li, Yihu Fang, Jianhua Gao, and Zhongchao Han

Abstract

Figure S1. Analysis of senescence in porcine UC-MSCs. Representative microphotographs of porcine UC-MSCs in passage 4 (A), passage 6 (B), passage 8 (C), and passage 6 with peroxide hydrogen treatment as positive control (D) after β-galactosidase staining. Scale bar = 5 μm. Quantitative summary of senescence porcine UC-MSCs (E). Data are presented as the mean ± SD (n = 6 per group) and represent two independent experiments. **P

Published
2018
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21. Additional file 1: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Meikuang Lim, Weiqiang Wang, Liang, Lu, Han, Zhi-Bo, Zongjin Li, Geng, Jie, Zhao, Meng, Honghong Jia, Feng, Jie, Wei, Zhe, Baoquan Song, Jiemin Zhang, Li, Jun, Tianwen Liu, Wang, Fan, Li, Ting, Jianming Li, Yihu Fang, Jianhua Gao, and Zhongchao Han

Abstract

Table S1. Primers used in this study (DOCX 17Â kb)

Published
2018
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22. Additional file 9: of Intravenous injection of allogeneic umbilical cord-derived multipotent mesenchymal stromal cells reduces the infarct area and ameliorates cardiac function in a porcine model of acute myocardial infarction

Author

Meikuang Lim, Weiqiang Wang, Liang, Lu, Han, Zhi-Bo, Zongjin Li, Geng, Jie, Zhao, Meng, Honghong Jia, Feng, Jie, Wei, Zhe, Baoquan Song, Jiemin Zhang, Li, Jun, Tianwen Liu, Wang, Fan, Li, Ting, Jianming Li, Yihu Fang, Jianhua Gao, and Zhongchao Han

Subjects
fungi
Abstract

Figure S8. In vivo trafficking of intravenous injection of allogeneic UC-MSCs-eGFP 7 days after AMI induction. (A) Biodistribution pattern of UC-MSCs-eGFP measured by DNA relative expression of eGFP in many tissues (heart, lung, liver, spleen, kidney, wound operation of skin). (B–D) Immunofluorescence on eGFP (green) and nuclei (blue) in lung tissue. (E–G) Immunofluorescence on eGFP (green) and nuclei (blue) in peri-infarct heart tissue. Scale bar = 20 μm. (PPTX 783 kb)

Published
2018
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24. Additional file 1: of VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity

Author

Wenjing Du, Li, Xue, Chi, Ying, Fengxia Ma, Zongjin Li, Shaoguang Yang, Baoquan Song, Junjie Cui, Ma, Tao, Juanjuan Li, Jianjian Tian, Zhouxin Yang, Xiaoming Feng, Chen, Fang, Shihong Lu, Liang, Lu, Han, Zhi-Bo, and Han, Zhong-Chao

Subjects
cardiovascular system
Abstract

is Table S1 presenting primers for real-time reverse transcription PCR, Table S2 presenting the description of the human cytokine antibody array (AAH-CYT-G1000), Table S3 presenting the phenotype of three donor-derived CV-MSCs, Table S4 presenting differential angiogenesis cytokines of VCAM-1â CV-MSCs and VCAM-1+CV-MSCs, Fig. S1 showing sVCAM-1 concentration in 48-hour CM of VCAM-1+CV-MSCs and VCAM-1â CV-MSCs measured by ELISA, and Fig. S2 showing the endothelial-like cells derived from VCAM-1+CV-MSCs and VCAM-1â CV-MSCs harvested after in vitro endothelial induction and immunostained by anti-vWF antibodies to evaluate their endothelial differentiation capacities. (PDF 524 kb)

Published
2016
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26. ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin

Author

Zhao, Tiansuo, primary, Jiang, Wenna, additional, Wang, Xiuchao, additional, Wang, Hongwei, additional, Zheng, Chen, additional, Li, Yang, additional, Sun, Yan, additional, Huang, Chongbiao, additional, Han, Zhi-bo, additional, Yang, Shengyu, additional, Jia, Zhiliang, additional, Xie, Keping, additional, Ren, He, additional, and Hao, Jihui, additional

Published
2017
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28. VCAM-1+ placenta chorionic villi-derived mesenchymal stem cells display potent pro-angiogenic activity

Author

Du, Wenjing, primary, Li, Xue, additional, Chi, Ying, additional, Ma, Fengxia, additional, Li, Zongjin, additional, Yang, Shaoguang, additional, Song, Baoquan, additional, Cui, Junjie, additional, Ma, Tao, additional, Li, Juanjuan, additional, Tian, Jianjian, additional, Yang, Zhouxin, additional, Feng, Xiaoming, additional, Chen, Fang, additional, Lu, Shihong, additional, Liang, Lu, additional, Han, Zhi-Bo, additional, and Han, Zhong-Chao, additional

Published
2016
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29. Safety of Mesenchymal Stem Cells for Clinical Application

Author

Wang, Youwei, Han, Zhi-bo, Song, Yong-ping, and Han, Zhong Chao

Subjects
Article Subject
Abstract

Mesenchymal stem cells (MSCs) hold great promise as therapeutic agents in regenerative medicine and autoimmune diseases, based on their differentiation abilities and immunosuppressive properties. However, the therapeutic applications raise a series of questions about the safety of culture-expanded MSCs for human use. This paper summarized recent findings about safety issues of MSCs, in particular their genetic stability in long-term in vitro expansion, their cryopreservation, banking, and the role of serum in the preparation of MSCs.

Published
2012
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30. Inhibition of Notch Signaling Promotes the Adipogenic Differentiation of Mesenchymal Stem Cells Through Autophagy Activation and PTEN-PI3K/AKT/mTOR Pathway

Author

Song, Bao-quan, primary, Chi, Ying, additional, Li, Xue, additional, Du, Wen-jing, additional, Han, Zhi-Bo, additional, Tian, Jian-jian, additional, Li, Juan-juan, additional, Chen, Fang, additional, Wu, He-he, additional, Han, Li-xin, additional, Lu, Shi-hong, additional, Zheng, Yi-zhou, additional, and Han, Zhong-chao, additional

Published
2015
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31. Human mesenchymal stem cells possess different biological characteristics but do not change their therapeutic potential when cultured in serum free medium

Author

Wang, Youwei, primary, Wu, Hehe, additional, Yang, Zhouxin, additional, Chi, Ying, additional, Meng, Lei, additional, Mao, Aibin, additional, Yan, Shulin, additional, Hu, Shanshan, additional, Zhang, Jianzhong, additional, Zhang, Yun, additional, Yu, Wenbo, additional, Ma, Yue, additional, Li, Tao, additional, Cheng, Yan, additional, Wang, Yongjuan, additional, Wang, Shanshan, additional, Liu, Jing, additional, Han, Jingwen, additional, Li, Caiyun, additional, Liu, Li, additional, Xu, Jian, additional, Han, Zhi Bo, additional, and Han, Zhong Chao, additional

Published
2014
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35. CD106 Identifies a Subpopulation of Mesenchymal Stem Cells with Unique Immunomodulatory Properties

Author

Yang, Zhou Xin, primary, Han, Zhi-Bo, additional, Ji, Yue Ru, additional, Wang, You Wei, additional, Liang, Lu, additional, Chi, Ying, additional, Yang, Shao Guang, additional, Li, Li Na, additional, Luo, Wei Feng, additional, Li, Jian Ping, additional, Chen, Dan Dan, additional, Du, Wen Jing, additional, Cao, Xiao Cang, additional, Zhuo, Guang Sheng, additional, Wang, Tao, additional, and Han, Zhong Chao, additional

Published
2013
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