19 results on '"Han-Xiao Sun"'
Search Results
2. The Anti-inflammatory Effect of the CXCR4 Antagonist-N15P Peptide and Its Modulation on Inflammation-Associated Mediators in LPS-Induced PBMC
- Author
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Xue-mei, Mo and Han-xiao, Sun
- Published
- 2015
- Full Text
- View/download PDF
3. Clinical laboratory investigation of a patient with an extremely high D-dimer level: A case report
- Author
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Hong Ge, Zhong-Qing Xu, Han-Xiao Sun, and Hui-Ming Sheng
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medicine.medical_specialty ,business.industry ,General Medicine ,medicine.disease_cause ,Epstein–Barr virus ,Dermatology ,03 medical and health sciences ,0302 clinical medicine ,D-dimer ,030220 oncology & carcinogenesis ,Case report ,Epstein-Barr virus ,Medicine ,030211 gastroenterology & hepatology ,business ,Heterophilic antibodies - Abstract
BACKGROUND D-dimer, a soluble degradation product of cross-linked fibrin, is commonly used as an important marker for the diagnosis of disseminated intravascular coagulation and differential diagnosis of thrombosis. Herein, we present a geriatric case with an unusually elevated D-dimer level. CASE SUMMARY An 82-year-old woman, admitted to the ward with a diagnosis of chronic heart failure, was noted to have a remarkably elevated D-dimer level, beyond the qualified range (> 100 mg/L), utilizing the Innovating D-dimer for Sysmex CS-5100 System™. However, no evidence, including clinical symptoms, radiographic evidence of thromboembolic disease, and parallel fibrinogen degradation product values, suggested that this patient was at high risk of thrombopenia. To confirm the discrepancy, a series of approaches including sample dilution, re-analysis via alternative methods, and sample treatment with blockage of specific heterophilic antibodies were performed. A remarkable disappearance of the elevated D-dimer values was observed in the samples after they were subjected to these approaches (4.49, 9.42, 9.06, and 12.58 mg/L, respectively). This confirmed the presence of heterophilic antibodies in this case. In addition, a reduction in cardiac output due to the presence of cardiac failure could also be responsible for the existence of a hypercoagulable state in this case. CONCLUSION In conclusion, the presence of heterophilic antibodies should be considered when an elevated D-dimer value is not in conformity with the clinical evidence, and a viral infection should be considered when interference by a heterophilic antibody exists.
- Published
- 2020
4. Finite-time boundary stabilization of reaction-diffusion systems
- Author
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Cheng-Chew Lim, Han-Xiao Sun, Kai-Ning Wu, and Peng Shi
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0209 industrial biotechnology ,Computer science ,Mechanical Engineering ,General Chemical Engineering ,Biomedical Engineering ,Aerospace Engineering ,Boundary (topology) ,02 engineering and technology ,Mechanics ,Industrial and Manufacturing Engineering ,020901 industrial engineering & automation ,Control and Systems Engineering ,Control theory ,Reaction–diffusion system ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Electrical and Electronic Engineering ,Finite time - Published
- 2017
5. Investigation on fatigue performance of cold expansion holes of 6061-T6 aluminum alloy
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Wang Yanli, Yong Zhou, You-li Zhu, Shuai Hou, and Han-xiao Sun
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Materials science ,business.industry ,Mechanical Engineering ,02 engineering and technology ,Structural engineering ,Paris' law ,021001 nanoscience & nanotechnology ,Industrial and Manufacturing Engineering ,Crack closure ,020303 mechanical engineering & transports ,Compressive strength ,0203 mechanical engineering ,Mechanics of Materials ,Residual stress ,Modeling and Simulation ,Fracture (geology) ,Shear stress ,General Materials Science ,Grain boundary ,Composite material ,0210 nano-technology ,business ,Stress concentration - Abstract
The effect of direct cold expansion on the fatigue behavior of fasten holes of AA6016-T6 was investigated. Results revealed that: (1) The fatigue life of the cold expanded (CE) specimens increased by 2.47 times compared to that of the non-cold expanded (NCE) specimens, and all the fatigue origins of the CE specimens initiated at the hole’s corner of the mandrel inlet side; (2) It was interesting to find that the fatigue crack has bypassed the tri-directional compressive stress domain in all the fracture surfaces of the CE specimens, which was believed to be beneficial to the fatigue life prolongation; (3) A ‘shear mode secondary crack’ different from ‘ordinary secondary crack’ was formed in the fracture surfaces of the CE specimens, which was generated by the residual shear stress imparted by the CE process; (4) Residual compressive stress could effectively slow down the fatigue crack growth rate; (5) Grain boundary and the angle of favored slipping planes of neighbor grains affected the fatigue crack propagation path evidently.
- Published
- 2017
6. Immunization with truncated envelope protein of Zika virus induces protective immune response in mice
- Author
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Xiaofeng Li, Hong-Jiang Wang, Jian-Feng Han, Jiu-Yang Yu, Cheng-Feng Qin, Yong-Qiang Deng, Han-Xiao Sun, Yang Qiu, and Hui Zhao
- Subjects
0301 basic medicine ,Microcephaly ,Protein subunit ,lcsh:Medicine ,Gene Expression ,medicine.disease_cause ,Antibodies, Viral ,Article ,Zika virus ,law.invention ,03 medical and health sciences ,Mice ,Immune system ,Viral Envelope Proteins ,law ,medicine ,Escherichia coli ,Animals ,Humans ,Cloning, Molecular ,lcsh:Science ,Antiserum ,Mice, Inbred BALB C ,Multidisciplinary ,biology ,Zika Virus Infection ,Immune Sera ,lcsh:R ,Viral Vaccines ,Zika Virus ,medicine.disease ,biology.organism_classification ,Virology ,Antibodies, Neutralizing ,Survival Analysis ,Recombinant Proteins ,Immunity, Humoral ,Disease Models, Animal ,030104 developmental biology ,Immunization ,Vaccines, Subunit ,Recombinant DNA ,lcsh:Q ,Female - Abstract
The global spread of Zika virus (ZIKV) as well as its unexpected link to infant microcephaly have resulted in serious public health concerns. No antiviral drugs against ZIKV is currently available, and vaccine development is of high priority to prepare for potential ZIKV pandemic. In the present study, a truncated E protein with the N-terminal 90% region reserved (E90) from a contemporary ZIKV strain was cloned and expressed in Escherichia coli, purified by a Ni-NTA column, and characterized by Western blotting assays. Immunization with recombinant E90 induced robust ZIKV-specific humoral response in adult BALB/c mice. Passive transfer of the antisera from E90-immunized mice conferred full protection against lethal ZIKV challenge in a neonatal mice model. Our results indicate that recombinant ZIKV E90 described here represents as a promising ZIKV subunit vaccine that deserves further clinical development.
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- 2017
7. Research on the Optimal Efficiency of Open-Loop Electromagnetic Ring Network
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Xun Cheng Huang, Yi Ming Li, Han Xiao Sun, and Su Qin Sun
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Electric power system ,Engineering ,Ring (mathematics) ,business.industry ,Reliability (computer networking) ,Stability (learning theory) ,Open-loop controller ,Control engineering ,Ring network ,General Medicine ,business ,Optimal control ,Power (physics) - Abstract
With the expansion of power network, Power network stability problems have arised up, the short-circuit current of the device will also significantly exceeded. There exist many problems such as the reliability of power supply reduced, the threat of natural disasters of all the contact line among electromagnetic loop increased, etc. This article is to explore how to achieve optimal efficiency goals. This paper attempt to discuss this problem from the respect of technology and economics, using the Application of Optimal Control Theory to calculate the best model of electromagnetic ring. It is a useful discussion on the economic operation of power systems.
- Published
- 2011
8. Biological Functions, Screen and Identify Research on Chemokine Receptor Antagonist Encoded by US28 of Human Cytomegalovirus*
- Author
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Han-Xiao Sun, Lu Li, Guang Zhang, Tao He, Xiu-Ying Li, and Xue-Mei Mo
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CCR1 ,CCR2 ,biology ,Chemistry ,Chemokine receptor CCR5 ,Biophysics ,C-C chemokine receptor type 7 ,C-C chemokine receptor type 6 ,CCR8 ,Biochemistry ,Virology ,Cell biology ,Chemokine Receptor Antagonist ,biology.protein ,CCL21 - Published
- 2010
9. Liraglutide, the glucagon-like peptide-1 receptor agonist, has anabolic bone effects in diabetic Goto-Kakizaki rats
- Author
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Han-xiao, Sun, Nan, Lu, Xiu, Luo, Lin, Zhao, and Jian-min, Liu
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Diabetes Mellitus ,Animals ,Liraglutide ,Bone and Bones ,Rats - Published
- 2014
10. Study on antitumor drug-induced apoptosis in human cancer cells by terminal deoxynucleotidyl transferase assay
- Author
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Han-xiao Sun, Naijun Han, Jinfeng Liang, Liying Liu, Shujun Cheng, Tong Tong, and Suping Guo
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Gel electrophoresis ,Cisplatin ,Cancer Research ,Chemotherapy ,medicine.medical_treatment ,Carboplatin ,chemistry.chemical_compound ,Ovarian tumor ,Oncology ,chemistry ,Terminal deoxynucleotidyl transferase ,Apoptosis ,Cell culture ,medicine ,Cancer research ,medicine.drug - Abstract
Objective: Considerable evidence has showed that apoptosis is involved in both cancer development and inhibition. A new assay (terminal deoxynucleotidyl tansferase, TdT) was recently reported to have advantages in the detection of apoptosis. In this study, this assay was used to investigate antitumor drug-induced apoptosis in human cancer cells. Methods: TdT assay, DNA gel electrophoresis, electron and light microscopy were used to observe apoptosis. Results: Our results showed that cisplatin-induced apoptosis in both HL-60 and SV40T-transformed human bronchial epithelial cells was detected with a good dosage and time response. The occurrence of the apoptosis was preceded by the decrease of bcl-2 mRNA expression. With the TdT assay, apoptotic cells were observed in ovarian tumor of patients treated with carboplatin. Conclusion: TdT assay may be applicable to monitor apoptosis in human cancers induced by chemotherapy, and to evaluate tumor cell response during treatment.
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- 1997
11. Anti-HCMV and KSHV effect of a trapping ligand antagonist for herpesvirus-encoded GPCR
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Hong-Ai, Liu, Han-Xiao, Sun, Xue-Mei, Mo, Shi-Yu, Li, Xiu-Ying, Li, Guang, Zhang, and Li, Lu
- Subjects
Mice ,Viral Proteins ,Herpesvirus 8, Human ,NIH 3T3 Cells ,Animals ,Cytomegalovirus ,Humans ,Receptors, Chemokine ,Ligands ,Peptides ,Receptors, G-Protein-Coupled - Abstract
We have found and synthesized a trapping ligand peptide H22-LP (the conservative sequence is NAHCALL) from a random phage library according to the broad-spectrum trapping receptor H22, which derived from the residue 14-35 near the N-terminal region of receptor US28 on HCMV. In this study, we will evaluate its potential as an efficient antagonist of US28 and the anti-virus activity, acting as a broad spectrum chemokine receptors antagonist. Stable expression of US28 and ORF74 in NIH/3T3 cells were successfully constructed in vitro. Flow cytomety was used to determine the concentration of Ca2+ induced by H22-LP, and the binding of H22-LP and US28 was confirmed by enzyme-linked immunosorbent assay (ELISA). Antivirus activity of H22-LP on HCMV and KSHV was evaluated by anti-virus experiments. Our data suggest that H22-LP is an effectual antagonist of receptor US28 of HCMV and ORF74 of KSHV in the transfection assay, and it has potential to inhibit infection of HCMV and KSHV. These results provide support for the development of anti-virus strategies based on targeted inhibiting the infection of herpesvirus.
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- 2012
12. [Acute toxicity of CCR5 antagonist C25P polypeptide in mice and its carcinogenicity in vitro]
- Author
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Xue-mei, Mo, Han-xiao, Sun, and Man-li, Tang
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Male ,Mice ,Carcinogenicity Tests ,Mutagenicity Tests ,CCR5 Receptor Antagonists ,Toxicity Tests, Acute ,Animals ,Female ,Mice, Inbred Strains ,Chemokines ,Peptides - Abstract
To study the acute toxicity of C25P polypeptide, a CCR5 antagonist, in mice and its carcinogenic effect in vitro.The acute toxicity of C25P polypeptide in mice was assessed by determining the maximum tolerated dose (MTD). The mice were given C25P at the dose of 3.64 g/kg by tail vein injection, and the control mice received saline (40 ml/kg) injection. The mice were continuously observed for 14 days after the administration and sacrificed on day 14 for routine blood test, examination of the blood biochemistry and pathological examination. The carcinogenicity of C25P polypeptide in vitro was evaluated in cultured cell lines by chromosome aberration test, cell transformation test and non-anchorage dependent growth test.No mice died following administration of the drug, but 3 mice showed mild adverse reactions. The rats in both groups showed an increase in the body weight at a comparable rate. GPT increased and ALP decreased significantly in C25P polypeptide group (P0.05). Most of the organs of the rats treated with in C25P polypeptide remained normal, but 3 mice showed pathologies in the lung, spleen and liver. Chromosome aberration test, cell transformation test and non-anchorage-dependent growth test all yielded negative results for C25P polypeptide.C25P polypeptide is a low-toxicity drug that produces no apparent acute toxicity in mice or obvious carcinogenicity in vitro.
- Published
- 2011
13. [The viral acceptor antagonist to entrapment ligand H9 in vitro activeness and the function to human acceptor CX3-CR1]
- Author
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Min, Zhang, Han-Xiao, Sun, Xue-Mei, Mo, Xiu-Ying, Li, and Guang, Zhang
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Binding Sites ,Chemotaxis ,CX3C Chemokine Receptor 1 ,Membrane Proteins ,Ligands ,Antiviral Agents ,Binding, Competitive ,Chemokines, CX3C ,Monocytes ,Viral Proteins ,Cell Movement ,Humans ,Receptors, Chemokine ,Peptides - Abstract
To clarify the activeness of H9 in vitro and internalization and modulation of the surface chemokine receptor CX3CR1 induced by H9, To discuss the influence of H9 on the chemokine receptor CX3CR1.Inhibition by chemotactic peptide on the physiological detection of chemokine induced cell migration activity. Flowcytometry examined the effection of H9 on intracellular calcium. Laser scanning confocal microscopy and flow cytometry were used to determine the quality and quantity of CX3CR1 internalization.H9 was able to block the migration induced by chemokine receptor. In the chemoattraction test, H9 was unable to induce the chemotactic movement, and it does not affect the signal transduction and activeness of cells. It was found that H9 could induce internalization with a maximal rate of 70%, at the concentration of 200 ng/mL. The internalized CX3CR1 molecules could recycled to the cell surface.H9 makes human CX3CR1 internalize. After internalizing, the CX3CR1 receptor recirculates the cell surface. It does not affect CX3CR1 physiology function. H9 could be used as a specificity anti-virus peptide.
- Published
- 2011
14. [Study on dengue virus infection of human dendritic cells]
- Author
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Zhen-You, Jiang, Yu-Jie, Shi, and Han-Xiao, Sun
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Dengue ,Humans ,Dendritic Cells ,Dengue Virus ,Cells, Cultured - Abstract
To study Dengue virus (DV) infection of human dendritic cells (DC). Monocyte isolated from healthy human peripheral blood were incubated in medium with GM-CSF and IL-4 for more than 7 days. DCs were then collected and identified by transmission electron microscope, immunohistochemistry and lymphocytes stimulatory ability. Dengue virus type II (DV-2) were infected with human dendritic cells(DC) in vitro, culture supernatants and cells were collected by different time postinfection (6h, 12h, 24h, 48h, 72h). Viral titers were evaluated by microplaque forming assay on C6/36 monolayer cells; DV antigen in human dendritic cells were demonstrated by an indirect immunofluorescent assay (IFA). Localization of DV in DC was observed under a transmission electron microscope. The viruses were detected in the culture supernatants as early as 6h after infection; the highest viral titers were obtained at 48h, and then declined to very low titers at 96h. DV-2 antigen was detected in infected DC by IFA. After infection for 48h, DV particles were obvious in cystic vesicle, vacuoles . Human dendritic cells are targets of dengue virus infection. DV could efficiently infect DC and produce virus particles, DC possibly plays a role in the pathogenesis of DV infection.
- Published
- 2005
15. [Inhibitory effect of viral macrophage inflammatory protein-II on metastasis of breast cancer cell line MCF-7 through antagonising CXCR4]
- Author
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Fu-Jin, Liu and Han-Xiao, Sun
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Receptors, CXCR4 ,Dose-Response Relationship, Drug ,Chemotaxis ,Breast Neoplasms ,Fibronectins ,Drug Combinations ,Cell Movement ,Cell Line, Tumor ,Cell Migration Inhibition ,Cell Adhesion ,Humans ,Female ,Proteoglycans ,Collagen ,Laminin ,Chemokines ,Neoplasm Metastasis ,Cell Proliferation - Abstract
CXCR4-stromal cell-derived factor-1 (CXCR4-SDF-1alpha) system has been proved to be involved in targeting metastasis of breast cancer. Some antagonists of CXCR4 have inhibitory effects on metastasis of breast cancer. This study was to investigate effect of viral macrophage inflammatory protein-II (vMIP-II), an antagonist of CXCR4, on metastasis of breast cancer cell line MCF-7.Proliferation of MCF-7 cells stimulated by vMIP-II of different concentrations (10, 50, 100, 500, and 1 000 ng /ml) was detected by MTT assay, clone formation rate was assessed by agar clone assay. Adhesion and chemotaxis assays were also used to evaluate the effect of vMIP-II on MCF-7 cells in different steps of metastasis.MCF-7 cells treated with vMIP-II of a series of concentrations for 72 h showed no proliferation change (P0.05). vMIP-II (50-1 000 ng /ml) suppressed colony formation of MCF-7 cells in a concentration-dependent manner. After MCF-7 cells treated with 300 ng/ml of vMIP-II for different time (0, 0.5, 2, and 6 h), inhibition peak of cell adherence to fibronectin (FN) and Matrigel was observed. The number of migration was low in MCF-7 cells in the presence of vMIP-II of 500 ng/ml (24+/-10) was lower than that of control MCF-7 cells (60+/-9) (P0.05).The clone formation rate of MCF-7 cells may negatively correlates with the concentration of vMIP-II. vMIP-II may inhibit MCF-7 cells adhesion to FN and Matrigel, and suppress chemotactic activity of MCF-7 cells toward extracts of human lung protein.
- Published
- 2004
16. Transformation of tracheal epithelial cells and the role of transforming growth factor (TGF) and p53 in lung cancer progression
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Han-xiao Sun, Shu-pin Guo, Li-min Lin, Lei Chen, Shujun Cheng, Naijun Han, Ji-nong Fen, and Hong Wang
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Pulmonary and Respiratory Medicine ,Cancer Research ,Transformation (genetics) ,TGF alpha ,Oncology ,Transforming growth factor, beta 3 ,business.industry ,medicine ,Cancer research ,Lung cancer ,medicine.disease ,business ,Transforming growth factor - Published
- 1996
17. Development of a Broad-Spectrum Antiviral Agent with Activity Against Herpesvirus Replication and Gene Expression.
- Author
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Wen-Jun Shi, Han-Xiao Sun, Xue-Mei Mo, Shi-Yu Li, Xiu-Ying Li, Guang Zhang, and Hong-Ai Liu
- Subjects
- *
ANTIVIRAL agents , *HERPESVIRUSES , *VIRAL replication , *GENE expression in viruses , *DRUG development , *MOLECULAR biology , *PEPTIDE drugs , *IN vitro studies , *HERPES simplex virus - Abstract
Purpose: To evaluate the broad-spectrum antiviral activity of peptide H9 (H9) in vitro in order to gain insight into its underlying molecular mechanisms Method: Antiviral activity against Herpes simplex virus type 1 (HSV-1) was determined using thiazolyl blue (MTT) assay. Polymerase Chain Reaction (PCR) was employed to assay H9 antiviral activity against human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The inhibitory effect of H9 on the replication of these viral genes including early genes was assayed by real time-Ppolymerase chain reaction (RT-PCR) and Western blot. Results: H9 possessed significant inhibitory effect on the four different herpesviruses with 50 % inhibitory concentration (IC50) of 1.21 ng/mL (HSV-1). AD169 infection was strongly inhibited with an EC50 value of 0.46 ng/ml. The anti-herpesviral activity of H9 was dose-dependent. The peptide acted primarily during the early stage of infection by detection of the early genes. Conclusion: The results demonstrate that H9 can inhibit the infection of HSV-1, EBV and HCMV. Furthermore, H9 has a broad-spectrum anti-herpesviral effect in vitro based on targeted killing of infected cells expressing genes [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
18. Synthetic Polypeptide Derived from Viral Macrophage Inflammatory Protein II Inhibit the Uninfected CD4+ T Cells Apoptosis Induced by HIV-1 Extracellular Nef.
- Author
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Gui-Jie An, Xiu-Ying Li, Han-Xiao Sun, Sha Liu, Jing-Guang Zhou, Qing Ding, Pi-Jin Wei, and Guang Zhang
- Subjects
- *
MACROPHAGE inflammatory proteins , *T cells , *APOPTOSIS , *HIV-1 glycoprotein 120 , *LYMPHOCYTES - Abstract
Purpose: To evaluate the potential role and cellular mechanism of the CXCR4 antagonist (N15P) derived from the N-terminal of viral macrophage inflammatory protein-II (vMIP-II) on the apoptosis induced by HIV-1 extracellular nef protein in vitro. Method: Peripheral blood mononuclear cells (PBMCs) and Jurkat cells were treated with HIV-1 nef protein alone or together with N15P at different doses and time points. The competitive binding effect of N15P against nef was assessed via radioligand binding assays. Apoptosis was evaluated via terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) assay. The level of nuclear FOXO3a and phospho-FOXO3a was assessed by Western blotting. Results: The interaction of 125I-nef with Jurkat cells was inhibited by N15P in a dose-dependent manner, with IC50 value of 0.3516 ng/ml. N15P protect against nef protein-induced apoptosis in a timeand concentration- dependent manner. The proapoptotic effect of extracellular nef protein in cells was associated with FOXO3a pathway and the changes in intracellular processes were blocked by N15P in a dose-dependent manner. Conclusion: N15P inhibits the apoptosis of uninfected CD4+ T lymphocytes induced by HIV-1 extracellular nef protein. Therefore, N15P is a potential effective CXCR4 antagonist in the course of HIV and could prevent or delay the onset of AIDS. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
19. Synthetic Polypeptide Derived from Viral Macrophage Inflammatory Protein II Inhibit VEGF Production of Human Glioma U87 Cells through SDF-1a/CXCR4-Mediated AKT Signaling Pathway.
- Author
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Bo Xu, Peng Tian, Gui-Jie An, Sha Liu, Xiu-Ying Li, Han-Xiao Sun, Jing-Gung Zhou, Qing Ding, and Pi-Jin Wei
- Subjects
- *
MACROPHAGE inflammatory proteins , *GLIOMAS , *POLYPEPTIDES , *CHEMICAL synthesis , *VASCULAR endothelial growth factors , *CXCR4 receptors , *PROTEIN kinase B regulation , *CELLULAR signal transduction - Abstract
Purpose: To evaluate the effect of synthetic polypeptide (N15P) derived from viral macrophage inflammatory protein II (vMIP-II) on the secretion of vascular endothelial growth factor (VEGF) as well as investigate the signaling pathways involved in stromal cell-derived factor-1a (SDF-1α)/CXC Chemokin Receptor 4 (CXCR4) axis-induced VEGF in glioblastoma U87 cells. Methods: Glioblastoma U87 cells were exposed to SDF-1α, N15P with various concentrations. The expression of CXCR4, SDF-1α and VEGF mRNA were assessed by RT-PCR, while expression level of VEGF was tested by ELISA and protein kinase B (Akt) phosphorylation detected by Western blot. Results: The results showed that CXCR4, SDF-1α, VEGF are expressed in human glioblastoma U87 cell lines. SDF-1α caused a dose-dependent sensitivity of cell proliferation with a maximum effect at 15 mole/ml, while N15P decreased cell viability in U87 cells in a dose-dependent manner. SDF-1α stimulated the activation of VEGF, and N15P inhibited the activation of VEGF with or without SDF-1α stimulation. VEGF production in U87 cells was associated with Akt pathway. These changes in intracellular processes were blocked by N15P in a dose-dependent manner. Conclusion: The results suggest that N15P suppress SDF-1α/CXCR4 Mediated VEGF production through Akt signaling pathway and this may be a potent therapeutic strategy in glioblastoma. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
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