Search

Your search keyword '"Handley, Nathan R."' showing total 23 results
Start Over Author "Handley, Nathan R."
23 results on '"Handley, Nathan R."'

2. Pretest Genetic Education Video Versus Genetic Counseling for Men Considering Prostate Cancer Germline Testing: A Patient-Choice Study to Address Urgent Practice Needs

Author

Russo, Jessica, McDougall, Carey, Bowler, Nicholas, Shimada, Ayako, Gross, Laura, Hyatt, Colette, Kelly, William K, Calvaresi, Anne, Handley, Nathan R, Hirsch, Irvin H, Izes, Joseph K, Lallas, Costas D, Mann, Mark, Mark, James Ryan, Mille, Patrick J, Preate, Donald, Trabulsi, Edouard J, Tsang, Miranda, Chandrasekar, Thenappan, Weiner, Perry R, Gomella, Leonard G, and Giri, Veda N

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Aging, Clinical Research, Urologic Diseases, Prostate Cancer, Cancer, Genetics, 7.1 Individual care needs, Management of diseases and conditions, Good Health and Well Being, Aged, Chi-Square Distribution, Choice Behavior, Genetic Counseling, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Patient Education as Topic, Prostatic Neoplasms, Surveys and Questionnaires, Oncology and carcinogenesis
Abstract

PurposeGermline testing (GT) for prostate cancer (PCA) is now central to treatment and hereditary cancer assessment. With rising demand for and shortage of genetic counseling (GC), tools to deliver pretest informed consent across practice settings are needed to improve access to GT and precision care. Here, we report on Evaluation and Management for Prostate Oncology, Wellness, and Risk (EMPOWER), a patient-choice study for pretest video-based genetic education (VBGE) versus GC to inform urgent practice needs.Patients and methodsMen with PCA or at risk for PCA (family history of PCA) were eligible and could choose pretest VBGE or GC. Outcomes included decisional conflict for GT, change in genetics knowledge, satisfaction, and intention to share results with family and/or providers. Descriptive statistics summarized results with counts and percentages for categorical variables and mean ± standard deviation for continuous variables. Data were compared with Fisher's exact, chi-squared, or Wilcoxon two-sample tests. Mean change in genetics knowledge was compared with t tests. The significance level was set a priori at .05.ResultsData on the first 127 participants were analyzed. Characteristics were White (85.8%), bachelor's degree (66.9%), and PCA diagnosis (90.6%). The majority chose VBGE (71%) versus GC (29%; P < .001). No differences were observed in decisional conflict for GT or satisfaction. Cancer genetics knowledge improved in both groups without significant difference (+0.9 VBGE, +1.8 GC, P = .056). Men who chose VBGE had higher intention to share GT results (96.4% VBGE v 86.4% GC, P = .02). Both groups had high rates of GT uptake (VBGE 94.4%, GC 92%).ConclusionA substantial proportion of men opted for pretest VBGE, with comparable patient-reported outcomes and uptake of GT. The results support the use of pretest video to address the critical GC shortage in the precision era.

Published
2021

7. Prostein expression on circulating tumor cells as a prognostic marker in metastatic castration-resistant prostate cancer

Author

Zhang, Zhenchao, primary, Luo, Rui, additional, Kelly, William K., additional, Chen, Joshua, additional, Donahue, Shane, additional, Ip, Kevan, additional, Handley, Nathan R., additional, Tester, William J., additional, Tsang, Miranda L., additional, Kim, Felix J., additional, Myers, Ronald, additional, Lu-Yao, Grace, additional, Gu, Jian, additional, Lin, Jianqing, additional, Li, Bingshan, additional, Wang, Chun, additional, and Yang, Hushan, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results