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1. Different pain phenotypes are associated with anti-Caspr2 autoantibodies

Author

Greguletz, Patrik, Plötz, Maria, Baade-Büttner, Carolin, Bien, Christian G., Eisenhut, Katharina, Geis, Christian, Handreka, Robert, Klausewitz, Jaqueline, Körtvelyessy, Peter, Kovac, Stjepana, Kraft, Andrea, Lewerenz, Jan, Malter, Michael, Nagel, Michael, von Podewils, Felix, Prüß, Harald, Rada, Anna, Rau, Johanna, Rauer, Sebastian, Rößling, Rosa, Seifert-Held, Thomas, Siebenbrodt, Kai, Sühs, Kurt-Wolfram, Tauber, Simone C., Thaler, Franziska, Wagner, Judith, Wickel, Jonathan, Leypoldt, Frank, Rittner, Heike L., Sommer, Claudia, Villmann, Carmen, and Doppler, Kathrin

Published
2024
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2. Clinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany

Author

Endres, Dominique, Lüngen, Eva, Hasan, Alkomiet, Kluge, Michael, Fröhlich, Sabrina, Lewerenz, Jan, Bschor, Tom, Haußleiter, Ida Sibylle, Juckel, Georg, Then Bergh, Florian, Ettrich, Barbara, Kertzscher, Lisa, Oviedo-Salcedo, Tatiana, Handreka, Robert, Lauer, Martin, Winter, Klaas, Zumdick, Norbert, Drews, Anna, Obrocki, Jost, Yalachkov, Yavor, Bubl, Anna, von Podewils, Felix, Schneider, Udo, Szabo, Kristina, Mattern, Margarete, Philipsen, Alexandra, Domschke, Katharina, Wandinger, Klaus-Peter, Neyazi, Alexandra, Stich, Oliver, Prüss, Harald, Leypoldt, Frank, and Tebartz van Elst, Ludger

Published
2022
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3. Seizure Semiology in Antibody-Associated Autoimmune Encephalitis

Author

Kaaden, Tillman, Madlener, Marie, Angstwurm, Klemens, Bien, Christian G., Bogarin, Yuri, Doppler, Kathrin, Finke, Alexander, Gerner, Stefan T., Reimann, Gernot, Häusler, Martin, Handreka, Robert, Hellwig, Kerstin, Kaufmann, Max, Kellinghaus, Christoph, Koertvelyessy, Peter, Kraft, Andrea, Lewerenz, Jan, Menge, Til, Paliantonis, Asterios, von Podewils, Felix, Prüss, Harald, Rauer, Sebastian, Ringelstein, Marius, Rostásy, Kevin, Schirotzek, Ingo, Schwabe, Julia, Sokolowski, Piotr, Suesse, Marie, Sühs, Kurt-Wolfram, Surges, Rainer, Tauber, Simone C., Thaler, Franziska, Bergh, Florian Then, Urbanek, Christian, Wandinger, Klaus-P., Wildemann, Brigitte, Mues, Sigrid, Zettl, Uwe, Leypoldt, Frank, Melzer, Nico, Geis, Christian, Malter, Michael, and Kunze, Albrecht

Published
2022
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4. Genome-wide Association Study Identifies 2 New Loci Associated With Anti-NMDAR Encephalitis

Author

Tietz, Anja K., Angstwurm, Klemens, Baumgartner, Tobias, Doppler, Kathrin, Eisenhut, Katharina, Elisak, Martin, Franke, Andre, Golombeck, Kristin S., Handreka, Robert, Kaufmann, Max, Kraemer, Markus, Kraft, Andrea, Lewerenz, Jan, Lieb, Wolfgang, Madlener, Marie, Melzer, Nico, Mojzisova, Hana, Möller, Peter, Pfefferkorn, Thomas, Prüss, Harald, Rostásy, Kevin, Schnegelsberg, Margret, Schröder, Ina, Siebenbrodt, Kai, Sühs, Kurt-Wolfram, Wickel, Jonathan, Wandinger, Klaus-Peter, Leypoldt, Frank, and Kuhlenbäumer, Gregor

Published
2021
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8. Genome-wide association study identifies two new loci associated with anti-NMDAR encephalitis

Author

Tietz, Anja K, primary, Angstwurm, Klemens, additional, Baumgartner, Tobias, additional, Doppler, Kathrin, additional, Eisenhut, Katharina, additional, Elišák, Martin, additional, Franke, Andre, additional, Golombeck, Kristin S, additional, Handreka, Robert, additional, Kaufmann, Max, additional, Kraemer, Markus, additional, Kraft, Andrea, additional, Lewerenz, Jan, additional, Lieb, Wolfgang, additional, Madlener, Marie, additional, Melzer, Nico, additional, Mojzisova, Hana, additional, Möller, Peter, additional, Pfefferkorn, Thomas, additional, Prüss, Harald, additional, Rostásy, Kevin, additional, Schnegelsberg, Margret, additional, Schröder, Ina, additional, Siebenbrodt, Kai, additional, Sühs, Kurt-Wolfram, additional, Wandinger, Klaus-Peter, additional, Wickel, Jonathan, additional, Leypoldt, Frank, additional, and Kuhlenbäumer, Gregor, additional

Published
2021
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9. Rituximab Treatment and Long-term Outcome of Patients With Autoimmune Encephalitis

Author

Thaler, Franziska S, Zimmermann, Luise, Urbanek, Christian, Pfefferkorn, Thomas, Philipsen, Alexandra, Piepgras, Johannes, von Podewils, Felix, Priller, Josef, Pröbstel, Anne-Katrin, Helena Rau, Johanna Maria, Räuber, Saskia Jania, Reimann, Gernot, Reinecke, Raphael, Sommer, Claudia, Ringelstein, Marius, Rohner, Hendrik, Rosenow, Felix, Rostásy, Kevin, Rüegg, Stephan, Schaumberg, Jens, Schmidt, Jens, Schmütz, Ina-Isabelle, Schreiber, Stephan, Schreyer, Gesa, Doppler, Kathrin, Schröder, Ina, Schuster, Simon, Seidel, Günter, Senel, Makbule, Siebenbrodt, Kai, Stammel, Oliver, Stangel, Martin, Stolze, Henning, Stoppe, Muriel, Storm Van's Gravesande, Karin, Penner, Loana, Sybre, Steffen, Tauber, Simone, Bergh, Florian Then, Trebst, Corinna, Trendelenburg, George, Trollmann, Regina, Tumani, Hayrettin, Türedi, Methab, von Mering, Matthias, Wagner, Judith, Lewerenz, Jan, Weissert, Robert, Wiendl, Heinz, Wildemann, Brigitte, Witt, Karsten, Wöpking, Sigrid, Wunderlich, Benjamin, Zieger, Lara, Roessling, Rosa, Finke, Carsten, Prüß, Harald, Melzer, Nico, Wandinger, Klaus-Peter, Kammermeier, Stefan, Leypoldt, Frank, Kümpfel, Tania, Encephalitis, German Network for Research on Autoimmune, Adelmann, Michael, Appeltshauser, Luise, Ayzenberg, Ilya, Baade-Büttner, Carolin, van Baalen, Andreas, Baatz, Sebastian, Balint, Bettina, Strippel, Christine, Bauer, Sebastian, Baumgartner, Annette, Benesch, Sonka, Berger, Robert, Berning, Sascha, Bernsen, Sarah, Bien, Christian, Bien, Corinna, Binder, Andreas, Bittner, Stefan, Bittner, Daniel, Blaes, Franz, Blaschek, Astrid, Dargvainiene, Justina, Dik, Andre, Dreesmann, Mona, Ebinger, Friedrich, Edelhoff, Lena, Ehrlich, Sven, Eisenhut, Katharina, Kraft, Andrea, Endres, Dominique, Entscheva, Marina, Faiss, Jürgen Hartmut, Fazeli, Walid Ahmad, Finke, Alexander, Fitzner, Dirk, Flotats-Bastardas, Marina, Paul, Friedemann, Friese, Manuel, Gallus, Marco, Sühs, Kurt-Wolfram, Gebhard, Marcel, Geis, Christian, Gorsler, Anna, Grau, Armin, Grauer, Oliver, Groß, Catharina, Gül, Halime, Handreka, Robert, Hansen, Niels, Häusler, Martin, Wickel, Jonathan, Havla, Joachim, Ha-Yeun, Chung, Heide, Wolfgang, Held, Valentin, Hellwig, Kerstin, Hillebrand, Philip, Hoffmann, Frank, Oy, Ulrich Hofstadt-van, Ismail, Fatme Seval, Jansen, Martina, Kaufmann, Max, Kellinghaus, Christoph, Knake, Susanne, Körtvelyessy, Peter, Kovac, Stjepana, Krämer, Markus, Krogias, Christos, Lehrich, Christoph, Linsa, Andreas, Lünemann, Jan, Markewitz, Robert, Malter, Michael, Melzer, Kristin Stefanie, Menge, Til, Meuth, Sven, Meyer Zu Hörste, Gerd, Mönig, Constanze, Mono, Marie-Luise, Nagel, Michael, Neumann-Haefelin, Tobias, and Obrocki, Jost

Subjects
Adult, Male, medicine.medical_specialty, immunology [Anti-N-Methyl-D-Aspartate Receptor Encephalitis], anti-GAD65 autoantibody, Disease, Real world evidence, Gastroenterology, immunology [Autoimmune Diseases of the Nervous System], pharmacology [Immunosuppressive Agents], anti-CASPR2 autoantibody, administration & dosage [Rituximab], Modified Rankin Scale, Internal medicine, Outcome Assessment, Health Care, immunology [Autoantibodies], Humans, Medicine, In patient, ddc:610, Registries, immunology [Encephalitis], anti-NMDA receptor autoantibody, Aged, Autoantibodies, Autoimmune encephalitis, pharmacology [Rituximab], biology, business.industry, Middle Aged, drug therapy [Encephalitis], Neurology, Cohort, administration & dosage [Immunosuppressive Agents], anti-leucine-rich glioma-inactivated 1 autoantibody, biology.protein, drug therapy [Autoimmune Diseases of the Nervous System], Female, Rituximab, Neurology (clinical), Antibody, drug therapy [Anti-N-Methyl-D-Aspartate Receptor Encephalitis], business, Immunosuppressive Agents, Follow-Up Studies, medicine.drug
Abstract

Background and ObjectivesTo determine the real-world use of rituximab in autoimmune encephalitis (AE) and to correlate rituximab treatment with the long-term outcome.MethodsPatients with NMDA receptor (NMDAR)-AE, leucine-rich glioma-inactivated-1 (LGI1)- AE, contactin-associated protein-like-2 (CASPR2)-AE, or glutamic acid decarboxylase 65 (GAD65) disease from the GErman Network for Research on AuToimmune Encephalitis who had received at least 1 rituximab dose and a control cohort of non–rituximab-treated patients were analyzed retrospectively.ResultsOf the 358 patients, 163 (46%) received rituximab (NMDAR-AE: 57%, CASPR2-AE: 44%, LGI1-AE: 43%, and GAD65 disease: 37%). Rituximab treatment was initiated significantly earlier in NMDAR- and LGI1-AE (median: 54 and 155 days from disease onset) compared with CASPR2-AE or GAD65 disease (median: 632 and 1,209 days). Modified Rankin Scale (mRS) scores improved significantly in patients with NMDAR-AE, both with and without rituximab treatment. Although being more severely affected at baseline, rituximab-treated patients with NMDAR-AE more frequently reached independent living (mRS score ≤2) (94% vs 88%). In LGI1-AE, rituximab-treated and nontreated patients improved, whereas in CASPR2-AE, only rituximab-treated patients improved significantly. No improvement was observed in patients with GAD65 disease. A significant reduction of the relapse rate was observed in rituximab-treated patients (5% vs 13%). Detection of NMDAR antibodies was significantly associated with mRS score improvement. A favorable outcome was also observed with early treatment initiation.DiscussionWe provide real-world data on immunosuppressive treatments with a focus on rituximab treatment for patients with AE in Germany. We suggest that early and short-term rituximab therapy might be an effective and safe treatment option in most patients with NMDAR-, LGI1-, and CASPR2-AE.Class of EvidenceThis study provides Class IV evidence that rituximab is an effective treatment for some types of AE.

Published
2021
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10. Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis

Author

Mueller, Stefanie H, Färber, Anna, Sühs, Kurt-Wolfram, Lempert, Thomas, Winter, Benjamin, Schluh, Giesela, Gass, Achim, Hagenah, Ulrich, Hausler, Martin Georg, König, Schiffner, C., Tauber, Simone, Ayzenbeig, Ilya, Ringelstein, Marius, Ingo, Kleiter, Hellwig, Kerstin, Krogias, Christos, Heneka, Michael, Widmann, Guido, Witt, Juri-Alexander, Niehusmann, Pitt, Wagner, Jan, Schoch, Susanne, Becker, Albert, Kellinghaus, Christoph, Helmstaedter, Christoph, Elger, Christian, Kehrer, Stefanie, Langenfurth, Anika, Spruth, Eike, Priller, Josef, Paul, Friedemann, Harms, Lutz, Finke, Carsten, Wöpking, Sigrid, Bien, Christian G, Schneider, Auke, Seitz, Rüdiger, Goebels, Norbert, Aktas, Orhan, Huttner, Hagen, Gemer, Stefan, Staykov, Dimitre, van Elst, Ludger Tebartz, Endres, Dominique, Kraft, Andrea, Stich, Oliver, Rauer, Sebastian, Baumgartner, Annette, Neubauer, Bemd, Hofmann, Regina, Schirotzek, Ingo, Döppner, Thorsten, von Podewils, Felix, Süße, M., Dressel, Alexander, Zettl, Uwe K, Kaufmann, Max, Fleischer, Sabine, Heesen, Christoph, Stellmann, Jan-Patrick, Friese, Manuel, Ufer, Frederike, Trebst, Corinna, Stangel, Martin, Schönenberger, Silvia, Ehrlich, Sven, Wildemann, Brigitte, Jarius, Sven, Bösel, Julian, Roepke, Luise, Brämer, Dirk, Strubl, Julia, Kunze, Albrecht, Geis, Christian, Günther, Albrecht, Grote, Susann, Handreka, Robert, Maker, Michael, Dohmen, Christian, Stoppe, Muriel, Bergh, Florian Then, Ettrich, Barbara, Schilling, Ruth, Koertvelyessy, Peter, Bittner, Daniel, Spreer, Annette, Methner, Axel, Rostásy, Kevin, Pledl, Hans-Wemer, Hoyer, Carolin, Anlonso, Angelika, Szabo, Kristina, Held, Valentin, Tackenberg, B., Meuth, Sven, Philipp, Konstanze, Golombeck, Stefanie, Posevitz-Fejfar, Anita, Then Bergh, Florian, Wuerdemann, Till, Dik, Andre, Strippel, Christine, Möning, Constanze, Wiendl, Heinz, Melzer, Nico, Weissert, Robert, Fuchs, Komelius, Retzlaff, Nele, Schroeder, Herr, Prüss, Harald, Faiss, Jürgen H, Zettl, Uwe, Fousse, Mathias, Ragoschke-Schumm, Andreas, van Baalen, Andreas, Stumer, Klarissa, Berg, Daniela, Peuser, Anna, Nissen, Gunnar, Schmütz, Isa, Leypoldt, Frank, Lieb, Wolfgang, Bartsch, Thorsten, Falk, Kim Christin, Hummel, Katja, Moser, Andreas, Wandinger, Klaus Peter, Becker, Felicitas, Krumbholz, Markus, Bischof, Felix, Ihle, Jennifer, Dürr, Marc, Franke, Andre, Tumani, Hayrettin, Lewerenz, Jan, Doppler, Kathrin, Sommer, Claudia, Kuhlenbäumer, Gregor, Wandinger, Klaus-Peter, Encephalitis, German Network for Research on Autoimmune, Krämer, Markus, Lyss, Birgit, Schreiber, Stephan, Faiss, J., Wallenfelsova, Eva, Othman, Jalal, Sinnecker, Tim, Riedlinger, Arne, Fonseca, Patricia, Kern, Peter, Bogarin, Yuri, Hoffmann, Anna, Schwabe, Julia, Golombeck, Kristin S, Seidel, Gunter, Herwig, Antje, Rostasy, Kevin, Stolze, Henning, Körber, Rüdiger, Wiese, Lars, Schulze-Amberger, Jörg, Heide, Wolfgang, Geis, Tobias, Kümpfel, Tania, Blaes, Franz, Köhler, Wolfgang, Dogan, Muejgan, Bien, Christian, Kramme, Corinna, Grofß, Martin, Thomsen, Jens, Pulkowski, Ulrich, Hoepner, Robert, Thaler, Franziska, Schindler, Kaspar, Lippert, Julian, Marziniak, Martin, Ewering, Carina, Reimann, Gemot, Juranek, Aleksandra, Kanitz, Rolf-Dieter, Obrocki, Jost, Pfefferkorn, Thomas, Schimrigk, Sebastian, Elisak, Martin, Urbanek, Christian, Schön, Frauke, Schabet, Martin, Melville, Jutta, Finke, Alexander, Henningsen, Henning, Hansen, Hans-Christian, Küpper, Philipp, Berning, Sascha, Nagel, Michael, Hofstadt, Ulrich, Trendelenburg, George, Heider, Steffen, Linsa, Andreas, Muth, Carolin, Borggräfe, Ingo, Blaschek, Astrid, Laurent, Sarah, Havla, Joachim, Menge, Til, Bieniek, Rolf, Hoffmann, Frank, Philipsen, Alexandra, Gorsler, Anna, Pomschlegel, Sebastian, and Tesch, Manfred

Subjects
Adult, Male, Adolescent, genetics [Protein Serine-Threonine Kinases], Hashimoto Disease, Protein Serine-Threonine Kinases, LGI1 protein, human, genetics [Protein-Serine-Threonine Kinases], Polymorphism, Single Nucleotide, Receptors, N-Methyl-D-Aspartate, Young Adult, Doublecortin-Like Kinases, immunology [Receptors, N-Methyl-D-Aspartate], genetics [Hashimoto Disease], Humans, Genetic Predisposition to Disease, ddc:610, immunology [Encephalitis], genetics [Genetic Predisposition to Disease], Aged, Autoantibodies, metabolism [Hashimoto Disease], Intracellular Signaling Peptides and Proteins, Proteins, genetics [Encephalitis], DCLK2 protein, human, Middle Aged, Protein-Serine-Threonine Kinases, genetics [Proteins], immunology [Proteins], immunology [Hashimoto Disease], genetics [Polymorphism, Single Nucleotide], metabolism [Encephalitis], Encephalitis, metabolism [Autoantibodies], Female, Genome-Wide Association Study
Abstract

We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10

Published
2017
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11. Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Author

Mueller, Stefanie H., Färber, Anna, Prüss, Harald, Melzer, Nico, Golombeck, Kristin S., Kümpfel, Tania, Thaler, Franziska, Elisak, Martin, Lewerenz, Jan, Kaufmann, Max, Sühs, Kurt‐Wolfram, Ringelstein, Marius, Kellinghaus, Christoph, Bien, Christian G., Kraft, Andrea, Zettl, Uwe K., Ehrlich, Sven, Handreka, Robert, Rostásy, Kevin, and Then Bergh, Florian

Subjects
METHYL aspartate receptors, SINGLE nucleotide polymorphisms, ENCEPHALITIS, ASPARTIC acid, HLA histocompatibility antigens, SEQUENCE analysis, GENETIC markers, GENOTYPES, DISEASE risk factors
Abstract

We performed a genome-wide association study in 1,194 controls and 150 patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR, n = 96) or anti-leucine-rich glioma-inactivated1 (anti-LGI1, n = 54) autoimmune encephalitis. Anti-LGI1 encephalitis was highly associated with 27 single-nucleotide polymorphisms (SNPs) in the HLA-II region (leading SNP rs2858870 p = 1.22 × 10-17 , OR = 13.66 [7.50-24.87]). Potential associations, below genome-wide significance, were found with rs72961463 close to the doublecortin-like kinase 2 gene (DCLK2) and rs62110161 in a cluster of zinc-finger genes. HLA allele imputation identified association of anti-LGI1 encephalitis with HLA-II haplotypes encompassing DRB1*07:01, DQA1*02:01 and DQB1*02:02 (p < 2.2 × 10-16 ) and anti-NMDAR encephalitis with HLA-I allele B*07:02 (p = 0.039). No shared genetic risk factors between encephalitides were identified. Ann Neurol 2018;83:863-869. [ABSTRACT FROM AUTHOR]

Published
2018
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