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1. Prognostic and predictive impact of NOTCH1 in early breast cancer

Author

Engel, Julia, Wieder, Vanessa, Bauer, Marcus, Kaufhold, Sandy, Stückrath, Kathrin, Wilke, Jochen, Hanf, Volker, Uleer, Christoph, Lantzsch, Tilmann, Peschel, Susanne, John, Jutta, Pöhler, Marleen, Weigert, Edith, Bürrig, Karl-Friedrich, Buchmann, Jörg, Santos, Pablo, Kantelhardt, Eva Johanna, Thomssen, Christoph, and Vetter, Martina

Published
2024
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2. Correction: Prognostic and predictive impact of NOTCH1 in early breast cancer

Author

Engel, Julia, Wieder, Vanessa, Bauer, Marcus, Kaufhold, Sandy, Stückrath, Kathrin, Wilke, Jochen, Hanf, Volker, Uleer, Christoph, Lantzsch, Tilmann, Peschel, Susanne, John, Jutta, Pöhler, Marleen, Weigert, Edith, Bürrig, Karl-Friedrich, Buchmann, Jörg, Santos, Pablo, Kantelhardt, Eva Johanna, Thomssen, Christoph, and Vetter, Martina

Published
2024
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3. Prognostic impact of selection criteria of current adjuvant endocrine therapy trials NATALEE and monarchE in postmenopausal HRpos/HER2neg breast cancer patients treated with upfront letrozole

Author

Fasching, Peter A., Hack, Carolin C., Nabieva, Naiba, Maass, Nicolai, Aktas, Bahriye, Kümmel, Sherko, Thomssen, Christoph, Wolf, Christopher, Kolberg, Hans-Christian, Brucker, Cosima, Janni, Wolfgang, Dall, Peter, Schneeweiss, Andreas, Marme, Frederik, Sütterlin, Marc W., Ruebner, Matthias, Theuser, Anna-Katharin, Kellner, Sara, Hofmann, Nadine M., Böhm, Sybille, Almstedt, Katrin, Lück, Hans-Joachim, Schmatloch, Sabine, Kalder, Matthias, Uleer, Christoph, Jurhasz-Böss, Ingolf, Hanf, Volker, Jackisch, Christian, Müller, Volkmar, Rack, Brigitte, Belleville, Erik, Wallwiener, Diethelm, Rody, Achim, Rauh, Claudia, Bayer, Christian M., Uhrig, Sabrina, Goossens, Chloë, Huebner, Hanna, Brucker, Sara Y., Hein, Alexander, Fehm, Tanja N., and Häberle, Lothar

Published
2024
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4. PIK3CA-mutations in breast cancer

Author

Reinhardt, Kristin, Stückrath, Kathrin, Hartung, Carolin, Kaufhold, Sandy, Uleer, Christoph, Hanf, Volker, Lantzsch, Tillmann, Peschel, Susanne, John, Jutta, Pöhler, Marleen, Bauer, Marcus, Bürrig, Friedrich Karl, Weigert, Edith, Buchmann, Jörg, Kantelhardt, Eva Johanna, Thomssen, Christoph, and Vetter, Martina

Published
2022
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6. Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study

Author

Hein, Alexander, primary, Fasching, Peter A., primary, Hack, Carolin C., additional, Maass, Nicolai, additional, Aktas, Bahriye, additional, Kümmel, Sherko, additional, Thomssen, Christoph, additional, Wolf, Christopher, additional, Kolberg, Hans-Christian, additional, Brucker, Cosima, additional, Janni, Wolfgang, additional, Dall, Peter, additional, Schneeweiss, Andreas, additional, Marme, Frederik, additional, Ruebner, Matthias, additional, Theuser, Anna-Katharin, additional, Hofmann, Nadine M., additional, Böhm, Sybille, additional, Almstedt, Katrin, additional, Kellner, Sara, additional, Nabieva, Naiba, additional, Gass, Paul, additional, Sütterlin, Marc W., additional, Lück, Hans-Joachim, additional, Schmatloch, Sabine, additional, Kalder, Matthias, additional, Uleer, Christoph, additional, Juhasz-Böss, Ingolf, additional, Hanf, Volker, additional, Jackisch, Christian, additional, Müller, Volkmar, additional, Rack, Brigitte, additional, Belleville, Erik, additional, Wallwiener, Diethelm, additional, Rody, Achim, additional, Rauh, Claudia, additional, Bayer, Christian M., additional, Uhrig, Sabrina, additional, Goossens, Chloë, additional, Huebner, Hanna, additional, Brucker, Sara Y., additional, Häberle, Lothar, additional, and Fehm, Tanja N., additional

Published
2024
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7. A Prospective, Multicenter Registry Study to Evaluate the Clinical Feasibility of Targeted Axillary Dissection (TAD) in Node-positive Breast Cancer Patients

Author

Kuemmel, Sherko, Heil, Joerg, Rueland, Anna, Seiberling, Christine, Harrach, Hakima, Schindowski, Dorothea, Lubitz, Juliane, Hellerhoff, Karin, Ankel, Christine, Graßhoff, Sven-Thomas, Deuschle, Petra, Hanf, Volker, Belke, Kerstin, Dall, Peter, Dorn, Julia, Kaltenecker, Gabriele, Kuehn, Thorsten, Beckmann, Ulrike, Potenberg, Jochem, Blohmer, Jens-Uwe, Kostara, Athina, Breit, Elisabeth, Holtschmidt, Johannes, Traut, Eugen, and Reinisch, Mattea

Published
2022
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8. Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial

Author

Ackermann, Sven, Anthuber, Christoph, Aydogdu, Mustafa, Baldauf, Angelika, Bauer, Wolfgang, Behringer, Dirk, Belau, Antje, Bender, Alexandra, Brucker, Cosima, Burges, Alexander, Canzler, Ulrich, Daabach, Trygve, Denschlag, Dominik, Deryal, Mustafa, Dörfel, Steffen, Ebert, Juliane, El-Balat, Ahmed, Fehm, Tanja, Feidicker, Susanne Maria, Feisel-Schwickardi, Gabriele, Felberbaum, Ricardo, Frank, Matthias, Gebauer, Gerhard, Gerber, Bernd, Gerhardt, Axel, Grafe, Andrea, Griesshammer, Martin, Grischke, Eva-Maria, Gröll, Isolde, Gropp-Meier, Martina, Hager, Dietrich, Hanf, Volker, Hannig, Carla Verena, Hantschmann, Peer, Harter, Philipp, Hauzenberger, Tanja, Herwig, Uwe, Heubner, Martin, Hielscher, Carsten, Hilpert, Felix, Hitschold, Thomas, Hofmann, Manfred, Jackisch, Christian, Janni, Wolfgang, Kiesel, Ludwig, Ko, Yon-Dschun, Koch, Hans-Joachim, Krabisch, Petra, Krieger, Peter, Kubin, Thomas, Kühn, Thorsten, Lampe, Björn, Ledwon, Peter, Lemster, Sabine, Lex, Benno, Liebrich, Clemens, Lorenz, Ralf, Lück, Hans-Joachim, Mahner, Sven, Mallmann, Peter, Marmé, Frederik, Meier, Werner, Meinerz, Wolfgang, Menke, Götz, Möbus, Volker, Müller, Thomas, Müller, Volker, Neunhöffer, Tanja, Ober, Angelika, Oskay-Özcelik, Gülten, Ostertag, Horst, Park-Simon, Tjoung-Won, Pölcher, Martin, Rautenberg, Beate, Rein, Daniel, Reiter, Wilhelm, Rempen, Andreas, Runnebaum, Ingo, Schmalfeldt, Barbara, Schmidt, Marcus, Schnohr, Sabine, Scholz, Heinz, Schröder, Willibald, Sehouli, Jalid, Simon, Eike, Sperfeld, Antje, Steckkönig, Annette, Strauß, Hans-Georg, Stuth, Ronaldo, Terhaag, Jürgen, Thiel, Falk, Thill, Marc, Tomé, Oliver, Uleer, Christoph, Vogel, Susanne, Voß, Hermann, Weigel, Michael, Winkler, Ulrich, Wischnik, Arthur, Zeiser, Tobias, Zorr, Andreas, Glasspool, Ros, Hudson, Emma, Jones, Rachel, Lafleur, Judith, Marth, Christian, Petru, Edgar, Reinthaller, Alexander, Antill, Yoland, Azer, Mary, Baron-Hay, Sally, Beale, Philip, Begbie, Stephen, Black, Allison, Briscoe, Karen, Dean, Andrew, Goh, Jeffrey, Harvey, Sandra, Lee, Chee, Matos, Marco, Meniawy, Tarek, Olesen, Inger, Shannon, Catherine, Vasey, Paul, Abadie-Lacourtoisie, Sophie, Arsene, Olivier, Barthier, Sophie, Becuwe-Roemer, Célia, Berton-Rigaud, Dominique, Cappiello-Bataller, Maria, Catala, Stéphanie, Costan, Cristina, Del Piano, Francesco, Deplanque, Gaël, Despax, Raymond, Dohollou, Nadine, Garnier-Tixidré, Claire, Grenier, Julien, Guardiola, Emmanuel, Hardy-Bessard, Anne-Claire, Joly, Florence, Kurtz, Jean-Emmanuel, Lefeuvre-Plesse, Claudia, Leheurteur, Marianne, Lesoin, Anne, Levache, Charles-Briac, L'Haridon, Tifenn, Longo, Raffaele, Lortholary, Alain, Meunier, Jérôme, Mouret-Reynier, Marie-Ange, Petit, Thierry, Raban, Nadia, Romano, Olivier, Vannetzel, Jean-Michel, Zannetti, Alain, Pfisterer, Jacobus, Shannon, Catherine M, Baumann, Klaus, Rau, Joern, Dean, Andrew P, Hein, Alexander, Zeimet, Alain G, Hanker, Lars C, Glasspool, Rosalind, de Gregorio, Nikolaus, Meniawy, Tarek M, Goh, Jeffrey C, Baron Hay, Sally, Kommoss, Stefan, and du Bois, Andreas

Published
2020
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9. Correction: Long-term Follow-up and Safety of Patients after an Upfront Therapy with Letrozole for Early Breast Cancer in Routine Clinical Care – The PreFace Study

Author

Hein, Alexander, primary, Fasching, Peter A., primary, Hack, Carolin C., additional, Maass, Nicolai, additional, Aktas, Bahriye, additional, Kümmel, Sherko, additional, Thomssen, Christoph, additional, Wolf, Christopher, additional, Kolberg, Hans-Christian, additional, Brucker, Cosima, additional, Janni, Wolfgang, additional, Dall, Peter, additional, Schneeweiss, Andreas, additional, Marme, Frederik, additional, Ruebner, Matthias, additional, Theuser, Anna-Katharin, additional, Hofmann, Nadine M., additional, Böhm, Sybille, additional, Almstedt, Katrin, additional, Kellner, Sara, additional, Nabieva, Naiba, additional, Gass, Paul, additional, Sütterlin, Marc W., additional, Lück, Hans-Joachim, additional, Schmatloch, Sabine, additional, Kalder, Matthias, additional, Uleer, Christoph, additional, Juhasz-Böss, Ingolf, additional, Hanf, Volker, additional, Jackisch, Christian, additional, Müller, Volkmar, additional, Rack, Brigitte, additional, Belleville, Erik, additional, Wallwiener, Diethelm, additional, Rody, Achim, additional, Rauh, Claudia, additional, Bayer, Christian M., additional, Uhrig, Sabrina, additional, Goossens, Chloë, additional, Huebner, Hanna, additional, Brucker, Sara Y., additional, Häberle, Lothar, additional, and Fehm, Tanja N., additional

Published
2024
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11. A Prospective, Multicenter Registry Study to Evaluate the Clinical Feasibility of Targeted Axillary Dissection (TAD) in Node-Positive Breast Cancer Patients

Author

Kuemmel, Sherko, Heil, Joerg, Rueland, Anna, Seiberling, Christine, Harrach, Hakima, Schindowski, Dorothea, Lubitz, Juliane, Hellerhoff, Karin, Ankel, Christine, Graßhoff, Sven-Thomas, Deuschle, Petra, Hanf, Volker, Belke, Kerstin, Dall, Peter, Dorn, Julia, Kaltenecker, Gabriele, Kuehn, Thorsten, Beckmann, Ulrike, Potenberg, Jochem, Blohmer, Jens-Uwe, Kostara, Athina, Breit, Elisabeth, Holtschmidt, Johannes, Traut, Eugen, and Reinisch, Mattea

Published
2020
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13. Safety of Targeted Axillary Dissection After Neoadjuvant Therapy in Patients With Node-Positive Breast Cancer

Author

Kuemmel, Sherko, primary, Heil, Joerg, additional, Bruzas, Simona, additional, Breit, Elisabeth, additional, Schindowski, Dorothea, additional, Harrach, Hakima, additional, Chiari, Ouafaa, additional, Hellerhoff, Karin, additional, Bensmann, Elena, additional, Hanf, Volker, additional, Graßhoff, Sven-Thomas, additional, Deuschle, Petra, additional, Belke, Kerstin, additional, Polata, Silke, additional, Paepke, Stefan, additional, Warm, Mathias, additional, Meiler, Johannes, additional, Schindlbeck, Christian, additional, Ruhwedel, Wencke, additional, Beckmann, Ulrike, additional, Groh, Ulrich, additional, Dall, Peter, additional, Blohmer, Jens-Uwe, additional, Traut, Alexander, additional, and Reinisch, Mattea, additional

Published
2023
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14. Adjuvant Docetaxel in Node-Negative Breast Cancer Patients: A Randomized Trial of AGO-Breast Study Group, German Breast Group, and EORTC-Pathobiology Group

Author

Thomssen, Christoph, primary, Vetter, Martina, additional, Kantelhardt, Eva J., additional, Meisner, Christoph, additional, Schmidt, Marcus, additional, Martin, Pierre M., additional, Clatot, Florian, additional, Augustin, Doris, additional, Hanf, Volker, additional, Paepke, Daniela, additional, Meinerz, Wolfgang, additional, Hoffmann, Gerald, additional, Wiest, Wolfgang, additional, Sweep, Fred C. G. J., additional, Schmitt, Manfred, additional, Jänicke, Fritz, additional, Loibl, Sibylle, additional, Minckwitz, Gunter von, additional, and Harbeck, Nadia, additional

Published
2023
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15. Gynecologic oncologists’ attitudes and practices relating to integrative medicine: results of a nationwide AGO survey

Author

Klein, Evelyn, Beckmann, Matthias W., Bader, Werner, Brucker, Cosima, Dobos, Gustav, Fischer, Dorothea, Hanf, Volker, Hasenburg, Annette, Jud, Sebastian M., Kalder, Matthias, Kiechle, Marion, Kümmel, Sherko, Müller, Andreas, Müller, Myrjam-Alice T., Paepke, Daniela, Rotmann, Andre-Robert, Schütz, Florian, Scharl, Anton, Voiss, Petra, Wallwiener, Markus, Witt, Claudia, and Hack, Carolin C.

Published
2017
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17. Solide Tumoren

Author

Possinger, Kurt, Regierer, Anne C., Börgermann, Christof, vom Dorp, Frank, Otto, Thomas, Rübben, Herbert, Krege, Susanne, Hanf, Volker, Kreienberg, Rolf, Eberhardt, Wilfried, Issels, Rolf D., Riess, Hanno, Bokemeyer, Carsten, Wierecky, Jan, and Schölmerich, Jürgen, editor

Published
2007
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18. Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022) – Part 2 with Recommendations on the Therapy of Precancerous Lesions and Early-stage Endometrial Cancer, Surgical Therapy, Radiotherapy and Drug-based Therapy, Follow-up Care, Recurrence and Metastases, Psycho-oncological Care, Palliative Care, Patient Education, and Rehabilitative and Physiotherapeutic Care

Author

Emons, Günter, Steiner, Eric, Vordermark, Dirk, Uleer, Christoph, Paradies, Kerstin, Tempfer, Clemens, Aretz, Stefan, Cremer, Wolfgang, Hanf, Volker, Mallmann, Peter, Ortmann, Olaf, Römer, Thomas, Schmutzler, Rita K., Horn, Lars-Christian, Kommoss, Stefan, Lax, Sigurd, Schmoeckel, Elisa, Mokry, Theresa, Grab, Dieter, and Reinhardt, Michael

Published
2023
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19. Endometrial Cancer. Guideline of the DGGG, DKG and DKH (S3-Level, AWMF Registry Number 032/034-OL, September 2022). Part 1 with Recommendations on the Epidemiology, Screening, Diagnosis and Hereditary Factors of Endometrial Cancer, Geriatric Assessment and Supply Structures

Author

Emons, Günter, Steiner, Eric, Vordermark, Dirk, Uleer, Christoph, Paradies, Kerstin, Tempfer, Clemens, Aretz, Stefan, Cremer, Wolfgang, Hanf, Volker, Mallmann, Peter, Ortmann, Olaf, Römer, Thomas, Schmutzler, Rita K., Horn, Lars-Christian, Kommoss, Stefan, Lax, Sigurd, Schmoeckel, Elisa, Mokry, Theresa, Grab, Dieter, and Reinhardt, Michael

Published
2023
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21. Solide Tumoren

Author

Possinger, Kurt, Regierer, Anne C., Otto, Thomas, Rübben, Herbert, Krege, Susanne, Hanf, Volker, Kreienberg, Rolf, Eberhardt, Wilfried, Issels, Rolf D., Riess, Hanno, Bokemeyer, Carsten, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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22. Prognostic Value of Tumour-Infiltrating Lymphocytes in an Unselected Cohort of Breast Cancer Patients

Author

Schüler, Kathleen, primary, Bethmann, Daniel, additional, Kaufhold, Sandy, additional, Hartung, Carolin, additional, Stückrath, Kathrin, additional, Lantzsch, Tilmann, additional, Uleer, Christoph, additional, Hanf, Volker, additional, Peschel, Susanne, additional, John, Jutta, additional, Pöhler, Marleen, additional, Buchmann, Jörg, additional, Bürrig, Karl-Friedrich, additional, Weigert, Edith, additional, Thomssen, Christoph, additional, Kantelhardt, Eva Johanna, additional, and Vetter, Martina, additional

Published
2022
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23. 2022-RA-576-ESGO Expression VIII – first study of individual perception and level of information of patients with low grade ovarian cancer and borderline tumor of the ovary in 321 patients

Author

Beckmann, Laura Naomi, primary, Alavi, Sara, additional, Keller, Maren, additional, Liebrich, Clemens, additional, Kubiak, Karol, additional, Wimberger, Pauline, additional, Czolk, Vera, additional, Ligl-Löhner, Anette, additional, Enzinger, Hans-Martin, additional, Burdack, Aline, additional, Fischer, Dorothea, additional, Terhaag, Jürgen, additional, Müller, Cornelia, additional, Hanf, Volker, additional, Condic, Mateja, additional, Kunz, Georg, additional, Lantzsch, Tilmann, additional, Schilling, Ute, additional, Oskay-Özcelik, Gülten, additional, and Sehouli, Jalid, additional

Published
2022
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24. Tumorerkrankungen

Author

Hiddemann, Wolfgang, Neubauer, Andreas, Possinger, Kurt, Dieing, Annette, Otto, Thomas, Krege, Susanne, Rübben, Herbert, Hanf, Volker, Kreienberg, Rolf, Eberhardt, Wilfried, Issels, Rolf D., Riess, Hanno, Bokemeyer, Carsten, Wandt, Hannes, Heidemann, Else, Kurzeder, Christian, Zehnpfennig, Dominique A., Wendtner, Clemens-Martin, Hallek, Michael, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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25. Prospective identification of prognostic factors for patients with early failure of advanced ovarian cancer who undergo primary cytoreductive surgery followed by chemotherapy: The AGO-OVAR 19/FRAGILE study (NCT02828618).

Author

Hilpert, Felix, primary, Burges, Alexander, additional, Kraemer, Bernhard, additional, Oerke, Britta, additional, Sehouli, Jalid, additional, Lampe, Bjoern, additional, Schmalfeldt, Barbara, additional, Wimberger, Pauline, additional, Witteler, Ralf, additional, Buderath, Paul, additional, Herwig, Uwe, additional, Bronger, Holger, additional, Mueller, Andreas, additional, Reuss, Alexander, additional, Peters, Norbert, additional, Hanf, Volker, additional, Du Bois, Andreas, additional, Harter, Philipp, additional, Mahner, Sven, additional, and Heitz, Florian, additional

Published
2022
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26. Epidemiology, risk factors, and genetics of endometrial cancer

Author

Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, Bloedt, Susanne, Tempfer, Clemens, Steinke-Lange, Verena, Aretz, Stefan, Schmutzler, Rita, Ortmann, Olaf, Roemer, Thomas, Hanf, Volker, Widhalm, Simone, Reents, Nicola, Jud, Sebastian, Kommoss, Stefan, Nothacker, Monika, and Bloedt, Susanne

Abstract

Background Endometrial cancer (EC) is the fifth most common female malignancy and the most common pelvic malignancy. Effective strategies for early detection, prevention, and genetic assessment are discussed in this article. Aim To review the literature on epidemiology, risk factors, and genetics. Materials and Methods This article is based on the current recommendations of the German Society of Obstetrics and Gynecology for the diagnosis and treatment of women with EC. The current literature was summarized based on expert knowledge. Systematic searches in the Medline database and in Cochrane Reviews were performed. The quality of the evidence was rated according to the 2011 Oxford classification. Recommendations and statements were formulated by a representative group using structured consensus methods. Results In Germany, 2.7% of cancer-specific deaths are due to EC. The incidence of EC increases with age and the disease is most often diagnosed in the age group of 75- to 79-year-old women. The lifetime risk of EC is 1.9%. Risk-modulating factors of EC include long-term use of estrogens, progestogen therapy, oral contraceptives, high body mass index, and impaired glucose metabolism. In addition, physical activity and dietary aspects, such as the amount of fat and red meat consumed, as well as soja foods, dietary fibers, vitamins, and specific beverages such as tea and coffee, play an important etiological role. EC also has a genetic component. Immunohistochemical and/or molecular screening is warranted for all patients with EC and has a significant impact on the genetic counselling of affected families as well as on treatment decisions.

Published
2022

27. PIK3CA mutations in breast cancer

Author

Reinhardt, Kristin, primary, Stückrath, Kathrin, additional, Kaufhold, Sandy, additional, Uleer, Christoph, additional, Hanf, Volker, additional, Lantzsch, Tilmann, additional, Peschel, Susanne, additional, John, Jutta, additional, Pöhler, Marleen, additional, Bauer, Marcus, additional, Bürrig, Friedrich Karl, additional, Weigert, Edith, additional, Buchmann, Jörg, additional, Kantelhardt, Eva Johanna, additional, Thomssen, Christoph, additional, and Vetter, Martina, additional

Published
2022
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28. AGO-Empfehlungen zur operativen Therapie der Axilla nach neoadjuvanter Chemotherapie: Update 2021

Author

Friedrich, Michael, additional, Kühn, Thorsten, additional, Janni, Wolfgang, additional, Müller, Volkmar, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Jackisch, Christian, additional, Krug, David, additional, Albert, Ute-Susann, additional, Bauerfeind, Ingo, additional, Blohmer, Jens, additional, Budach, Wilfried, additional, Dall, Peter, additional, Fallenberg, Eva M., additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Hanf, Volker, additional, Harbeck, Nadia, additional, Heil, Jörg, additional, Huober, Jens, additional, Kreipe, Hans-Heinrich, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Möbus, Volker, additional, Mundhenke, Christoph, additional, Nitz, Ulrike, additional, Park-Simon, Tjoung-Won, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans-Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Thill, Marc, additional, and Ditsch, Nina, additional

Published
2022
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29. Abstract P4-07-15: Tumor infiltrating lymphocytes as a prognostic factor

Author

Schüler, Kathleen, primary, Bethmann, Daniel, additional, Lantzsch, Tilmann, additional, Uleer, Christoph, additional, Hanf, Volker, additional, Peschel, Susanne, additional, John, Jutta, additional, Pöhler, Marleen, additional, Buchmann, Joerg, additional, Buerrig, Karl-Friedrich, additional, Weigert, Edith, additional, Kantelhardt, Eva Johanna, additional, Thomssen, Christoph, additional, and Vetter, Martina, additional

Published
2022
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30. Prevalence of SARS-CoV-2 in Pregnant Women Assessed by RT-PCR in Franconia, Germany: First Results of the SCENARIO Study (SARS-CoV-2 prEvalence in pregNAncy and at biRth In FrancOnia)

Author

Hein, Alexander, additional, Kehl, Sven, additional, Häberle, Lothar, additional, Tiemann, Carsten, additional, Peuker, Rebecca, additional, Mereutanu, Denise, additional, Stumpfe, Florian M., additional, Faschingbauer, Florian, additional, Meyer-Schlinkmann, Kirstin, additional, Koch, Martin C., additional, Kainer, Franz, additional, Dammer, Ulf, additional, Philipp, Hanna, additional, Kladt, Carolin, additional, Schrauder, Michael G., additional, Weingärtler, Stefan, additional, Hanf, Volker, additional, Hartmann, Arndt, additional, Rübner, Matthias, additional, Schneider, Holm, additional, Lelieveld, Jos, additional, Beckmann, Matthias W., additional, Wurmthaler, Lena A., additional, Fasching, Peter A., additional, and Schneider, Michael O., additional

Published
2022
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31. AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update

Author

Friedrich, Michael, additional, Kühn, Thorsten, additional, Janni, Wolfgang, additional, Müller, Volkmar, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Jackisch, Christian, additional, Krug, David, additional, Albert, Ute-Susann, additional, Bauerfeind, Ingo, additional, Blohmer, Jens, additional, Budach, Wilfried, additional, Dall, Peter, additional, Fallenberg, Eva M., additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Hanf, Volker, additional, Harbeck, Nadia, additional, Heil, Jörg, additional, Huober, Jens, additional, Kreipe, Hans-Heinrich, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Möbus, Volker, additional, Mundhenke, Christoph, additional, Nitz, Ulrike, additional, Park-Simon, Tjoung-Won, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans-Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Thill, Marc, additional, and Ditsch, Nina, additional

Published
2021
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32. Correction: AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update

Author

Friedrich, Michael, additional, Kühn, Thorsten, additional, Janni, Wolfgang, additional, Müller, Volkmar, additional, Banys-Paluchowski, Maggie, additional, Kolberg-Liedtke, Cornelia, additional, Jackisch, Christian, additional, Krug, David, additional, Albert, Ute-Susann, additional, Bauerfeind, Ingo, additional, Blohmer, Jens, additional, Budach, Wilfried, additional, Dall, Peter, additional, Fallenberg, Eva M., additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Hanf, Volker, additional, Harbeck, Nadia, additional, Heil, Jörg, additional, Huober, Jens, additional, Kreipe, Hans-Heinrich, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael Patrick, additional, Maass, Nicolai, additional, Möbus, Volker, additional, Mundhenke, Christoph, additional, Nitz, Ulrike, additional, Park-Simon, Tjoung-Won, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Schütz, Florian, additional, Sinn, Hans-Peter, additional, Solbach, Christine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Untch, Michael, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, Thill, Marc, additional, and Ditsch, Nina, additional

Published
2021
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33. AGO Recommendations for the Surgical Therapy of the Axilla After Neoadjuvant Chemotherapy: 2021 Update

Author

Friedrich, Michael, Kuehn, Thorsten, Janni, Wolfgang, Mueller, Volkmar, Banys-Pachulowski, Maggie, Kolberg-Liedtke, Cornelia, Jackisch, Christian, Krug, David, Albert, Ute-Susann, Bauerfeind, Ingo, Blohmer, Jens, Budach, Wilfried, Dall, Peter, Fallenberg, Eva M., Fasching, Peter A., Fehm, Tanja, Gerber, Bernd, Gluz, Oleg, Hanf, Volker, Harbeck, Nadia, Heil, Joerg, Huober, Jens, Kreipe, Hans-Heinrich, Kuemmel, Sherko, Loibl, Sibylle, Lueftner, Diana, Lux, Michael Patrick, Maass, Nicolai, Moebus, Volker, Mundhenke, Christoph, Nitz, Ulrike, Park-Simon, Tjoung-Won, Reimer, Toralf, Rhiem, Kerstin, Rody, Achim, Schmidt, Marcus, Schneeweiss, Andreas, Schuetz, Florian, Sinn, Hans-Peter, Solbach, Christine, Solomayer, Erich-Franz, Stickeler, Elmar, Thomssen, Christoph, Untch, Michael, Witzel, Isabell, Woeckel, Achim, Thill, Marc, Ditsch, Nina, Friedrich, Michael, Kuehn, Thorsten, Janni, Wolfgang, Mueller, Volkmar, Banys-Pachulowski, Maggie, Kolberg-Liedtke, Cornelia, Jackisch, Christian, Krug, David, Albert, Ute-Susann, Bauerfeind, Ingo, Blohmer, Jens, Budach, Wilfried, Dall, Peter, Fallenberg, Eva M., Fasching, Peter A., Fehm, Tanja, Gerber, Bernd, Gluz, Oleg, Hanf, Volker, Harbeck, Nadia, Heil, Joerg, Huober, Jens, Kreipe, Hans-Heinrich, Kuemmel, Sherko, Loibl, Sibylle, Lueftner, Diana, Lux, Michael Patrick, Maass, Nicolai, Moebus, Volker, Mundhenke, Christoph, Nitz, Ulrike, Park-Simon, Tjoung-Won, Reimer, Toralf, Rhiem, Kerstin, Rody, Achim, Schmidt, Marcus, Schneeweiss, Andreas, Schuetz, Florian, Sinn, Hans-Peter, Solbach, Christine, Solomayer, Erich-Franz, Stickeler, Elmar, Thomssen, Christoph, Untch, Michael, Witzel, Isabell, Woeckel, Achim, Thill, Marc, and Ditsch, Nina

Abstract

For many decades, the standard procedure to treat breast cancer included complete dissection of the axillary lymph nodes. The aim was to determine histological node status, which was then used as the basis for adjuvant therapy, and to ensure locoregional tumour control. In addition to the debate on how to optimise the therapeutic strategies of systemic treatment and radiotherapy, the current discussion focuses on improving surgical procedures to treat breast cancer. As neoadjuvant chemotherapy is becoming increasingly important, the surgical procedures used to treat breast cancer, whether they are breast surgery or axillary dissection, are changing. Based on the currently available data, carrying out SLNE prior to neoadjuvant chemotherapy is not recommended. In contrast, surgical axillary management after neoadjuvant chemotherapy is considered the procedure of choice for axillary staging and can range from SLNE to TAD and ALND. To reduce the rate of false negatives during surgical staging of the axilla in pN+(CNB) stage before NACT and ycN0 after NACT, targeted axillary dissection (TAD), the removal of > 2 SLNs (SLNE, no untargeted axillary sampling), immunohistochemistry to detect isolated tumour cells and micro-metastases, and marking positive lymph nodes before NACT should be the standard approach. This most recent update on surgical axillary management describes the significance of isolated tumour cells and micro-metastasis after neoadjuvant chemotherapy and the clinical consequences of low volume residual disease diagnosed using SLNE and TAD and provides an overview of this year's AGO recommendations for surgical management of the axilla during primary surgery and in relation to neoadjuvant chemotherapy.

Published
2021

36. Identifying High-Risk Triple-Negative Breast Cancer Patients by Molecular Subtyping

Author

Hartung, Carolin, primary, Porsch, Martin, additional, Stückrath, Kathrin, additional, Kaufhold, Sandy, additional, Staege, Martin S., additional, Hanf, Volker, additional, Lantzsch, Tilmann, additional, Uleer, Christoph, additional, Peschel, Susanne, additional, John, Jutta, additional, Pöhler, Marleen, additional, Weigert, Edith, additional, Buchmann, Jörg, additional, Bürrig, Karl-Friedrich, additional, Schüler, Kathleen, additional, Bethmann, Daniel, additional, Große, Ivo, additional, Kantelhardt, Eva Johanna, additional, Thomssen, Christoph, additional, and Vetter, Martina, additional

Published
2021
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38. LION-PAW (lymphadenectomy in ovarian neoplasm) sexual function assessment: a prospective sub-study of the LION trial

Author

Hasenburg, Annette, primary, Sehouli, Jalid, additional, Lampe, Bjoern, additional, Reuss, Alexander, additional, Schmalfeld, Barbara, additional, Belau, Antje Kristina, additional, Bossart, Michaela, additional, Mahner, Sven, additional, Hillemanns, Peter, additional, Petry, Ulrich, additional, du Bois, Andreas, additional, Herwig, Uwe, additional, Hilpert, Felix, additional, Gropp-Meier, Martina, additional, Hanf, Volker, additional, Greimel, Elfriede, additional, Wagner, Uwe, additional, and Harter, Philipp, additional

Published
2020
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40. Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial

Author

Pfisterer, Jacobus, primary, Shannon, Catherine M, additional, Baumann, Klaus, additional, Rau, Joern, additional, Harter, Philipp, additional, Joly, Florence, additional, Sehouli, Jalid, additional, Canzler, Ulrich, additional, Schmalfeldt, Barbara, additional, Dean, Andrew P, additional, Hein, Alexander, additional, Zeimet, Alain G, additional, Hanker, Lars C, additional, Petit, Thierry, additional, Marmé, Frederik, additional, El-Balat, Ahmed, additional, Glasspool, Rosalind, additional, de Gregorio, Nikolaus, additional, Mahner, Sven, additional, Meniawy, Tarek M, additional, Park-Simon, Tjoung-Won, additional, Mouret-Reynier, Marie-Ange, additional, Costan, Cristina, additional, Meier, Werner, additional, Reinthaller, Alexander, additional, Goh, Jeffrey C, additional, L'Haridon, Tifenn, additional, Baron Hay, Sally, additional, Kommoss, Stefan, additional, du Bois, Andreas, additional, Kurtz, Jean-Emmanuel, additional, Ackermann, Sven, additional, Anthuber, Christoph, additional, Aydogdu, Mustafa, additional, Baldauf, Angelika, additional, Bauer, Wolfgang, additional, Behringer, Dirk, additional, Belau, Antje, additional, Bender, Alexandra, additional, Brucker, Cosima, additional, Burges, Alexander, additional, Daabach, Trygve, additional, Denschlag, Dominik, additional, Deryal, Mustafa, additional, Dörfel, Steffen, additional, Ebert, Juliane, additional, Fehm, Tanja, additional, Feidicker, Susanne Maria, additional, Feisel-Schwickardi, Gabriele, additional, Felberbaum, Ricardo, additional, Frank, Matthias, additional, Gebauer, Gerhard, additional, Gerber, Bernd, additional, Gerhardt, Axel, additional, Grafe, Andrea, additional, Griesshammer, Martin, additional, Grischke, Eva-Maria, additional, Gröll, Isolde, additional, Gropp-Meier, Martina, additional, Hager, Dietrich, additional, Hanf, Volker, additional, Hannig, Carla Verena, additional, Hantschmann, Peer, additional, Hauzenberger, Tanja, additional, Herwig, Uwe, additional, Heubner, Martin, additional, Hielscher, Carsten, additional, Hilpert, Felix, additional, Hitschold, Thomas, additional, Hofmann, Manfred, additional, Jackisch, Christian, additional, Janni, Wolfgang, additional, Kiesel, Ludwig, additional, Ko, Yon-Dschun, additional, Koch, Hans-Joachim, additional, Krabisch, Petra, additional, Krieger, Peter, additional, Kubin, Thomas, additional, Kühn, Thorsten, additional, Lampe, Björn, additional, Ledwon, Peter, additional, Lemster, Sabine, additional, Lex, Benno, additional, Liebrich, Clemens, additional, Lorenz, Ralf, additional, Lück, Hans-Joachim, additional, Mallmann, Peter, additional, Meinerz, Wolfgang, additional, Menke, Götz, additional, Möbus, Volker, additional, Müller, Thomas, additional, Müller, Volker, additional, Neunhöffer, Tanja, additional, Ober, Angelika, additional, Oskay-Özcelik, Gülten, additional, Ostertag, Horst, additional, Pölcher, Martin, additional, Rautenberg, Beate, additional, Rein, Daniel, additional, Reiter, Wilhelm, additional, Rempen, Andreas, additional, Runnebaum, Ingo, additional, Schmidt, Marcus, additional, Schnohr, Sabine, additional, Scholz, Heinz, additional, Schröder, Willibald, additional, Simon, Eike, additional, Sperfeld, Antje, additional, Steckkönig, Annette, additional, Strauß, Hans-Georg, additional, Stuth, Ronaldo, additional, Terhaag, Jürgen, additional, Thiel, Falk, additional, Thill, Marc, additional, Tomé, Oliver, additional, Uleer, Christoph, additional, Vogel, Susanne, additional, Voß, Hermann, additional, Weigel, Michael, additional, Winkler, Ulrich, additional, Wischnik, Arthur, additional, Zeiser, Tobias, additional, Zorr, Andreas, additional, Glasspool, Ros, additional, Hudson, Emma, additional, Jones, Rachel, additional, Lafleur, Judith, additional, Marth, Christian, additional, Petru, Edgar, additional, Antill, Yoland, additional, Azer, Mary, additional, Baron-Hay, Sally, additional, Beale, Philip, additional, Begbie, Stephen, additional, Black, Allison, additional, Briscoe, Karen, additional, Dean, Andrew, additional, Goh, Jeffrey, additional, Harvey, Sandra, additional, Lee, Chee, additional, Matos, Marco, additional, Meniawy, Tarek, additional, Olesen, Inger, additional, Shannon, Catherine, additional, Vasey, Paul, additional, Abadie-Lacourtoisie, Sophie, additional, Arsene, Olivier, additional, Barthier, Sophie, additional, Becuwe-Roemer, Célia, additional, Berton-Rigaud, Dominique, additional, Cappiello-Bataller, Maria, additional, Catala, Stéphanie, additional, Del Piano, Francesco, additional, Deplanque, Gaël, additional, Despax, Raymond, additional, Dohollou, Nadine, additional, Garnier-Tixidré, Claire, additional, Grenier, Julien, additional, Guardiola, Emmanuel, additional, Hardy-Bessard, Anne-Claire, additional, Lefeuvre-Plesse, Claudia, additional, Leheurteur, Marianne, additional, Lesoin, Anne, additional, Levache, Charles-Briac, additional, Longo, Raffaele, additional, Lortholary, Alain, additional, Meunier, Jérôme, additional, Raban, Nadia, additional, Romano, Olivier, additional, Vannetzel, Jean-Michel, additional, and Zannetti, Alain, additional

Published
2020
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41. Abstract P4-06-13: Prospective analysis of molecular subtypes in triple negative breast cancer

Author

Vetter, Martina, primary, Hartung, Carolin, additional, Lantzsch, Tilmann, additional, Hanf, Volker, additional, Uleer, Christoph, additional, Peschel, Susanne, additional, John, Jutta, additional, Buchmann, Joerg, additional, Weigert, Edith, additional, Buerrig, Karl-Friedrich, additional, Kantelhardt, Eva-Johanna, additional, and Thomssen, Christoph, additional

Published
2020
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45. AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2020

Author

Ditsch, Nina, Untch, Michael, Kolberg-Liedtke, Cornelia, Jackisch, Christian, Krug, David, Friedrich, Michael, Janni, Wolfgang, Mueller, Volkmar, Albert, Ute-Susann, Banys-Paluchowski, Malgorzata, Bauerfeind, Ingo, Blohmer, Jens-Uwe, Budach, Wilfried, Dall, Peter, Diel, Ingo, Fallenberg, Eva Maria, Fasching, Peter A., Fehm, Tanja, Gerber, Bernd, Gluz, Oleg, Hanf, Volker, Harbeck, Nadia, Heil, Joerg, Huober, Jens, Kreipe, Hans H., Kuehn, Thorsten, Kuemmel, Sherko, Loibl, Sibylle, Lueftner, Diana, Lux, Michael, Maass, Nicolai, Moebus, Volker, Mundhenke, Christoph, Park-Simon, Tjoung-Won, Reimer, Toralf, Rhiem, Kerstin, Rody, Achim, Schmidt, Marcus, Schneeweiss, Andreas, Solbach, Chistine, Solomayer, Erich-Franz, Stickeler, Elmar, Thomssen, Christoph, Witzel, Isabell, Woeckel, Achim, Thill, Marc, Ditsch, Nina, Untch, Michael, Kolberg-Liedtke, Cornelia, Jackisch, Christian, Krug, David, Friedrich, Michael, Janni, Wolfgang, Mueller, Volkmar, Albert, Ute-Susann, Banys-Paluchowski, Malgorzata, Bauerfeind, Ingo, Blohmer, Jens-Uwe, Budach, Wilfried, Dall, Peter, Diel, Ingo, Fallenberg, Eva Maria, Fasching, Peter A., Fehm, Tanja, Gerber, Bernd, Gluz, Oleg, Hanf, Volker, Harbeck, Nadia, Heil, Joerg, Huober, Jens, Kreipe, Hans H., Kuehn, Thorsten, Kuemmel, Sherko, Loibl, Sibylle, Lueftner, Diana, Lux, Michael, Maass, Nicolai, Moebus, Volker, Mundhenke, Christoph, Park-Simon, Tjoung-Won, Reimer, Toralf, Rhiem, Kerstin, Rody, Achim, Schmidt, Marcus, Schneeweiss, Andreas, Solbach, Chistine, Solomayer, Erich-Franz, Stickeler, Elmar, Thomssen, Christoph, Witzel, Isabell, Woeckel, Achim, and Thill, Marc

Published
2020

47. AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2020

Author

Ditsch, Nina, primary, Untch, Michael, additional, Kolberg-Liedtke, Cornelia, additional, Jackisch, Christian, additional, Krug, David, additional, Friedrich, Michael, additional, Janni, Wolfgang, additional, Müller, Volkmar, additional, Albert, Ute-Susann, additional, Banys-Paluchowski, Malgorzata, additional, Bauerfeind, Ingo, additional, Blohmer, Jens-Uwe, additional, Budach, Wilfried, additional, Dall, Peter, additional, Diel, Ingo, additional, Fallenberg, Eva Maria, additional, Fasching, Peter A., additional, Fehm, Tanja, additional, Gerber, Bernd, additional, Gluz, Oleg, additional, Hanf, Volker, additional, Harbeck, Nadia, additional, Heil, Jörg, additional, Huober, Jens, additional, Kreipe, Hans H., additional, Kühn, Thorsten, additional, Kümmel, Sherko, additional, Loibl, Sibylle, additional, Lüftner, Diana, additional, Lux, Michael, additional, Maass, Nicolai, additional, Moebus, Volker, additional, Mundhenke, Christoph, additional, Park-Simon, Tjoung-Won, additional, Reimer, Toralf, additional, Rhiem, Kerstin, additional, Rody, Achim, additional, Schmidt, Marcus, additional, Schneeweiss, Andreas, additional, Solbach, Chistine, additional, Solomayer, Erich-Franz, additional, Stickeler, Elmar, additional, Thomssen, Christoph, additional, Witzel, Isabell, additional, Wöckel, Achim, additional, and Thill, Marc, additional

Published
2020
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48. Interdisziplinäre Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms : Leitlinie der DGGG und DKG (S3-Level, AWMF-Registernummer 032/045OL, Dezember 2017) – Teil 1 mit Empfehlungen zur Früherkennung, Diagnostik und Nachsorge des Mammakarzinoms

Author

Wöckel, Achim, Festl, Jasmin, Stüber, Tanja, Brust, Katharina, Stangl, Stephanie, Heuschmann, Peter Ulrich, Albert, Ute Susann, Budach, Wilfried, Follmann, Markus, Janni, Wolfgang, Kopp, Ina, Kreienberg, Rolf, Kühn, Thorsten, Langer, Thomas, Nothacker, Monika, Scharl, Anton, Schreer, Ingrid, Link, Hartmut, Engel, Jutta, Fehm, Tanja, Weis, Joachim, Welt, Anja, Steckelberg, Anke, Feyer, Petra, König, Klaus, Hahne, Andrea, Kreipe, Hans H., Knoefel, Wolfram Trudo, Denkinger, Michael, Brucker, Sara, Lüftner, Diana, Kubisch, Christian, Gerlach, Christina, Lebeau, Annette, Siedentopf, Friederike, Petersen, Cordula, Bartsch, Hans Helge, Schulz-Wendtland, Rüdiger, Hahn, Markus, Hanf, Volker, Müller-Schimpfle, Markus, Henscher, Ulla, Roncarati, Renza, Katalinic, Alexander, Heitmann, Christoph, Honegger, Christoph, Paradies, Kerstin, Bjelic-Radisic, Vesna, Degenhardt, Friedrich, Wenz, Frederik, Rick, Oliver, Hölzel, Dieter, Zaiss, Matthias, Kemper, Gudrun, Budach, Volker, Denkert, Carsten Michael, Gerber , Bernd, Tesch, Hans, Hirsmüller, Susanne, Sinn, Hans-Peter, Dunst, Jürgen, Münstedt, Karsten, Bick, Ulrich, Fallenberg, Eva, Tholen, Reina, Hung, Roswita, Baumann, Freerk T., Beckmann, Matthias Wilhelm, Blohmer, Jens-Uwe, Fasching, Peter Andreas, Lux, Michael Patrick, Harbeck, Nadia, Hadji, Peyman, Hauner, Hans, Heywang-Köbrunner, Sylvia H., Huober, Jens, Hübner, Jutta, Jackisch, Christian, Loibl, Sibylle, Lück, Hans-Jürgen, Minckwitz, Gunter von, Möbus, Volker, Müller, Volkmar, Nöthlings, Ute, Schmidt, Marcus, Schmutzler, Rita Katharina, Schneeweiss, Andreas, Schütz, Florian, Stickeler, Elmar, Thomssen, Christoph, Untch, Michael, Wesselmann, Simone, Bücker, Arno, and Krockenberger, Mathias

Subjects
ddc:610
Abstract

Purpose: The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. Methods: The process of updating the S3 guideline dating from 2012 was based on the adaptation of identified source guidelines which were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and the results of a systematic search of literature databases and the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point to develop recommendations and statements which were modified and graded in a structured consensus procedure. Recommendations: Part 1 of this short version of the guideline presents recommendations for the screening, diagnosis and follow-up care of breast cancer. The importance of mammography for screening is confirmed in this updated version of the guideline and forms the basis for all screening. In addition to the conventional methods used to diagnose breast cancer, computed tomography (CT) is recommended for staging in women with a higher risk of recurrence. The follow-up concept includes suggested intervals between physical, ultrasound and mammography examinations, additional high-tech diagnostic procedures, and the determination of tumor markers for the evaluation of metastatic disease. Ziele: Das Ziel dieser offiziellen Leitlinie, die von der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) und der Deutschen Krebsgesellschaft (DKG) publiziert und koordiniert wurde, ist es, die Früherkennung, Diagnostik, Therapie und Nachsorge des Mammakarzinoms zu optimieren. Methoden: Der Aktualisierungsprozess der S3-Leitlinie aus 2012 basierte zum einen auf der Adaptation identifizierter Quellleitlinien und zum anderen auf Evidenzübersichten, die nach Entwicklung von PICO-(Patients/Interventions/Control/Outcome-)Fragen, systematischer Recherche in Literaturdatenbanken sowie Selektion und Bewertung der gefundenen Literatur angefertigt wurden. In den interdisziplinären Arbeitsgruppen wurden auf dieser Grundlage Vorschläge für Empfehlungen und Statements erarbeitet, die im Rahmen von strukturierten Konsensusverfahren modifiziert und graduiert wurden. Empfehlungen: Der Teil 1 dieser Kurzversion der Leitlinie zeigt Empfehlungen zur Früherkennung, Diagnostik und Nachsorge des Mammakarzinoms: Der Stellenwert des Mammografie-Screenings wird in der aktualisierten Leitlinienversion bestätigt und bildet damit die Grundlage der Früherkennung. Neben den konventionellen Methoden der Karzinomdiagnostik wird die Computertomografie (CT) zum Staging bei höherem Rückfallrisiko empfohlen. Die Nachsorgekonzepte beinhalten Untersuchungsintervalle für die körperliche Untersuchung, Ultraschall und Mammografie, während weiterführende Gerätediagnostik und Tumormarkerbestimmungen bei der metastasierten Erkrankung Anwendung finden.

Published
2018

49. Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

Author

Bauer, Marcus, primary, Kantelhardt, Eva Johanna, additional, Stiewe, Thorsten, additional, Nist, Andrea, additional, Mernberger, Marco, additional, Politt, Katharina, additional, Hanf, Volker, additional, Lantzsch, Tilmann, additional, Uleer, Christoph, additional, Peschel, Susanne, additional, John, Jutta, additional, Buchmann, Jörg, additional, Weigert, Edith, additional, Bürrig, Karl-Friedrich, additional, Wickenhauser, Claudia, additional, Thomssen, Christoph, additional, Bartel, Frank, additional, and Vetter, Martina, additional

Published
2019
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50. Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel

Author

von Minckwitz Gunter, Sweep Fred, Schmitt Manfred, Paepke Daniela, Meisner Christoph, Hanf Volker, Augustin Doris, Veyret Corinne, Schmidt Marcus, Vetter Martina, Kantelhardt Eva J, Martin Pierre-Marie, Jaenicke Fritz, Thomssen Christoph, and Harbeck Nadia

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Today, more than 70% of patients with primary node-negative breast cancer are cured by local therapy alone. Many patients receive overtreatment by adjuvant chemotherapy due to inadequate risk assessment. So far, few clinical trials have prospectively evaluated tumor biology based prognostic factors. Risk assessment by a biological algorithm including invasion factors urokinase-type plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor type 1 (PAI-1) will assess up to 35-55% of node-negative patients as low-risk and thus avoid chemotherapy. In contrast, a clinical-pathological algorithm will only classify 20-40% of patients as low-risk. High-risk node-negative patients should receive chemotherapy. Anthracycline-based regimens are accepted as a standard, the additional benefit of taxanes remains an open question. Methods/Design The international NNBC3 ("Node Negative Breast Cancer 3-Europe") trial compares biological risk assessment (UP) using invasion factors uPA/PAI-1 with a clinical-pathological algorithm (CP). In this trial, the type of risk assessment (CP or UP) was chosen upfront by each center for its patients. Fresh frozen tissue was obtained to determine uPA/PAI-1 using an enzyme-linked immunosorbent assay (ELISA). Patients assessed as high-risk were stratified by human epidermal growth factor receptor 2 (HER2) status and then randomised to receive anthracycline-containing chemotherapy 5-Fluorouracil (F)/Epirubicin (E)/Cyclophosphymide (C) or an anthracycline-taxane sequence (FE100C*6 versus FE100C*3 followed by Docetaxel100*3). Discussion In this trial, 4,149 node-negative patients with operable breast cancer from 153 centers in Germany and France were included since 2002. Measurement of uPA/PAI-1 by ELISA was performed with standardised central quality assurance for 2,497 patients (60%) from 56 "UP"-centers. The NNBC 3-Europe trial showed that inclusion of patients into a clinical phase III trial is feasible based on biological testing of fresh frozen tumor material. In addition, 2,661 patients were classified as high-risk and thus received chemotherapy. As adjuvant chemotherapy, 1,334 high-risk patients received FE100C-Docetaxel100, and 1,327 received French FE100C. No unexpected toxicities were observed. Chemotherapy efficacy and comparison of UP with CP will be evaluated after longer follow-up. Trial Registration clinical Trials.gov NCT01222052.

Published
2011
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