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186 results on '"Hang, Chunhua"'

12. Evidence‐based guideline for the prevention and management of perioperative infection

Author

Wang, Qiaoyu, primary, Cao, Mingnan, additional, Tao, Hua, additional, Fei, Zhimin, additional, Huang, Xiufeng, additional, Liang, Pixia, additional, Liu, Baiyun, additional, Liu, Jianping, additional, Lu, Xiaoyang, additional, Ma, Penglin, additional, Si, Shuyi, additional, Wang, Shuo, additional, Zhang, Yuewei, additional, Zheng, Yingli, additional, Zang, Lei, additional, Chen, Xiao, additional, Dong, Zhanjun, additional, Ge, Weihong, additional, Guo, Wei, additional, Hu, Xin, additional, Huang, Xin, additional, Li, Ling, additional, Liang, Jianshu, additional, Liu, Baoge, additional, Liu, Dong, additional, Liu, Linna, additional, Liu, Songqing, additional, Liu, Xianghong, additional, Miao, Liyan, additional, Ren, Haixia, additional, Shi, Guangzhi, additional, Shi, Luwen, additional, Sun, Shumei, additional, Tao, Xia, additional, Tong, Rongsheng, additional, Wang, Cheng, additional, Wang, Bin, additional, Wang, Jincheng, additional, Wang, Jingwen, additional, Wang, Xiaoling, additional, Wang, Xiaoyan, additional, Xie, Jian, additional, Xie, Shouxia, additional, Yang, Hua, additional, Yang, Jianxin, additional, You, Chao, additional, Zhang, Hongyi, additional, Zhang, Yi, additional, Zhao, Chengson, additional, Zhao, Qingchun, additional, Zhu, Jiangguo, additional, Ji, Bo, additional, Guo, Ruichen, additional, Hang, Chunhua, additional, Xi, Xiaowei, additional, Li, Sheyu, additional, Gong, Zhicheng, additional, Zhou, Jianxin, additional, Wang, Rui, additional, and Zhao, Zhigang, additional

Published
2023
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14. Extracranial-Intracranial Bypass and Risk of Stroke and Death in Patients With Symptomatic Artery Occlusion: The CMOSS Randomized Clinical Trial.

Author

Ma, Yan, Wang, Tao, Wang, Haibo, Amin-Hanjani, Sepideh, Tong, Xiaoguang, Wang, Jiyue, Tong, Zhiyong, Kuai, Dong, Cai, Yiling, Ren, Jun, Wang, Donghai, Duan, Lian, Maimaitili, Aisha, Hang, Chunhua, Yu, Jiasheng, Bai, Xuesong, Powers, William J., Derdeyn, Colin P., Wu, Yangfeng, and Ling, Feng

Subjects
CEREBRAL revascularization, STROKE patients, TRANSIENT ischemic attack, ARTERIAL occlusions, INTERNAL carotid artery, GASTRIC bypass, TRANSCRANIAL Doppler ultrasonography
Abstract

Key Points: Question: Among symptomatic patients with atherosclerotic occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA) with evidence of hemodynamic insufficiency in the affected territory, does extracranial-intracranial (EC-IC) bypass surgery plus medical therapy reduce stroke or death compared with medical therapy alone? Findings: In this randomized clinical trial that included 324 patients, the addition of bypass surgery to medical therapy did not significantly change the risk of the composite outcome of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years compared with medical therapy alone (8.6% vs 12.3%, respectively; hazard ratio, 0.71). Meaning: The findings do not support the addition of EC-IC bypass surgery to medical therapy for the treatment of patients with symptomatic atherosclerotic occlusion of the ICA or MCA. Importance: Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA), but there have been subsequent improvements in surgical techniques and patient selection. Objective: To evaluate EC-IC bypass surgery in symptomatic patients with atherosclerotic occlusion of the ICA or MCA, using refined patient and operator selection. Design, Setting, and Participants: This was a randomized, open-label, outcome assessor–blinded trial conducted at 13 centers in China. A total of 324 patients with ICA or MCA occlusion with transient ischemic attack or nondisabling ischemic stroke attributed to hemodynamic insufficiency based on computed tomography perfusion imaging were recruited between June 2013 and March 2018 (final follow-up: March 18, 2020). Interventions: EC-IC bypass surgery plus medical therapy (surgical group; n = 161) or medical therapy alone (medical group; n = 163). Medical therapy included antiplatelet therapy and stroke risk factor control. Main Outcomes and Measures: The primary outcome was a composite of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years after randomization. There were 9 secondary outcomes, including any stroke or death within 2 years and fatal stroke within 2 years. Results: Among 330 patients who were enrolled, 324 patients were confirmed eligible (median age, 52.7 years; 257 men [79.3%]) and 309 (95.4%) completed the trial. For the surgical group vs medical group, no significant difference was found for the composite primary outcome (8.6% [13/151] vs 12.3% [19/155]; incidence difference, −3.6% [95% CI, −10.1% to 2.9%]; hazard ratio [HR], 0.71 [95% CI, 0.33-1.54]; P =.39). The 30-day risk of stroke or death was 6.2% (10/161) in the surgical group and 1.8% (3/163) in the medical group, and the risk of ipsilateral ischemic stroke beyond 30 days through 2 years was 2.0% (3/151) and 10.3% (16/155), respectively. Of the 9 prespecified secondary end points, none showed a significant difference including any stroke or death within 2 years (9.9% [15/152] vs 15.3% [24/157]; incidence difference, −5.4% [95% CI, −12.5% to 1.7%]; HR, 0.69 [95% CI, 0.34-1.39]; P =.30) and fatal stroke within 2 years (2.0% [3/150] vs 0% [0/153]; incidence difference, 1.9% [95% CI, −0.2% to 4.0%]; P =.08). Conclusions and Relevance: Among patients with symptomatic ICA or MCA occlusion and hemodynamic insufficiency, the addition of bypass surgery to medical therapy did not significantly change the risk of the composite outcome of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years. Trial Registration: ClinicalTrials.gov Identifier: NCT01758614 This clinical trial compares the efficacy of extracranial-intracranial bypass surgery plus medical therapy vs medical therapy alone in symptomatic patients with internal carotid artery or middle cerebral artery occlusion and hemodynamic insufficiency on a composite of stroke or death within 30 days or ipsilateral ischemic stroke beyond 30 days through 2 years after randomization. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Intraoperative Hemodynamics of Parasylvian Cortical Arteries for Predicting Postoperative Symptomatic Cerebral Hyperperfusion after Direct Revascularization in Patients with Moyamoya Disease: A Preliminary Study.

Author

Shi, Zhiyong, Wu, Lingyun, Wang, Yi, Li, Wei, Wang, Juan, Yang, Yongbo, and Hang, Chunhua

Subjects
MOYAMOYA disease, HEMODYNAMICS, HYPERPERFUSION, ARTERIES, DOPPLER ultrasonography
Abstract

Objective. The search for methods by which to predict the risks of cerebral hyperperfusion syn-drome (CHS) in adults with moyamoya disease (MMD), including those utilizing new biomarkers, still deserves further research. The objective of this study was to investigate the association between the hemodynamics of parasylvian cortical arteries (PSCAs) and postoperative CHS. Methods. A consecutive number of adults with MMD who had undergone direct bypass between September 2020 and December 2022 were recruited. Intraoperative microvascular doppler ultrasonography (MDU) was performed to evaluate the hemodynamics of PSCAs. The intraoperative flow direction, mean value of velocity (MVV) of recipient artery (RA) and bypass graft were recorded. According to flow direction after bypass, RA was divided into entering sylvian (RA.ES) and leaving sylvian (RA.LS) subtypes. Univariate, multivariate, and ROC analyses of the risk factors for postoperative CHS were performed. Results. A total of 16 (15.09%) cases in 106 consecutive hemispheres (101 patients) sat-isfied the postoperative CHS criteria. According to univariate analysis, advanced Suzuki stage, MVV of RA before bypass, and fold increase of MVV in RA.ES after bypass were significantly associated with postoperative CHS (p < 0.05). Multivariate analysis indicated that left-operated hemisphere (OR (95%CI), 4.58 (1.05–19.97), p = 0.043), advanced Suzuki stage (OR (95%CI), 5.47 (1.99–15.05), p = 0.017), and fold increase of MVV in RA.ES (OR (95%CI), 1.17 (1.06–1.30), p = 0.003) were statistically significantly associated with the occurrence of CHS. The cut-off value of fold increase of MVV in RA.ES was 2.7-fold (p < 0.05). Conclusions. Left-operated hemisphere, advanced Suzuki stage, and postoperative fold increase of MVV in RA.ES were potential risk factors for postoperative CHS. Intraoperative MDU was useful for evaluating hemodynamics and predicting CHS. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4

Author

Huang, Tengfei, primary, Xu, Tianqi, additional, Wang, Yangfan, additional, Zhou, Yan, additional, Yu, Dandan, additional, Wang, Zhiyuan, additional, He, Linfang, additional, Chen, Zhangpeng, additional, Zhang, Yaliang, additional, Davidson, Don, additional, Dai, Yuyuan, additional, Hang, Chunhua, additional, Liu, Xiangyu, additional, and Yan, Chao, additional

Published
2021
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33. Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

Author

Wang, Han, primary, Zhou, Xiaoming, additional, Wu, Lingyun, additional, Liu, Guangjie, additional, Xu, Weidong, additional, Zhang, Xiangsheng, additional, Gao, Yongyue, additional, Tao, Tao, additional, Zhou, Yan, additional, Lu, Yue, additional, Wang, Juan, additional, Deng, Chulei, additional, Zhuang, Zong, additional, Hang, Chunhua, additional, and Li, Wei, additional

Published
2020
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37. Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

Author

Gao, YongYue, primary, Zhuang, Zong, additional, Lu, Yue, additional, Tao, Tao, additional, Zhou, Yan, additional, Liu, GuangJie, additional, Wang, Han, additional, Zhang, DingDing, additional, Wu, LingYun, additional, Dai, HaiBin, additional, Li, Wei, additional, and Hang, ChunHua, additional

Published
2019
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49. Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment

Author

Zhou, Chenhui, primary, Xie, Guangbin, additional, Wang, Chunxi, additional, Zhang, Zihuan, additional, Chen, Qiang, additional, Zhang, Li, additional, Wu, Lingyun, additional, Wei, Yongxiang, additional, Ding, Hui, additional, Hang, Chunhua, additional, Zhou, Mengliang, additional, and Shi, Jixin, additional

Published
2015
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