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5. Genetic characterization of highly pathogenic avian influenza (H5N8) virus from domestic ducks, England, November 2014

Author

Hanna, Amanda, Banks, Jill, Marston, Denise A., Ellis, Richard J., Brookes, Sharon M., and Brown, Ian H.

Subjects
Avian influenza -- Genetic aspects, Avian influenza viruses, Health
Abstract

Aquatic birds are considered to be the natural reservoir of low pathogenicity avian influenza viruses of subtypes H1-H16; in these birds, including ducks, they generally do not cause clinical signs [...]

Published
2015
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7. THE INFLUENCE OF ORGANIZATIONAL CULTURE AND PERCEIVED ORGANIZATIONAL SUPPORT ON EMPLOYEE ENGAGEMENT WITH ORGANIZATIONAL COMMITMENT AS A MEDIATOR

Author

Hanna Amanda and Pantius Drahen Soeling

Subjects
Data collection, Perception, media_common.quotation_subject, Phenomenon, Employee engagement, Organizational culture, Organizational commitment, Psychology, Affect (psychology), Social psychology, Perceived organizational support, media_common
Abstract

The focus of this research is how to improve employee engagement at the PT.X head office by examining the relationship between organizational culture and organizational perceptions of employee engagement with organizational commitment as a mediator. This research uses quantitative approach, which is a study that aims to explain a cause of the occurrence of social phenomena, which the phenomenon will be explained by conducting an objective measurement. Primary data collection through the dissemination of questionnaires to 74 respondents. Data analysis using the partial least square equation model or can be known as SEM-PLS. Based on the results of research that has been found, it can be concluded that organizational culture variable does not give a significant direct positive influence on employee engagement, whereas when viewed on variables perceived organizational support and organizational commitment, these two variables have a significant positive direct affect on employee engagement. If the direct influence relationship between organizational culture and employee engagement does not have a significant influence, but when the variable is mediated by organizational commitment, then the results state that there is a significant positive influence relationship between the two variables. This shows that the organization's commitment to succeed has a significant role in mediating the relationship between organizational culture and employee engagement.

Published
2021
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12. Taking on pet obesity

Author

Angliss, Gillian, primary, Ebers, Kathleen L., additional, Landis-Hanna, Amanda, additional, Vale, Alina, additional, Stomack, Kayla, additional, Niino, Tak, additional, O'Connell, Jananne, additional, Janezcko, Stephanie, additional, Shearer, Jonathan P., additional, and Lyle, L. Tiffany, additional

Published
2019
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13. Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea

Author

Hill, Sarah Catherine, Lee, Youn Jeong, Song, Byung Min, Kang, Hyun Mi, Lee, Eun Kyoung, Hanna, Amanda, Brown, Ian H., Gilbert, Marius, and Pybus, Oliver George

Subjects
Microbiology (medical), Genes, Viral, ROK, Republic of Korea, Avian influenza, Microbiology, Article, Disease Outbreaks, H5N8, Republic of Korea, Genetics, Animals, Molecular Biology, Phylogeny, Poultry Diseases, Ecology, Evolution, Behavior and Systematics, Korea, Ecology, Sequence Analysis, DNA, Sciences bio-médicales et agricoles, Molecular Typing, Phylogenetics, Phylogeography, Ducks, Infectious Diseases, Influenza A virus, Influenza in Birds, Animal Migration
Abstract

Highly pathogenic avian influenza (HPAI) viruses threaten human and animal health yet their emergence is poorly understood, partly because sampling of the HPAI Asian-origin H5N1 lineage immediately after its identification in 1996 was comparatively sparse. The discovery of a novel H5N8 virus in 2013 provides a new opportunity to investigate HPAI emergence in greater detail. Here we investigate the origin and transmission of H5N8 in the Republic of Korea, the second country to report the new strain. We reconstruct viral spread using phylogeographic methods and interpret the results in the context of ecological data on poultry density, overwintering wild bird numbers, and bird migration patterns. Our results indicate that wild waterfowl migration and domestic duck density were important to H5N8 epidemiology. Specifically, we infer that H5N8 entered the Republic of Korea via Jeonbuk province, then spread rapidly among western provinces where densities of overwintering waterfowl and domestic ducks are higher, yet rarely persisted in eastern regions. The common ancestor of H5N8 in the Republic of Korea was estimated to have arrived during the peak of inward migration of overwintering birds. Recent virus isolations likely represent re-introductions via bird migration from an as-yet unsampled reservoir. Based on the limited data from outside the Republic of Korea, our data suggest that H5N8 may have entered Europe at least twice, and Asia at least three times from this reservoir, most likely carried by wild migrating birds., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015
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14. Normal cognition in transgenic BRI2-Aβ mice

Author

Kim, Jungsu, primary, Chakrabarty, Paramita, additional, Hanna, Amanda, additional, March, Amelia, additional, Dickson, Dennis W, additional, Borchelt, David R, additional, Golde, Todd, additional, and Janus, Christopher, additional

Published
2013
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15. Challenges for accurate and prompt molecular diagnosis of clades of highly pathogenic avian influenza H5N1 viruses emerging in Vietnam

Author

Slomka, Marek J., primary, To, Thanh L., additional, Tong, Hien H., additional, Coward, Vivien J., additional, Hanna, Amanda, additional, Shell, Wendy, additional, Pavlidis, Theo, additional, Densham, Anstice L. E., additional, Kargiolakis, Georgios, additional, Arnold, Mark E., additional, Banks, Jill, additional, and Brown, Ian H., additional

Published
2012
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19. Original Article: Real time reverse transcription (RRT)-polymerase chain reaction (PCR) methods for detection of pandemic (H1N1) 2009 influenza virus and European swine influenza A virus infections in pigs

Author

Slomka, Marek J., primary, Densham, Anstice L. E., additional, Coward, Vivien J., additional, Essen, Steve, additional, Brookes, Sharon M., additional, Irvine, Richard M., additional, Spackman, Erica, additional, Ridgeon, Jonathan, additional, Gardner, Rebecca, additional, Hanna, Amanda, additional, Suarez, David L., additional, and Brown, Ian H., additional

Published
2010
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20. Replication, Pathogenesis and Transmission of Pandemic (H1N1) 2009 Virus in Non-Immune Pigs

Author

Brookes, Sharon M., primary, Núñez, Alejandro, additional, Choudhury, Bhudipa, additional, Matrosovich, Mikhail, additional, Essen, Stephen C., additional, Clifford, Derek, additional, Slomka, Marek J., additional, Kuntz-Simon, Gaëlle, additional, Garcon, Fanny, additional, Nash, Bethany, additional, Hanna, Amanda, additional, Heegaard, Peter M. H., additional, Quéguiner, Stéphane, additional, Chiapponi, Chiara, additional, Bublot, Michel, additional, Garcia, Jaime Maldonado, additional, Gardner, Rebecca, additional, Foni, Emanuela, additional, Loeffen, Willie, additional, Larsen, Lars, additional, Van Reeth, Kristien, additional, Banks, Jill, additional, Irvine, Richard M., additional, and Brown, Ian H., additional

Published
2010
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22. Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy

Author

Berger, Zdenek, primary, Roder, Hanno, additional, Hanna, Amanda, additional, Carlson, Aaron, additional, Rangachari, Vijayaraghavan, additional, Yue, Mei, additional, Wszolek, Zbigniew, additional, Ashe, Karen, additional, Knight, Joshua, additional, Dickson, Dennis, additional, Andorfer, Cathy, additional, Rosenberry, Terrone L., additional, Lewis, Jada, additional, Hutton, Mike, additional, and Janus, Christopher, additional

Published
2007
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23. Cortical Neuronal and Glial Pathology in TgTauP301L Transgenic Mice

Author

Murakami, Tetsuro, primary, Paitel, Erwan, additional, Kawarabayashi, Takeshi, additional, Ikeda, Masaki, additional, Chishti, M. Azhar, additional, Janus, Christopher, additional, Matsubara, Etsuro, additional, Sasaki, Atsushi, additional, Kawarai, Toshitaka, additional, Phinney, Amie L., additional, Harigaya, Yasuo, additional, Horne, Patrick, additional, Egashira, Nobuaki, additional, Mishima, Kenichi, additional, Hanna, Amanda, additional, Yang, Jing, additional, Iwasaki, Katsunori, additional, Takahashi, Mitsuo, additional, Fujiwara, Michihiro, additional, Ishiguro, Koichi, additional, Bergeron, Catherine, additional, Carlson, George A., additional, Abe, Koji, additional, Westaway, David, additional, St. George-Hyslop, Peter, additional, and Shoji, Mikio, additional

Published
2006
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25. O4-05-01: Methods of cell death and recovery in the rTg4510 and iP301L inducible mouse models of tauopathy

Author

Lewis, Jada, primary, Zehr, Cindy, additional, Andorfer, Cathy, additional, Eriksen, Jason, additional, Knight, Joshua, additional, Yue, Mei, additional, Robinson, Todd, additional, Berger, Zdenek, additional, Hanna, Amanda, additional, Dickson, Dennis W., additional, Janus, Chris, additional, McGowan, Eileen, additional, and Hutton, Mike, additional

Published
2006
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26. Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027.

Author

Barten, Donna M., Fanara, Patrizia, Andorfer, Cathy, Hoque, Nina, Wong, P. Y. Anne, Husted, Kristofor H., Cadelina, Gregory W., DeCarr, Lynn B., Ling Yang, Victoria Liu, Fessler, Chancy, Protassio, Joan, Riff, Timothy, Turner, Holly, Janus, Christopher G., Sankaranarayanan, Sethu, Polson, Craig, Meredith, Jere E., Gray, Gemma, and Hanna, Amanda

Subjects
TRANSGENIC mice, MICROTUBULES, PATHOLOGY, TAU proteins, ALZHEIMER'S disease, ANIMAL models in research
Abstract

Tau is a microtubule (MT)-stabilizing protein that is altered in Alzheimer's disease (AD) and other tauopathies. It is hypothesized that the hyperphosphorylated, conformationally altered, and multimeric forms of tau lead to a disruption of MT stability; however, direct evidence is lacking in vivo. In this study, an in vivo stable isotope-mass spectrometric technique was used to measure the turnover, or dynamicity, of MTs in brains of living animals. We demonstrated an age-dependent increase in MT dynamics in two different tau transgenic mouse models, 3xTg and rTg4510. MT hyperdynamicity was dependent on tau expression, since a reduction of transgene expression with doxycycline reversed the MT changes. Treatment of rTg4510 mice with the epothilone, BMS-241027, also restored MT dynamics to baseline levels. In addition, MT stabilization with BMS-241027 had beneficial effects on Morris water maze deficits, tau pathology, and neurodegeneration. Interestingly, pathological and functional benefits of BMS-241027 were observed at doses that only partially reversed MT hyperdynamicity. Together, these data suggest that tau-mediated loss of MT stability may contribute to disease progression and that very low doses of BMS-241027 may be useful in the treatment of AD and other tauopathies. [ABSTRACT FROM AUTHOR]

Published
2012
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27. Abnormal Long-Lasting Synaptic Plasticity and Cognition in Mice Lacking the Mental Retardation Gene Pak3.

Author

Jinsong Meng, Yanghong Meng, Hanna, Amanda, Janus, Christopher, and Zhengping Jia

Subjects
INTELLECTUAL disabilities, GENETIC mutation, ACTIN, MEMORY, LABORATORY mice
Abstract

Mutations in the Pak3 gene lead to nonsyndromic mental retardation characterized by selective deficits in cognition. However, the underlying mechanisms are yet to be elucidated. We report here that the knock-out mice deficient in the expression of p21-activated kinase 3 (PAK3) exhibit significant abnormalities in synaptic plasticity, specifically hippocampal late-phase long-term potentiation, and deficiencies in learning and memory. A dramatic reduction in the active form of transcription factor cAMP-responsive element-binding protein in the knock-out mice implicates a novel signaling mechanism by which PAK3 and Rho signaling regulate synaptic function and cognition. [ABSTRACT FROM AUTHOR]

Published
2005
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28. Cortical Neuronal and Glial Pathology in TgTauP301LTransgenic Mice

Author

Murakami, Tetsuro, Paitel, Erwan, Kawarabayashi, Takeshi, Ikeda, Masaki, Chishti, M. Azhar, Janus, Christopher, Matsubara, Etsuro, Sasaki, Atsushi, Kawarai, Toshitaka, Phinney, Amie L., Harigaya, Yasuo, Horne, Patrick, Egashira, Nobuaki, Mishima, Kenichi, Hanna, Amanda, Yang, Jing, Iwasaki, Katsunori, Takahashi, Mitsuo, Fujiwara, Michihiro, Ishiguro, Koichi, Bergeron, Catherine, Carlson, George A., Abe, Koji, Westaway, David, St. George-Hyslop, Peter, and Shoji, Mikio

Abstract

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTauP301L) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-17) mutation within the longest form of tau (2N, 4R). TgTauP301Lmice developed florid pathology including neuronal pretangles, numerous Gallyas-Braak-positive neurofibrillary tangles, and glial fibrillary tangles in the frontotemporal areas of the cerebrum, in the brainstem, and to a lesser extent in the spinal cord. These features were accompanied by gliosis, neuronal loss, and cerebral atrophy. Accumulated tau was hyperphosphorylated, conformationally changed, ubiquitinated, and sarkosyl-insoluble, with electron microscopy demonstrating wavy filaments. Aged TgTauP301Lmice exhibited impairment in hippocampally dependent and independent behavioral paradigms, with impairments closely related to the presence of tau pathologies and levels of insoluble tau protein. We conclude that TgTauP301Lmice recreate the substantial phenotypic variation and spectrum of pathologies seen in FTDP-17 patients. Identification of genetic and/or environmental factors modifying the tau phenotype in these mice may shed light on factors modulating human tauopathies. These transgenic mice may aid therapeutic development for FTDP-17 and other diseases featuring accumulations of four-repeat tau, such as Alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy.

Published
2006
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29. Access to Veterinary Care.

Author

Landis-Hanna, Amanda

Subjects
*VETERINARY hospitals, *PET owners, *VETERINARY care teams
Published
2018

30. SOS: Pet Mess.

Author

Dodd, Jessica, Cobb, Linda, Landis-hanna, Amanda, and Nichols, Amy

Subjects
HOUSE cleaning, DOGS, HYDROGEN peroxide, AMMONIA, GUINEA pigs
Abstract

The article offers suggestion for maintaining house cleaning, amid mess by pets. It mentions use a squeegee or a damp rubber glove to collect the dog fur, while using combination of a half cup of hydrogen peroxide with one teaspoon of ammonia to clean drool. It also mentions separation and removal of guinea pig's droppings with a plastic scoop or a paper towel daily.

Published
2018

31. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3.

Author

Meng J, Meng Y, Hanna A, Janus C, and Jia Z

Subjects
Animals, Avoidance Learning, Brain Chemistry, Conditioning, Classical, Cyclic AMP Response Element-Binding Protein physiology, Dendrites ultrastructure, Hippocampus chemistry, Learning Disabilities genetics, Long-Term Potentiation genetics, Male, Maze Learning, Memory Disorders genetics, Mice, Mice, Inbred C57BL, Mice, Knockout, Nerve Tissue Proteins analysis, Nerve Tissue Proteins physiology, Neurons ultrastructure, Phosphorylation, Protein Processing, Post-Translational, Protein Serine-Threonine Kinases deficiency, Protein Serine-Threonine Kinases genetics, Signal Transduction, p21-Activated Kinases, rho GTP-Binding Proteins physiology, Cognition Disorders genetics, Hippocampus physiopathology, Intellectual Disability genetics, Neuronal Plasticity genetics, Protein Serine-Threonine Kinases physiology
Abstract

Mutations in the Pak3 gene lead to nonsyndromic mental retardation characterized by selective deficits in cognition. However, the underlying mechanisms are yet to be elucidated. We report here that the knock-out mice deficient in the expression of p21-activated kinase 3 (PAK3) exhibit significant abnormalities in synaptic plasticity, specifically hippocampal late-phase long-term potentiation, and deficiencies in learning and memory. A dramatic reduction in the active form of transcription factor cAMP-responsive element-binding protein in the knock-out mice implicates a novel signaling mechanism by which PAK3 and Rho signaling regulate synaptic function and cognition.

Published
2005
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