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196 results on '"Hansen, S E"'

14. Health-Related Quality-of-Life in patients with chronic rheumatic disease after a multidisciplinary rehabilitation regimen

Author

Couppé, C, Comins, J., Beyer, N., Hansen, S. E., Stodolsky, D. S., Siersma, V., Couppé, C, Comins, J., Beyer, N., Hansen, S. E., Stodolsky, D. S., and Siersma, V.

Abstract

Introduction: Multidisciplinary rehabilitation has beneficial effects on health-related quality of life (HRQoL) in patients with chronic rheumatic diseases. However, whether this intervention benefits different age groups in women or men is largely unknown. Purpose: To investigate HRQoL in patients with chronic rheumatic disease after completion of a 3-week multidisciplinary treatment, with special focus on differences in effect between age and gender groups. Method: HRQoL was measured with SF-36. Mean scores for all SF-36 domains were compared before and after the 3-week regimen and again at 3-, 6-, and 12-month follow-ups. Multivariable linear regression models using generalized estimating equations to account for repeated measurement were employed. A weighting procedure to account for differential dropouts was applied. Results: Three hundred fifty-six women and 74 men with chronic rheumatic disease were included. There were short-term improvements in all SF-36 domains irrespective of age or gender. These effects persisted for up to 1 year in the psychological, social, and energy domains for women under 50. We found no lasting effects for men; however, young men showed similar trends. Conclusion: Inpatient multidisciplinary rehabilitation improves short-term HRQoL in all patients. Younger women maintain these beneficial effects for up to 1 year. Additional intervention should be considered for elderly women and for men in order to sustain rehabilitation effects.

Published
2017

22. Crustal and upper-mantle structure beneath ice-covered regions in Antarctica from S-wave receiver functions and implications for heat flow.

Author

Ramirez, C., Nyblade, A., Hansen, S. E., Wiens, D. A., Anandakrishnan, S., Aster, R. C., Huerta, A. D., Shore, P., and Wilson, T.

Subjects
SHEAR waves, EARTH'S mantle, INTERNAL structure of the Earth, HEAT transfer, CENOZOIC paleoecology
Abstract

S-wave receiver functions (SRFs) are used to investigate crustal and upper-mantle structure beneath several ice-covered areas of Antarctica. Moho S-to-P (Sp) arrivals are observed at ~6-8 s in SRF stacks for stations in the Gamburtsev Mountains (GAM) and Vostok Highlands (VHIG), ~5-6 s for stations in the Transantarctic Mountains (TAM) and the Wilkes Basin (WILK), and ~3-4 s for stations in the West Antarctic Rift System (WARS) and the Marie Byrd Land Dome (MBLD). A grid search is used to model the Moho Sp conversion time with Rayleigh wave phase velocities from 18 to 30 s period to estimate crustal thickness and mean crustal shear wave velocity. The Moho depths obtained are between 43 and 58 km for GAM, 36 and 47 km for VHIG, 39 and 46 km for WILK, 39 and 45 km for TAM, 19 and 29 km for WARS and 20 and 35 km for MBLD. SRF stacks for GAM, VHIG, WILK and TAM show little evidence of Sp arrivals coming from upper-mantle depths. SRF stacks for WARS and MBLD show Sp energy arriving from upper-mantle depths but arrival amplitudes do not rise above bootstrapped uncertainty bounds. The age and thickness of the crust is used as a heat flow proxy through comparison with other similar terrains where heat flow has been measured. Crustal structure in GAM, VHIG and WILK is similar to Precambrian terrains in other continents where heat flow ranges from ~41 to 58 mW m-2, suggesting that heat flow across those areas of East Antarctica is not elevated. For the WARS, we use the Cretaceous Newfoundland-Iberia rifted margins and the Mesozoic-Tertiary North Sea rift as tectonic analogues. The low-to-moderate heat flow reported for the Newfoundland-Iberia margins (40-65 mW m-2) and North Sea rift (60-85 mW m-2) suggest that heat flow across the WARS also may not be elevated. However, the possibility of high heat flow associated with localized Cenozoic extension or Cenozoic-recent magmatic activity in some parts of the WARS cannot be ruled out. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Arginine residue 120 of the human GABAAreceptor α1subunit is essential for GABA binding and chloride ion current gating

Author

Westh-Hansen, S E., Witt, M R., Dekermendjian, K, Liljefors, T, Rasmussen, P B., and Nielsen, M

Abstract

The effect of mutating the conserved amino acid residue arginine 120 to lysine in the GABAAreceptor α1subunit was studied. In electrophysiological experiments, the arginine 120 lysine (R120K) mutation in the α1subunit, when co-expressed with β2and γ2subunits in Sf-9 insect cells, induces a 180-fold rightward shift of the GABA dose–response curve compared with wild type α1β2γ2sGABAAreceptors. The diazepam potentiation of GABA-gated chloride ion currents was not affected. The binding of the GABAAligands [3H]muscimol and [3H]SR 95531 to α1(R120K)β2γ2sGABAAreceptors was abolished but the binding affinity of the benzodiazepine receptor ligand [3H]flunitrazepam was unchanged. These results suggest that the arginine residue 120 in the α1subtype of the GABAAreceptor is essential for GABA binding.

Published
1999

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