48 results on '"Hanumegowda, Umesh"'
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2. Assessing the risk of drug crystallization in vivo
3. Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies
4. Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold
5. Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity
6. The Role of Drug Metabolism in Toxicity
7. The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation
8. Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor
9. Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs
10. Core Modifications to the 4-(4,4-Dimethylpiperidinyl) 2,6-Dimethylpyridinyl Class of Hiv-1 Allosteric Integrase Inhibitors
11. Erratum to: Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies
12. Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition
13. Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds
14. Erratum to: Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies
15. Drug-Induced Phospholipidosis: Prediction, Detection, and Mitigation Strategies
16. Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice
17. Basement Membrane and Matrix Metalloproteinases in Monocrotaline-Induced Liver Injury
18. Endothelial Cell Injury and Coagulation System Activation during Synergistic Hepatotoxicity from Monocrotaline and Bacterial Lipopolysaccharide Coexposure
19. Role of Neutrophils in the Synergistic Liver Injury from Monocrotaline and Bacterial Lipopolysaccharide Exposure
20. The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation
21. Mechanism of Secalonic Acid D-Induced Inhibition of Transcription Factor Binding to Cyclic AMP Response Element in the Developing Murine Palate
22. Selective Inhibition of Murine Palatal Mesenchymal Cell Proliferation in Vitro by Secalonic Acid D
23. Second Generation Inhibitors of HIV-1 Maturation
24. Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase
25. Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential
26. Secalonic Acid D Alters the Nature of and Inhibits the Binding of the Transcription Factors to the Phorbol 12-O-Tetradecanoate-13 Acetate-Response Element in the Developing Murine Secondary Palate
27. Inhibitors of HIV-1 maturation: Development of structure–activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids
28. Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase
29. Modeling Liver Biology and the Tissue Response to Injury in Bioprinted Human Liver Tissues
30. Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)
31. Systemic Loss of C-terminal Src Kinase Expression Elicits Spontaneous Suppurative Inflammation in Conditional Knockout Mice
32. Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
33. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies
34. The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase
35. Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression
36. Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage
37. Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity
38. Discovery and Preclinical Evaluation of BMS-955829, a Potent Positive Allosteric Modulator of mGluR5
39. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
40. The Role of Drug Metabolism in Toxicity
41. Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
42. P4-020: Separation of Aβ Reduction from Notch Toxicity with Gamma Secretase Inhibitors in Rats
43. Phospholipidosis as a Function of Basicity, Lipophilicity, and Volume of Distribution of Compounds
44. The Role of Drug Metabolism in Toxicity
45. Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers
46. Separation of Aβ Reduction from Notch Toxicity with Gamma Secretase Inhibitors in Rats
47. Synthesis, Structure–Activity Relationships, and In VivoEvaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity
48. Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
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