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Abstract Background To examine if pregnancy affects the prognosis of uveal melanoma (UM) patients undergoing plaque brachytherapy (PBT) and to assess if PBT has any subsequent impact on pregnancy outcomes. Methods A retrospective, single-center study was carried out at Beijing Tongren Hospital, focusing on women of childbearing age diagnosed with UM and treated with iodine-125 plaque brachytherapy. Both the outcomes of pregnancies and the health status of the fetuses were monitored. Survival analyses were conducted using the Kaplan-Meier method, with endpoints being metastasis and death. Results A total of 13 patients who had full-term pregnancies and 96 non-pregnant women matched by age and tumor size were included. The mean follow-up time was 67.0 ± 27.7 months (median:66.0 months, range:21.0 to 116.0 months). In the pregnant group, two patients developed metastases, one of whom died shortly after delivery; local recurrence of UM occurred in 2 patients after or during delivery, and 2 other patients developed secondary glaucoma due to radiation retinopathy. None of the other pregnant patients reported any signs of disease progression. In the control group, 18 metastasis cases including 12 deaths were documented. Pregnant patients and matched control subjects showed no statistical difference in both Metastasis-free survival (hazard ratio (HR): 0.66, 95% confidence interval (CI): 0.15–2.86; P = 0.576) and overall survival (HR: 0.48, 95% CI: 0.06–3.66; P = 0.464). All pregnant patients carried the pregnancy to term and delivered healthy children with no report of placental or infant metastases to date. Conclusion Pregnancy does not appear to negatively impact the prognosis of UM patients undergoing PBT. PBT showed no observable detriment to maternal fertility and exhibited no teratogenic effects on the fetus. However, the long-term implications of PBT on pregnancy remain uncertain, necessitating additional, prolonged follow-up studies.

Most existing deepfake detection methods often fail to maintain their performance when confronting new test domains. To address this issue, we propose a generalizable deepfake detection system to implement style diversification by alternately learning the domain generalization (DG)-based detector and the stylized fake face synthesizer (SFFS). For the DG-based detector, we first adopt instance normalization- and batch normalization-based structures to extract the local and global image statistics as the style and content features, which are then leveraged to obtain the more diverse feature space. Subsequently, contrastive learning is used to emphasize common style features while suppressing domain-specific ones, and adversarial learning is performed to obtain the domain-invariant features. These optimized features help the DG-based detector to learn generalized classification features and also encourage the SFFS to simulate possibly unseen domain data. In return, the samples generated by the SFFS would contribute to the detector's learning of more generalized features from augmented training data. Such a joint learning and training process enhances both the detector's and the synthesizer's feature representation capability for generalizable deepfake detection. Experimental results demonstrate that our method outperforms the state-of-the-art competitors not only in intra-domain tests but particularly in cross-domain tests.

Abstract Background To investigate the relationship between body weight and Axial length in guinea pigs. Methods Forty pigmented guinea pigs were randomly divided into two groups, namely control group and negative lens-induced myopization (LIM) group. After measuring the baseline axial length and body weight (BW), guinea pigs of LIM group received bilateral negative lens-induced myopization using − 10.0 diopters lenses. One week later, the lenses were removed and biometric and ophthalmoscopic examinations were repeated. Results Two groups of guinea pigs showed no statistical difference in initial body weight and eye axis length. Compared to the control group, the lens-induced group had a lower weight (P = 0.02) and a longer axial length (P 0.05). Conclusion In guinea pigs of the same age, axial length was not correlated with body weight. Also, baseline body weight had no impact on natural axial length growth or lens-induced myopia. Lens-induction caused a significant reduction in body weight gain.

Objective To investigate the prevalence of depression and anxiety in patients undergoing maintenance hemodialysis (MHD) in Hohhot, a large city on the northern border of China, and to identify independent risk factors for depression and anxiety in these patients.Methods Patients receiving MHD for >3 months were enrolled in the four largest hemodialysis centers between September 2020 and December 2020. Depression and anxiety were assessed using the Zung self-rated depression scale (SDS) and Zung self-rated anxiety scale (SAS), respectively, with demographic and other data collected for logistic regression analyses.Results Among 305 MHD patients included in this study, the prevalence of depression was 55.1%, including 27.5%, 21.0%, and 6.6% with mild, moderate and severe cases, respectively. The prevalence of anxiety was 25.9%, with 20.0%, 4.6%, and 1.3% having mild, moderate, and severe cases, respectively. An independent protective factor for depression was family income of ≥1415 US dollars/month relative to

Abstract Background To examine an effect of intravitreally applied antibodies against epidermal growth factor family members, namely epiregulin, epigen and betacellulin, on ocular axial elongation. Methods The experimental study included 30 guinea pigs (age:3–4 weeks) which underwent bilateral lens-induced myopization and received three intraocular injections of 20 µg of epiregulin antibody, epigen antibody and betacellulin antibody in weekly intervals into their right eyes, and of phosphate-buffered saline into their left eyes. Seven days after the last injection, the animals were sacrificed. Axial length was measured by sonographic biometry. Results At baseline, right eyes and left eyes did not differ (all P > 0.10) in axial length in neither group, nor did the interocular difference in axial length vary between the groups (P = 0.19). During the study period, right and left eyes elongated (P

Abstract Background To evaluate global burden of refraction disorders by year, age, region, gender, socioeconomic status and other national characteristics in terms of disability adjusted life years (DALYs) and prevalence from Global Burden of Disease (GBD) study 2019 and World Bank Open Data 2019. Methods Global, regional, and national DALY numbers, crude DALY rates, age-standardized DALY and prevalence rates of refraction disorders were acquired from the GBD study 2019. Mobile cellular subscriptions, urban population, GDP per capita, access to electricity and total fertility rate were obtained from the World Bank to explore the factors that influenced the health burden of refraction disorders. Kruskal-Wallis test, linear regression and multiple linear regression were performed to evaluate the associations between the health burden with socioeconomic levels and other national characteristics. Wilcoxon Signed-Rank Test was used to investigate the gender disparity. Results Globally, age-standardized DALY rates of refraction disorders decreased from 88.9 (95% UI: 60.5–120.3) in 1990 to 81.5 (95% UI: 55.0–114.8) in 2019, and might fall to 73.16 (95% UI: 67.81–78.51) by 2050. Age-standardized prevalence rates would also reduce to 1830 (95% UI: 1700–1960) by 2050, from 2080 (95% UI: 1870–2310) in 1990 to 1960 (95% UI: 1750–2180) in 2019. In low SDI region, age-standardized DALY rates (equation: Y = 114.05*X + 27.88) and prevalence rates (equation: Y = 3171.1*X + 403.2) were positively correlated with SDI in linear regression respectively. East Asia had the highest blindness rate caused by refraction disorders in terms of age-standardized DALY rates (11.20, 95% UI: 7.38–16.36). Gender inequality was found among different age groups and SDI regions. Conclusion Health burden of refraction disorders decreased in recent years, and may continue to alleviate in the next three decades. Older ages, females and lower socioeconomic status were associated with higher refraction disorders health burden.

Abstract Crystal structure of conjugated molecules and polymers is fundamentally critical to understand their multilevel microstructures, carrier transport, and diverse functions. However, to determine the crystal structure of conjugated polymers is a significant challenge, mainly due to the poor crystallinity, weak diffraction, and instability under high‐energy radiation. Here, we build the possible crystal structures of eight typical conjugated polymers, covering several widely used molecular segments in organic optoelectronics. We model the packing structures of these seed polymers based on synchrotron X‐ray diffractions and molecular simulations. These crystal structures provide a new platform to predict the packing structures of more related polymer systems, extending the molecular scope. Based on this polymer crystal structure database, the multiscale microstructures and charge transport properties of conjugated polymers can be predicted before experiments. This study sets up a polymer crystal structure database to eliminate the current trial‐and‐error approaches and accelerating the design of high‐performance conjugated polymers.

It is important to detect recurrent retinal detachment (RD) among patients after retinal reattachment surgery. The application of deep learning (DL) methods to detect recurrent RD with ultra‐widefield (UWF) fundus images is promising, but the feasibility and efficiency have not been studied. A DL system with ResNet‐50 and Inception‐ResNet‐V2 is developed and internally validated to identify recurrent RD and retina reattachment after surgery. The performance is further validated and compared with human ophthalmologists in a prospective dataset assessed by area under curve (AUC), accuracy, sensitivity, and specificity. Five hundred fifty‐four UWF fundus images from 173 RD patients (mean [standard deviation] age: 39.2 ± 16.2 years; male: 115 [66.5%]) are used to develop the DL system. DL shows AUCs of 0.912 (95% confidence interval [CI]: 0.855–0.968) and 0.906 (95% CI: 0.818–0.995) for the two models. Eighty‐nine UWF fundus images from 23 RD patients (mean [standard deviation] age: 31.4 ± 12.3 years; male: 15 [65.2%]) are collected as prospective dataset. DL also shows the ability to detect recurrent RD with the AUCs of 0.929 and 0.930 for the two models, respectively. DL reaches a similar and even better diagnostic performance than junior ophthalmologists and performs much better than medical students.

Blockchain and smart contracts have seen significant application over the last decade, revolutionising many industries, including cryptocurrency, finance and banking, and supply chain management. In many cases, however, the transparency provided potentially comes at the cost of privacy. Blockchain does have potential uses to increase privacy-preservation. This paper outlines the current state of privacy preservation utilising Blockchain and Smart Contracts, as applied to a number of fields and problem domains. It provides a background of blockchain, outlines the challenges in blockchain as they relate to privacy, and then classifies into areas in which this paradigm can be applied to increase or protect privacy. These areas are cryptocurrency, data management and storage, e-voting, the Internet of Things, and smart agriculture. This work then proposes PPSAF, a new privacy-preserving framework designed explicitly for the issues that are present in smart agriculture. Finally, this work outlines future directions of research in areas combining future technologies, privacy-preservation and blockchain.

Objective: To investigate the hepatorenoprotective effects of Origanum vulgare L. against finasteride-induced oxidative injury in the liver and kidney of mice. Methods: Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI/MS) analysis was utilized to yield a fingerprint of Origanum vulgare polyphenolic constituents. Thirty BALB/c mice received 0.5 mL/day distilled water, finasteride (25 mg/kg/day for 10 d), and 100, 200, or 400 mg/kg/day finasteride + Origanum vulgare extract with 6 mice per group for five weeks. On day 36, liver and kidney function as well as pro- and antiinflammatory (IFN-γ, IL-12, IL-6, TNF-α, IL-1β, and IL-10) cytokines were measured. The total antioxidant status, nitric oxide (NO), and malondialdehyde levels as well as the activities of NO synthase and catalase were also evaluated. Histopathological study was conducted to assess the effect of Origanum vulgare extract on finasteride-induced renal and hepatic toxicities. Results: Twenty-five major polyphenolic compounds were identified in the Origanum vulgare extract by LC-ESI/MS. Origanum vulgare extract, especially at 200 and 400 mg/kg/day doses, significantly improved liver and kidney biochemical indices, decreased inflammatory cytokines, increased total antioxidant status and NO synthase and catalase activities, as well as decreased plasma NO and malondialdehyde levels in a dose-dependent manner as compared to the finasteride group. Histopathological results further confirmed the protective effect of Origanum vulgare extract. Conclusions: Origanum vulgare extract ameliorates finasteride-induced hepatic and renal biochemical and histopathological alterations, and restores antioxidant/oxidant balance.

BackgroundCause-specific prevalence data of vision loss and blindness is fundamental for making public health policies and is essential for prioritizing scientific advances and industry research.MethodsCause-specific vision loss data from the Global Health Data Exchange was used. The burden of vision loss was measured by prevalence and years lived with disability (YLDs).FindingsIn 2019, uncorrected refractory error and cataract were the most common causes for vision loss and blindness globally. Women have higher rates of cataract, age-related macular degeneration (AMD), and diabetic retinopathy (DR) than men. In the past 30 years, the prevalence of moderate/severe vision loss and blindness due to neonatal disorders has increased by 13.73 and 33.53%, respectively. Retinopathy of prematurity (ROP) is the major cause of neonatal disorders related vision loss. In 2019, ROP caused 101.6 thousand [95% uncertainty intervals (UI) 77.5–128.2] cases of vision impairment, including 49.1 thousand (95% UI 28.1–75.1) moderate vision loss, 27.5 thousand (95% UI 19.3–36.60) severe vision loss and, 25.0 thousand (95% UI 14.6–35.8) blindness. The prevalence of new-onset ROP in Africa and East Asia was significantly higher than other regions. Variation of preterm birth prevalence can explain 49.8% geometry variation of ROP-related vision loss burden among 204 countries and territories. After adjusting for preterm prevalence, government health spending per total health spending (%), rather than total health spending per person, was associated with a reduced burden of ROP-related vision loss in 2019 (−0.19 YLDs for 10% increment). By 2050, prevalence of moderate, severe vision loss and blindness due to ROP is expected to reach 43.6 (95% UI 35.1–52.0), 23.2 (95% UI 19.4–27.1), 31.9 (95% UI 29.7–34.1) per 100,000 population.ConclusionThe global burden of vision loss and blindness highlights the prevalent of ROP, a major and avoidable cause for childhood vision loss. Advanced screening techniques and treatments have shown to be effective in preventing ROP-related vision loss and are urgently needed in regions with high ROP-related blindness rates, including Africa and East Asia.

For uveal melanoma (UM) patients, it is significant to establish diagnosis and prognosis evaluation systems through imaging techniques. However, imaging examinations are short of quantitative biomarkers and it is difficult to finish early diagnosis of UM. In order to discover new molecular biomarkers for the diagnosis and prognostic evaluation of UM, six circulating miRNAs (mir-132-3p, mir-21-5p, mir-34a-5p, mir-126-3p, mir-199a-3p, mir-214-3p) were chosen as candidates for independent validation. Validation of these miRNAs was performed in a cohort of 20 patients, including 10 spindle-shaped melanoma and 10 epithelioid cell melanoma, and 10 healthy donors. Then 5 patients with metastatic UM were included to validate the performance of miRNAs in advanced UM. Serum levels of miRNAs were determined using quantitative real-time PCR. We confirmed significantly higher levels of three miRNAs in serum of UM patients in comparison to healthy controls, and miR-199a-3p had the best performance (p < 0.0001; AUC = 0.985). MiR-214-3p and miR-21-5p were significantly upregulated in serum of epithelioid cell melanoma patients compared to spindle-shaped melanoma patients and miR-132-3p and, conversely, were significantly downregulated in serum of epithelioid cell melanoma patients. MiR-21-5p shows their best performance (p < 0.0001; AUC = 0.980). Both miR-199a-3p and miR-21-5p showed great performance in advanced UM. Significantly higher levels of miR-21-5p (p < 0.001) were found in serum of metastatic UM patients compared to patients with localized spindle-shaped melanoma, and significantly higher levels of miR-199a-3p (p < 0.001) were detected in serum of metastatic UM patients compared to healthy controls. Our preliminary data indicate promising diagnostic utility of circulating miR-199a-3p and promising prognostic utility of circulating miR-21-5p in both early and advanced UM patients.

Abstract. Background:. The effect of short-segment decompression/fusion versus long-segment decompression/fusion and osteotomy for Lenke-Silva type VI adult degenerative scoliosis (ADS) has not been clarified. This study aimed to compare the clinical and radiographic results of short-segment fusion vs. long-segment fusion and osteotomy for patients with Lenke-Silva type VI ADS. Methods:. Data of 28 patients who underwent spinal surgery for ADS from January 2012 to January 2014 in the General Hospital of Northern Theater Command were reviewed. Of the 28 patients, 12 received long-segment fusion and osteotomy and 16 received short-segment fusion. Radiographic imaging parameters and clinical outcomes, including the sagittal vertical axis (SVA), lumbar lordosis (LL) angle, pelvic tilt (PT), sacral slope (SS), the visual analog scale (VAS), Japanese Orthopedic Association (JOA), Oswestry disability index (ODI), and lumbar stiffness disability index (LSDI) scores, were recorded. The difference between groups was compared using the dependent t test or Chi-squared test. Results:. The Cobb and LL angles and SVA improved in both groups; however, PT and SS angles did not improve following short fusion. There were significant differences in the post-operative SVA (26.8 ± 5.4 mm vs. 47.5 ± 7.6 mm, t = –8.066, P 0.05). The post-operative LSDI score was 3.5 ± 0.5 in the long fusion group, which was significantly higher than that of the short fusion group (1.4 ± 0.7; P

This paper proposes a high-capacity scheme for reversible data hiding (RDH) in encrypted images. The proposed scheme is based on a new preprocessing method by bit plane partition. Specifically, the values in the less significant bit planes are reversibly hidden into the other bit planes. Consequently, the room in the less significant bit planes can be vacated to generate a preprocessed image, from which the original image can be recovered by extracting the hidden bit values and writing them back. After encrypting the preprocessed image with a stream cipher, the vacated room can be used to accommodate extra data, which can be retrieved without image decryption. In addition, the embedding capacity can be further increased by adopting an efficient most significant bit (MSB) prediction method before image encryption. Compared with the state-of-the-art RDH schemes for encrypted images, the experimental results show that higher embedding capacity can be achieved with our proposed one. The numerical results are provided to show the performances of the proposed scheme in different cases of bit-plane partition and MSB prediction.

Recently, reversible image data hiding with contrast enhancement (CE) has been proposed so that a contrast-changed image can be converted to its original version when needed. Several reversible image CE methods have been proposed by adopting the technique of reversible data hiding (RDH) to embed the recovery information into the contrast-enhanced images. In these methods, the 1D histogram is calculated and then modified to achieve the effects of histogram equalization (HE). Meanwhile, the 2D histogram has been used in image CE and demonstrated remarkable advantages in improving the image quality. In this paper, the method based on the 2D histogram modification is proposed to perform image CE and RDH simultaneously. In particular, a preprocessing strategy is developed to merge the adjacent bins in 2D histogram to prevent the overflow and underflow of the pixel values due to HE. The changes made in preprocessing is minimized by choosing the lowest bins for merging, while the CE effects can be achieved by expanding the highest bins for data embedding. The experimental results on two sets of test images have clearly demonstrated the efficacy of the proposed method for reversible image CE. The evaluation results are given to show its superior performances in CE and image quality preservation by comparing with the state-of-the-art approaches.

Background: Th9 cells are a newly discovered CD4+ T helper cell subtype, characterized by high interleukin (IL)-9 secretion. Growing evidences suggest that Th9 cells are involved in the pathogenic mechanism of multiple sclerosis (MS). Mast cells are multifunctional innate immune cells, which are perhaps best known for their role as dominant effector cells in allergies and asthma. Several lines of evidence point to an important role for mast cells in MS and its animal models. Simultaneously, there is dynamic “cross-talk” between Th9 and mast cells. The aim of the present study was to examine the IL-9-mast cell axis in experimental autoimmune encephalomyelitis (EAE) and determine its interaction after neutralizing anti-IL-9 antibody treatment. Methods: Female C57BL/6 mice were randomly divided into three groups (n = 5 in each group): mice with myelin oligodendrocyte glycoprotein (MOG)-induced EAE (EAE group), EAE mice treated with anti-IL-9 antibody (anti-IL-9 Abs group), and EAE mice treated with IgG isotype control (IgG group). EAE clinical score was evaluated. Mast cells from central nervous system (CNS) were detected by flow cytometry. The production of chemokine recruiting mast cells in the CNS was explored by reverse transcription-polymerase chain reaction (RT-PCR). In mice with MOG-induced EAE, the expression of IL-9 receptor (IL-9R) complexes in CNS and spleen mast cells was also explored by RT-PCR, and then was repeating validated by immunocytochemistry. In vitro, spleen cells from EAE mice were cultured with anti-IL-9 antibody, and quantity of mast cells was counted by flow cytometry after co-culture. Results: Compared with IgG group, IL-9 blockade delayed clinical disease onset and ameliorated EAE severity (t = −2.217, P = 0.031), accompany with mast cells infiltration decreases (day 5: t = −8.005, P < 0.001; day 15: t = −11.857, P < 0.001; day 20: t = −5.243, P = 0.001) in anti-IL-9 Abs group. The messenger RNA expressions of C-C motif chemokine ligand 5 (t = −5.932, P = 0.003) and vascular cell adhesion molecule-1 (t = −4.029, P = 0.004) were significantly decreased after IL-9 neutralization in anti-IL-9 Abs group, compared with IgG group. In MOG-induced EAE, the IL-9R complexes were expressed in CNS and spleen mast cells. In vitro, splenocytes cultured with anti-IL-9 antibody showed significantly lower levels of mast cells in a dose-dependent manner, compared with splenocytes cultured with anti-mouse IgG (5 μg/ml: t = −0.894, P = 0.397; 10 μg/ml: t = −3.348, P = 0.019; 20 μg/ml: t = −7.639, P < 0.001). Conclusions: This study revealed that IL-9 neutralization reduced mast cell infiltration in CNS and ameliorated EAE, which might be relate to the interaction between IL-9 and mast cells.

In the past two decades, reversible data hiding (RDH), also referred to as lossless or invertible data hiding, has gradually become a very active research area in the field of data hiding. This has been verified by more and more papers on increasingly wide-spread subjects in the field of RDH research that have been published these days. In this paper, the various RDH algorithms and researches have been classified into the following six categories: 1) RDH into image spatial domain; 2) RDH into image compressed domain (e.g., JPEG); 3) RDH suitable for image semi-fragile authentication; 4) RDH with image contrast enhancement; 5) RDH into encrypted images, which is expected to have wide application in the cloud computation; and 6) RDH into video and into audio. For each of these six categories, the history of technical developments, the current state of the arts, and the possible future researches are presented and discussed. It is expected that the RDH technology and its applications in the real word will continue to move ahead.

With the popularity of cloud computing and social networks, more and more JPEG images are stored and distributed. Consequently, how to protect privacy and content in JPEG images has become an important issue. Although traditional encryption schemes can be employed, the file format of JPEG images is changed so that their usage may be affected. In this paper, a reversible visual transformation algorithm is proposed to protect content in JPEG images. Specifically, the DC coefficient in each user-selected block is modified, while the information required to recover it is reversibly hidden into AC coefficients. Then the signs of AC coefficients in the selected blocks are flipped and the blocks are further scrambled with a secret key. By embedding the location information of the selected blocks in a transformed image, the original image can be exactly recovered when needed. Besides, regions to be protected can be arbitrarily chosen without substantially affecting the rest of the image. The experimental results on a set of JPEG images validate the efficacy and reversibility of the proposed algorithm. In addition, good performance is achieved in terms of invisibility of the protected content, image quality, file size preservation and security.

Previous work has explored link between mitochondrial biology and fungal pathogenicity in F1Fo-ATP synthase in Candida albicans. In this work we have detailed the more specific roles of the F1Fo-ATP synthase β subunit, a key protein subunit of F1Fo-ATP synthase. The ability to assimilate alternative carbons in glucose-limited host niches is known to be a critical factor for infection caused by opportunistic pathogens including C. albicans. The function of the F1Fo-ATP synthase β subunit was characterized through the construction of an ATP2 gene null mutant (atp2Δ/Δ) and the gene-reconstituted strain (atp2Δ/ATP2) in order to understand the link between carbon metabolism and C. albicans pathogenesis. Cell growth, viability, cellular ATP content, mitochondrial membrane potential (ΔΨm), and intracellular ROS were compared between null mutant and control strain. Results showed that growth of the atp2Δ/Δ mutant in synthetic medium was slower than in complex medium. However, the synthetic medium delayed the onset of reduced cell viability and kept cellular ATP content from becoming fully depleted. Consistent with these observations, we identified transcriptional changes in metabolic response that activated other ATP-generating pathways, thereby improving cell viability during the initial phase. Unlike glucose effects, the atp2Δ/Δ mutant exhibited an immediate and sharp reduction in cell viability on non-fermentable carbon sources, consistent with an immediate depletion of cellular ATP content. Along with a reduced viability in non-fermentable carbon sources, the atp2Δ/Δ mutant displayed avirulence in a murine model of disseminated candidiasis as well as lower fungal loads in mouse organs. Regardless of the medium, however, a decrease in mitochondrial membrane potential (ΔΨm) was found in the atp2Δ/Δ mutant but ROS levels remained in the normal range. These results suggest that the F1Fo-ATP synthase β subunit is required for C. albicans pathogenicity and operates by affecting metabolic flexibility in carbon consumption.

Recently, lossless contrast enhancement (CE) has been proposed so that a contrast-changed image can be converted to its original version by maintaining information entropy in it. As most of the lossless CE methods are proposed for grayscale images, artifacts are probably introduced after directly applying them to color images. For instance, color distortions may be caused after CE is separately conducted in each channel of the RGB (red, green, and blue) model. To cope with this issue, a new scheme is proposed based on the HSV (hue, saturation, and value) color model. Specifically, both hue and saturation components are kept unchanged while only the value component is modified. More precisely, the ratios between the RGB components are maintained while a reversible data hiding method is applied to the value component to achieve CE effects. The experimental results clearly show CE effects obtained with the proposed scheme, while the original color images can be perfectly recovered. Several metrics including image entropy were adopted to measure the changes made in CE procedure, while the performances were compared with those of one existing scheme. The evaluation results demonstrate that better image quality and increased information entropy can be simultaneously achieved with our proposed scheme.