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142 results on '"Hara, Toshihide"'

1. MEFV variants are a predisposing factor for generalized pustular psoriasis

Author

Yoshikawa, Takenori, primary, Takeichi, Takuya, additional, Nishida, Kazuki, additional, Kobayashi, Yumiko, additional, Sano, Hozumi, additional, Shibata, Akitaka, additional, Koizumi, Haruka, additional, Tsutsumi, Reiko, additional, Fukaura, Ryo, additional, Hayashi, Masahiro, additional, Imanishi, Akiko, additional, Nakamura, Kenta, additional, Mikoshiba, Yasutomo, additional, Ogawa, Eisaku, additional, Sano, Shinya, additional, Kinoshita, Manao, additional, Okamoto, Takashi, additional, Kageyama, Reiko, additional, Sano, Yuko, additional, Kaneko, Sakae, additional, Aoi, Jun, additional, Hara, Toshihide, additional, Togawa, Yaei, additional, Kishibe, Mari, additional, Yoshida, Yuichi, additional, Yagi, Hiroaki, additional, Honda, Tetsuya, additional, Sugiura, Kazumitsu, additional, Sano, Shigetoshi, additional, Suzuki, Tamio, additional, Ogi, Tomoo, additional, Muro, Yoshinao, additional, and Akiyama, Masashi, additional

Published
2023
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2. MEFV variants are a predisposing factor for generalized pustular psoriasis

Author

Yoshikawa, Takenori, Takeichi, Takuya, Nishida, Kazuki, Kobayashi, Yumiko, Sano, Hozumi, Shibata, Akitaka, Koizumi, Haruka, Tsutsumi, Reiko, Fukaura, Ryo, Hayashi, Masahiro, Imanishi, Akiko, Nakamura, Kenta, Mikoshiba, Yasutomo, Ogawa, Eisaku, Sano, Shinya, Kinoshita, Manao, Okamoto, Takashi, Kageyama, Reiko, Sano, Yuko, Kaneko, Sakae, Aoi, Jun, Hara, Toshihide, Togawa, Yaei, Kishibe, Mari, Yoshida, Yuichi, Yagi, Hiroaki, Honda, Tetsuya, Sugiura, Kazumitsu, Sano, Shigetoshi, Suzuki, Tamio, Ogi, Tomoo, Muro, Yoshinao, and Akiyama, Masashi

Published
2024
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13. Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease

Author

Tabuchi, Maiko, primary, Minami, Hitomi, additional, Akazawa, Yuko, additional, Ashida, Miwa, additional, Hara, Toshihide, additional, Ichinose, Kunihiro, additional, Kitayama, Moto, additional, Hashiguchi, Keiichi, additional, Matsushima, Kayoko, additional, Yamaguchi, Naoyuki, additional, Takeshima, Fuminao, additional, Kondo, Hisayoshi, additional, Kawakami, Atsushi, additional, and Nakao, Kazuhiko, additional

Published
2020
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19. MTRAP: Pairwise sequence alignment algorithm by a new measure based on transition probability between two consecutive pairs of residues

Author

Ohya Masanori, Sato Keiko, and Hara Toshihide

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background Sequence alignment is one of the most important techniques to analyze biological systems. It is also true that the alignment is not complete and we have to develop it to look for more accurate method. In particular, an alignment for homologous sequences with low sequence similarity is not in satisfactory level. Usual methods for aligning protein sequences in recent years use a measure empirically determined. As an example, a measure is usually defined by a combination of two quantities (1) and (2) below: (1) the sum of substitutions between two residue segments, (2) the sum of gap penalties in insertion/deletion region. Such a measure is determined on the assumption that there is no an intersite correlation on the sequences. In this paper, we improve the alignment by taking the correlation of consecutive residues. Results We introduced a new method of alignment, called MTRAP by introducing a metric defined on compound systems of two sequences. In the benchmark tests by PREFAB 4.0 and HOMSTRAD, our pairwise alignment method gives higher accuracy than other methods such as ClustalW2, TCoffee, MAFFT. Especially for the sequences with sequence identity less than 15%, our method improves the alignment accuracy significantly. Moreover, we also showed that our algorithm works well together with a consistency-based progressive multiple alignment by modifying the TCoffee to use our measure. Conclusions We indicated that our method leads to a significant increase in alignment accuracy compared with other methods. Our improvement is especially clear in low identity range of sequences. The source code is available at our web page, whose address is found in the section "Availability and requirements".

Published
2010
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20. Subacute thyroiditis in a patient with psoriatic arthritis switched from secukinumab to adalimumab: a case report and literature review.

Author

Nakagawa, Jun, Fujikawa, Keita, Akagi, Midori, Nakaji, Keita, Yasui, Junichi, Hanatani, Yumi, Hara, Toshihide, Mizokami, Akinari, and Kawakami, Atsushi

Subjects
PSORIATIC arthritis, ADALIMUMAB, INTERLEUKIN-17, TUMOR necrosis factors, PREDNISOLONE
Abstract

A 71-year-old Japanese female with psoriatic arthritis (PsA) was admitted for fever and neck pain. Her medication had been switched from secukinumab, an interleukin (IL)-17A inhibitor, to adalimumab, a tumour necrosis factor (TNF)-α inhibitor, due to secondary failure for PsA. She was diagnosed with subacute thyroiditis (SAT) on the basis of thyroid hormone levels and thyroid ultrasound findings. Her SAT symptoms improved with prednisolone administration (15 mg/day). Following the administration of ixekizumab, an IL-17A inhibitor, her PsA improved without SAT relapse. SAT mechanism associated with TNF inhibitors remains unknown, but cytokine imbalance may be involved. [ABSTRACT FROM AUTHOR]

Published
2021
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21. CCL13 is a promising diagnostic marker for systemic sclerosis

Author

Yanaba, Koichi, Yoshizaki, Ayumi, Muroi, Eiji, Hara, Toshihide, Ogawa, Fumihide, Shimizu, Kazuhiro, Hasegawa, Minoru, Fujimoto, Manabu, Takehara, Kazuhiko, and Sato, Shinichi

Subjects
integumentary system, Enzyme-linked immunosorbent assay, Chemokine, CCL13, Systemic sclerosis, skin and connective tissue diseases
Abstract

Summary Background Previous studies suggest that CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc). Objectives To determine serum levels of CCL13 and its clinical associations in patients with SSc. Methods Serum CCL13 levels were examined by enzyme-linked immunosorbent assay in 80 patients with SSc, 20 patients with systemic lupus erythematosus (SLE), 20 patients with dermatomyositis (DM), 29 patients with atopic dermatitis (AD) and 50 healthy individuals. Results Mean +/- SD serum CCL13 levels were elevated in patients with SSc (81.3 +/- 55.8 pg mL(-1)) compared with healthy controls (15.0 +/- 9.9 pg mL(-1); P < 0.001) and patients with SLE (22.0 +/- 6.9 pg mL(-1); P < 0.001), DM (24.4 +/- 36.1 pg mL(-1); P < 0.001) and AD (18.0 +/- 6.4 pg mL(-1); P < 0.001). Among patients with SSc, there were no differences in serum CCL13 levels between limited cutaneous SSc and diffuse cutaneous SSc. In a longitudinal study, CCL13 levels were generally unchanged during the follow-up. Conclusions Serum CCL13 was specifically increased in patients with SSc, but not in patients with SLE, DM or AD or in healthy controls. CCL13 could be a promising serological marker for SSc., The British journal of dermatology, 162(2), pp.332-336; 2010

Published
2010

23. Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis

Author

Sakamoto, Noriho, primary, Kakugawa, Tomoyuki, additional, Hara, Atsuko, additional, Nakashima, Shota, additional, Yura, Hirokazu, additional, Harada, Tatsuhiko, additional, Ishimoto, Hiroshi, additional, Yatera, Kazuhiro, additional, Kuwatsuka, Yutaka, additional, Hara, Toshihide, additional, Ichinose, Kunihiro, additional, Obase, Yasushi, additional, Ishimatsu, Yuji, additional, Kohno, Shigeru, additional, and Mukae, Hiroshi, additional

Published
2015
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28. Cell Adhesion Molecules Regulate Fibrotic Process via Th1/Th2/Th17 Cell Balance in a Bleomycin-Induced Scleroderma Model

Author

Yoshizaki, Ayumi, primary, Yanaba, Koichi, additional, Iwata, Yohei, additional, Komura, Kazuhiro, additional, Ogawa, Asako, additional, Akiyama, Yuichiro, additional, Muroi, Eiji, additional, Hara, Toshihide, additional, Ogawa, Fumihide, additional, Takenaka, Motoi, additional, Shimizu, Kazuhiro, additional, Hasegawa, Minoru, additional, Fujimoto, Manabu, additional, Tedder, Thomas F., additional, and Sato, Shinichi, additional

Published
2010
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33. Elevated Serum Concentrations of Triggering Receptor Expressed on Myeloid Cells-1 in Diffuse Cutaneous Systemic Sclerosis: Association with Severity of Pulmonary Fibrosis

Author

TOMITA, HAJIME, primary, OGAWA, FUMIHIDE, additional, HARA, TOSHIHIDE, additional, YANABA, KOICHI, additional, IWATA, YOHEI, additional, MUROI, EIJI, additional, YOSHIZAKI, AYUMI, additional, KOMURA, KAZUHIRO, additional, TAKENAKA, MOTOI, additional, SHIMIZU, KAZUHIRO, additional, HASEGAWA, MINORU, additional, FUJIMOTO, MANABU, additional, and SATO, SHINICHI, additional

Published
2010
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39. Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage

Author

Ogawa, Fumihide, primary, Shimizu, Kazuhiro, additional, Hara, Toshihide, additional, Muroi, Eiji, additional, Komura, Kazuhiro, additional, Takenaka, Motoi, additional, Hasegawa, Minoru, additional, Fujimoto, Manabu, additional, Takehara, Kazuhiko, additional, and Sato, Shinichi, additional

Published
2009
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40. P-Selectin Glycoprotein Ligand-1 Contributes to Wound Healing Predominantly as a P-Selectin Ligand and Partly as an E-Selectin Ligand

Author

Tomita, Hajime, primary, Iwata, Yohei, additional, Ogawa, Fumihide, additional, Komura, Kazuhiro, additional, Shimizu, Kazuhiro, additional, Yoshizaki, Ayumi, additional, Hara, Toshihide, additional, Muroi, Eiji, additional, Yanaba, Koichi, additional, Bae, Sangjae, additional, Takenaka, Motoi, additional, Hasegawa, Minoru, additional, Fujimoto, Manabu, additional, and Sato, Shinichi, additional

Published
2009
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41. CD19, a Response Regulator of B Lymphocytes, Regulates Wound Healing through Hyaluronan-Induced TLR4 Signaling

Author

Iwata, Yohei, primary, Yoshizaki, Ayumi, additional, Komura, Kazuhiro, additional, Shimizu, Kazuhiro, additional, Ogawa, Fumihide, additional, Hara, Toshihide, additional, Muroi, Eiji, additional, Bae, Sangjae, additional, Takenaka, Motoi, additional, Yukami, Toru, additional, Hasegawa, Minoru, additional, Fujimoto, Manabu, additional, Tomita, Yasushi, additional, Tedder, Thomas F., additional, and Sato, Shinichi, additional

Published
2009
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45. Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis

Author

IWATA, YOHEI, primary, YOSHIZAKI, AYUMI, additional, OGAWA, FUMIHIDE, additional, KOMURA, KAZUHIRO, additional, HARA, TOSHIHIDE, additional, MUROI, EIJI, additional, TAKENAKA, MOTOI, additional, SHIMIZU, KAZUHIRO, additional, HASEGAWA, MINORU, additional, FUJIMOTO, MANABU, additional, TAKEHARA, KAZUHIKO, additional, and SATO, SHINICHI, additional

Published
2009
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47. Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis

Author

HARA, TOSHIHIDE, primary, OGAWA, FUMIHIDE, additional, YANABA, KOICHI, additional, IWATA, YOHEI, additional, MUROI, EIJI, additional, KOMURA, KAZUHIRO, additional, TAKENAKA, MOTOI, additional, SHIMIZU, KAZUHIRO, additional, HASEGAWA, MINORU, additional, FUJIMOTO, MANABU, additional, and SATO, SHINICHI, additional

Published
2009
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