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1,093 results on '"Harder, S."'

1. Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study

Author

Kann G, Owasil J, Kuczka K, Haberl A, Wolf T, Khaykin P, Harder S, Stephan C, and von Hentig N

Subjects
hiv protease inhibitors, platelets, leucocytes, pac-1, giib/iiia-receptor, Immunologic diseases. Allergy, RC581-607
Abstract

Gerrit Kann,1,* Junaid Owasil,1,* Karina Kuczka,2 Annette Haberl,1 Timo Wolf,1 Pavel Khaykin,1 Sebastian Harder,2 Christoph Stephan,1 Nils von Hentig1 1HIVCENTER, Medical HIV Treatment and Research Unit, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany; 2Pharmazentrum Frankfurt, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany*These authors contributed equally to this workCorrespondence: Nils von HentigHIVCENTER, Medical HIV Treatment and Research Unit, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main, 60590, GermanyTel +49-69-63017680Fax +49-69-630183442Email Hentig@em.uni-frankfurt.deBackground: In the past, protease inhibitors (PIs) and the reverse transcriptase inhibitor abacavir were identified increasing the risk for thromboembolic complications and cardiovascular events (CVE) of HIV infected patients taking a combination antiretroviral therapy (cART). Results of the previous HIV-PLA I-study lead to the assumption that platelet activation could play a substantial role in increasing CVE risks.Methods: The open label, monocentric HIV-PLA II-study investigated HIV-1-infected, therapy-naïve adults (n=45) starting with cART, consisting either of boosted PI (atazanavir, n= 6, darunavir, n=11), NNRTI (efavirenz, n=14) or integrase inhibitor (raltegravir, n=14), each plus tenofovir/emtricitabine co-medication. Main exclusion criteria were tobacco smoking, the intake of NSAIDs or abacavir or past CVE. Platelet adhesive molecule p-selectin (CD62P) and FITC anti-human Integrin α-IIb/Integrin β-3 (CD41/CD61) antibody (PAC-1) binding, monocyte CD11b/monocyte-associated CD41 expression and the endogenous thrombin potential (ETP) were assessed ex vivo-in vitro at baseline, weeks 4, 12 and 24. Therapy regimens were blinded to the investigators for laboratory and statistical analyses.Results: CD11b and ETP showed no significant changes or differences between all study groups. In contrast, the mean + SD mean fluorescence units (MFI) of CD62P and PAC-1 increased significantly in patients taking PI, indicating an enhanced potential for thrombocyte activation and aggregation.Conclusion: CD62P expression, detecting the ɑ-platelet degranulation of pro-inflammatory and pro-thrombotic factors and adhesive proteins, and PAC-1 expression, representing a marker for conformation changes of the GIIb/IIIa receptor, increased significantly in patients taking HIV protease inhibitors. The findings of this study revealed a yet unknown pathway of platelet activation, possibly contributing to the increased risk for CVE under HIV protease inhibitor containing cART.Clinical Trial Registration No.: DRKS00000288.Keywords: HIV protease inhibitors, platelets, leucocytes, PAC-1, GIIb/IIIa-receptor

Published
2021

2. Strongly reducing magnesium(0) complexes

Author

Rösch, B., Gentner, T. X., Eyselein, J., Langer, J., Elsen, H., and Harder, S.

Subjects
Magnesium -- Chemical properties, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A complex of a metal in its zero oxidation state can be considered a stabilized, but highly reactive, form of a single metal atom. Such complexes are common for the more noble transition metals. Although rare examples are known for electronegative late-main-group p-block metals or semimetals.sup.1-6, it is a challenge to isolate early-main-group s-block metals in their zero oxidation state.sup.7-11. This is directly related to their very low electronegativity and strong tendency to oxidize. Here we present examples of zero-oxidation-state magnesium (that is, magnesium(0)) complexes that are stabilized by superbulky, monoanionic, [beta]-diketiminate ligands. Whereas the reactivity of an organomagnesium compound is typically defined by the nucleophilicity of its organic groups and the electrophilicity of Mg.sup.2+ cations, the Mg.sup.0 complexes reported here feature electron-rich Mg centres that are nucleophilic and strongly reducing. The latter property is exemplified by the ability to reduce Na.sup.+ to Na.sup.0. We also present a complex with a linear Mg.sub.3 core that formally could be described as a Mg.sup.I-Mg.sup.0-Mg.sup.I unit. Such multinuclear mixed-valence Mg.sub.n clusters are discussed as fleeting intermediates during the early stages of Grignard reagent formation. Their remarkably strong reducing power implies a rich reactivity and application as specialized reducing agents. Strongly reducing [beta]-diketiminate complexes containing magnesium in its zero oxidation state are reported, among which is a compound with a linear triatomic Mg-Mg-Mg core., Author(s): B. Rösch [sup.1] , T. X. Gentner [sup.1] , J. Eyselein [sup.1] , J. Langer [sup.1] , H. Elsen [sup.1] , S. Harder [sup.1] Author Affiliations: (1) Department of [...]

Published
2021
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5. The latent structure of the adult attachment interview: Large sample evidence from the collaboration on attachment transmission synthesis

Author

Lee Raby, K, Verhage, M, Pasco Fearon, R, Chris Fraley, R, Roisman, G, van IJzendoorn, M, Schuengel, C, Madigan, S, Oosterman, M, Bakermans-Kranenburg, M, Bernier, A, Ensink, K, Hautamaki, A, Mangelsdorf, S, Priddis, L, Wong, M, Aviezer, O, Behrens, K, Brisch, K, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Dozier, M, Duschinsky, R, Ierardi, E, Finger, B, de Millan, S, Harder, S, Hazen, N, Jin, M, Myung, S, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Pederson, D, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Speranza, A, Steele, H, Tarabulsy, G, Vaever, M, Ward, M, Arnott, B, Bailey, H, Behringer, J, Brice, P, Castoro, G, Costantino, E, Cyr, C, George, C, Gloger-Tippelt, G, Howes, C, Jacobsen, H, Jacobvitz, D, Juffer, F, Kazui, M, Koppe, S, Millan, S, Murray, L, Simonelli, A, Solomon, J, Steele, M, Teti, D, Monique van Londen-Barentsen, W, Lee Raby K., Verhage M. L., Pasco Fearon R. M., Chris Fraley R., Roisman G. I., van IJzendoorn M. H., Schuengel C., Madigan S., Oosterman M., Bakermans-Kranenburg M. J., Bernier A., Ensink K., Hautamaki A., Mangelsdorf S., Priddis L. E., Wong M. S., Aviezer O., Behrens K. Y., Brisch K. -H., Cassibba R., Cassidy J., Coppola G., Costantini A., Dozier M., Duschinsky R., Ierardi E., Finger B., de Millan S. G., Harder S., Hazen N. L., Jin M. M., Myung S., Jongenelen I., Leerkes E. M., Lionetti F., Lyons-Ruth K., McMahon C., Meins E., Pace C. S., Pederson D. R., Riva Crugnola C., Sagi-Schwartz A., Schoppe-Sullivan S. J., Speranza A. M., Steele H., Tarabulsy G. M., Vaever M. S., Ward M. J., Arnott B., Bailey H., Behringer J., Brice P. J., Castoro G., Costantino E., Cyr C., George C., Gloger-Tippelt G., Howes C., Jacobsen H., Jacobvitz D., Juffer F., Kazui M., Koppe S., Millan S., Murray L., Simonelli A., Solomon J., Steele M., Teti D. M., Monique van Londen-Barentsen W., Lee Raby, K, Verhage, M, Pasco Fearon, R, Chris Fraley, R, Roisman, G, van IJzendoorn, M, Schuengel, C, Madigan, S, Oosterman, M, Bakermans-Kranenburg, M, Bernier, A, Ensink, K, Hautamaki, A, Mangelsdorf, S, Priddis, L, Wong, M, Aviezer, O, Behrens, K, Brisch, K, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Dozier, M, Duschinsky, R, Ierardi, E, Finger, B, de Millan, S, Harder, S, Hazen, N, Jin, M, Myung, S, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Pederson, D, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Speranza, A, Steele, H, Tarabulsy, G, Vaever, M, Ward, M, Arnott, B, Bailey, H, Behringer, J, Brice, P, Castoro, G, Costantino, E, Cyr, C, George, C, Gloger-Tippelt, G, Howes, C, Jacobsen, H, Jacobvitz, D, Juffer, F, Kazui, M, Koppe, S, Millan, S, Murray, L, Simonelli, A, Solomon, J, Steele, M, Teti, D, Monique van Londen-Barentsen, W, Lee Raby K., Verhage M. L., Pasco Fearon R. M., Chris Fraley R., Roisman G. I., van IJzendoorn M. H., Schuengel C., Madigan S., Oosterman M., Bakermans-Kranenburg M. J., Bernier A., Ensink K., Hautamaki A., Mangelsdorf S., Priddis L. E., Wong M. S., Aviezer O., Behrens K. Y., Brisch K. -H., Cassibba R., Cassidy J., Coppola G., Costantini A., Dozier M., Duschinsky R., Ierardi E., Finger B., de Millan S. G., Harder S., Hazen N. L., Jin M. M., Myung S., Jongenelen I., Leerkes E. M., Lionetti F., Lyons-Ruth K., McMahon C., Meins E., Pace C. S., Pederson D. R., Riva Crugnola C., Sagi-Schwartz A., Schoppe-Sullivan S. J., Speranza A. M., Steele H., Tarabulsy G. M., Vaever M. S., Ward M. J., Arnott B., Bailey H., Behringer J., Brice P. J., Castoro G., Costantino E., Cyr C., George C., Gloger-Tippelt G., Howes C., Jacobsen H., Jacobvitz D., Juffer F., Kazui M., Koppe S., Millan S., Murray L., Simonelli A., Solomon J., Steele M., Teti D. M., and Monique van Londen-Barentsen W.

Abstract

The Adult Attachment Interview (AAI) is a widely used measure in developmental science that assesses adults' current states of mind regarding early attachment-related experiences with their primary caregivers. The standard system for coding the AAI recommends classifying individuals categorically as having an autonomous, dismissing, preoccupied, or unresolved attachment state of mind. However, previous factor and taxometric analyses suggest that: (a) adults' attachment states of mind are captured by two weakly correlated factors reflecting adults' dismissing and preoccupied states of mind and (b) individual differences on these factors are continuously rather than categorically distributed. The current study revisited these suggestions about the latent structure of AAI scales by leveraging individual participant data from 40 studies (N = 3,218), with a particular focus on the controversial observation from prior factor analytic work that indicators of preoccupied states of mind and indicators of unresolved states of mind about loss and trauma loaded on a common factor. Confirmatory factor analyses indicated that: (a) a 2-factor model with weakly correlated dismissing and preoccupied factors and (b) a 3-factor model that further distinguished unresolved from preoccupied states of mind were both compatible with the data. The preoccupied and unresolved factors in the 3-factor model were highly correlated. Taxometric analyses suggested that individual differences in dismissing, preoccupied, and unresolved states of mind were more consistent with a continuous than a categorical model. The importance of additional tests of predictive validity of the various models is emphasized.

Published
2022

6. Conceptual comparison of constructs as first step in data harmonization: Parental sensitivity, child temperament, and social support as illustrations

Author

Verhage, M, Schuengel, C, Holopainen, A, Bakermans-Kranenburg, M, Bernier, A, Brown, G, Madigan, S, Roisman, G, Vaever, M, Wong, M, Barone, L, Behrens, K, Behringer, J, Bovenschen, I, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Dozier, M, Ensink, K, Fearon, R, Finger, B, Hautamaki, A, Hazen, N, Ierardi, E, Jongenelen, I, Koppe, S, Lionetti, F, Mangelsdorf, S, Oosterman, M, Pace, C, Raby, K, Riva Crugnola, C, Simonelli, A, Spangler, G, Tarabulsy, G, Arnott, B, Bailey, H, Brice, P, Brisch, K, Castoro, G, Costantino, E, Cyr, C, George, C, Gloger-Tippelt, G, Gojman, S, Harder, S, Howes, C, Jacobsen, H, Jacobvitz, D, Jin, M, Juffer, F, Kazui, M, Leerkes, E, Lyons-Ruth, K, Mcmahon, C, Meins, E, Millan, S, Murray, L, Nowacki, K, Pederson, D, Priddis, L, Sagi-Schwartz, A, Schoppe-Sullivan, S, Solomon, J, Speranza, A, Steele, M, Steele, H, Teti, D, van IJzendoorn, M, van Londen-Barentsen, W, Ward, M, Verhage M. L., Schuengel C., Holopainen A., Bakermans-Kranenburg M. J., Bernier A., Brown G. L., Madigan S., Roisman G. I., Vaever M. S., Wong M. S., Barone L., Behrens K. Y., Behringer J., Bovenschen I., Cassibba R., Cassidy J., Coppola G., Costantini A., Dozier M., Ensink K., Fearon R. M. P., Finger B., Hautamaki A., Hazen N. L., Ierardi E., Jongenelen I., Koppe S., Lionetti F., Mangelsdorf S., Oosterman M., Pace C. S., Raby K. L., Riva Crugnola C., Simonelli A., Spangler G., Tarabulsy G. M., Arnott B., Bailey H., Brice P. J., Brisch K. -H., Castoro G., Costantino E., Cyr C., George C., Gloger-Tippelt G., Gojman S., Harder S., Howes C., Jacobsen H., Jacobvitz D., Jin M. K., Juffer F., Kazui M., Leerkes E. M., Lyons-Ruth K., McMahon C., Meins E., Millan S., Murray L., Nowacki K., Pederson D. R., Priddis L., Sagi-Schwartz A., Schoppe-Sullivan S. J., Solomon J., Speranza A. M., Steele M., Steele H., Teti D. M., van IJzendoorn M. H., van Londen-Barentsen W. M., Ward M. J., Verhage, M, Schuengel, C, Holopainen, A, Bakermans-Kranenburg, M, Bernier, A, Brown, G, Madigan, S, Roisman, G, Vaever, M, Wong, M, Barone, L, Behrens, K, Behringer, J, Bovenschen, I, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Dozier, M, Ensink, K, Fearon, R, Finger, B, Hautamaki, A, Hazen, N, Ierardi, E, Jongenelen, I, Koppe, S, Lionetti, F, Mangelsdorf, S, Oosterman, M, Pace, C, Raby, K, Riva Crugnola, C, Simonelli, A, Spangler, G, Tarabulsy, G, Arnott, B, Bailey, H, Brice, P, Brisch, K, Castoro, G, Costantino, E, Cyr, C, George, C, Gloger-Tippelt, G, Gojman, S, Harder, S, Howes, C, Jacobsen, H, Jacobvitz, D, Jin, M, Juffer, F, Kazui, M, Leerkes, E, Lyons-Ruth, K, Mcmahon, C, Meins, E, Millan, S, Murray, L, Nowacki, K, Pederson, D, Priddis, L, Sagi-Schwartz, A, Schoppe-Sullivan, S, Solomon, J, Speranza, A, Steele, M, Steele, H, Teti, D, van IJzendoorn, M, van Londen-Barentsen, W, Ward, M, Verhage M. L., Schuengel C., Holopainen A., Bakermans-Kranenburg M. J., Bernier A., Brown G. L., Madigan S., Roisman G. I., Vaever M. S., Wong M. S., Barone L., Behrens K. Y., Behringer J., Bovenschen I., Cassibba R., Cassidy J., Coppola G., Costantini A., Dozier M., Ensink K., Fearon R. M. P., Finger B., Hautamaki A., Hazen N. L., Ierardi E., Jongenelen I., Koppe S., Lionetti F., Mangelsdorf S., Oosterman M., Pace C. S., Raby K. L., Riva Crugnola C., Simonelli A., Spangler G., Tarabulsy G. M., Arnott B., Bailey H., Brice P. J., Brisch K. -H., Castoro G., Costantino E., Cyr C., George C., Gloger-Tippelt G., Gojman S., Harder S., Howes C., Jacobsen H., Jacobvitz D., Jin M. K., Juffer F., Kazui M., Leerkes E. M., Lyons-Ruth K., McMahon C., Meins E., Millan S., Murray L., Nowacki K., Pederson D. R., Priddis L., Sagi-Schwartz A., Schoppe-Sullivan S. J., Solomon J., Speranza A. M., Steele M., Steele H., Teti D. M., van IJzendoorn M. H., van Londen-Barentsen W. M., and Ward M. J.

Abstract

This article presents a strategy for the initial step of data harmonization in Individual Participant Data syntheses, i.e., making decisions as to which measures operationalize the constructs of interest - and which do not. This step is vital in the process of data harmonization, because a study can only be as good as its measures. If the construct validity of the measures is in question, study results are questionable as well. Our proposed strategy for data harmonization consists of three steps. First, a unitary construct is defined based on the existing literature, preferably on the theoretical framework surrounding the construct. Second, the various instruments used to measure the construct are evaluated as operationalizations of this construct, and retained or excluded based on this evaluation. Third, the scores of the included measures are recoded on the same metric. We illustrate the use of this method with three example constructs focal to the Collaboration on Attachment Transmission Synthesis (CATS) study: parental sensitivity, child temperament, and social support. This process description may aid researchers in their data pooling studies, filling a gap in the literature on the first step of data harmonization. • Data harmonization in studies using combined datasets is of vital importance for the validity of the study results. • We have developed and illustrated a strategy on how to define a unitary construct and evaluate whether instruments are operationalizations of this construct as the initial step in the harmonization process. • This strategy is a transferable and reproducible method to apply to the data harmonization process.

Published
2022

7. The latent structure of the adult attachment interview: Large sample evidence from the collaboration on attachment transmission synthesis

Author

Lee Raby K., Verhage M. L., Pasco Fearon R. M., Chris Fraley R., Roisman G. I., van IJzendoorn M. H., Schuengel C., Madigan S., Oosterman M., Bakermans-Kranenburg M. J., Bernier A., Ensink K., Hautamaki A., Mangelsdorf S., Priddis L. E., Wong M. S., Aviezer O., Behrens K. Y., Brisch K. -H., Cassibba R., Cassidy J., Coppola G., Costantini A., Dozier M., Duschinsky R., Ierardi E., Finger B., de Millan S. G., Harder S., Hazen N. L., Jin M. M., Myung S., Jongenelen I., Leerkes E. M., Lionetti F., Lyons-Ruth K., McMahon C., Meins E., Pace C. S., Pederson D. R., Riva Crugnola C., Sagi-Schwartz A., Schoppe-Sullivan S. J., Speranza A. M., Steele H., Tarabulsy G. M., Vaever M. S., Ward M. J., Arnott B., Bailey H., Behringer J., Brice P. J., Castoro G., Costantino E., Cyr C., George C., Gloger-Tippelt G., Howes C., Jacobsen H., Jacobvitz D., Juffer F., Kazui M., Koppe S., Millan S., Murray L., Simonelli A., Solomon J., Steele M., Teti D. M., Monique van Londen-Barentsen W., Lee Raby, K, Verhage, M, Pasco Fearon, R, Chris Fraley, R, Roisman, G, van IJzendoorn, M, Schuengel, C, Madigan, S, Oosterman, M, Bakermans-Kranenburg, M, Bernier, A, Ensink, K, Hautamaki, A, Mangelsdorf, S, Priddis, L, Wong, M, Aviezer, O, Behrens, K, Brisch, K, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Dozier, M, Duschinsky, R, Ierardi, E, Finger, B, de Millan, S, Harder, S, Hazen, N, Jin, M, Myung, S, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Pederson, D, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Speranza, A, Steele, H, Tarabulsy, G, Vaever, M, Ward, M, Arnott, B, Bailey, H, Behringer, J, Brice, P, Castoro, G, Costantino, E, Cyr, C, George, C, Gloger-Tippelt, G, Howes, C, Jacobsen, H, Jacobvitz, D, Juffer, F, Kazui, M, Koppe, S, Millan, S, Murray, L, Simonelli, A, Solomon, J, Steele, M, Teti, D, and Monique van Londen-Barentsen, W

Subjects
Adult, Predictive validity, Individuality, 050109 social psychology, taxometric, Developmental Science, Developmental psychology, Interview, Psychological, Developmental and Educational Psychology, Categorical models, Humans, 0501 psychology and cognitive sciences, Latent structure, Individual participant data, 05 social sciences, 16. Peace & justice, Object Attachment, Large sample, Standard system, Psychiatry and Mental health, factor analysi, Psychology, latent structure, Attachment measures, Adult Attachment Interview, 050104 developmental & child psychology
Abstract

The Adult Attachment Interview (AAI) is a widely used measure in developmental science that assesses adults’ current states of mind regarding early attachment-related experiences with their primary caregivers. The standard system for coding the AAI recommends classifying individuals categorically as having an autonomous, dismissing, preoccupied, or unresolved attachment state of mind. However, previous factor and taxometric analyses suggest that: (a) adults’ attachment states of mind are captured by two weakly correlated factors reflecting adults’ dismissing and preoccupied states of mind and (b) individual differences on these factors are continuously rather than categorically distributed. The current study revisited these suggestions about the latent structure of AAI scales by leveraging individual participant data from 40 studies (N = 3,218), with a particular focus on the controversial observation from prior factor analytic work that indicators of preoccupied states of mind and indicators of unresolved states of mind about loss and trauma loaded on a common factor. Confirmatory factor analyses indicated that: (a) a 2-factor model with weakly correlated dismissing and preoccupied factors and (b) a 3-factor model that further distinguished unresolved from preoccupied states of mind were both compatible with the data. The preoccupied and unresolved factors in the 3-factor model were highly correlated. Taxometric analyses suggested that individual differences in dismissing, preoccupied, and unresolved states of mind were more consistent with a continuous than a categorical model. The importance of additional tests of predictive validity of the various models is emphasized.

Published
2020
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10. Hypertonie

Author

Harder, S., Rietbrock, N., Rietbrock, Norbert, editor, Staib, A. Horst, editor, and Loew, Dieter, editor

Published
2001
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11. Herzinsuffizienz

Author

Rietbrock, N., Harder, S., Rietbrock, Norbert, editor, Staib, A. Horst, editor, and Loew, Dieter, editor

Published
2001
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12. Digital image analysis of intraepithelial B-lymphocytes as an objective alternative to assess lymphoepithelial lesions in salivary glands of Sjögren's syndrome patients

Author

Van Ginkel, M. S., Van der Sluis, T., Bulthuis, M. L. C., Buikema, H. J., Haacke, E. A., Arends, S., Harder, S., Spijkervet, F. K. L., Bootsma, H., Vissink, A., Kroese, F. G. M., Van der Vegt, B., Translational Immunology Groningen (TRIGR), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Personalized Healthcare Technology (PHT), and Damage and Repair in Cancer Development and Cancer Treatment (DARE)

Published
2022

13. Quantifizierung des prädiktiven Wertes von Instrumenten zur Messung von anticholinerger Last und Symptomen zur Vorhersage von Stürzen bei älteren Patient:innen mit Multimedikation

Author

Dinh, TS, Meid, AD, Rudolf, H, Brückle, MS, González-González, AI, Bencheva, V, Gogolin, M, Snell, KIE, Elders, PJM, Thürmann, P, Donner-Banzhoff, N, Blom, JW, van den Akker, M, Gerlach, FM, Harder, S, Thiem, U, Glasziou, P, Haefeli, WE, Muth, C, Dinh, TS, Meid, AD, Rudolf, H, Brückle, MS, González-González, AI, Bencheva, V, Gogolin, M, Snell, KIE, Elders, PJM, Thürmann, P, Donner-Banzhoff, N, Blom, JW, van den Akker, M, Gerlach, FM, Harder, S, Thiem, U, Glasziou, P, Haefeli, WE, and Muth, C

Published
2022

15. POS0454 DIGITAL IMAGE ANALYSIS OF INTRAEPITHELIAL B-LYMPHOCYTES AS AN OBJECTIVE ALTERNATIVE TO ASSESS LYMPHOEPITHELIAL LESIONS IN SALIVARY GLANDS OF SJÖGREN’S SYNDROME PATIENTS

Author

Van Ginkel, M. S., primary, Van der Sluis, T., additional, Bulthuis, M. L. C., additional, Buikema, H. J., additional, Haacke, E. A., additional, Arends, S., additional, Harder, S., additional, Spijkervet, F. K. L., additional, Bootsma, H., additional, Vissink, A., additional, Kroese, F. G. M., additional, and Van der Vegt, B., additional

Published
2022
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16. Evidence-Based Decision Support for a Structured Care Program on Polypharmacy in Multimorbidity: A Guideline Upgrade Based on a Realist Synthesis

Author

Dinh, T.S., Brueckle, M.S., Gonzalez-Gonzalez, A.I., Fessler, J., Marschall, U., Schubert-Zsilavesz, M., Gerlach, F.M., Harder, S., van den Akker, M., Schubert, I., Muth, C., RS: CAPHRI - R6 - Promoting Health & Personalised Care, and Family Medicine

Subjects
Science & Technology, multimorbidity, stakeholder analysis, medication management, evidence-based guideline, elderly, Article, Health Care Sciences & Services, Medicine, General & Internal, continuity of care, realist synthesis, General & Internal Medicine, patient centered care, polypharmacy, OLDER-ADULTS, Life Sciences & Biomedicine
Abstract

Evidence-based clinical guidelines generally consider single conditions, and rarely multimorbidity. We developed an evidence-based guideline for a structured care program to manage polypharmacy in multimorbidity by using a realist synthesis to update the German polypharmacy guideline including the following five methods: formal prioritization in focus groups; systematic guideline review of evidence-based multimorbidity/polypharmacy guidelines; evidence search/synthesis and recommendation development; multidisciplinary consent of recommendations; feasibility test of updated guideline. We identified the need for a better description of the target group, decision support, prioritization of medication, consideration of patient preferences and anticholinergic properties, and of healthcare interfaces. We conducted a systematic guideline review of eight guidelines and extracted and synthesized recommendations using the Ariadne principles. We also included 48 systematic reviews. We formulated and agreed upon 34 recommendations for the revised guideline. During the feasibility test, guideline use enabled 57% of GPs to identify problems, leading to medication changes in 49% and self-assessed improvement in 56% of patients. Although 58% of GPs felt that it was too long, 92% recommended it. Polypharmacy should be systematically reviewed at least annually. Patients, family members, and healthcare professionals should monitor and adjust it using prospective process validation, taking into account patient preferences and agreed treatment goals., Beteiligte Organisation: The Evita Study Group

Published
2022
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18. Hypertonie

Author

Rietbrock, N., Harder, S., Rietbrock, Norbert, editor, Staib, A. Horst, editor, and Loew, Dieter, editor

Published
1996
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23. Therapy monitoring

Author

Matzander, G., Klingelhöfer, J., Wittich, I., Sander, D., Conrad, B., Kessler, Ch., Maravic, M. v., Müller, M., Dorndorf, D., Kömpf, D., Delcker, A., Timmann, D., Diener, H. C., Kaps, M., Trittmacher, S., Seidel, G., Damian, M. S., Thie, A., Carvajal-Lizano, M., Steinmetz, J., Zanella, F., Spitzer, K., Zeumer, H., Kunze, K., Ries, F., Keller, E., Grünwald, F., Honisch, C., Rosanowski, F., Kurthen, M., Solymosi, L., Weiller, Cornelius, Friston, Karl J., Frackowiak, Richard S. J., Harms, L., Enchtuja, S., Timm, G., Zschenderlein, R., Schnackenburg, B., Walter, S., Kraus, P. H., Fritsch, T., Tran-Gia, P., Przuntek, H., Spitzer, Klaus, Kunze, Klaus, Thie, Andreas, Krämer, G., Group, Study, Lindemuth, R., Mielke, U., Jost, W., Maurer, I., Marian, A., Kuhn, W., Hilz, M. J., Faatz, U., Weis, M., Erbguth, F., Neundörfer, B., Maier-Hauff, K., Barzen, G., Gottschalk, H., Schwarz, J., Tatsch, K., Arnold, G., Trenwalder, C., Scherer, J., Kirsch, C. M., Oertel, W. H., Wißmeyer, Th., Hülser, P. J., Kutter, T., Kinzl, L., Baas, H., Demisch, L., Harder, S., Fischer, P. A., Dressnandt, J., Konstanzer, A., Bogdahn, U., Jäger, A., Richter, J., Krone, A., Dekant, A., Beck, A., Pfeufer, B., Strik, H., Krauseneck, P., Richter, E., Zahner, B., Stefan, H., Feistel, H., Harrer, M., Treib, J., Stoll, M., Haaß, A., Jost, V., Nahser, H. C., Kühne, D., Berg-Dammer, E., Henkes, H., Möbius, E., Dannheim, F., Wessel, St., and Schimrigk, K.

Published
1992
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28. Hausärztliche Leitlinie ‚Multimedikation‘ – Empfehlungen zum Umgang mit Multimedikation bei Erwachsenen und geriatrischen Patient*innen (S3-LL, AWMF-Register-Nr.: 053 – 043)

Author

Brueckle, MS, Dinh, TS, Harder, S, Fessler, J, Seffrin, J, Vetter, G, Graafen, S, Grenz, S, Beyer, M, Braun, M, Meissl, S, Reincke, S, Schubert, I, and Muth, C

Subjects
ddc: 610, Medicine and health
Abstract

Hintergrund: 2013 erschien die erste evidenzbasierte Leitlinie (AWMF-S2e-Niveau) „Multimedikation“. Im Rahmen der vorgesehenen Aktualisierung wurde zugleich ein Upgrade auf AWMF S3 Niveau geplant und im Rahmen des EVITA-Projekts (Evidenzbasiertes Multimedikations-Programm mit Implementierung [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2021
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29. Abstracts

Author

Weissofner, A., Micallef, J., Baerlocher, K., Karl, H., Haffner, B., Trawöger, R., Maurer, H., Ausserer, B., Krassnitzer, S., Könner, Ch., Covi, P., Rücker, J., Schneider, W., Harder, S., Zielen, S., Zin-U, B., Bock, U., Lauffer, H., Rey, M., Scharf, J., Wenzel, D., Wölfel, D., Wagner, J., Exner, H., Hagmüller, G., Weinstabl, C., Richling, B., Plainer, B., Aloy, A., Czech, T., Spiss, C. K., Mast, M., Erbs, G., Stöllberger, C., Bachl, J. Ch., Peschl, L., Slany, J., Brainin, M., Heß, M., Nowak, G., Schwohl, Th., Diederich, K.-W., Sheikhzadeh, A., Seit, E., Loeb, M., Eich, F. X., Leititis, J. U., Kronenberg, H., Ulrich, M., Lang, M., Kraft, A., Rohling, R., Link, J., Kretz, F. J., Siebenlist, D., Gattenlöhner, W., Loimer, N., Lenz, K., Presslich, O., Schmid, R., Lechner, P., Anderhuber, F., Thies, P., Janisch, H. D., v. Kleist, D. H., Hoeft, S., Hampel, K. E., Donner, A., Seidler, D., Fitzgerald, R., Lackner, F., Graninger, W., Schwarz, S., Hlozanek, Ch., Jaspert, A., Kotterba, S., Tegenthoff, M., Malin, J.-P., Schmidt, A., Binner, L., Hombach, V., König, P., Künz, A., Harf, Ch., van Vyve, Th., Welter, R., Simbruner, G., Kirchner, L., Glatzl-Hawlik, M., Weninger, M., Paltinger, N., Wieland, W., Mertes, N., Sciuk, J., Wendt, M., Bock, T. A., Heintz, B., Sieberth, H. G., Peters, P., Saborowski, F., Genuß, G.-R., Brusis, T., Feldges, A., Kalff, R., Rosenthal, E., Grote, W., Lenz, Kurt, editor, Laggner, Anton N., editor, Deutsch, Erwin, editor, Binder, Heinrich, editor, Gadner, Helmut, editor, Grimm, Georg, editor, Kleinberger, Gunther, editor, Ritz, Rudolf, editor, Schuster, Hans Peter, editor, and Zaunschirm, Harald Andrew, editor

Published
1990
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31. Are Anticholinergic Symptoms a Risk Factor for Falls in Older General Practice Patients With Polypharmacy? Study Protocol for the Development and Validation of a Prognostic Model

Author

Dinh, TS, González-González, AI, Meid, AD, Snell, KIE, Rudolf, H, Brueckle, M-S, Blom, JW, Thiem, U, Trampisch, H-J, Elders, PJM, Donner-Banzhoff, N, Gerlach, FM, Harder, S, van den Akker, M, Glasziou, PP, Haefeli, WE, Muth, C, General practice, APH - Health Behaviors & Chronic Diseases, and ACS - Diabetes & metabolism

Subjects
RM, EXTERNAL VALIDATION, DRUG BURDEN INDEX, anticholinergic burden, PEOPLE, Methods, Pharmacology (medical), ddc:610, Pharmacology & Pharmacy, LOAD, polypharmacy, accidental falls [MeSH], SCALE, ASSOCIATIONS, Pharmacology, general practice, OUTCOMES, Science & Technology, MEDICATIONS, ADULTS, multimorbidity [MeSH], INJURIOUS FALLS, prediction model, prognosis research, aged [MesH], Life Sciences & Biomedicine
Abstract

Background: Cumulative anticholinergic exposure, also known as anticholinergic burden, is associated with a variety of adverse outcomes. However, studies show that anticholinergic effects tend to be underestimated by prescribers, and anticholinergics are the most frequently prescribed potentially inappropriate medication in older patients. The grading systems and drugs included in existing scales to quantify anticholinergic burden differ considerably and do not adequately account for patients’ susceptibility to medications. Furthermore, their ability to link anticholinergic burden with adverse outcomes such as falls is unclear. This study aims to develop a prognostic model that predicts falls in older general practice patients, to assess the performance of several anticholinergic burden scales, and to quantify the added predictive value of anticholinergic symptoms in this context. Methods: Data from two cluster-randomized controlled trials investigating medication optimization in older general practice patients in Germany will be used. One trial (RIME, n = 1,197) will be used for the model development and the other trial (PRIMUM, n = 502) will be used to externally validate the model. A priori, candidate predictors will be selected based on a literature search, predictor availability, and clinical reasoning. Candidate predictors will include socio-demographics (e.g. age, sex), morbidity (e.g. single conditions), medication (e.g. polypharmacy, anticholinergic burden as defined by scales), and well-being (e.g. quality of life, physical function). A prognostic model including sociodemographic and lifestyle-related factors, as well as variables on morbidity, medication, health status, and well-being, will be developed, whereby the prognostic value of extending the model to include additional patient-reported symptoms will be also assessed. Logistic regression will be used for the binary outcome, which will be defined as “no falls” vs. “≥1 fall” within six months of baseline, as reported in patient interviews. Discussion: As the ability of different anticholinergic burden scales to predict falls in older patients is unclear, this study may provide insights into their relative importance as well as into the overall contribution of anticholinergic symptoms and other patient characteristics. The results may support general practitioners in their clinical decision-making and in prescribing fewer medications with anticholinergic properties.

Published
2021
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33. Examining Ecological Constraints on the Intergenerational Transmission of Attachment Via Individual Participant Data Meta-analysis

Author

Verhage, M, Fearon, R, Schuengel, C, van IJzendoorn, M, Bakermans-Kranenburg, M, Madigan, S, Roisman, G, Oosterman, M, Behrens, K, Wong, M, Mangelsdorf, S, Priddis, L, Brisch, K, Arnott, B, Aviezer, O, Bailey, H, Behringer, J, Bernier, A, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Cyr, C, Dozier, M, Ensink, K, Finger, B, Gojman, S, Harder, S, Hautamaki, A, Hazen, N, Ierardi, E, Jin, M, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Raby, K, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Steele, H, Steele, M, Tarabulsy, G, Væver, M, Brice, P, Castoro, G, Costantino, E, George, C, Gloger-Tippelt, G, Howes, C, Jacobvitz, D, Juffer, F, Kazui, M, Køppe, S, Millán, S, Murray, L, Pederson, D, Simonelli, A, Solomon, J, Speranza, A, Teti, D, van Londen-Barentsen, W, Ward, M, The Collaboration on Attachment Transmission, S, Verhage, Marije L., Fearon, R. M. Pasco, Schuengel, Carlo, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Madigan, Sheri, Roisman, Glenn I., Oosterman, Mirjam, Behrens, Kazuko Y., Wong, Maria S., Mangelsdorf, Sarah, Priddis, Lynn E., Brisch, Karl-Heinz, Arnott, B., Aviezer, O., Bailey, H., Behringer, J., Bernier, A., Cassibba, R., Cassidy, J., Coppola, G., Costantini, A., Cyr, C., Dozier, M., Ensink, K., Finger, B., Gojman, S., Harder, S., Hautamaki, A., Hazen, N. L., Ierardi, E., Jin, M. K., Jongenelen, I., Leerkes, E. M., Lionetti, F., Lyons-Ruth, K., McMahon, C., Meins, E., Pace, C. S., Priddis, L., Raby, K. L., Riva Crugnola, C., Sagi-Schwartz, A., Schoppe-Sullivan, S. J., Steele, H., Steele, M., Tarabulsy, G. M., Væver, M. S., Brice, P. J., Castoro, G., Costantino, E., George, C., Gloger-Tippelt, G., Howes, C., Jacobvitz, D., Juffer, F., Kazui, M., Køppe, S., Millán, S., Murray, L., Pederson, D. R., Simonelli, A., Solomon J., Speranza A. M., Teti, D. M., van Londen-Barentsen, W. M., Ward, M. J., The Collaboration on Attachment Transmission Synthesis, Verhage, M, Fearon, R, Schuengel, C, van IJzendoorn, M, Bakermans-Kranenburg, M, Madigan, S, Roisman, G, Oosterman, M, Behrens, K, Wong, M, Mangelsdorf, S, Priddis, L, Brisch, K, Arnott, B, Aviezer, O, Bailey, H, Behringer, J, Bernier, A, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Cyr, C, Dozier, M, Ensink, K, Finger, B, Gojman, S, Harder, S, Hautamaki, A, Hazen, N, Ierardi, E, Jin, M, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Raby, K, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Steele, H, Steele, M, Tarabulsy, G, Væver, M, Brice, P, Castoro, G, Costantino, E, George, C, Gloger-Tippelt, G, Howes, C, Jacobvitz, D, Juffer, F, Kazui, M, Køppe, S, Millán, S, Murray, L, Pederson, D, Simonelli, A, Solomon, J, Speranza, A, Teti, D, van Londen-Barentsen, W, Ward, M, The Collaboration on Attachment Transmission, S, Verhage, Marije L., Fearon, R. M. Pasco, Schuengel, Carlo, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Madigan, Sheri, Roisman, Glenn I., Oosterman, Mirjam, Behrens, Kazuko Y., Wong, Maria S., Mangelsdorf, Sarah, Priddis, Lynn E., Brisch, Karl-Heinz, Arnott, B., Aviezer, O., Bailey, H., Behringer, J., Bernier, A., Cassibba, R., Cassidy, J., Coppola, G., Costantini, A., Cyr, C., Dozier, M., Ensink, K., Finger, B., Gojman, S., Harder, S., Hautamaki, A., Hazen, N. L., Ierardi, E., Jin, M. K., Jongenelen, I., Leerkes, E. M., Lionetti, F., Lyons-Ruth, K., McMahon, C., Meins, E., Pace, C. S., Priddis, L., Raby, K. L., Riva Crugnola, C., Sagi-Schwartz, A., Schoppe-Sullivan, S. J., Steele, H., Steele, M., Tarabulsy, G. M., Væver, M. S., Brice, P. J., Castoro, G., Costantino, E., George, C., Gloger-Tippelt, G., Howes, C., Jacobvitz, D., Juffer, F., Kazui, M., Køppe, S., Millán, S., Murray, L., Pederson, D. R., Simonelli, A., Solomon J., Speranza A. M., Teti, D. M., van Londen-Barentsen, W. M., Ward, M. J., and The Collaboration on Attachment Transmission Synthesis

Abstract

Parents’ attachment representations and child–parent attachment have been shown to be associated, but these associations vary across populations (Verhage et al., 2016). The current study examined whether ecological factors may explain variability in the strength of intergenerational transmission of attachment, using individual participant data (IPD) meta-analysis. Analyses on 4,396 parent–child dyads (58 studies, child age 11–96 months) revealed a combined effect size of r =.29. IPD meta-analyses revealed that effect sizes for the transmission of autonomous-secure representations to secure attachments were weaker under risk conditions and weaker in adolescent parent–child dyads, whereas transmission was stronger for older children. Findings support the ecological constraints hypothesis on attachment transmission. Implications for attachment theory and the use of IPD meta-analysis are discussed.

Published
2018

34. Quantifizierung des prädiktiven Wertes von anticholinergen Symptomen zur Vorhersage von Stürzen bei älteren hausärztlichen Patienten mit Multimedikation

Author

Nguyen, TS, Meid, AD, González-González, AI, Thiem, U, Rudolf, H, Trampisch, HJ, van den Akker, M, Brueckle, MS, Blom, JW, Elders, PJ, Hafaeli, WE, Gerlach, FM, Harder, S, Donner-Banzhoff, N, Glasziou, PP, and Muth, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund/Fragestellung: Medikamente mit anticholinergen Effekten stellen die am häufigsten potentiell altersinadäquaten Verordnungen dar und sind insbesondere für ältere Patienten mit einer Reihe von negativen gesundheitlichen Outcomes, wie z.B. Stürzen, verbunden. Existierende[zum vollständigen Text gelangen Sie über die oben angegebene URL], Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Published
2020
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35. Wirksamkeit der ‚Anwendung für ein digital unterstütztes Arzneimitteltherapie-Management (AdAM)‘ – Studienprotokoll der cluster-randomisierten kontrollierten Studie

Author

Müller, BS, González-González, AI, Klaaßen-Mielke, R, Nguyen, TS, Flaig, B, Meyer, I, Ihle, P, Greiner, W, Surmann, B, Karbach, U, Pfaff, H, Söling, S, Köberlein-Neu, J, Kellermann-Mühlhoff, P, Beckmann, T, Düvel, L, Grandt, D, Perera, R, Harder, S, Glasziou, P, Trampisch, HJ, Timmesfeld, N, and Muth, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund/Fragestellung: Das Risiko für Medikationsfehler und unerwünschte Arzneimittelwirkungen steigt bei Multimedikation. In einer der weltweit größten cluster-randomisierten Multimedikationsstudien wird eine neue Versorgungsform (NVF, Innov.-fonds, Fkz 01NVF16006) zur [zum vollständigen Text gelangen Sie über die oben angegebene URL], Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Published
2020
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38. Special Contribution: An Overview of Recent Seismic Refraction Experiments in Central Europe

Author

Guterch, A., Grad, M., Špičák, A., Brückl, E., Hegedüs, E., Keller, G.R., Thybo, H., Aric, K., Acevedo, S., Asudeh, I., Behm, M., Belinsky, A. A., Bodoky, T., Brinkmann, R., Brož, M., Brückl, E., Chwatal, W., Clowes, R., Czuba, W., Fancsik, T., Forkmann, B., Fort, M., Gaczyński, E., Gebrande, H., Geissler, H., Gosar, A., Grad, M., Grassi, H., Greschke, R., Guterch, A., Hajnal, Z., Harder, S., Hegedüs, E., Hemmann, A., Hock, S., Hoeck, V., Hrubcová, P., Janik, T., Jentzsch, G., Joergensen, P., Kaip, G., Keller, G.R., Komminaho, K., Korn, M., Karousová, O., Kostiuchenko, S.L., Kohlbeck, F., Kracke, D., Majdański, M., Malinowski, M., Miller, K.C., Morozov, A.F., Rumpfhuber, E.-M., Schmid, Ch., Snelson, C., Špičák, A., Środa, P., Sumanovac, F., Takacs, E., Thybo, H., Tiira, T., Tomek, Č., Vozár, J., Weber, F., Wilde-Piórko, M., Yliniemi, J., and Żelaźniewicz, A.

Published
2003
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39. Special Contribution: CELEBRATION 2000 Seismic Experiment

Author

Guterch, A., Grad, M., Keller, G.R., Posgay, K., Vozár, J., Špičák, A., Brückl, E., Hajnal, Z., Thybo, H., Selvi, O., Acevedo, S., Aric, K., Asudeh, I., Belinsky, A.A., Bodoky, T., Brückl, E., Chwatal, W., Clowes, R., Czuba, W., Fancsik, T., Gaczyński, E., Grad, M., Guterch, A., Hajnal, Z., Harder, S., Hegedüs, E., Hrubcová, P., Janik, T., Jentzsch, G., Joergensen, P., Kaip, G., Keller, G.R., Komminaho, K., Kostiuchenko, S.L., Kracke, D., Kohlbeck, F., Miller, K.C., Morozov, A.F., Posgay, K., Selvi, O., Špičák, A., Snelson, C., Środa, P., Takács, E., Thybo, H., Tiira, T., Vozár, J., Wilde-Piórko, M., and Yliniemi, J.

Published
2003
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40. Special Contribution: SUDETES 2003 Seismic Experiment

Author

Grad, M., Špičák, A., Keller, G.R., Guterch, A., Brož, M., Hegedüs, E., Behm, M., Bodoky, T., Brinkmann, R., Brož, M., Brückl, E., Czuba, W., Fancsik, T., Forkmann, B., Fort, M., Gaczynski, E., Geissler, W.H., Grad, M., Greschke, R., Guterch, A., Harder, S., Hegedüs, E., Hemmann, A., Hrubcová, P., Janik, T., Jentzsch, G., Kaip, G., Keller, G.R., Komminaho, K., Korn, M., Karousová, O., Majdański, M., Málek, J., Malinowski, M., Miller, K.C., Rumpfhuber, E.-M., Spicak, A., Środa, P., Takács, E., Tiira, T., Vozár, J., Wilde-Piórko, M., Yliniemi, J., and Żelaźniewicz, A.

Published
2003
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45. Examining Ecological Constraints on the Intergenerational Transmission of Attachment Via Individual Participant Data Meta-analysis

Author

Verhage, Marije L., Fearon, R. M. Pasco, Schuengel, Carlo, van IJzendoorn, Marinus H., Bakermans-Kranenburg, Marian J., Madigan, Sheri, Roisman, Glenn I., Oosterman, Mirjam, Behrens, Kazuko Y., Wong, Maria S., Mangelsdorf, Sarah, Priddis, Lynn E., Brisch, Karl-Heinz, Arnott, B., Aviezer, O., Bailey, H., Behringer, J., Bernier, A., Cassibba, R., Cassidy, J., Coppola, G., Costantini, A., Cyr, C., Dozier, M., Ensink, K., Finger, B., Gojman, S., Harder, S., Hautamaki, A., Hazen, N. L., Ierardi, E., Jin, M. K., Jongenelen, I., Leerkes, E. M., Lionetti, F., Lyons-Ruth, K., McMahon, C., Meins, E., Pace, C. S., Priddis, L., Raby, K. L., Riva Crugnola, C., Sagi-Schwartz, A., Schoppe-Sullivan, S. J., Steele, H., Steele, M., Tarabulsy, G. M., Væver, M. S., Brice, P. J., Castoro, G., Costantino, E., George, C., Gloger-Tippelt, G., Howes, C., Jacobvitz, D., Juffer, F., Kazui, M., Køppe, S., Millán, S., Murray, L., Pederson, D. R., Simonelli, A., Solomon J., Speranza A. M., Teti, D. M., van Londen-Barentsen, W. M., Ward, M. J., The Collaboration on Attachment Transmission Synthesis, Verhage, M, Fearon, R, Schuengel, C, van IJzendoorn, M, Bakermans-Kranenburg, M, Madigan, S, Roisman, G, Oosterman, M, Behrens, K, Wong, M, Mangelsdorf, S, Priddis, L, Brisch, K, Arnott, B, Aviezer, O, Bailey, H, Behringer, J, Bernier, A, Cassibba, R, Cassidy, J, Coppola, G, Costantini, A, Cyr, C, Dozier, M, Ensink, K, Finger, B, Gojman, S, Harder, S, Hautamaki, A, Hazen, N, Ierardi, E, Jin, M, Jongenelen, I, Leerkes, E, Lionetti, F, Lyons-Ruth, K, Mcmahon, C, Meins, E, Pace, C, Raby, K, Riva Crugnola, C, Sagi-Schwartz, A, Schoppe-Sullivan, S, Steele, H, Steele, M, Tarabulsy, G, Væver, M, Brice, P, Castoro, G, Costantino, E, George, C, Gloger-Tippelt, G, Howes, C, Jacobvitz, D, Juffer, F, Kazui, M, Køppe, S, Millán, S, Murray, L, Pederson, D, Simonelli, A, Solomon, J, Speranza, A, Teti, D, van Londen-Barentsen, W, Ward, M, The Collaboration on Attachment Transmission, S, Clinical Child and Family Studies, APH - Mental Health, LEARN! - Social cognition and learning, and LEARN! - Brain, learning and development

Subjects
Male, Parents, Adolescent, Child age, Education, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Sex factors, Developmental and Educational Psychology, Attachment theory, Humans, 0501 psychology and cognitive sciences, 030212 general & internal medicine, Parent-Child Relations, Child, Object Attachment, Intergenerational transmission, Parenting, Ecology, Individual participant data, 05 social sciences, Age Factors, Intergenerational Transmission of Attachment, Meta-analysis, Child, Preschool, Pediatrics, Perinatology and Child Health, Educational Status, Female, Psychology, 050104 developmental & child psychology
Abstract

Parents' attachment representations and child-parent attachment have been shown to be associated, but these associations vary across populations (Verhage et al., 2016). The current study examined whether ecological factors may explain variability in the strength of intergenerational transmission of attachment, using individual participant data (IPD) meta-analysis. Analyses on 4,396 parent-child dyads (58 studies, child age 11-96 months) revealed a combined effect size of r = .29. IPD meta-analyses revealed that effect sizes for the transmission of autonomous-secure representations to secure attachments were weaker under risk conditions and weaker in adolescent parent-child dyads, whereas transmission was stronger for older children. Findings support the ecological constraints hypothesis on attachment transmission. Implications for attachment theory and the use of IPD meta-analysis are discussed.

Published
2018
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47. Multi-Indikations-Review und Metaanalyse zur Quantifizierung anticholinerger Effekte von Amitriptylin: ein Studienprotokoll

Author

Brueckle, MS, Thomas, ET, Nguyen, TS, Gonzalez-Gonzalez, AI, Seide, S, Pilz, M, Harder, S, Glasziou, PP, Gerlach, FM, and Muth, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Amitriptylin ist eines der am häufigsten verschriebenen Antidepressiva und wird bei zahlreichen weiteren Konditionen (z.B. Harninkontinenz, Kardiovaskuläre Erkrankungen, Parkinson, Allergien, Übelkeit, Hyperacidität, COPD) eingesetzt. Durch eine veränderte Pharmakokinetik[zum vollständigen Text gelangen Sie über die oben angegebene URL], 53. Kongress für Allgemeinmedizin und Familienmedizin

Published
2019
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48. Welche Symptome sind ‚Red Flags‘ bei Verschreibungen anticholinerg wirkender Medikamente? Studienprotokoll zur Entwicklung von Vorhersagemodellen auf der Basis von PROPERmed-Daten

Author

Nguyen, TS, Meid, AD, González-González, AI, Thiem, U, Trampisch, HJ, Rudolf, H, van den Akker, M, Blom, JW, Elders, PJM, Haefeli, WE, Swart, K, Snell, KIE, Perera, R, Brückle, MS, Donner-Banzhoff, N, Gerlach, FM, Harder, S, Glasziou, PP, and Muth, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Ältere Patienten in der Hausarztpraxis sind häufig multimorbid und erhalten Multimedikation. Darunter sind oft auch Medikamente mit anticholinergen (ACh) Nebenwirkungen, deren Verträglichkeit im Alter häufig eingeschränkt ist. Bei Multimedikation können Ach-Effekte[zum vollständigen Text gelangen Sie über die oben angegebene URL], 53. Kongress für Allgemeinmedizin und Familienmedizin

Published
2019
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49. Wirksamkeit der ‚Anwendung für ein digital unterstütztes Arzneimitteltherapie-Management (AdAM)‘ – Studienprotokoll der Cluster-randomisierten kontrollierten Studie

Author

Müller, BS, González-González, AI, Klaaßen-Mielke, R, Nguyen, TS, Flaig, B, Schubert, I, Ihle, P, Greiner, W, Surmann, B, Karbach, U, Pfaff, H, Söling, S, Köberlein-Neu, J, Perera, R, Harder, S, Glaziou, P, Trampisch, HJ, and Muth, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Patienten mit Multimedikation sind durch Medikationsfehler und unerwünschte Arzneimittelwirkungen gefährdet. Zur Medikationsoptimierung wird in AdAM eine digitale Intervention („eMMa“=elektronisches Medikations-Management ambulant) als neue Versorgungsform (Innovationsfonds,[zum vollständigen Text gelangen Sie über die oben angegebene URL], 53. Kongress für Allgemeinmedizin und Familienmedizin

Published
2019
Full Text
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