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229 results on '"Harikumar, Kuzhuvelil B."'

9. Supplementary Data from A Novel Small-Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In vitro and In vivo

Author

Harikumar, Kuzhuvelil B., primary, Kunnumakkara, Ajaikumar B., primary, Ochi, Nobuo, primary, Tong, Zhimin, primary, Deorukhkar, Amit, primary, Sung, Bokyung, primary, Kelland, Lloyd, primary, Jamieson, Stephen, primary, Sutherland, Rachel, primary, Raynham, Tony, primary, Charles, Mark, primary, Bagherzadeh, Azadeh, primary, Foxton, Caroline, primary, Boakes, Alexandra, primary, Farooq, Muddasar, primary, Maru, Dipen, primary, Diagaradjane, Parmeswaran, primary, Matsuo, Yoichi, primary, Sinnett-Smith, James, primary, Gelovani, Juri, primary, Krishnan, Sunil, primary, Aggarwal, Bharat B., primary, Rozengurt, Enrique, primary, Ireson, Christopher R., primary, and Guha, Sushovan, primary

Published
2023
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11. Supplementary Figure 1 from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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12. Data from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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13. Supplementary Figure 4 from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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14. Supplementary Figure Legends 1-4 from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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15. Supplementary Figure 2 from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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16. Supplementary Figure 3 from Neutrophil Gelatinase–Associated Lipocalin: A Novel Suppressor of Invasion and Angiogenesis in Pancreatic Cancer

Author

Tong, Zhimin, primary, Kunnumakkara, Ajaikumar B., primary, Wang, Huamin, primary, Matsuo, Yoichi, primary, Diagaradjane, Parmeswaran, primary, Harikumar, Kuzhuvelil B., primary, Ramachandran, Vijaya, primary, Sung, Bokyung, primary, Chakraborty, Arup, primary, Bresalier, Robert S., primary, Logsdon, Craig, primary, Aggarwal, Bharat B., primary, Krishnan, Sunil, primary, and Guha, Sushovan, primary

Published
2023
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17. Contributors

Author

Aggarwal, Bharat Bhushan, primary, Agnihotri, Navneet, additional, Amirruddin, Nur S., additional, Aneja, Ritu, additional, Banerjee, Sanjeev, additional, Bhandari, Chetna, additional, Bharti, Alok Chandra, additional, Bhat, Anjali, additional, Bordoloi, Devivasha, additional, Chakraborty, Arup, additional, Checker, Rahul, additional, Dheeraj, Arpit, additional, Gilhooley, Patrick J., additional, Gupta, Subash Chandra, additional, Harikumar, Kuzhuvelil B., additional, Husain, Kazim, additional, Jadli, Mohit, additional, Jagadeeshan, Sankar, additional, Jha, Abhimanyu Kumar, additional, Kale, Vijay P., additional, Kumar, Alan P., additional, Kumar, Sandeep, additional, Kumari, Rani, additional, Kunnumakkara, Ajaikumar B., additional, Singh, Sukh Mahendra, additional, Malafa, Mokenge P., additional, Mohammed, Sabira, additional, Nabavizadeh, Ali, additional, Nair, Shivakumari Asha, additional, Pande, Deepti, additional, Pandey, Manoj K., additional, Parasramka, Mansi A., additional, Paruthy, Shivani B., additional, Patwardhan, Raghavendra S., additional, Phadtare, Sangita, additional, Prasad, M. Manu, additional, Prasad, Sahdeo, additional, Rai, Vipin, additional, Rajan, Priyanka, additional, Rawat, Kavita, additional, Sandur, Santosh K., additional, Saxena, Roopali, additional, Sethi, Gautam, additional, Sharma, Deepak, additional, Sharma, Prerna, additional, Shrivastava, Anju, additional, Shukla, Anand Swaroop, additional, Singh, Rana P., additional, Singh, Surya P., additional, Singh, Tejveer, additional, Sung, Bokyung, additional, Syeda, Saima, additional, Tailor, Dhanir, additional, Teo, Adrian K.K., additional, Tyagi, Amit K., additional, and Vishnoi, Kanchan, additional

Published
2018
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21. Immunomodulatory properties of D-sorbitol/D-mannitol incorporated linear step-growth Co-polymers

Author

Kiran, S., Parvathy, J., Sukumaran, Thenmozhi, Varghese, Jeslin, Lakshmi, S, Kumar, Sreesha S., Babu, Anu, Harikumar, Kuzhuvelil B., and Ragupathy, Lakshminarayanan

Subjects
Polymers and Plastics, General Chemical Engineering, Analytical Chemistry
Abstract

A range of D-sorbitol/D-mannitol incorporated co-polymers were synthesized via solvent free enzyme catalyzed polycondensation with adipic acid and polyethylene glycol. In-vitro cytotoxic studies on breast cancer and fibroblast cell lines showed that the co-polymers are biocompatible up to 500 and 250 µg/mL, respectively. However, THP-1 and RAW 264.7 cell lines showed a dose dependent cytotoxicity. Furthermore, these co-polymers did not produce excessive cytokines (TNFα/IL-6) and chemokines (CXCL-5/CXCL-10) when interacting with THP-1 cells, thereby, not causing any inflammation. Whilst, the expression of IL-1b, CXCL-1 and IFNβ were upregulated. The results suggest that these co-polymers could be promising vaccine adjuvants.

Published
2023
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24. Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma

Author

Swetha, Mundanattu, primary, Keerthana, Chenicheri K., additional, Rayginia, Tennyson P., additional, Nath, Lekshmi R., additional, Haritha, Nair Hariprasad, additional, Shabna, Anwar, additional, Kalimuthu, Kalishwaralal, additional, Thangarasu, Arun K., additional, Aiswarya, Sreekumar U., additional, Jannet, Somaraj, additional, Pillai, Sreekumar, additional, Harikumar, Kuzhuvelil B., additional, Sundaram, Sankar, additional, Anto, Nikhil Ponnoor, additional, Wu, Dee H., additional, Lankalapalli, Ravi S., additional, Towner, Rheal, additional, Isakov, Noah, additional, Deepa, Sathyaseelan S., additional, and Anto, Ruby John, additional

Published
2022
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25. Development and Functional Characterization of a Versatile Radio-/Immunotheranostic Tool for Prostate Cancer Management

Author

Arndt, Claudia, primary, Bergmann, Ralf, additional, Striese, Franziska, additional, Merkel, Keresztély, additional, Máthé, Domokos, additional, Loureiro, Liliana R., additional, Mitwasi, Nicola, additional, Kegler, Alexandra, additional, Fasslrinner, Frederick, additional, González Soto, Karla Elizabeth, additional, Neuber, Christin, additional, Berndt, Nicole, additional, Kovács, Noemi, additional, Szöllősi, David, additional, Hegedűs, Nikolett, additional, Tóth, Gyula, additional, Emmermann, Jan-Philipp, additional, Harikumar, Kuzhuvelil B., additional, Kovacs, Tibor, additional, Bachmann, Michael, additional, and Feldmann, Anja, additional

Published
2022
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28. DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer

Author

Kurani, Hetakshi, primary, Razavipour, Seyedeh Fatemeh, additional, Harikumar, Kuzhuvelil B., additional, Dunworth, Matthew, additional, Ewald, Andrew J., additional, Nasir, Apsra, additional, Pearson, Gray, additional, Van Booven, Derek, additional, Zhou, Zhiqun, additional, Azzam, Diana, additional, Wahlestedt, Claes, additional, and Slingerland, Joyce, additional

Published
2022
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34. Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer

Author

James, Shirley, primary, Aparna, Jayasekharan S., additional, Babu, Anu, additional, Paul, Aswathy Mary, additional, Lankadasari, Manendra Babu, additional, Athira, Subha R., additional, Kumar, Sreesha S., additional, Vijayan, Yadu, additional, Namitha, Narayanan N., additional, Mohammed, Sabira, additional, Reshmi, Girijadevi, additional, and Harikumar, Kuzhuvelil B., additional

Published
2021
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42. The effect of Caries, Periodontitis and Substance abuse on Salivary Interleukin - 6 levels.

Author

Prasanna, Ranimol, Babu, Anu, Balan, Anita, and Harikumar, Kuzhuvelil B.

Subjects
SUBSTANCE abuse, MANN Whitney U Test, PERIODONTITIS, ALCOHOLISM, EARLY detection of cancer
Abstract

Objective Early stage diagnosis of oral cancer will help in complete control of the progression of the lesion. Salivary biomarker analysis is a non-invasive and inexpensive method in the early detection of oral cancer. Materials and Methods The study aimed at the detection of the changes of salivary IL-6 in caries, periodontitis and substance abuse. Sociodemographic details, habits like tobacco and alcohol abuse were recorded. Clinical factors like caries and periodontal status of subjects were assessed using dentition status and treatment need index and modified CPITN index, respectively. Whole unstimulated saliva was collected and IL-6 estimated using ELISA. Mann Whitney U test was used to compare between clinical groups and demographic variables using ANOVA. Results The median and mean baseline salivary IL-6 value of the 48 samples were 4.13 and 5.998 ±2.76 pg/ml. Subjects with substance abuse had highest median: 6.82 pg/ml (IQR: 4.871-13.110) and mean values:15.073 ±15.47pg/ml. The median of other groups,caries- 3.53, periodontitis- 4.2 and normal- 4.0, pg/ml respectively. ROC analysis showed AUC for the substance abuse and normal was 78 (sensitivity 71% specificity 82%) substance abuse and all groups was 75 (sensitivity 86% specificity 61%). The cut off was 6.41and 4.2 pg/ml respectively. Summary and Conclusions Based on the higher AUC value, salivary IL-6 levels of more than 6.41pg/ml can be taken as cutoff for clinical evaluation with higher potential for malignant change. The fact that cases with periodontitis did not show a statistically significant difference in IL-6 levels when compared to substance abuse, needs further consideration. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Abrogation of Pancreatic Cancer Using a Brain Malady Drug

Author

Lankadasari, Manendra Babu, primary, Jayasekharan, Aparna S, additional, Mohammed, Sabira, additional, James, Shirley, additional, Aoki, Kazunori, additional, Binu, Valasalakumari S, additional, Nair, Sindhu, additional, and Harikumar, Kuzhuvelil B, additional

Published
2019
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49. K63-linked polyubiquitylation of IRF1 transcription factor is essential for IL-1-induced CCL5 and CXCL10 chemokine production

Author

Harikumar, Kuzhuvelil B., Yester, Jessie W., Surace, Michael J., Oyeniran, Clement, Price, Megan M., Huang, Wei-Ching, Hait, Nitai C., Allegood, Jeremy C., Yamada, Akimitsu, Kong, Xiangqian, Lazear, Helen M., Bhardwaj, Reetika, Takabe, Kazuaki, Diamond, Michael S., Luo, Cheng, Milstien, Sheldon, Spiegel, Sarah, and Kordula, Tomasz

Subjects
Chemokine CXCL10, Animals, Humans, Chemokine CCL5, Article, Interferon Regulatory Factor-1, Interleukin-1, Signal Transduction
Abstract

Although interleukin-1 (IL-1) induces expression of interferon regulatory factor 1 (IRF1), its roles in immune and inflammatory responses and mechanisms of activation remain elusive. Here, we show that IRF1 is essential for IL-1-induced expression of chemokines CXCL10 and CCL5 that recruit mononuclear cells into sites of sterile inflammation. Newly synthesized IRF1 acquires K63-linked polyubiquitylation mediated by cellular inhibitor of apoptosis 2 (cIAP2), which is enhanced by the bioactive lipid sphingosine-1 phosphate (S1P). In response to IL-1, cIAP2 and sphingosine kinase 1, the enzyme that generates S1P, form a complex with IRF1, which leads to its activation. Thus, IL-1 triggers a hitherto unknown signaling cascade that controls induction of IRF1-dependent genes important for sterile inflammation.

Published
2014

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