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2. Maintenance Duration Estimate for a DEMO Fusion Power Plant, based on the EFDA WP12 pre-conceptual studies

Author

Crofts, O. and Harman, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

The erosion and high neutron flux in a fusion power plant results in the need for frequent remote replacement of the plasma facing components. This is a complex and time consuming remote handling operation and its duration directly affects the availability and therefore the commercial viability of the power plant. A tool is needed to allow the maintenance duration to be determined so that developments in component design can be assessed in terms of their effect on the maintenance duration. This allows the correct balance to be drawn between component cost and performance on the one hand and the remote handling cost and plant availability on the other., Comment: 6 pages, 3 figures

Published
2014
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3. 2024 joint BMC Ecology and Evolution and BMC Zoology image competition: the winning images. Editorial

Author

Harman, J., Nödl, M.-T., Fenton, B., Hipsley, C.A., Liberles, D.A., Narayan, E., Settele, Josef, Traulsen, A., Harman, J., Nödl, M.-T., Fenton, B., Hipsley, C.A., Liberles, D.A., Narayan, E., Settele, Josef, and Traulsen, A.

Abstract

In 2024, researchers from around the world entered the joint BMC Ecology and Evolution and BMC Zoology image competition. The photos, a celebration of the wonders and mysteries of the natural world, emphasise the importance of protecting life on our planet. This editorial announces the winning images chosen by the Editors and senior members of the journal’s editorial boards.

Published
2024

4. Pre-conceptual Design Assessment of DEMO Remote Maintenance

Author

Loving, A., Crofts, O., Sykes, N., Iglesias, D., Coleman, M., Thomas, J., Harman, J., Fischer, U., Sanz, J., Siuko, M., Mittwollen, M., and others

Subjects
Physics - Plasma Physics, Physics - Instrumentation and Detectors
Abstract

EDFA, as part of the Power Plant Physics and Technology programme, has been working on the pre-conceptual design of a Demonstration Power Plant (DEMO). As part of this programme, a review of the remote maintenance strategy considered maintenance solutions compatible with expected environmental conditions, whilst showing potential for meeting the plant availability targets. A key finding was that, for practical purposes, the expected radiation levels prohibit the use of complex remote handling operations to replace the first wall. In 2012/13, these remote maintenance activities were further extended, providing an insight into the requirements, constraints and challenges. In particular, the assessment of blanket and divertor maintenance, in light of the expected radiation conditions and availability, has elaborated the need for a very different approach from that of ITER. This activity has produced some very informative virtual reality simulations of the blanket segments and pipe removal that are exceptionally valuable in communicating the complexity and scale of the required operations. Through these simulations, estimates of the maintenance task durations have been possible demonstrating that a full replacement of the blankets within 6 months could be achieved. The design of the first wall, including the need to use sacrificial limiters must still be investigated. In support of the maintenance operations, a first indication of the requirements of an Active Maintenance Facility (AMF) has been elaborated., Comment: 6 pages, 5 figures

Published
2013
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5. Mindfulness, Emotional Availability, and Emotional Attachment: Three Pillars of Daily Practice

Author

Biringen, Zeynep, Closson, Lia, Derr-Moore, Abigail, Pratt, Deborah, Pybus, Kylie, Saunders, Hannah, Warren, Virginia, Lucas-Thompson, Rachel G., Harman, J. J., and Neu, Madalynn

Abstract

Caregiver-child relationships offer the first opportunity for a healthy start and the possibility for a secure attachment. Balanced and healthy dyadic emotional communication is referred to as "emotional availability" (EA; Biringen, Robinson, & Emde, 1998). EA in a family is enhanced when there is lower stress, often addressed through meditations. In addition, EA is facilitated when a family is aware of the impact of intergenerational issues and current attachment with one's child. Here, we describe these three pillars of our work (EA, attachment, and mindfulness) and put forth the idea that these are all practices that should be done on a daily basis.

Published
2015

6. 2022 BMC Ecology and Evolution image competition: the winning images. Editorial

Author

Harman, J., Hipsley, C.A., Jacobus, L.M., Liberles, D.A., Settele, Josef, Traulsen, A., Harman, J., Hipsley, C.A., Jacobus, L.M., Liberles, D.A., Settele, Josef, and Traulsen, A.

Abstract

In 2023, researchers from around the world entered the BMC Ecology and Evolution photography competition. As a result, we received a spectacular collection of photographs that capture the wonder of nature, those looking to understand it and glimpses into long lost worlds. This editorial celebrates the winning images selected by the Editor of BMC Ecology and Evolution and senior members of the journal’s editorial board

Published
2023

10. Examining the generalizability of research findings from archival data

Author

Delios, A., Clemente, E. G., Wu, T., Tan, H., Wang, Y., Gordon, M., Viganola, D., Chen, Z., Dreber, A., Johannesson, M., Pfeiffer, T., Uhlmann, E. L., Al-Aziz, A. M. A., Abraham, A. T., Trojan, J., Adamkovic, M., Agadullina, E., Ahn, J., Akinci, C., Akkas, H., Albrecht, D., Alzahawi, S., Amaral-Baptista, M., Anand, R., Ang, K. F. U., Anseel, F., Aruta, J. J. B. R., Ashraf, M., Baker, B. J., Bao, X., Baskin, E., Bathula, H., Bauman, C. W., Bavolar, J., Bayraktar, S., Beckman, S. E., Benjamin, A. S., Brown, S. E. V., Buckley, J., Buitrago, R. E., Bution, J. L., Byrd, N., Carrera, C., Caruso, E. M., Chen, M., Chen, L., Cicerali, E. E., Cohen, E. D., Crede, M., Cummins, J., Dahlander, L., Daniels, D. P., Daskalo, L. L., Dawson, I. G. J., Day, M. V., Dietl, E., Domurat, A., Dsilva, J., Du Plessis, C., Dubrov, D. I., Edris, S., Elbaek, C. T., Elsherif, M. M., Evans, T. R., Fellenz, M. R., Fiedler, S., Firat, M., Freitag, R., Furrer, R. A., Gautam, R., Gautam, D. K., Gearin, B., Gerschewski, S., Ghasemi, O., Ghasemi, Z., Ghosh, A., Giani, C., Goldberg, M. H., Goswami, M., Graf-Vlachy, L., Rajeshwari, H., Griffith, J. A., Grigoryev, D., Gu, J., Hadida, A. L., Hafenbrack, A. C., Hafenbradl, S., Hammersley, J. J., Han, H., Harman, J. L., Hartanto, A., Henkel, A. P., Y. -C., Ho, Holding, B. C., Holzmeister, F., Horobet, A., Huang, T. S. -T., Huang, Y., Huntsinger, J. R., Idzikowska, K., Imada, H., Imran, R., Ingels, M. J., Jaeger, B., Janssen, S. M. J., Jia, F., Jimenez, A., Jin, J. L., Johannes, N., Jolles, D., Jozefiakova, B., Kacmar, P., Kalandadze, T., Kalimeri, K., Kang, P., Kantorowicz, J., Karada, D., Karimi-Rouzbahani, H., Kee, D. M. H., Keller, L., Khan, H. A., Knutsson, M., Kombeiz, O., Korniychuk, A., Kowal, M., Leder, J., Liang, L. W., Liew, T., Lin, F., Liu, C., Liu, B., Longo, M. C., Lovakov, A., Low, M. P., Lucas, G. J. M., Lukason, O., A. L., Ly, Ma, Z., Mafael, A., Mahmoudkalayeh, S., Manheim, D., Marcus, A., Marsh, M. S., Martin, J. M., Martinez, L. E., Martinoli, M., Martoncik, M., Masters-Waage, T. C., Mata, R., Mazloomi, H., Mccarthy, R. J., Millroth, P., Mishra, M., Mishra, S., Mohr, A., Moreau, D., Myer, A., Nadler, A., Nair, S., Nilsonne, G., Niszczota, P., O'Mahony, A., Oberhauser, M., Obloj, T., Orhan, M. A., Oswald, F., Otterbring, T., Otto, P. E., Padron-Hernandez, I., Pan, A. J., Paruzel-Czachura, M., Pfuhl, G., Pirrone, A., Porcher, S., Protzko, J., Qi, S., Rahal, R. -M., Rahman, Md. S., Reina, M. L., Rentala, S., Riaz, Z., Ropovik, I., Roseler, L., Ross, R. M., Rotella, A., Roth, L. H. O., Roulet, T. J., Rubin, M. M., Sammartino, A., Sanchez, J., Saville, A. D., Schaerer, M., Schleu, J. E., Schmallenbach, L., Schnabel, L., Spuntrup, F. S., Schumpe, B. M., Senanayake, T., Seri, R., Sheng, F., Snider, R. E., Song, D., Song, V., Starnawska, S. E., Stern, K. A., Stevens, S. M., Stromland, E., Su, W., Sun, H., Sweeney, K. P., Takamatsu, R., Terskova, M., Tey, K. S., Tierney, W., Todorova, M. M., Tolstoy, D., Torkkeli, L., Tybur, J. M., Valderrey, F. J., Vallina-Hernandez, A. M., Vasudevan, R. P., Rao, G. V., Vernet, A., Vissak, T., Voss, H., Wahle, T., Wai, J., Wakabayashi, L. E. T., Wang, J., Wang, P., Warmenhoven, R. W., Wennberg, K., Wernicke, G., Woike, J. K., Wollbrant, C. E., Woodin, G., Wright, J. D., Xia, Q., Xie, Z., Yoon, S., Yuan, W., Yuan, L., Yucel, M., Zheng, Z., Zhou, H., Zogmaister, C., Zultan, R., Research Group: Strategy and Organization, Department of Management, Department of Social Psychology, Organizational Psychology, Social Psychology, IBBA, Delios, A, Giulia Clemente, E, Wu, T, Tan, H, Wang, Y, Gordon, M, Viganola, D, Chen, Z, Dreber, A, Johannesson, M, Pfeiffer, T, Luis Uhlmann, E, Zogmaister, C, University of St Andrews. School of Economics and Finance, University of St Andrews. School of Management, and Lucas, Gerardus J.M.

Subjects
research reliability, Multidisciplinary, ZA4050 Electronic information resources, DAS, VDP::Matematikk og Naturvitenskap: 400, M-PSI/06 - PSICOLOGIA DEL LAVORO E DELLE ORGANIZZAZIONI, archival data, context sensitivity, generalizability, reproducibility, Research reliability, generalizability, archival data, reproducibility, context sensitivity, Ciências Sociais::Economia e Gestão [Domínio/Área Científica], ZA4050, Inequality, cohesion and modernization, M-PSI/03 - PSICOMETRIA, VDP::Medisinske Fag: 700, Ongelijkheid, cohesie en modernisering, Work, Health and Performance
Abstract

This research project benefitted from Ministry of Education (Singapore) Tier 1 Grant R-313-000-131-115 (to A. Delios), National Science Foundation of China Grants 72002158 (to H.T.) and 71810107002 (to H.T.), grants from the Knut and Alice Wallenberg Foundation (to A. Dreber) and the Marianne and Marcus Wallenberg Foundation (through a Wallenberg Scholar grant; to A. Dreber), Austrian Science Fund (FWF) Grant SFB F63 (to A. Dreber), grants from the Jan Wallander and Tom Hedelius Foundation (Svenska Handelsbankens Forskningsstiftelser; to A. Dreber), and an Research & Development (R&D) research grant from Institut Européen d'Administration des Affaires (INSEAD) (to E.L.U.). Dmitrii Dubrov, of the G.T.F.C., was supported by the National Research University Higher School of Economics (HSE University) Basic Research Program. This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples. Publisher PDF

Published
2022
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11. H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

Author

Godfrey, L., Crump, N. T., O'Byrne, S., Lau, I. J., Rice, S., Harman, J. R., Jackson, T., Elliott, N., Buck, G., Connor, C., Thorne, R., Knapp, D. J. H. F., Heidenreich, O., Vyas, P., Menéndez, Pablo, Inglott, S., Ancliff, P., Geng, H., Roberts, I., Roy, A., Milne, T. A., and Universitat Autònoma de Barcelona

Subjects
Cancer Research, Oncogene Proteins, Fusion, Stem cell marker, Cell Transformation, Histones, Models, hemic and lymphatic diseases, Cancer genomics, 2.1 Biological and endogenous factors, AC133 Antigen, Aetiology, Promoter Regions, Genetic, Cancer, Oncogene Proteins, Leukemic, Pediatric, Tumor, Leukemia, biology, Gene Expression Regulation, Leukemic, Hematology, Cell biology, Cell Transformation, Neoplastic, Enhancer Elements, Genetic, Oncology, Neoplastic Stem Cells, Stem Cell Research - Nonembryonic - Non-Human, Stem cell, PRC2, Myeloid-Lymphoid Leukemia Protein, Protein Binding, Enhancer Elements, Pediatric Cancer, Clinical Sciences, Oncology and Carcinogenesis, Immunology, Locus (genetics), Models, Biological, Article, Cell Line, Immunophenotyping, Promoter Regions, Histone H3, Rare Diseases, Genetic, Cell Line, Tumor, Genetics, Biomarkers, Tumor, Humans, Gene Silencing, Enhancer, Fusion, Gene, neoplasms, Neoplastic, Acute lymphocytic leukaemia, DOT1L, Biological, Stem Cell Research, Orphan Drug, Gene Expression Regulation, biology.protein, Biomarkers
Abstract

Altres ajuts: Acknowledgements TAM, LG, NTC, I-JL, RT, JRH, and SR were funded by Medical Research Council (MRC, UK) Molecular Haematology Unit grant MC_UU_12009/6, MC_UU_00016/6, and MR/ M003221/1. AR was supported by a Bloodwise Clinician Scientist Fellowship (grants: 14041 and 17001), Wellcome Trust Clinical Research Career Development Fellowship (216632/Z/19/Z), Lady Tata Memorial International Fellowship, and EHA-ASH Translational Research Training in Hematology Fellowship. SOB was funded by the Department of Paediatrics and Alexander Thatte Fund, University of Oxford. DJHFK is funded by a CIHR Postdoctoral Fellowship. IR is supported by the NIHR Oxford BRC, by a Bloodwise Program Grant (13001) and by the MRC Molecular Haematology Unit (MC_UU_12009/14). PV via the Molecular Haematology Unit (MC_UU_12009) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC) Programme. We would like to acknowledge the WIMM Flow Cytometry Facility which is supported by the MRC HIU, MRC MHU (MC_UU_12009), NIHR Oxford BRC, Kay Kendall Leukemia Fund (KKL1057), John Fell Fund (131/030 and 101/517), the EPA fund (CF182 and CF170), and by the WIMM Strategic Alliance awards G0902418 and MC_UU_12025. We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics (funded by Wellcome Trust Grant Reference 090532/Z/09/Z); the MRC WIMM Centre for Computational Biology (CCB), Radcliffe Department of Medicine, University of Oxford; and Jelena Telenius for the use of her pipelines. B-ALL work in PM's lab is financially supported by [...], the Fundación Uno entre Cienmil, the Fundación Leo Messi. PM also acknowledges structural support from the Obra Social La Caixa-Fundaciò Josep Carreras. The human fetal material was provided by the Joint MRC/ Wellcome Trust Grant 099175/Z/ 12/Z Human Developmental Biology Resource (http://hdbr.org). We gratefully acknowledge the kind generosity of patients, their parents, and staff at Great Ormond Street Hospital, London. MLL gene rearrangements (MLLr) are a common cause of aggressive, incurable acute lymphoblastic leukemias (ALL) in infants and children, most of which originate in utero. The most common MLLr produces an MLL-AF4 fusion protein. MLL-AF4 promotes leukemogenesis by activating key target genes, mainly through recruitment of DOT1L and increased histone H3 lysine-79 methylation (H3K79me2/3). One key MLL-AF4 target gene is PROM1, which encodes CD133 (Prominin-1). CD133 is a pentaspan transmembrane glycoprotein that represents a potential pan-cancer target as it is found on multiple cancer stem cells. Here we demonstrate that aberrant PROM1/CD133 expression is essential for leukemic cell growth, mediated by direct binding of MLL-AF4. Activation is controlled by an intragenic H3K79me2/3 enhancer element (KEE) leading to increased enhancer-promoter interactions between PROM1 and the nearby gene TAPT1. This dual locus regulation is reflected in a strong correlation of expression in leukemia. We find that in PROM1/CD133 non-expressing cells, the PROM1 locus is repressed by polycomb repressive complex 2 (PRC2) binding, associated with reduced expression of TAPT1, partially due to loss of interactions with the PROM1 locus. Together, these results provide the first detailed analysis of PROM1/CD133 regulation that explains CD133 expression in MLLr ALL.

Published
2020

12. 2022 BMC Ecology and Evolution image competition: the winning images

Author

Harman, J, Hipsley, CA, Jacobus, LM, Liberles, DA, Settele, J, Traulsen, A, Harman, J, Hipsley, CA, Jacobus, LM, Liberles, DA, Settele, J, and Traulsen, A

Abstract

In 2022, researchers from around the world entered the BMC Ecology and Evolution photography competition. The contest produced a spectacular collection of photographs that capture the wonder of the natural world and the growing need to protect it as the human impact on the planet intensifies. This editorial celebrates the winning images selected by the Editor of BMC Ecology and Evolution and senior members of the journal's editorial board.

Published
2022

13. 2022 BMC Ecology and Evolution image competition: the winning images. Editorial

Author

Harman, J., Hipsley, C.A., Jacobus, L.M., Liberles, D.A., Settele, Josef, Traulsen, A., Harman, J., Hipsley, C.A., Jacobus, L.M., Liberles, D.A., Settele, Josef, and Traulsen, A.

Abstract

In 2022, researchers from around the world entered the BMC Ecology and Evolution photography competition. The contest produced a spectacular collection of photographs that capture the wonder of the natural world and the growing need to protect it as the human impact on the planet intensifies. This editorial celebrates the winning images selected by the Editor of BMC Ecology and Evolution and senior members of the journal’s editorial board.

Published
2022

18. The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

Author

Azzoni, E, Frontera, V, Anselmi, G, Rode, C, James, C, Deltcheva, E, Demian, A, Brown, J, Barone, C, Patelli, A, Harman, J, Nicholls, M, Conway, S, Morrissey, E, Jacobsen, S, Sparrow, D, Harris, A, Enver, T, de Bruijn, M, Azzoni, Emanuele, Frontera, Vincent, Anselmi, Giorgio, Rode, Christina, James, Chela, Deltcheva, Elitza M, Demian, Atanasiu S, Brown, John, Barone, Cristiana, Patelli, Arianna, Harman, Joe R, Nicholls, Matthew, Conway, Simon J, Morrissey, Edward, Jacobsen, Sten Eirik W, Sparrow, Duncan B, Harris, Adrian L, Enver, Tariq, de Bruijn, Marella F T R, Azzoni, E, Frontera, V, Anselmi, G, Rode, C, James, C, Deltcheva, E, Demian, A, Brown, J, Barone, C, Patelli, A, Harman, J, Nicholls, M, Conway, S, Morrissey, E, Jacobsen, S, Sparrow, D, Harris, A, Enver, T, de Bruijn, M, Azzoni, Emanuele, Frontera, Vincent, Anselmi, Giorgio, Rode, Christina, James, Chela, Deltcheva, Elitza M, Demian, Atanasiu S, Brown, John, Barone, Cristiana, Patelli, Arianna, Harman, Joe R, Nicholls, Matthew, Conway, Simon J, Morrissey, Edward, Jacobsen, Sten Eirik W, Sparrow, Duncan B, Harris, Adrian L, Enver, Tariq, and de Bruijn, Marella F T R

Abstract

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC lineage develops until the phenotypic pro-HSC stage. However, these cells reside in an abnormal microenvironment, fail to activate the hematopoietic program downstream of Runx1, and are functionally impaired. Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1−/− cells fail to undergo a glycolysis to oxidative phosphorylation metabolic switch present in wild-type cells. Interestingly, experimental activation of glycolysis results in decreased intraembryonic hematopoiesis. Our results suggest that the onset of circulation triggers metabolic changes that allow HSC generation to proceed.

Published
2021

25. Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis

Author

Azzoni, E, Frontera, V, McGrath, K, Harman, J, Carrelha, J, Nerlov, C, Palis, J, Jacobsen, S, De Bruijn, M, Azzoni, E, Frontera, V, Mcgrath, K, Harman, J, Carrelha, J, Nerlov, C, Palis, J, Jacobsen, S, and de Bruijn, M

Subjects
Embryonic Development, embryo, Mice, Transgenic, Biochemistry, Article, Mice, Genetics, Animals, Cell Lineage, Erythropoiesis, AGM, Stem Cell Niche, Gonads, Molecular Biology, Aorta, Cell Proliferation, Yolk Sac, Stem Cell Factor, integumentary system, Kit ligand, Stem Cells, BIO/13 - BIOLOGIA APPLICATA, Endothelial Cells, Gene Expression Regulation, Developmental, Articles, Hematopoietic Stem Cells, hematopoiesis, niche, hematopoiesi, Mesonephros, embryonic structures, Development & Differentiation, Signal Transduction
Abstract

Few studies report on the in vivo requirement for hematopoietic niche factors in the mammalian embryo. Here, we comprehensively analyze the requirement for Kit ligand (Kitl) in the yolk sac and aorta–gonad–mesonephros (AGM) niche. In‐depth analysis of loss‐of‐function and transgenic reporter mouse models show that Kitl‐deficient embryos harbor decreased numbers of yolk sac erythro‐myeloid progenitor (EMP) cells, resulting from a proliferation defect following their initial emergence. This EMP defect causes a dramatic decrease in fetal liver erythroid cells prior to the onset of hematopoietic stem cell (HSC)‐derived erythropoiesis, and a reduction in tissue‐resident macrophages. Pre‐HSCs in the AGM require Kitl for survival and maturation, but not proliferation. Although Kitl is expressed widely in all embryonic hematopoietic niches, conditional deletion in endothelial cells recapitulates germline loss‐of‐function phenotypes in AGM and yolk sac, with phenotypic HSCs but not EMPs remaining dependent on endothelial Kitl upon migration to the fetal liver. In conclusion, our data establish Kitl as a critical regulator in the in vivo AGM and yolk sac endothelial niche.

Published
2018

26. Phosphate plume persistence at two decommissioned septic system sites

Author

Robertson, W.D. and Harman, J.

Subjects
Septic tanks -- Research -- Analysis, Plumes (Fluid dynamics) -- Research -- Analysis, Phosphates -- Analysis -- Research, Earth sciences, Analysis, Research
Abstract

Introduction Laboratory studies of phosphate transport through sediments invariably note a high degree of P[O.sub.[4.sup.3]]- retardation. This is generally attributed to P[O.sub.[4.sub.3]]- adsorption onto the sediment solids, particularly the metal [...]

Published
1999

31. Impacts on a sand aquifer from an old septic system: nitrate and phosphate

Author

Harman, J., Robertson, W.D., Cherry, J.A., and Zanini, L.

Subjects
Prentice-Hall Inc. -- Market research, Water -- Management, Book publishing -- Market research, Phosphate industry -- Market research, Earth sciences, Marketing research, Market research
Abstract

Abstract Four hundred ground-water sampling points were used to delineate a plume in an unconfined sand aquifer at a 44 year old septic system servicing a school in Ontario, Canada. [...]

Published
1996

37. Inheritance of proliferative breast disease in breast cancer kindred

Author

Skolnick, Mark H., Cannon-Albright, Lisa A., Goldgar, David E., Ward, John H., Marshall, C. Jay, Schumann, G. Berry, Hogle, Hugh, McWhorter, William P., Wright, Eileen C., Tran, Thao D., Bishop, D. Timothy, Kushner, James P., and Eyre, Harman J.

Subjects
Genetic aspects, Risk factors, Breast diseases -- Genetic aspects -- Risk factors, Breast cancer -- Risk factors -- Genetic aspects
Abstract

Previous studies have emphasized that genetic susceptibility to breast cancer is rare and is expressed primarily as premenopausal breast cancer, bilateral breast cancer, or both. Proliferative breast disease (PBD) is [...]

Published
1990

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