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2. Komplexes Regionales Schmerzsyndrom (CRPS) – Teil 2

Author

Harnik, M A, Streitberger, K, Brunner, F, Hanusch, K U, Reisig, F, Harnik, M A, Streitberger, K, Brunner, F, Hanusch, K U, and Reisig, F

Abstract

Ähnlich komplex, wie das Symptom-Mosaik eines CRPS sich klinisch zeigen kann, besteht auch dessen Therapie aus vielen Einzelkomponenten. Im vorliegenden zweiten Teil1 dieses Übersichtsartikels sollen die einzelnen Behandlungen des CRPS genauer erläutert werden, inklusive ihrer Besonderheiten. Wir beenden den Artikel mit konkreten Handlungsvorschlägen für die ersten therapeutischen Schritte.

Published
2021

3. Komplexes Regionales Schmerzsyndrom (CRPS) – Teil 1

Author

Harnik, M A, Streitberger, Konrad, Brunner, F, Hanusch, K U, Reisig, F, Harnik, M A, Streitberger, Konrad, Brunner, F, Hanusch, K U, and Reisig, F

Abstract

Vordergründig unerklärliche, dysproportional auftretende posttraumatische Schmerzen beschäftigen Ärzte nach wie vor. Ein besonders anspruchsvoller Sym­ptomkomplex ist das komplexe regionale Schmerzsyndrom, dessen Diagnostik und Therapie selbst für erfahrene Spezialisten schwierig sein können. Dieser zweiteilige Übersichtsartikel1 stellt die wichtigsten aktuellen Erkenntnisse aus Diagnostik und Therapie sowie pragmatische Empfehlungen für die Praxis vor.

Published
2021

4. Effectiveness of Communication Strategies in the Management of Chronic Postsurgical Pain: Protocol for a Systematic Review and Meta-Analysis

Author

Ferrante AN, Keller BK, Flury JS, Harnik MA, grosse Holtforth M, and Wertli MM

Subjects
chronic post-surgical pain, communication, education, pain prevention, systematic review, Medicine (General), R5-920
Abstract

Asha-Naima Ferrante,1,2 Barbara K Keller,1 Julian S Flury,1 Michael A Harnik,3 Martin grosse Holtforth,2,4 Maria M Wertli1,5 1Department of General Internal Medicine, University Hospital of Bern, Inselspital, University of Bern, Bern, 3010, Switzerland; 2Department of Psychology, University of Bern, Bern, 3012, Switzerland; 3Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; 4Psychosomatic Competence Center, University Hospital of Bern, Inselspital, University of Bern, Bern, 3010, Switzerland; 5Department of Internal Medicine, Kantonsspital Baden, Baden, 5404, SwitzerlandCorrespondence: Asha-Naima Ferrante, Department of General Internal Medicine, University Hospital, Inselspital, Freiburgstrasse 18, Bern, 3010, Switzerland, Email asha-naima.ferrante@students.unibe.chPurpose: To describe the details of a systematic review to assess the current evidence about the efficacy of communication strategies on the prevention of chronic postsurgical pain (CPSP).Methods: The protocol for this systematic review was based on the Cochrane Handbook methodology and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) recommendations. A systematic search of the literature on electronic databases Medline, Embase, Cochrane Library, CINAHL, PsycINFO, and Web of Science (from the inception to 19 June 2022) was carried out using predefined search terms to identify relevant studies. This review will include randomized clinical trials or observational studies. The search strategy consisted of keywords and index terms related to “clinician”, “communication” or “post-surgical pain”. Inclusion criteria are as follows: randomized clinical trials or observational studies using a parallel group design that assess the efficacy of communication interventions in patients undergoing surgery and that assess pain and pain-related disability. We considered interventions that included any type of written, verbal, and non-verbal communication in combination with other interventions or without. Control groups may include no communication intervention or another intervention distinctly different. We excluded studies with follow-up duration of less than 3 months, patients aged < 18 years, and studies for which no reviewer had language proficiency (eg, Chinese, Korean). Descriptive statistics will be used to summarize quantitative findings. Meta-analysis will only be considered if at least three studies used the same outcome with comparable interventions, as we expect a wide heterogeneity of study population and settings.Conclusion: This systematic review and meta-analysis will be an important source for clinicians and researchers to understand the influence of communication to prevent CPSP.Study Registration: This protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO). Registration number: CRD42021241596.Keywords: chronic post-surgical pain, communication, education, pain prevention, systematic review

Published
2023

12. 16‐Isopropylidene‐6‐Hydroxyequilenin Dimethyl Ether

Author

Harnik, M. and Danieli, N.

Abstract

An unknown product previously obtained was now shown to have the structure (III) by hydrogenation and determination of the nuclear magnetic resonance, infrared, ultraviolet and mass spectra. Final proof was obtained by an independent synthesis.

Published
1965
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13. Total Synthesis of 3,6‐Dimethoxy‐17β‐Acetyl‐1,3,5(10),6,8‐Estrapentaene

Author

Harnik, M. and Jensen, E. V.

Abstract

A Friedel‐Crafts reaction of 2,8‐dimethoxynaphthalene with β‐methyltricarballylic acid anhydride (I) gave the ketoacid (IId), which upon catalytic hydrogenation and cyclization with hydrogen fluoride afforded the tricyclic ketone (V). Addition of methyl acrylate yielded the tetracyclic ester (VI), which was dehydrated and then decarboxylated at carbon 15. The reactions could be controlled to produce either the 17α‐ or the 17β epimers (IX) and (X). Their hydrogenation furnished the 14β, 17α‐ and 14α, 17β isomers (XII) and (XIb), respectively. The latter was transformed into the 17β‐acetyl derivative (XIe).

Published
1965
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14. Preparation of 6‐Methoxy Aromatic Steroids from Estradiol and by Total Synthesis

Author

Harnik, M.

Abstract

An easy synthesis of 6‐methoxy equilenin derivatives is described starting with 7α‐bromo‐6‐ketoestradiol 17‐acetate (Va). The resulting 6‐hydroxyequilenin dimethyl ether (VIIIa) was transformed into 17β‐acetamido‐3,6‐dimethoxy‐1,3,5(10), 6,8‐estrapentaene (IXd), the racemic form (XIIId) of which was made from the totally synthetic compounds (Xa) and (XIa), Also the D‐antipode (XXI) of 3,6‐dimethoxy‐176 ‐acetyl‐1,3,5(10), 6,8‐estrapentaene was synthesized from (VIIIa) and compared with its racemic form (XIa). Treatment of the estrapentaene (VIb) with sodium and isopropanol afforded the ketone (XVIb) which was further reduced to the triol (XVII).

Published
1965
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16. Synthesis of Compounds Related to Steroids. Reactions of β‐Methyltricarballylic Acid Anhydride with Benzene and Naphthalene

Author

Harnik, M.

Abstract

β‐Methyltricarballylic acid anhydride (I) undergoes an efficient three‐step reaction sequence whereby it is transformed into known intermediates useful in the synthesis of aromatic steroids. Experiments are described in the benzene series leading to the preparation of the tetralone derivative (VIIa), and in the naphthalene series giving the tetrahydrophenanthrene acids (XV) and (XIII).

Published
1965
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17. Synthesis of Compounds Related to Steroids. Reactions of β‐Methyltricarballylic Acid Anhydride with Substituted Naphthalenes

Author

Harnik, M. and Jensen, E. V.

Abstract

β‐Methyltricarballylic acid anhydride (I) reacted with the Grignard reagent from 1‐iodo‐6‐methoxynaphthalene to give the keto acid (III) which was converted into the tricyclic intermediate (VIb). Friedel‐Crafts condensation of the anhydride (1) with 2‐methoxynaphthalene led to the isolation of the acids (XII) and (IXc). As in the case of 7‐methoxy‐1‐acetnaphthalide, condensation of 7‐bromo‐1‐acetnaphthalide with succinic anhydride gave only the 3‐substituted product (XVIIa). Condensation of 1‐acetnaphthalide with succinic anhydride lead to acidic products in which the naphthalene nucleus is substituted mostly in the β‐position.

Published
1965
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18. Studies in Syntheses of Steroid Metabolites. I.

Author

Harnik, M.

Abstract

Several approaches to the synthesis of 3α, 11β‐dihydroxy‐5α‐androstane‐17‐one (Vila) and 3α‐hydroxy‐5α‐androstane‐11,17‐dione (XIIa) are discussed. The preferred route involves selective sodium borohydride reduction of 5α‐androstane‐3,11,17‐trione (V) to 3β‐hydroxy‐5α‐androstane‐11,17‐dione (VIa) and solvolysis of its tosylate (VIc) to afford a mixture of the ketoalcohol (XIIa) and the olefin (VIIIb). The latter is then converted, through the ketals (XIb) and (XIIIb), into the diolone (VIIa).

Published
1963
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