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1. Benign Clear Cell Thyroid Tumor with 'Balloon Cell' Change: Evidence Suggesting its Pathogenesis

Author

Harold J. Sobel, Marija Us-Krašovec, Vesna Žitnik, and Janez Lamovec

Subjects
Adult, Pathology, medicine.medical_specialty, Nevi and melanomas, Oncocyte, Pathology and Forensic Medicine, Lesion, Structural Biology, medicine, Humans, Thyroid Neoplasms, Melanoma, Nevus, medicine.diagnostic_test, business.industry, Vesicle, Biopsy, Needle, Thyroid, medicine.disease, Microscopy, Electron, Fine-needle aspiration, medicine.anatomical_structure, Transitional Cell, Female, medicine.symptom, business, Clear cell
Abstract

A unique benign clear cell tumor of the thyroid is described. The lesion was composed of swollen thyroid acinar cells distended by large membrane-bound vesicles. This picture was identical to the "balloon cell" change seen in nevi and melanomas. Only balloon cells with many relatively normal-appearing mitochondria but few membranous organelles were noted in all blocks of this tissue. On fine-needle aspiration biopsy smears, oncocytes and transitional cells with oncocytic and clear cell features were also observed. On the basis of the light and electron microscopic findings, the described vesicles are probably degenerative as in nevi and melanomas and are associated with membranous organelles. The observation of oncocytic areas indicates the strength of fine-needle aspiration biopsy as a sampling technique. There is no evidence that these vesicles are of mitochondrial origin as in some clear cell thyroid lesions. Clear cell lesions of the thyroid are a heterogeneous group and may be benign, malignant, or metastatic.

Published
1993
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2. Epithelioid Hemangioendothelioma of the Anterior Mediastinum with Osteoclast-Like Giant Cells: Light Microscopic, Immunohistochemical, and Electron Microscopic Study

Author

Harold J. Sobel, Janez Lamovec, Joze Jerman, and Andreja Zidar

Subjects
Adult, Pathology, medicine.medical_specialty, Osteoclasts, Anterior mediastinum, Giant Cells, Mediastinal Neoplasms, Lesion, Osteoclast, hemic and lymphatic diseases, medicine, Humans, Electron microscopic, Epithelioid hemangioendothelioma, business.industry, Mediastinum, General Medicine, Anatomy, medicine.disease, Immunohistochemistry, Microscopy, Electron, medicine.anatomical_structure, Giant cell, Hemangioendothelioma, Female, medicine.symptom, business
Abstract

A case of epithelioid hemangioendothelioma of the anterior mediastinum in a 40-year-old woman is presented. It showed typical features described in such tumors, but in addition there were foci of osteoclast-like giant cells that were not previously reported in this lesion.

Published
1990
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3. Complete remissions in chemotherapy of lung cancer models induced in mice by asbestos

Author

William E, Smith, Doras D, Hubert, Ebrahim, Yazdi, Stephen M, Holiat, Elizabeth Cutler, Bissell, Laurel Melcher, Watts, Raymond A, Baylouny, and Harold J, Sobel

Subjects
Male, Mice, Inbred BALB C, Lung Neoplasms, Asbestos, Serpentine, Triazines, Aziridines, Remission Induction, Antineoplastic Agents, Survival Analysis, Nitrosourea Compounds, Mice, Models, Animal, Benzoquinones, Carcinoma, Squamous Cell, Animals, Dianhydrogalactitol, Cisplatin, Mitoxantrone, Pentostatin
Abstract

Chemotherapy trials were run with mice bearing transplants of carcinomas originally induced from fetal mouse lung cells by asbestos. After treatments with a nitrosourea (PCNU), mice bearing transplants of a large-cell carcinoma (ASB XIV) had complete remissions (CR) in 13 of 20 animals on a 15 mg/kg regimen, in 6 of 20 on an 8 mg/kg regimen, and in none of 10 on a 4 mg/kg regimen. With comparable total doses, treatment was most effective when PCNU was given in a few large doses. In groups where CRs occurred, continued PCNU treatment of animals without CRs prolonged survival but yielded no additional CRs. No CRs of ASB XIV occurred in 80 mice treated with eight other anticancer agents or in 50 controls injected with 0.9% NaCl solution. In mice bearing transplants of a squamous cell carcinoma (ASB XIII), treatments with PCNU were followed by CRs in 3 of 38 animals on 15 mg/kg regimens and in 3 of 28 animals on 8 mg/kg regimens. In groups of 6 mice fed a retinoid (Ro 10-9359) and treated with PCNU, CRs of ASB XIII occurred in 3 animals in each of two trials and in none in a third trial. Ro 10-9359 inhibited growth of transplants of squamous cell carcinoma LC 12 that had been induced from fetal mouse lung cells by a polycyclic hydrocarbon. In trials of four other anticancer agents vs. ASB XIII, CRs occurred only with cyclophosphamide (CPA). There were 7 CRs among 8 mice treated with CPA 100 mg/kg x 3, no CRs in 10 after 100 mg/kg x 2, one CR in 8 after 50 mg/kg x 3, and no CRs in 6 after 50 mg/kg x 4. With the 50 mg/kg x 4 regimen of CPA and 7.5 mg/kg PCNU on the same days, there were 5 CRs in 8 mice. As a single agent, aziridinylbenzoquinone (AZQ) increased life span but gave no CRs. There were CRs of ASB XIII in all of 8 mice after toxic combined therapy with PCNU and AZQ. There were no CRs in 66 control mice bearing ASB XIII.

Published
2005

6. Contents, Vol. 44, 1983

Author

Dan B. Teculescu, G. Velluti, M. Kakoura, M. Lusuardi, K. Kastritsi, O. Capelli, W. T. Ulmer, J.V. Cereceda, Michael D. Nyby, Daniel Silverstein, Bernard Michlin, K. Hochstrasser, Silvio Pitlik, Gilbert Jenouri, Murray D Altose, Abraham Bohadana, A.S. Rebuck, M. Rabinovitz, S. Lustig, M. Pellegrino, K.R. Chapman, Joseph B. Rosenfeld, Marvin A. Sackner, S. Sundberg, D. Patakas, George Louridas, Steven G. Kelsen, Neil S. Cherniack, R. Peslin, Keith Jasberg, N. Galanis, G. Milanti, G.J. Albrecht, M. Greenwald, Michael R. Littner, Martin J. Tobin, Marc H. Lavietes, Musa A. Haxhiu, Harold J. Sobel, B. Rasche, Alberto Braghiroli, and L. Benedetti

Subjects
Pulmonary and Respiratory Medicine, Traditional medicine, business.industry, Medicine, business
Published
1983
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7. Right Ventricular Failure in a Patient with Diabetic Neuropathy (Myopathy) and Central Alveolar Hypoventilation

Author

Marc H. Lavietes, Harold J. Sobel, Daniel Silverstein, and Bernard Michlin

Subjects
Male, inorganic chemicals, Pulmonary and Respiratory Medicine, Diabetic neuropathy, Heart Ventricles, Hypoxemia, Diabetic Neuropathies, Diabetes mellitus, medicine, Humans, Myopathy, Progesterone, Heart Failure, Muscle biopsy, medicine.diagnostic_test, business.industry, Respiratory disease, Hypoventilation, pathological conditions, signs and symptoms, Middle Aged, medicine.disease, respiratory tract diseases, Oxygen, Pulmonary Alveoli, Anesthesia, Right ventricular failure, medicine.symptom, business, Hypercapnia, circulatory and respiratory physiology
Abstract

An unusual patient with hypoxemia, hypercapnia, and right ventricular failure is presented. Minimal skeletal muscle weakness, although present, cannot explain hypercapnia. Muscle biopsy revealed diabetic microangiopathy. Carbon dioxide stimulation demonstrated a diminished hypercapnic ventilatory response. The patient benefited from progesterone therapy. In this unusual patient, mild muscular weakness, caused by diabetes, and central alveolar hypoventilation have acted in synergism to cause abnormal ventilation and right ventricular failure.

Published
1983
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8. Congo Red—Negative Amyloidosis-Like Glomerulopathy: Report of a Case

Author

Seyed A. Sadjadi and Harold J. Sobel

Subjects
Male, Pathology, medicine.medical_specialty, Nephrotic Syndrome, Amyloid, Basement Membrane, law.invention, chemistry.chemical_compound, Glomerulonephritis, law, Glomerulopathy, Humans, Medicine, Aged, urogenital system, business.industry, Amyloidosis, Congo Red, medicine.disease, Glomerular Mesangium, Congo red, Glomerular capillary, chemistry, Nephrology, Mesangium, Electron microscope, business, Nephrotic syndrome
Abstract

An elderly patient who had nephrotic syndrome for many years was found to have mesangial expansion and thickening of the glomerular capillary basement membranes (GBMs) on light microscopy. Electron microscopy (EM) showed tubular structures measuring 24 to 27 nm in the mesangium and the subepithelial areas. Congo red staining for amyloid was negative. This case represents another instance of congo red-negative amyloidosis-like glomerulopathy.

Published
1987
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9. Null Cell (Non-T, Non-B) Acute Lymphoblastic Leukemia Terminating as Malignant Histiocytosis

Author

Sidney Trubowitz, Stephen Davis, and Harold J. Sobel

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Rosette Formation, Malignant histiocytosis, General Medicine, Biology, medicine.disease, Leukemia, Lymphoid, Microscopy, Electron, Leukemia, medicine.anatomical_structure, Terminal deoxynucleotidyl transferase, Bone Marrow, Acute lymphocytic leukemia, Acute Disease, medicine, Null cell, Humans, B Acute Lymphoblastic Leukemia, Bone marrow, Lymphatic Diseases, Histiocyte
Abstract

A case of null cell acute lymphoblastic leukemia (ALL) terminating in malignant histiocytosis (HMR) is discussed. The patient was a 22-year-old man who presented in January 1976 with ALL. Cell surface markers on the bone-marrow blasts showed that 1% formed rosettes with sheep erythrocytes (T cells) and 4% showed immunofluorescent staining for immunoglobulin; terminal transferase levels were elevated, confirming the diagnosis of null cell ALL. The patient was treated intensively with a combination of chemotherapy and cranial irradiation. One year after diagnosis, he was maintained in partial relapse (10-15% blasts). His terminal episode was characterized by pancytopenia. The bone marrow was replaced by malignant histiocytes. Cell surface membrane staining for cytophilic antibody was positive, whereas terminal transferase levels were in the range of nonlymphoid malignancies.

Published
1980
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10. An experimental model for treatment of mesothelioma

Author

Stephan M. Holiat, Doras D. Hubert, Stephen Davis, William E. Smith, and Harold J. Sobel

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Cyclophosphamide, Experimental model, business.industry, Hamster, medicine.disease, medicine.disease_cause, Peritoneal Effusion, Asbestos, Oncology, Peritoneal mesothelioma, medicine, Doxorubicin, Mesothelioma, business, medicine.drug
Abstract

A peritoneal mesothelioma was induced by asbestos in a hamster, and was established in serial transfer to new hosts by injection of peritoneal effusion containing tumor cells. Biologically and histopathologically, this tumor is similar to its human counterpart. Three drugs were tested for efficacy using this model. Survival time was used as the only parameter of response and was compared with survival time of controls. Survival time increased 25 to 50% after short regimens of doxorubicin or 5-fluorouracil. Survival time increased up to 308% after long-continued treatments with cyclophosphamide. No cures were achieved.

Published
1981
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11. THE LOCALIZATION OF ACID PHOSPHATASE ACTIVITY IN THE RAT PITUITARY AND THYROID GLANDS, AND ITS RELATION TO SECRETORY ACTIVITY1

Author

Harold J. Sobel

Subjects
medicine.medical_specialty, Pituitary gland, biology, Chemistry, Thyroid, Acid phosphatase, Golgi apparatus, Enzyme assay, Rat Pituitary, symbols.namesake, Endocrinology, medicine.anatomical_structure, Biochemistry, Internal medicine, medicine, symbols, biology.protein, Secretion, Hormone
Abstract

The histochemical distribution and quantitative chemical and histochemical changes in acid phosphatase activity were studied in rat pituitary and thyroid glands in various phases of secretory activity. The histochemically determined enzyme activity paralleled hormonal secretion. This could be confirmed chemically for the thyroid. The acid phosphatase activity appeared to be localized in the Golgi apparatus in these organs.

Published
1961
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12. Secretion by ependymal cells of the neurohypophysis and saccus vasculosus ofPolypterus ornatipinnis (osteichthyes)

Author

Martin Weiss, Harold J. Sobel, Ruth Schwarz, and Eugene Marquet

Subjects
Ependymal Cell, Polypterus ornatipinnis, Biology, Cytoplasmic Granules, Microtubules, Basement Membrane, Cerebrospinal fluid, Ependyma, Animals, Microscopy, Phase-Contrast, Secretion, Cilia, Bichir, Inosine Nucleotides, Electron microscopic, Adenosine Triphosphatases, Cell Nucleus, Neurons, Histocytochemistry, Fishes, Apocrine, Anatomy, biology.organism_classification, Adenosine Monophosphate, Phosphoric Monoester Hydrolases, Microscopy, Electron, Hypothalamus, Pituitary Gland, Animal Science and Zoology, Collagen, Developmental Biology
Abstract

Electron microscopic studies of the neurohypophysis and saccus vasculosus of the bichir (Polypterus ornatipinnis) reveal an apocrine release of secretory material by ependymal cells (e.g., crown cells). The secretory material appears to migrate along the microtubular apparatus and the ciliary filaments to the cell buds. It is postulated that the formation of the buds and their release is mediated by cilial action. Secretion buds are noted in the cerebrospinal fluid and vascular sinusoids. Bulbous projections of neurohypophyseal secretory tracts extend into the ependymal lumen which also contains elementary secretion granules. Specialized “liquorkontaktneurone” are interspersed with ependymal cells. An interrelation between the hypothalamus, neurohypophysis, saccus vasculosus, and the meta-adenohypophysis is postulated.

Published
1972
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13. Subject Index, Vol. 44, 1983

Author

Marc H. Lavietes, Michael D. Nyby, G. Milanti, Harold J. Sobel, L. Benedetti, Joseph B. Rosenfeld, N. Galanis, Marvin A. Sackner, G.J. Albrecht, Michael R. Littner, M. Kakoura, M. Lusuardi, Bernard Michlin, Gilbert Jenouri, A.S. Rebuck, Murray D Altose, Dan B. Teculescu, K. Kastritsi, O. Capelli, G. Velluti, Musa A. Haxhiu, B. Rasche, D. Patakas, Daniel Silverstein, M. Rabinovitz, S. Lustig, M. Pellegrino, K.R. Chapman, K. Hochstrasser, Steven G. Kelsen, R. Peslin, Keith Jasberg, W. T. Ulmer, J.V. Cereceda, Alberto Braghiroli, Abraham Bohadana, Silvio Pitlik, Martin J. Tobin, M. Greenwald, S. Sundberg, George Louridas, and Neil S. Cherniack

Subjects
Pulmonary and Respiratory Medicine, Index (economics), business.industry, Statistics, Medicine, Subject (documents), business
Published
1983
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14. Rapid Development of Metastases from Basal Cell Carcinoma Presenting as Cranial Nerve Palsies

Author

Mirysed A. Mohit-Tabatabai, Robert A. Ambros, Alaim Haim, Steven B. Standiford, and Harold J. Sobel

Subjects
Adult, Male, Pathology, medicine.medical_specialty, business.industry, Bone Neoplasms, Dermatology, medicine.disease, Primary lesion, Metastatic basal cell carcinoma, Metastasis, Oncology, Carcinoma, Basal Cell, Paralysis, Carcinoma, Humans, Orbital Neoplasms, Medicine, Cranial Nerve Neoplasms, Basal cell carcinoma, medicine.symptom, business
Abstract

A case is reported of metastatic basal cell carcinoma presenting with multiple neurologic deficits 20 months after excision of the primary lesion with good local control. Many features associated with the development of metastasis from basal cell carcinoma were not present in this case.

Published
1988
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15. Mycobacterium xenopi Infection in a Patient with Acquired Immunodeficiency Syndrome

Author

Robert H. K. Eng, Harold J. Sobel, Sharon M. Smith, and Catherine Forrester

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Acquired Immunodeficiency Syndrome, Mycobacterium Infections, biology, business.industry, medicine.drug_class, Antibiotics, Critical Care and Intensive Care Medicine, biology.organism_classification, medicine.disease, Virology, Acquired immunodeficiency syndrome (AIDS), Immunopathology, parasitic diseases, Immunology, medicine, Humans, Mycobacterium xenopi, Cardiology and Cardiovascular Medicine, business, Organism, Mycobacterium
Abstract

A case of Mycobacterium xenopi infection in a patient with acquired immunodeficiency syndrome (AIDS) is described and the clinical experience of others in the United States with this organism is reviewed. Disseminated infection by this organism appears to occur only in the immunocompromised host. Because M xenopi has been found in hot water systems by others and is an organism more susceptible to the traditional antituberculosis antibiotics, recognition and distinction of this organism from the more resistant and difficult to treat Mycobacterium avium-intracellulare in the patients with AIDS may be important.

Published
1984
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16. The Quarterly Case:Undifferentiated Malignant Tumor with Clear Cells

Author

Eugene Marquet, Laurence I Alpert, and Harold J. Sobel

Subjects
Pathology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Nodule (medicine), Physical examination, Bone scans, Pathology and Forensic Medicine, Lesion, medicine.anatomical_structure, Structural Biology, Lung disease, Nodular lesions, medicine, Forehead, Abdomen, medicine.symptom, business
Abstract

Case HistoryA 53-year-old man with chronic lung disease presented with fever. Physical examination revealed a nodular lesion of the forehead, said to have developed over 2 months It was ulcerated, measured 2 cm in diameter, and extended to but did not involve the cranial bone. Liver and bone scans showed multiple metastases. CA T scan of abdomen revealed retroperitoneal adenopath y. Another primary site was not found. The forehead lesion and a liver nodule were biopsied.

Published
1982
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17. Solid Glycogen-rich Clear Cell Carcinoma of the Breast (A Light and Ultrastructural Study)

Author

Barry Benisch, Richard Newman, Eugene Marquet, Harold J. Sobel, and Bernard Peison

Subjects
Pathology, medicine.medical_specialty, Lobular carcinoma, Estrogen receptor, Breast Neoplasms, Adenocarcinoma, medicine, Carcinoma, Humans, skin and connective tissue diseases, Aged, business.industry, General Medicine, medicine.disease, Microscopy, Electron, Axilla, medicine.anatomical_structure, Receptors, Estrogen, Clear cell carcinoma, Ultrastructure, Female, Receptors, Progesterone, business, Glycogen, Clear cell
Abstract

A solid glycogen-rich clear cell carcinoma of the breast is described. Its distinction from other breast tumors with a clear cell component is discussed. The previously reported example of glycogen-rich clear cell carcinoma of the breast and our case both were positive for estrogen receptors, and neither showed axillary nodal involvement or distant spread. It is suggested that glycogen-rich carcinoma may behave in a less aggressive fashion than either infiltrating ductal or lobular carcinoma of the breast.

Published
1983
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18. LOCALIZATION OF ACID PHOSPHATASE ACTIVITY IN RAT PANCREATIC ACINAR CELLS: A LIGHT AND ELECTRON MICROSCOPIC STUDY

Author

Harold J. Sobel and Erna Avrin

Subjects
Pancreatic acinar cells, Microscopy, Histology, Staining and Labeling, biology, Chemistry, Research, Acid Phosphatase, Acid phosphatase, Electrons, Acinar Cells, Anatomy, Molecular biology, Pancreas, Exocrine, Rats, Microscopy, Electron, medicine.anatomical_structure, biology.protein, medicine, Coloring Agents, Pancreas, Electron microscopic
Published
1965
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19. Neuroendocrine carcinomas with multiple immunoreactive peptides and melanin production

Author

Sheldon C. Somers, Loren E. Dardi, Vincent A. Memoli, Harold J. Sobel, Jan Vincents Johannessen, and Victor E. Gould

Subjects
Adult, Pathology, medicine.medical_specialty, Skin Neoplasms, Biology, Pathology and Forensic Medicine, Thyroid carcinoma, Melanin, Adrenocorticotropic Hormone, Structural Biology, medicine, Humans, Insulin, Thyroid Neoplasms, Melanosome, Aged, Melanins, Bronchial Neoplasms, Hormones, Neuroendocrine Carcinomas, medicine.anatomical_structure, Somatostatin, Calcitonin, Immunohistochemistry, Melanocytes, Female, Merkel cell
Abstract

Two primary neuroendocrine skin carcinomas, one bronchial carcinoma, and one typical medullary thyroid carcinoma have been shown by immunohistochemical and electron microscopy to contain two or more immunoreactive peptides as well as melanosomes and premelanosomes. Of the battery of antisera tested, somatostatin was the only material present in all four tumors; calcitonin and ACTH were present in three of the four neoplasms. Neurosecretory granules on the one hand and melanosomes on the other were more readily identifiable in separate cells. However, in at least 2 cases, individual cells were thought to contain both types of structures. Of the various explanations possible, we choose to interpret these tumors as complex neuroendocrine carcinomas comprising cellular populations capable of synchronous production of immunoreactive peptides and melanin. since melanocytes are members of the dispersed neuroendocrine (APUD) system, these observations may not appear entirely surprising. Note-worthy, however, is that melanin synthesis seemingly remains a synchronously available option to neoplastic neuroendocrine cell populations of possibly diverse histogenesis that are actively engaged in the production of multiple hormonal peptides. We consider that these phenomena represent yet another facet of neoplastic multidirectional differentiation. It is possible that the determination of immunoreactive peptides as "markers" may play a future role in the diagnosis, therapy, and prognosis of these and similar tumors and in the study of the dysplasias that may precede them.

Published
1981

20. Fibrous mesotheliomas (pseudofibroma) of the scrotal sac: a light and ultrastructural study

Author

Bernard Peison, Harold J. Sobel, Eugene Marquet, and Barry Benisch

Subjects
Male, Mesothelioma, Cancer Research, Pathology, medicine.medical_specialty, business.industry, Middle Aged, Oncology, Scrotal sac, Ultrastructure, Genital Neoplasms, Male, Scrotum, Medicine, Humans, business
Abstract

Fibrous mesotheliomas of the scrotal sac are described. Similar tumors have been previously reported as fibromas and pseudofibromas and have been considered to be non-neoplastic, reactive, fibrous lesions. Ultrastructural evidence for a mesothelial origin for these tumors is presented. The value of ultrastructural study in the classification of tumors arising in or on mesothelial lined surfaces is stressed.

Published
1981

21. Extracellular viruslike particles

Author

Harold J. Sobel, Eugene Marquet, and Schwarz R

Subjects
Adult, Male, Text mining, Liver, Structural Biology, business.industry, Chemistry, Extracellular, Humans, Collagen, business, Pathology and Forensic Medicine, Cell biology
Published
1983

22. Ultracytochemistry of the lung of Polypterus ornatipinnis

Author

Eugene Marquet, Ruth Schwarz, and Harold J. Sobel

Subjects
Ruthenium red, Histology, Biology, Endoplasmic Reticulum, Epithelium, Ruthenium, Inclusion bodies, Pathology and Forensic Medicine, chemistry.chemical_compound, Pulmonary surfactant, medicine, Animals, Coloring Agents, Lung, Phospholipids, Glycosaminoglycans, Cell Nucleus, Inclusion Bodies, Histocytochemistry, Fishes, Biological Transport, Epithelial Cells, Cell Biology, biology.organism_classification, Rats, Staining, Microscopy, Electron, Intercellular Junctions, medicine.anatomical_structure, Biochemistry, chemistry, Vacuoles, Cytochemistry, Ultrastructure, Pinocytosis, Polypterus
Abstract

Cytochemical similarities between the polypterine and mammalian lung are presented. The ultrastructural localization of reaction products from ruthenium red and tricomplex flocculation staining indicates that the epithelial surface is coated by saturated phospholipids and mucopolysaccharides. Utilization of various chemical markers demonstrates the epithelial cell to be physiologically active in the transport of certain substances. Evidence supporting the concept that the lamellar inclusion bodies are responsible for the surfactant lining is presented.

Published
1974
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23. Histologic subtypes of small cell carcinoma of the lung: response to therapy

Author

Stephen Davis and Harold J. Sobel

Subjects
Oncology, Adult, Male, medicine.medical_specialty, Lung Neoplasms, Cyclophosphamide, medicine.medical_treatment, Biology, Small-cell carcinoma, Internal medicine, medicine, Humans, Doxorubicin, Carcinoma, Small Cell, Lung cancer, Aged, Chemotherapy, Lung, Performance status, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, medicine.anatomical_structure, Drug Therapy, Combination, Female, medicine.drug
Abstract

Seventy-seven patients with extensive small cell carcinoma of the lung were initially treated with the same combination chemotherapy consisting of cyclophosphamide and doxorubicin. All cases were retrospectively subdivided according to their histological subtype as proposed by the World Health Organization Lung Cancer Classification (WHO): the classic lymphocyte-like (oat cell), type 21 , and intermediate cell, type 22 . Type 21 has an objective response rate of 43% and type 22 a response rate of 23% . Analysis of the data revealed that the median survival for WHO type 21 was 30.4 weeks; whereas median survival for type 22 was 17.2 weeks (P = 0.04 ). This difference in subtype response was also seen when response was corrected for Karnofsky initial performance status 40–70 but not for performance status 80–100 . Type 21 small cell carcinoma appears to offer a higher response rate to chemotherapy and a longer survival than type 22 .

Published
1981

24. Endocardial Tumors in Rats Exposed to Durable Fibrous Materials<xref ref-type='fn' rid='FN2'>2</xref>

Author

Bernard Sass, Harold J. Sobel, Harold L. Stewart, and Cornelia Hoch-Ligeti

Subjects
Cancer Research, Pathology, medicine.medical_specialty, Oncology, Chemistry, Chrysotile, medicine, Cigarette smoke, Endocardial Tumor, medicine.disease_cause, Endocardium, Asbestos, Heart septum
Abstract

Endocardial tumors in the rat found in association with intrathoracic implantation of durable fibrous materials are reported here for the first time. In Osborne-Mendel female rats, endocardial tumors occurred in 3 of 50 rats associated with the implantation of fiberglass greater than 5 micron in length and 1-3 micron in diameter, in 1 of 15 rats associated with fiberglass of 0.03 X 3 micron, and in 1 of 15 rats associated with pulverized glass fiber. The intrathoracic administrations of pulverized chrysotile, of cigarette smoke condensate and crocidolite, and of coarse cotton lint, and of intravenous injections of air particulate extract were associated with endocardial tumor in 1 of 15 rats each. The dimensions of the durable fibers associated with endocardial tumors were similar to those of carcinogenic asbestos. Endocardial tumors were not observed in concurrently studied control rats.

Published
1983
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25. Pre-elastofibroma and elastofibroma (the continuum of elastic-producing fibrous tumors). A light and ultrastructural study

Author

Bernard Peison, Harold J. Sobel, Barry Benisch, and Eugene Marquet

Subjects
Pathology, medicine.medical_specialty, Elastofibroma, biology, Chemistry, Bone Neoplasms, General Medicine, Anatomy, Fibroma, Middle Aged, medicine.disease, Elastin, body regions, Scapula, Ultrastructure, medicine, biology.protein, Humans, Female, Precancerous Conditions
Abstract

A fibroproliferative lesion arising anterior to the lower end of the scapula and containing polymorphic often fiberlike deposits of weakly elastinophilic fibrillary material is described. It is compared on the light and ultrastructural level to a typical elastofibroma. The fibrillary material seen in this tumor strongly resembles that which surrounds the strongly elastinophilic deposits in the typical elastofibroma and from which the elastin is thought to be derived. It is concluded that elastin-producing tumors form a continuum; at one end of which lies the tumor we have designated pre-elastofibroma and at the other, the typical elastofibroma.

Published
1983

26. Electron microscopic and immunohistochemical analysis of glomerular deposits in patients with bronchogenic carcinoma

Author

Stephen Davis, Pietro Rambotti, Eugene Marquet, and Harold J. Sobel

Subjects
Male, Pathology, medicine.medical_specialty, Lung Neoplasms, biology, Renal glomerulus, Glomerular deposits, Kidney Glomerulus, Antigen-Antibody Complex, Middle Aged, medicine.disease, Stain, Fibrin, Pathology and Forensic Medicine, Immune system, Carcinoma, Bronchogenic, Structural Biology, biology.protein, medicine, Immunohistochemistry, Humans, Antibody, Lung cancer, Aged
Abstract

Kidneys of 27 consecutive autopsied patients with bronchogenic carcinoma without clinical renal disease were studied by electron microscopy and immuno-histochemistry for the presence of glomerular deposits. Two patients had subepithelial electron-dense deposits compatible with immune complexes but failed to stain histochemically for immunoglobu-lin; most cases (19 of 27). including the two with complexes, demonstrated subendothelial deposition of fibrin. No tissue samples had histochemically detectable immunoglobulin. From this study it is suggested that renal immune complexes in lung cancer are rare.

Published
1980

27. Reactive granular cells in sites of trauma. A cytochemical and ultrastructural study

Author

Ruth Schwarz, Harold J. Sobel, Eugene Marquet, and Erna Avrin

Subjects
Pathology, medicine.medical_specialty, Duodenum, Acid Phosphatase, Biology, Endoplasmic Reticulum, Basement Membrane, chemistry.chemical_compound, Neoplasms, Muscle Tissue, Gastrectomy, medicine, Myocyte, Humans, Fibroblast, Histiocyte, Basement membrane, Microscopy, Glycogen, Cesarean Section, Histocytochemistry, Endoplasmic reticulum, Uterus, Acid phosphatase, Histiocytes, General Medicine, Mitochondria, Microscopy, Electron, medicine.anatomical_structure, chemistry, Ultrastructure, biology.protein, Female, Lysosomes
Abstract

Granular cells resembling the cells of true myoblastoma have been observed in various sites of previous trauma (usually surgical). They may be differentiated from myoblastoma cells in routine light microscopic sections, with simple histochemical procedures, and with electron microscopic studies. The granules are dense bodies with acid phosphatase activity (lysosomes). Most cells resemble histiocytes, but some have a prominent endoplasmic reticulum and many mitochondria. Others have basement membranes, marked surface activity, a fibrillar system with condensations resembling that in smooth muscle, glycogen and desmosomal connections. These observations suggest their derivation from multipotential cells capable of forming either fibroblasts or smooth muscle cells.

Published
1974

28. Relation of thickness of floor of mouth stage I and II cancers to regional metastasis

Author

Benjamin F. Rush, Arthur Mashberg, Mirseyed A. Mohit-Tabatabai, and Harold J. Sobel

Subjects
Adult, Male, medicine.medical_specialty, Metastasis, Lesion, medicine, Carcinoma, Humans, Mouth Floor, Aged, Neoplasm Staging, Retrospective Studies, Mouth neoplasm, Floor of mouth, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Prognosis, Squamous carcinoma, Surgery, Dissection, Lymphatic Metastasis, Carcinoma, Squamous Cell, Lymph Node Excision, Mouth Neoplasms, Radiology, medicine.symptom, business, Neck
Abstract

We have reviewed the clinical course and histologic findings in 84 patients with stage I and II squamous carcinoma of the mouth floor. We concluded that lesion thickness may offer a useful method for predicting the probability of cervical metastasis in node negative (N0) patients. Moreover, surface area of the lesion did not correlate with subsequent nodal disease, whereas thickness did. Elective node dissection appears to be strongly indicated in any patient with a N0 lesion measuring more than 1.5 mm in thickness.

Published
1986

29. Spontaneous nephroblastoma in a strain CE/J mouse. A case report

Author

Robert M. Werner, Bernard Sass, Harold J. Sobel, and Annabel G. Liebelt

Subjects
Pathology, medicine.medical_specialty, Strain (chemistry), 040301 veterinary sciences, business.industry, Mice, Inbred Strains, 04 agricultural and veterinary sciences, Cell Biology, Neoplasms, Experimental, Toxicology, 030226 pharmacology & pharmacy, Wilms Tumor, Kidney Neoplasms, Pathology and Forensic Medicine, 0403 veterinary science, 03 medical and health sciences, Mice, 0302 clinical medicine, Medicine, Animals, CE/J Mouse, Female, business, Molecular Biology
Published
1989

30. RETROPERITONEAL RUPTURE OF THE COMMON BILE DUCT

Author

Harold J. Sobel and Albert E. Kalderon

Subjects
medicine.medical_specialty, Abdominal pain, Peritonitis, Jaundice, Abdominal Injuries, Scrotum, medicine, Pathology, Retroperitoneal space, Humans, Retroperitoneal Space, Common Bile Duct, Rupture, Common bile duct, business.industry, General surgery, medicine.disease, Surgery, medicine.anatomical_structure, Abdominal trauma, Vomiting, medicine.symptom, business
Abstract

ONE HUNDRED years ago Fizeau 1 first reported traumatic rupture of the common bile duct followed by jaundice. Subsequently this clinicopathologic entity was recognized as a syndrome characterized by an initial onset of shock of short duration followed by a symptom-free interval and gradual appearance of abdominal pain, vomiting, and jaundice. Although this syndrome is fairly characteristic and can occur after abdominal trauma in this mechanized age, it is rarely considered. Most of the reported cases were not clinically recognized and the patients succumbed to the bile peritonitis. This report concerns a fatal case of ruptured common bile duct, revealing at necropsy severe retroperitoneal bile seepage extending into the scrotum without evidence of bile peritonitis. Case Report A 49-year-old white male alcoholic was admitted for the first time to the Bronx Municipal Hospital Center on Feb 6, 1963, with complaints of swollen scrotum, anorexia, weight loss, and darkening of the

Published
1965

31. Hemorrhagic rheumatoid pericarditis

Author

Harold J. Sobel and Jere B. Stern

Subjects
musculoskeletal diseases, medicine.medical_specialty, business.industry, Arthritis, Rheumatic Heart Disease, Rheumatoid pericarditis, Autopsy, medicine.disease, Arthritis, Rheumatoid, Pericarditis, Rheumatoid arthritis, Internal medicine, medicine, Cardiology, Humans, Cardiology and Cardiovascular Medicine, business, Cause of death
Abstract

A case of hemorrhagic pericarditis as a systemic manifestation of rheumatoid arthritis is described which is apparently the second reported. Pericarditis is a frequent autopsy finding in rheumatoid arthritis. It represents a rare cause of death which developed in both instances following the withdrawal of steroids.

Published
1961

32. Endokrine Organe · Endocrine Organs · Glandes endocrines

Author

Ira Ghosh, Sydney S. Lazarus, Mariapia Viola, T. P. J. Vanha-Perttula, Sally B. Fand, Jozef Mestdagh, Jack Geller, S. R. Chiochio, Giulio Muratori, Hubert J. Wolfe, Harold J. Sobel, G. F. Wassermann, Asok Ghosh, Helmut H. Wolff, Richard B. Cohen, J. H. Tramezzani, and Karoly Balogh

Subjects
Pituitary stalk, endocrine system, medicine.anatomical_structure, Anterior pituitary, Thyrotropic cell, Hypothalamus, medicine, Pars intermedia, Pars tuberalis, Anatomy, Biology, Lobe, Staining
Abstract

We have previously reported the utility of the histochemical method for the oxidative enzyme α-glycerophosphate dehydrogenase in depicting certain cells of the anterior pituitary in the rat. Extension of these studies to more than 50 human pituitary glands reveals similar selective anterior lobe enzymic staining in cells which may be thyrotrophs. In addition, cells running along pituitary stalk in the human have been demonstrated to have high complements of this enzyme. These are the cells of the pars tuberalis. Of particular interest is the clear cut finding that these positively stained cells enter into and merge with the basophils of the coronal portion of anterior lobe at their junction with the pars intermedia. They do not enter posterior lobe as does the stalk. Since these cells accompany stalk along much of its course from hypothalamus to hypophysis, it is suggested that they may serve as an anatomical link between brain, on the one hand, and the non-nervous portion of the hypophysis, on the other.

Published
1964
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33. Third International Congress of Histochemistry and Cytochemistry

Author

J. E. Kephart, Zenon Steplewski, Kokichi Kanazawa, F. Cisotti, M. P. Ehrlich, K. Holubar, D. F. Swaab, Erich Künzel, J. Thomas Danzi, Erna Avrin, L. Konopska, B. Korych, M. T. Tchaika, Donald W. Misch, Peter W. Neurath, M. M. Coombs, N. H. Bass, Gianfranco Ballare, J. D. Vigario, A. Tixier-Vidal, J. W. Anderson, Peter H. Bartels, Floyd E. Bloom, J. M. S. Prewitt, W. Gössner, V. D. Novikov, Masanori Takeda, A. S. Vecher, Gunter F. Bahr, A. Stammler, Ellen M. Rasch, R. Thalmann, Vick Williams, Lois W. Tice, N. T. Raikhlin, Torbjörn Caspersson, Gianmario Mariuzzi, M. M. Salpeter, Jacques Lipetz, Franca Porcelli, V. Preto Parvis, P. B. Gahan, Hans-Jürgen Herrmann, Karoly Balogh, F. L. Schuster, Z. Lojda, Frederick T. Zugibe, B. Hershenov, Moshe Kalina, Heinz Von Mayersbach, Gordon L. Rosene, C. C. Orton, Jan Wieckowski, M. P. King, Charles E. Hughes, A. L. Bastos, A. A. Castellani, E. E. McGarry, G. Szegly, George L. Wied, Lawrence S. Hurwitz, Jerome P. Horwitz, L. K. Sharashidze, George B. Koelle, Sin Hang Lee, G. C. Budd, Gerhard Müller, A. Björklund, Hilde E. Hirsch, Carlo Alberto Beltrami, R. Håkanson, L. D. Lukyanova, G. G. Glenner, J. Drukker, M. Z. M. Ibrahim, Doina Onicescu, Cornelia Prundeanu, N. V. Samosudova, J. A. F. Silva, S. O. Enenko, C. Pilgrim, Takaharu Matsumoto, Masa-Oki Yamada, Allen Costoff, Peter V. Moulder, F. Patocka, P. Tournier, Bo Thorell, Alberto Candiotti, Vinci Mizuhira, Carl Ritter, A. Simard, Donald R. Hodges, S. Guha, M. I. Parfanovich, D. Bootsma, Wesley J. Birge, J. Hartman, Lloyd J. Roth, Sidney Goldfischer, Blake W. Moore, R. Rigler, M. Rizzotti, M. S. Aksyutina, Lucien J. Rubinstein, William J. Dougherty, V. R. Switsur, Richard M. Torack, B. Perry, Paul J. McMillan, Hélio B. Coutinho, B. Ehinger, Leonard F. Bélanger, K. H. Jaeger, O. Macovschi, D. Zaccheo, Stefan Hovmark, Andre Gerard, Robert S. Ledley, Ferdinando Rossi, R. J. Barrnett, Herbert A. Lubs, J. E. Jirasek, Harold Koenig, M. Stroun, B. Sylvén, V. D. Arutyunov, Richard L. Tyndall, Elisabeth Von der Muehll, X. Yataganas, Brian H. Mayall, J. C. Liu, A. Pope, P. X. Callahan, Susan P. Gaffney, Ei-ichi Yokomura, E. A. Kirianova, L. Monus, Fritz Ruch, Josef V. Freisler, A. M. Terrinha, A. Heller, B. Gabara, Peter J. Stoward, David S. Alkek, G. Kiefer, Alfredo Mariano Garcia, H. H. Hess, Gottfried Werner, Alessandra Forni, Josef Vittek, G. A. Jurzina, P. E. Norgren, H. G. Goslar, Ulrich Welsch, Margaret C. Boadle, Katsumi Wakabayashi, Jean McLean, P. Grigoriadis, Jean R. Adams, C. Bode, M. M. Ogieveckaja, Joseph Rigatuso, Tadao Takeuchi, John E. Pauly, Kendall Preston, Patricia D. Wilson, A. G. E. Pearse, David M. Maeir, T. Abe, O. S. Frankfurt, Jan L. E. Ericsson, Karel Philippens, Gy. Vadasz, E. T. Angelakos, F. Hernández, Frank H. Ruddle, Sally B. Fand, Richard Heitsch, Hideo Takamatsu, M. Matsuda, L. Ya. Yablonovskaya, Wiecher H. VanHouten, Hildegard E. Enesco, I. Törö, Takanori Amakawa, T. J. Conway, M. J. Olszewska, V. E. Shungskaya, Joh. Koudstaal, R. S. Morgan, C. Vladescu, Boris Gueft, A. Urano, Viviane Maggi, Totada R. Shantha, Nicolas Zenker, Lawrence E. Scheving, A. Goldstone, E. N. Sarch, Dean E. Abrahamson, K. Felgenhauer, Thomas B. Shows, J. P. Mitchell, Jeffrey P. Chang, A. A. Masko, Ovidio Duarte-Escalante, L. Roizin, Klaus Wächtler, Lenore Wagner, C. P. Leblond, M. L. Mendelsohn, L. Luksys, K. C. Tsou, Erik Zeuthen, M. Kazama, Helen P. Sorokin, K. A. Gornak, Jácia T. Rocha, T. H. Schiebler, C. W. Goodwin, L. M. Franks, K. Wolff, Sun K. Song, Bun-Ichi Tamaoki, D. A. Sakharov, W. King Engel, Shinichi Imura, Rachele Alberti, J. Ken McDonald, V. Áubrechtova, Patricia A. Kinnison, Yoshihiro Hamashima, Z. A. Cohn, Stanley Scher, C. E. Grossi, J. Jos, Arline D. Deitch, N. V. Donskikh, J.-E. Edström, E. Bajusz, M. F. Kramer, Seth W. Gilkerson, H. Benoit, M. A. Van Dilla, G. Freytag, G. Aureli, E. J. Dupraw, H. R. Tyagi, A. Jarrett, A. I. Bukhonova, C. A. Squier, B. Daneholt, Sunao Iwata, K. Yokoyama, Giovanni Lanza, Margaret S. Misch, F. Gregoire, M. Kage, Ryuei Maeda, Eleanor Rita Lappano-Colletta, L. A. Kamentsky, S-U. Kim, U. M. Gross, Halina Sierakowska, M. Dauwalder, Patricia L. Haley, Shunta Hirose, Dorothy J. Moore, E. B. Masurovsky, Firoze B. Jungalwala, Walter E. Stumpf, Howard I. Siegel, M. Chyle, C. Balduini, A. L. Shnaper, Kei-Ichi Hirai, R. E. Smith, M. Serban, J. R. Coulter, A.-M. Bullens, Voldemar Vilter, Ph. J. Hoedemaeker, N. I. Tsirelnikov, Ines Mandl, K. I. Predkel, Dwo Lynm, Shigeru Morikawa, L. V. Danilova, Masasuke Akamatsu, J. Bolubasz, J. C. Beck, Amour F. Liber, Hans-Georg Schiemer, Peter F. Schatzki, J. D. Elema, J. Bernsohn, N. A. Probatova, Barbara Penar, Masando Hayashi, Tibor Barka, G. Gahrton, Annunzia Fraschini, U. Filotto, Paul F. Doolin, G. Fabris, Sergei P. Sorokin, Mildred Y. Chang, H. Dariush Fahimi, Mitsuo Sasaki, Nina D. Gracheva, Tinrat Stitnimankarn, T. Adesanya Ige Grillo, Gösta Jonsson, Regina Leske, A. Huszczuk, Sophia Kakari, W. Straus, J. Martinez De Morentin, M. F. Sheff, Frank Wohlrab, Timothy C. Appleton, T. Gilbert Scott, Eric A. Barnard, N. S. Sturua, Maria Popescu, Junichi Totsu, Takuma Saito, Lew Cunningham, Benito Monis, Ch. Owman, L. Ya. Lomakina, Alvin M. Burt, Z. Lodin, Satimaru Seno, K. P. M. Heirwegh, Giuseppe Gerzeli, Elliott F. Osserman, K. Nakashio, E. Brodie, W. Sandritter, M. H. Himes, John Pryse-Davis, R. S. Santti, Benjamin F. Trump, Nencioni T, B. Falck, Shinsuke Kanamura, Benjamin F. Jales, Attila Tanyolac, Konrad Akert, Eugene H. Blackstone, Donald B. Fisher, Theodore Peters, Zay B. Curtis, C. Mittermayer, B. Sporrong, Kazuko Uchida, Mortimer L. Mendelsohn, Daniel S. Friend, Yasuo Kishino, William D. Selles, A. V. Sakharova, Hazel Cheng, R. Daoust, Vernon J. Perez, W. Gepts, Stanley Ellis, Philip Ohringer, S. A. Burnasheva, J. E. Scott, A. Ingrami, M. J. Hardonk, Yvonne Hosannah, Carlton E. Blackwood, Jerome P. Miksche, Ludmila Fotin, S. Matsukawa, Otfried Müller, A. M. Baptista, V. Genta, P. F. Mullaney, Antti U. Arstila, G. Mori, H. Goebell, M. Ya. Subbotin, H. Kim, Niel Wald, E. Pascoe, Harold J. Sobel, Hideo Shindo, Merton Sandler, Richard Cornell, A. Riva, Sten W. Jakobsson, R. G. J. Willighagen, P. Sadauskas, V. J. Desmet, Roy O. Weller, Bjarne Pearson, L. Kalevi Korhonen, J. P. Waterhouse, Bernard Droz, Frank S. LaBella, H. Galjaard, C. L. Rosales, Andrzej Vorbrodt, Gerard M. Lehrer, Barry W. Wilson, Maria Gabriella, Stanley G. Sawicki, P. Leth Jørgensen, Nobuo Ohuchi, M. Bradshaw, Ju. J. Tendetnik, S. Virág, Norman G. Anderson, C. Burdick, Alex B. Novikoff, Christopher ’Seinde Adeoye, M. Zamfirescu-Gheorghiu, A. Gropp, K. D. Rokhlenko, H. Ooms, Eli Shuter, J. S. Hugon, V. V. Terskikh, C. Bona, Anne B. Johnson, J. M. Nunes, D. M. Conning, Nobutaka Itoh, S. R. Pelc, Z. Chirulescu, Walter C. Schneider, H. Kobayashi, Sohan L. Manocha, John R. Esterly, Marilyn G. Farquhar, O. E. Rjadneva, J. Lindner, N. G. Stepanova, N. N. Shiukashvili, Russell Ranshaw, A. Schauer, Väinö K. Hopsu-Havu, A. W. Carbonell, George B. Jerzy Glass, F. M. Matschinsky, Moshe Wolman, Edgar E. Smith, P. Satir, Claudia Joandrea-Casian, J. Tappeiner, Hans E. Kaiser, Fran Morriss, K. Grasedyck, J. F. Jongkind, Murray B. Bornstein, Winifred W. Doane, K. D. Eristawi, Giovanni Prenna, L. Matturri, Alexander M. Rutenburg, J. R. Garrett, J. Svejda, Muneaki Abe, B. Lederer, Waine C. Johnson, F. W. D. Rost, J. M. Hewitt, K. P. Ganina, Judith M. S. Prewitt, M. B. Kalamkarova, Robert M. Rosenbaum, Sheldon C. Sommers, Alfred C. Standen, W. G. Whaley, A. V. Zelenin, Paul K. Nakane, N. R. Ringertz, Robert Lev, L. L. Fadeeva, J. De Groote, Jacob S. Hanker, N. N. Sokolov, Jürgen Schlüns, V. I. Malyuk, William Bennett, Italo Nenci, E. O. Riecken, Milan R. Henzl, J. P. Fouquet, Vincent Spitaleri, Frank H. Moyer, T. John Leppi, P. Anker, Chandicharan Deb, Tomichi Masuya, L. Bolund, H. G. Godlewski, A. M. Souza Toledo, Jacques de Graef, Robert Katzman, David Glick, Eli Robins, Horst Zimmermann, Premysl Fric, P. J. Melnick, R. Nayak, S. Stroman, C. W. M. Adams, Charles A. Ashley, Teresa I. Mercado, Margaret E. Long, L. Glismann, D. J. Marshall, C. Velican, Gy. Rappay, Falls B. Hershey, M. Bergeron, A. S. Petrova, Ian T. Young, V. N. Reshetnikov, M. van der Ploeg, I. Diculescu, M. G. Manfredi Romanini, Godfrey C. Hoskins, Henri G. Vetter, Maurice Sandler, Takayuki Harada, E. Bacsy, Robert C. Allen, A. J. Hale, O. I. Epifanova, Geoffrey H. Bourne, Hisao Yamaguchi, Antti Penttilä, P. van Duijn, K. D. Barron, Michio Yamamoto, Georg W. Kreutzberg, D. S. Van Fleet, Akira Mizutani, William H. Fishman, Irmin Sternlieb, Thomas H. Roderick, M. R. Murray, G. Johannes, Theodore A. Wilcox, L. Silverman, J. W. Fischbein, A. H. Koeppen, N. O. Jacobsen, B. M. Pollock, E. S. Ruchadse, W. B. Quay, Victor Dubowitz, Janusz Komender, S. I. Zacks, Paul J. Anderson, Annette Herscovics, H. B. Tewari, J. Filkuka, O. K. Langley, W. H. McShan, E. Birch, Philip Pizzolato, Francesco Della Corte, U. A. Gabunia, Eric Holtzman, Yoshihisa Morizono, Nobuo Ihara, L. Vollrath, L. Guerra, Ezio Giacobini, Jose J. Bubis, S. Curri, M. Borgers, C. Vendrely, A. Lageron, A. Weinstock, Morris J. Karnovsky, Arnold Vogt, V. Dabkevcius, P. N. Dean, B. B. Fuchs, McCormick Templeton, M. A. Presnov, E. Thomas, L. P. Lipchina, D. C. Livingston, D. Killander, Maffo Vialli, Doina Velican, M. Guigon, Dante Marques, Paul L. Wolf, L. C. Junqueira, Bette Seamond, Frederick H. Kasten, J. Srajer, Günter Steinbach, H. H. Benitez, J. F. Lhotka, J. Merzel, Arnold M. Seligman, M. P. Viola-Magni, C. L. Rutherford, E. Szabo, R. D. Lillie, N. J. Nadler, Walter Chavin, Masao Yamamura, A. Lauria, Regina O’Brien, F. L. Leites, N. Marcus, Janice Vazquez, Gabriel C. Godman, C. Poort, R. Barer, Friedrich A. O. Eckner, Daniel Roth, Ludwig Sternberger, Ikuo Suesada, and O. N. Berezina

Subjects
0303 health sciences, Pathology, medicine.medical_specialty, biology, 030302 biochemistry & molecular biology, Acridine orange, Acid phosphatase, Chronic gastritis, Intestinal metaplasia, medicine.disease, Small intestine, 03 medical and health sciences, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, International congress, medicine, Cytochemistry, biology.protein, Immunohistochemistry, 030304 developmental biology
Abstract

The tissue distribution of enzymatic activities in intestinal metaplasia stomachs exhibiting chronic gastritis was compared histochemically with that of the small intestine in man.

Published
1968
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34. Plant cells resembling tumor cells in routine cytology

Author

Harold J. Sobel, Eucene Marquet, Erna Avrin, and Ruth Schwarz

Subjects
Vaginal Smears, Pathology, medicine.medical_specialty, Staining and Labeling, Genital Neoplasms, Female, Cells, Guar, Tumor cells, General Medicine, Biology, Plants, Plant cell, Cell wall, Cellular material, Cytology, Lubrication, medicine, Humans, Female, Diagnostic Errors, Drug Labeling
Abstract

Cells with large, dark, clumped nucleus-like bodies are occasionally observed in routine vaginal cytologic preparations. They resemble tumor cells, but often on closer scrutiny are found to have thick cell walls like those of plant cells, and are identical to structures found in gum guar and lubricating jelly which contains gum guar. The composition of every product should be marked clearly on the container. Lubricating jellies which contain cellular material should not be used for cytologic preparations.

Published
1972

35. Third International Congress of Histochemistry and Cytochemistry

Author

P. Tournier, Bo Thorell, F. Cisotti, Nicolas Zenker, M. P. Ehrlich, K. Holubar, Jose J. Bubis, J. Fischbein, Shinichi Imura, S. Curri, Susan P. Gaffney, Ellen M. Rasch, Totada R. Shantha, Lawrence E. Scheving, Hirose Shunta, G. Freytag, U. M. Gross, M. Borgers, G. Fabris, D. A. Sakharov, G. C. Budd, M. F. Kramer, C. Vendrely, A. Lageron, V. K. Hopsu-Havu, A. Weinstock, D. F. Swaab, Arnold Vogt, J. A. F. Silva, J. F. Jongkind, Murray B. Bornstein, B. Lederer, Zay B. Curtis, B. Sporrong, S. O. Enenko, Kazuko Uchida, P. N. Dean, F. W. D. Rost, B. B. Fuchs, M. Kage, M. B. Kalamkarova, Erna Avrin, William Bennett, M. J. Hardonk, K. H. Jaeger, McCormick Templeton, Z. Lojda, M. Chyle, C. A. Squier, M. T. Tchaika, Paul K. Nakane, Firoze B. Jungalwala, O. N. Berezina, Italo Nenci, E. O. Riecken, J. E. Kephart, Zenon Steplewski, Halina Slerakowska, M. M. Coombs, Joandrea-Casian Claudia, L. L. Fadeeva, J. De Groote, Sergei P. Sorokin, M. A. Presnov, Fritz Ruch, Milan R. Henzl, Ellis Stanley, Lloyd J. Roth, Masasuke Akamatsu, Eleanor Rita Lappano-Colletta, J. P. Fouquet, N. I. Tsirelnikov, K. I. Predkel, Dwo Lynm, L. Konopska, R. Rigler, A. Tixier-Vidal, U. Filotto, Paul F. Doolin, G. Gahrton, Junichi Totsu, M. Wolman, L. V. Danilova, Vincent Spitaleri, Takuma Saito, T. Adesanya Ige Grillo, W. Gössner, Katsumi Wakabayashi, J. J. Bubis, E. Thomas, W. Straus, J. Martinez De Morentin, Shinsuke Kanamura, Harold Koenig, P. X. Callahan, A. S. Vecher, Tinrat Stitnimankarn, Eugene H. Blackstone, E. N. Sarch, Dean E. Abrahamson, Thomas B. Shows, J. P. Mitchell, Droz Bernard, Takanori Amakawa, F. Hernández, Frank H. Moyer, Hazel Cheng, R. Daoust, Forni Alessandra, Josef Vittek, F. L. Schuster, Paul L. Wolf, L. C. Junqueira, Bette Seamond, Alex B. Novikoff, Tadao Takeuchi, J. Tappeiner, Abe Muneaki, E. Pascoe, A. M. Rutenburg, Harold J. Sobel, Jean R. Adams, P. Grigoriadis, Patricia D. Wilson, A. G. E. Pearse, A. Pope, Hideo Shindo, Frederick H. Kasten, Heinz Von Mayersbach, Gordon L. Rosene, L. D. Lukyanova, G. G. Glenner, N. H. Bass, K. Nakashio, Gianfranco Ballare, R. Thalmann, George B. Koelle, Jeffre Y. P. Chang, Frank H. Ruddle, John Pryse-Davis, Jerome P. Miksche, R. S. Santti, M. Ya. Subbotin, J. Srajer, Günter Steinbach, Chandicharan Deb, Tomichi Masuya, R. G. J. Willighagen, L. Bolund, H. G. Godlewski, Gerzeli Giuseppe, A. Gropp, Sin Hang Lee, Seth W. Gilkerson, M. A. Van Dilla, C. Burdick, J. D. Vigario, Hilde E. Hirsch, Stanley Ellis, Carlo Alberto Beltrami, Philip Ohringer, Erik Zeuthen, G. Szegly, M. Kazama, Helen P. Sorokin, J. W. Anderson, R. Håkanson, Merton Sandler, O. S. Frankfurt, H. H. Benitez, C. Pilgrim, J. Lindner, Väinö K. Hopsu-Havu, Peter H. Bartels, J. P. Waterhouse, Bernard Droz, Floyd E. Bloom, Masa-Oki Yamada, B. Perry, Paul J. McMillan, Allen Costoff, A. A. Masko, Takaharu Matsumoto, H. Benoit, G. M. Mariuzzi, F. Patocka, Joh. Koudstaal, McDonald J. Ken, J. Ken McDonald, J. M. S. Prewitt, H. R. Tyagi, Hélio B. Coutinho, Rachele Alberti, M. Stroun, E. B. Masurovsky, Jacques Lipetz, V. D. Novikov, G. Gries, Wiecher H. Van Houten, Balogh Kåroly, Patricia L. Haley, O. Macovschi, S-U. Kim, C. Vladescu, I. Törö, V. E. Shungskaya, Wesley J. Birge, Ines Mandl, C. P. Leblond, Wald Niel, Shigeru Morikawa, Dariush H. Fahimi, Anne B. Johnson, J. E. Jirasek, T. H. Schiebler, H. Kobayashi, C. L. Rosales, A. Jarrett, K. Wolff, Nina D. Gracheva, Gösta Jonsson, Hans-Georg Schiemer, Torbjörn Caspersson, K. P. M. Heirwegh, D. Zaccheo, M. M. Salpeter, L. Monus, E. T. Angelakos, Marilyn G. Farquhar, Gy. Vadasz, Franca Porcelli, K. Yokoyama, M. J. Olszewska, H. Koenig, A. L. Shnaper, A. M. Terrinha, L. P. Lipchina, Ryuei Maeda, Ulrich Welsch, Peter J. Stoward, David S. Alkek, Kalevi L. Korhonen, Jan Wieckowski, Mitsuo Sasaki, M. L. Mendelsohn, Maggi Viviane, L. Luksys, Satimaru Seno, A. M. Souza Toledo, Herbert A. Lubs, Josef V. Freisler, Sophia Kakari, C. Mittermayer, N. A. Probatova, Elisabeth Von der Muehll, David M. Maeir, Jan L. E. Ericsson, Karel Philippens, D. C. Livingston, M. Kalina, J. Drukker, L. Ya. Lomakina, Alvin M. Burt, Z. Lodin, J. C. Liu, G. Kiefer, H. G. Goslar, V. Áubrechtova, Patricia A. Kinnison, A. Heller, E. Brodie, Eli Robins, K. C. Tsou, Z. A. Cohn, Stanley Scher, E. Bajusz, Attila Tanyolac, Theodore Peters, Cornell Richard, D. Killander, John E. Pauly, Vernon J. Perez, Maffo Vialli, J. Hartman, K. D. Rokhlenko, H. Ooms, M. Serban, Voldemar Vilter, Margaret C. Boadle, Jean McLean, M. M. Ogieveckaja, C. W. Goodwin, W. Sandritter, M. H. Himes, William D. Selles, A. V. Sakharova, A. Ingrami, A.-M. Bullens, Roy O. Weller, B. Hershenov, Lenore Wagner, Doina Velican, P. B. Gahan, Brian H. Mayall, G. A. Jurzina, Blake W. Moore, P. E. Norgren, Hildegard E. Enesco, Ju. J. Tendetnik, S. Virág, Norman G. Anderson, Carlton E. Blackwood, Annunzia Fraschini, Boris Gueft, A. Goldstone, Mildred Y. Chang, Nobutaka Itoh, Ch. Owman, Della Corte Francesco, Sally B. Fand, M. Guigon, Daniel S. Friend, Howard I. Siegel, T. Gilbert Scott, B. Ehinger, Donald B. Fisher, K. Felgenhauer, J. S. Hugon, Mortimer L. Mendelsohn, Benito Monis, C. Bode, Richard M. Torack, A. Riva, Elliott F. Osserman, A. A. Castellani, A. Simard, Donald R. Hodges, Dante Marques, Leonard F. Bélanger, A. Urano, B. Thorell, Giacobini Ezio, S. A. Burnasheva, A. Schauer, B. Korych, V. V. Terskikh, Klaus Wächtler, S. Guha, M. I. Parfanovich, D. Bootsma, H. Kim, Richard L. Tyndall, N. G. Stepanova, N. N. Shiukashvili, M. Rizzotti, X. Yataganas, J. M. Nunes, M. F. Sheff, Waine C. Johnson, J. E. Scott, Sun K. Song, O‘brien Regina, G. E. Mazza, J. M. Hewitt, Robert M. Rosenbaum, Andre Gerard, Robert S. Ledley, Ferdinando Rossi, Frank S. LaBella, Christopher ’Seinde Adeoye, B. Sylvén, V. D. Arutyunov, Moshe Kalina, Sheldon C. Sommers, P. Sadauskas, Kishino Yasuo, M. Dauwalder, Alfredo Mariano Garcia, H. H. Hess, V. J. Desmet, H. Galjaard, O. E. Rjadneva, Benjamin F. Jales, Ei-ichi Yokomura, L. Roizin, Erich Künzel, J. Thomas Danzi, Peter V. Moulder, Konrad Akert, Moshe Wolman, M. Zamfirescu-Gheorghiu, J. Bolubasz, J. C. Beck, Amour F. Liber, B. Daneholt, Donald W. Misch, Peter W. Neurath, Masanori Takeda, Arline D. Deitch, C. Bona, Alberto Candiotti, Yvonne Hosannah, Sunao Iwata, Giovanni Lanza, Winifred W. Doane, K. D. Eristawi, Giovanni Prenna, P. F. Mullaney, Vinci Mizuhira, Sohan L. Manocha, John R. Esterly, L. Matturri, J. R. Garrett, Sidney Goldfischer, A. Stammler, Antti U. Arstila, George B. Jerzy Glass, A. W. Carbonell, Stefan Hovmark, F. M. Matschinsky, Hans E. Kaiser, K. P. Ganina, L. K. Sharashidze, Judith M. S. Prewitt, Barbara Penar, Edgar E. Smith, A. L. Bastos, Dorothy J. Moore, Gerhard Müller, A. Björklund, E. A. Kirianova, Jürgen Schlüns, Eric A. Barnard, N. S. Sturua, Maria Popescu, Bjarne Pearson, Kokichi Kanazawa, N. N. Sokolov, V. Parvis Preto, G. Mori, Regina Leske, Glick David, V. I. Malyuk, R. J. Barrnett, M. Bradshaw, W. Gepts, Lois W. Tice, N. T. Raikhlin, L. M. Franks, P. Anker, Gerard M. Lehrer, Barry W. Wilson, H. Goebell, Hideo Takamatsu, Jacques de Graef, Frederick T. Zugibe, C. E. Grossi, J. Jos, S. R. Pelc, Z. Chirulescu, E. E. McGarry, George L. Wied, A. I. Bukhonova, Walter C. Schneider, Margaret S. Misch, Lawrence S. Hurwitz, M. Z. M. Ibrahim, Doina Onicescu, N. V. Samosudova, Penttilä Antti, Shuter Eli, Premysl Fric, Sten W. Jakobsson, Frank Wohlrab, M. Matsuda, L. Ya. Yablonovskaya, T. Abe, C. Balduini, R. Nayak, S. Stroman, Masando Hayashi, Tibor Barka, A. Huszczuk, C. W. M. Adams, Margaret E. Long, L. Glismann, K. A. Gornak, Jácia T. Rocha, D. J. Marshall, Nobuo Ohuchi, A. S. Petrova, Yoshihiro Hamashima, Henri G. Vetter, J.-E. Edström, Peter F. Schatzki, E. Bacsy, D. S. Van Fleet, William H. Fishman, J. D. Elema, Annette Herscovics, J. Bernsohn, Williams Vick, L. A. Kamentsky, H. B. Tewari, Walter E. Stumpf, Kei-Ichi Hirai, R. E. Smith, Timothy C. Appleton, Benjamin F. Trump, P. Satir, Nencioni T, B. Falck, Fran Morriss, K. Grasedyck, J. Svejda, Alfred C. Standen, W. G. Whaley, A. V. Zelenin, N. R. Ringertz, Hisao Yamaguchi, Jacob S. Hanker, Cornelia Prundeanu, K. D. Barron, B. Gabara, R. S. Morgan, Michio Yamamoto, G. Aureli, E. J. Dupraw, F. Gregoire, J. R. Coulter, V. N. Reshetnikov, M. van der Ploeg, Irmin Sternlieb, Robert C. Allen, A. J. Hale, O. I. Epifanova, P. van Duijn, Thomas H. Roderick, Georg W. Kreutzberg, Robert Katzman, David Glick, Horst Zimmermann, Tamaoki Bun-Ichis, A. H. Koeppen, Herrmann Hans-Jürgen, M. Bergeron, Joseph Rigatuso, Gottfried Werner, Kendall Preston, Richard Heitsch, T. J. Conway, Ovidio Duarte-Escalante, N. V. Donskikh, Ph. J. Hoedemaeker, N. O. Jacobsen, B. M. Pollock, E. S. Ruchadse, P. Leth Jørgensen, Lew Cunningham, D. M. Conning, Theodore A. Wilcox, L. Silverman, G. F. Bahr, J. W. Fischbein, Ian T. Young, Vorbrodt Andrzej, Geoffrey H. Bourne, W. B. Quay, Victor Dubowitz, Janusz Komender, S. I. Zacks, Akira Mizutani, J. Filkuka, O. K. Langley, W. H. McShan, E. Birch, M. R. Murray, Paul J. Anderson, Philip Pizzolato, Yoshihisa Morizono, U. A. Gabunia, Eric Holtzman, Nobuo Ihara, L. Vollrath, S. Matsukawa, Otfried Müller, A. M. Baptista, V. Genta, L. Guerra, Maria Gabriella, Stanley G. Sawicki, Russell Ranshaw, Robert Lev, T. John Leppi, P. J. Melnick, Morris J. Karnovsky, Charles A. Ashley, Fotin Ludmila, V. Dabkevcius, Teresa I. Mercado, C. Velican, Gy. Rappay, Falls B. Hershey, I. Diculescu, M. G. Manfredi Romanini, Godfrey C. Hoskins, Maurice Sandler, Takayuki Harada, G. Johannes, J. F. Lhotka, J. Merzel, Arnold M. Seligman, M. P. Viola-Magni, C. L. Rutherford, E. Szabo, R. D. Lillie, N. J. Nadler, Walter Chavin, Masao Yamamura, A. Lauria, F. L. Leites, N. Marcus, Janice Vazquez, Gabriel C. Godman, C. Poort, R. Barer, Friedrich A. O. Eckner, Daniel Roth, Ludwig Sternberger, Ikuo Suesada, C. C. Orton, M. P. King, Charles E. Hughes, Jerome P. Horwitz, Ritter Carl, M. S. Aksyutina, Lucien J. Rubinstein, William J. Dougherty, and V. R. Switsur

Subjects
0303 health sciences, 03 medical and health sciences, Chemistry, International congress, 030302 biochemistry & molecular biology, Cytochemistry, Anatomy, 030304 developmental biology
Published
1968
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36. Multiple and infraductal coarctations of the aorta

Author

Harold J. Sobel, Lawrence I. Zaroff, Ivan D. Baronofsky, and Isadore Kreel

Subjects
Aorta, medicine.medical_specialty, business.industry, Physiology (medical), medicine.artery, Medicine, Humans, Radiology, Cardiology and Cardiovascular Medicine, business, Aortic Coarctation, Surgery
Abstract

Reports of multiple and infraductal coarctations are appearing more frequently in the literature as interest in the treatment of cardiovascular disease grows. A case with 4 distinct coarctations is presented.

Published
1959

37. Relationship of three lysosomal enzymes to the Golgi zone and secretory activity in the rat pituitary and thyroid glands

Author

Harold J. Sobel

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Hydrolases, Thyroid, Thyroid Gland, Golgi Apparatus, Biological Transport, Golgi apparatus, Biology, Agricultural and Biological Sciences (miscellaneous), Enzymes, Rats, Rat Pituitary, symbols.namesake, Enzyme, medicine.anatomical_structure, Endocrinology, chemistry, Internal medicine, Pituitary Gland, symbols, medicine, Endocrine system, Animals, Anatomy
Published
1962

39. Letters to the case

Author

Harold J Sobel

Subjects
business.industry, Medicine, Cell Biology, business, Pathology and Forensic Medicine
Published
1986
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40. Unidentified Structures in Tumor Cells

Author

Eugene Marquet and Harold J. Sobel

Subjects
Male, Lung Neoplasms, CD30, Chemistry, Tumor cells, Adenocarcinoma, Middle Aged, Endoplasmic Reticulum, Pathology and Forensic Medicine, Microscopy, Electron, Structural Biology, Lymphatic Metastasis, Cancer research, Humans
Published
1981
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