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3. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group.

Author

Groenewold, Nynke, Bas-Hoogendam, Janna, Amod, Alyssa, Laansma, Max, Van Velzen, Laura, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea, Pan, Pedro, Salum, Giovanni, Blair, James, Blair, Karina, Hirsch, Joy, Pantazatos, Spiro, Schneier, Franklin, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher, Thomopoulos, Sophia, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P, Heeren, Alexandre, Cremers, Henk, Hofmann, David, Straube, Thomas, Doruyter, Alexander, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel, Kaczkurkin, Antonia, Larsen, Bart, Satterthwaite, Theodore, Filippi, Courtney, Gold, Andrea, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth, Sindermann, Lisa, Ball, Tali, Fonzo, Gregory, Paulus, Martin, Stein, Murray, Klumpp, Heide, Phan, K, Furmark, Tomas, Månsson, Kristoffer, Manzouri, Amirhossein, Avery, Suzanne, Blackford, Jennifer, Clauss, Jacqueline, Feola, Brandee, Harper, Jennifer, Sylvester, Chad, Lueken, Ulrike, Veltman, Dick, Winkler, Anderson, Jahanshad, Neda, Pine, Daniel, Thompson, Paul, Stein, Dan, Van der Wee, Nic, and Simmons, Alan

Subjects
Adult, Adolescent, Humans, Phobia, Social, Magnetic Resonance Imaging, Brain, Anxiety, Neuroimaging
Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, pFWE = 0.037; right: d = -0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, pFWE

Published
2023

4. Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Author

Bruin, Willem B., Zhutovsky, Paul, van Wingen, Guido A., Bas-Hoogendam, Janna Marie, Groenewold, Nynke A., Hilbert, Kevin, Winkler, Anderson M., Zugman, Andre, Agosta, Federica, Åhs, Fredrik, Andreescu, Carmen, Antonacci, Chase, Asami, Takeshi, Assaf, Michal, Barber, Jacques P., Bauer, Jochen, Bavdekar, Shreya Y., Beesdo-Baum, Katja, Benedetti, Francesco, Bernstein, Rachel, Björkstrand, Johannes, Blair, Robert J., Blair, Karina S., Blanco-Hinojo, Laura, Böhnlein, Joscha, Brambilla, Paolo, Bressan, Rodrigo A., Breuer, Fabian, Cano, Marta, Canu, Elisa, Cardinale, Elise M., Cardoner, Narcís, Cividini, Camilla, Cremers, Henk, Dannlowski, Udo, Diefenbach, Gretchen J., Domschke, Katharina, Doruyter, Alexander G. G., Dresler, Thomas, Erhardt, Angelika, Filippi, Massimo, Fonzo, Gregory A., Freitag, Gabrielle F., Furmark, Tomas, Ge, Tian, Gerber, Andrew J., Gosnell, Savannah N., Grabe, Hans J., Grotegerd, Dominik, Gur, Ruben C., Gur, Raquel E., Hamm, Alfons O., Han, Laura K. M., Harper, Jennifer C., Harrewijn, Anita, Heeren, Alexandre, Hofmann, David, Jackowski, Andrea P., Jahanshad, Neda, Jett, Laura, Kaczkurkin, Antonia N., Khosravi, Parmis, Kingsley, Ellen N., Kircher, Tilo, Kostic, Milutin, Larsen, Bart, Lee, Sang-Hyuk, Leehr, Elisabeth J., Leibenluft, Ellen, Lochner, Christine, Lui, Su, Maggioni, Eleonora, Manfro, Gisele G., Månsson, Kristoffer N. T., Marino, Claire E., Meeten, Frances, Milrod, Barbara, Jovanovic, Ana Munjiza, Mwangi, Benson, Myers, Michael J., Neufang, Susanne, Nielsen, Jared A., Ohrmann, Patricia A., Ottaviani, Cristina, Paulus, Martin P., Perino, Michael T., Phan, K. Luan, Poletti, Sara, Porta-Casteràs, Daniel, Pujol, Jesus, Reinecke, Andrea, Ringlein, Grace V., Rjabtsenkov, Pavel, Roelofs, Karin, Salas, Ramiro, Salum, Giovanni A., Satterthwaite, Theodore D., Schrammen, Elisabeth, Sindermann, Lisa, Smoller, Jordan W., Soares, Jair C., Stark, Rudolf, Stein, Frederike, Straube, Thomas, Straube, Benjamin, Strawn, Jeffrey R., Suarez-Jimenez, Benjamin, Sylvester, Chad M., Talati, Ardesheer, Thomopoulos, Sophia I., Tükel, Raşit, van Nieuwenhuizen, Helena, Werwath, Kathryn, Wittfeld, Katharina, Wright, Barry, Wu, Mon-Ju, Yang, Yunbo, Zilverstand, Anna, Zwanzger, Peter, Blackford, Jennifer U., Avery, Suzanne N., Clauss, Jacqueline A., Lueken, Ulrike, Thompson, Paul M., Pine, Daniel S., Stein, Dan J., van der Wee, Nic J. A., Veltman, Dick J., and Aghajani, Moji

Published
2024
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5. Eye-tracking measurement of attention bias to social threat among youth: A replication and extension study

Author

Meghan E. Byrne, Sara Kirschner, Anita Harrewijn, Rany Abend, Amit Lazarov, Lucrezia Liuzzi, Katharina Kircanski, Simone P. Haller, Yair Bar-Haim, and Daniel S. Pine

Subjects
Attention bias, Eye-tracking, Youth, Anxiety, Irritability, Negative affect, Mental healing, RZ400-408, Psychiatry, RC435-571
Abstract

Attentional bias to social threat cues has been linked to heightened anxiety and irritability in youth. Yet, inconsistent methodology has limited replication and led to mixed findings. The current study aims to 1) replicate and extend two previous pediatric studies demonstrating a relationship between negative affectivity and attentional bias to social threat and 2) examine the test-retest reliability of an eye-tracking paradigm among a subsample of youth. Attention allocation to negative versus non-negative emotional faces was measured using a free-viewing eye-tracking task among youth (N = 185 total, 60 % female, Mage = 13.10 years, SDage = 2.77) with three face-pair conditions: happy-angry, neutral-disgust, sad-happy. Replicating procedures of two previous studies, linear mixed-effects models compared attention bias between children with anxiety disorders and healthy controls. Bifactor analysis was used to parse shared versus unique facets of general negative affectivity (i.e., anxiety, irritability), which were then examined in relation to attention bias. Test-retest reliability of the bias-index was estimated among a subsample of youth (N = 36). No significant differences in attention allocation or bias emerged between anxiety and healthy control groups. While general negative affectivity across the sample was not associated with attention bias, there was a positive relationship for anxiety and irritability on duration of attention allocation toward negative faces. Test-retest reliability for attention bias was moderate (r = 0.50, p

Published
2024
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6. Getting closer to social interactions using electroencephalography in developmental cognitive neuroscience

Author

Yvette Grootjans, Anita Harrewijn, Laura Fornari, Tieme Janssen, Ellen R.A. de Bruijn, Nienke van Atteveldt, and Ingmar H.A. Franken

Subjects
Electroencephalography, Hyperscanning, Social interactions, Mobile EEG, Ecological validity, Real-life settings, Neurophysiology and neuropsychology, QP351-495
Abstract

The field of developmental cognitive neuroscience is advancing rapidly, with large-scale, population-wide, longitudinal studies emerging as a key means of unraveling the complexity of the developing brain and cognitive processes in children. While numerous neuroscientific techniques like functional magnetic resonance imaging (fMRI), functional near-infrared spectroscopy (fNIRS), magnetoencephalography (MEG), and transcranial magnetic stimulation (TMS) have proved advantageous in such investigations, this perspective proposes a renewed focus on electroencephalography (EEG), leveraging underexplored possibilities of EEG. In addition to its temporal precision, low costs, and ease of application, EEG distinguishes itself with its ability to capture neural activity linked to social interactions in increasingly ecologically valid settings. Specifically, EEG can be measured during social interactions in the lab, hyperscanning can be used to study brain activity in two (or more) people simultaneously, and mobile EEG can be used to measure brain activity in real-life settings. This perspective paper summarizes research in these three areas, making a persuasive argument for the renewed inclusion of EEG into the toolkit of developmental cognitive and social neuroscientists.

Published
2024
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10. Assessing the Degree of Ecological Validity of Your Study: Introducing the Multidimensional Assessment of Research in Context (MARC) Tool

Author

Naumann, Sandra, Byrne, Michelle L., de la Fuente, Alethia, Harrewijn, Anita, Nugiel, Tehila, Rosen, Maya, van Atteveldt, Nienke, and Matusz, Pawel J.

Abstract

In cognitive neurosciences, fundamental principles of mental processes and functional brain organization have been established with highly controlled tasks and testing environments. Recent technical advances allowed the investigation of these functions and their brain mechanisms in naturalistic settings. The diversity in those approaches have been recently (Matusz, P. J., Dikker, S., Huth, A. G., & Perrodin, C. (2019). Are we ready for real-world neuroscience? "Journal of Cognitive Neuroscience," 31(3), 327-338. doi:10.1162/jocn_e_01276) classified via a three-category cycle, including "controlled laboratory," "partially naturalistic laboratory," and "naturalistic real-world research." Based on this model, we developed the Multidimensional Assessment of Research in Context (MARC) tool to easily delineate the approach researchers have taken in their study. MARC provides means to describe the degree of ecological validity for each component of a study (e.g., sample, stimuli, measures, etc.), and the study's location on the cycle. The tool comprises seven questions concerning a study's characteristics. It outputs a summary of those and a compass plot, which can be used for presentations, preregistration, grant proposals, and papers. It aims to improve drawing conclusions across studies and raise awareness about the generalizability of research findings.

Published
2022
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11. Risk factors for unexpected infant death among very premature infants in France

Author

Cécile, Dubois, Pétronela, Rachieru-Sourisseau, Estelle, Darviot, Alain, De Broca, Clémence, Mougey, Adèle, Schiby, Julia, Pauls-Barsanti, Adeline, Robelin, Stéphane, Rioualen, Anne-Laure, Duigou, Mathilde, Granjon, Anne-Sophie, Trentesaux, Djamel, Sebbouh, Assia, Smail, Noella, Lode, Stéphanie, Perez-Martin, Anne-Pascale, Michard-Lenoir, Adbelihah, Tahir, Christine, Laguille, Delphine, Brouet, Camille, Le Stradic, Béatrice, Kugener, Alice, Cartallas, Patricia, Garcia-Meric, Inge, Harrewijn, Odile, Pidoux, Bénédicte, Vrignaud, Anne, Borsa-Dorion, Mickael, Afanetti, Caroline, Robin, Marie, Lebeau, Mariana, Englender, Célin, Farges, Juliette, Raghani, Maëlle, Monnier, Hugues, Patural, Audrey, Breining, Alexandre, Pupin, Gilles, Duthoit, Lucile, Barnet, Blandine, Cabaret, Yasmine, Plee, Aurélien, Galerne, Camille, Aupiais, Morgane, Dubourg, Marie, Kieffer, Blandine, Muanza, Guen, Christèle Gras Le, Bourneuf, Anne-Laure, Pabic, Estelle Le, de Visme, Sophie, Levieux, Karine, and Pladys, Patrick

Published
2024
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15. Inconsistency Between Pictures on Baby Diaper Packaging in Europe and Safe Infant Sleep Recommendations

Author

de Visme, Sophie, Korevaar, Daniel A., Gras-Le Guen, Christèle, Flamant, Alix, Bevacqua, Martina, Stanzelova, Anna, Trinh, Nhung TH., Ciobanu, Dalia-Alexandra, Carvalho, Ana Araújo, Kyriakoglou, Ifigeneia, Fuentes, Maria, Refes, Yacine, Briand-Huchet, Elisabeth, Sellier, Anne-Laure, Harrewijn, Inge, Cohen, Jérémie F., and Chalumeau, Martin

Published
2023
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16. Cortical and Subcortical Brain Alterations in Specific Phobia and Its Animal and Blood-Injection-Injury Subtypes: A Mega-Analysis From the ENIGMA Anxiety Working Group

Author

Hilbert, Kevin, primary, Boeken, Ole Jonas, additional, Langhammer, Till, additional, Groenewold, Nynke A., additional, Bas-Hoogendam, Janna Marie, additional, Aghajani, Moji, additional, Zugman, André, additional, Åhs, Fredrik, additional, Arolt, Volker, additional, Beesdo-Baum, Katja, additional, Björkstrand, Johannes, additional, Blackford, Jennifer U., additional, Blanco-Hinojo, Laura, additional, Böhnlein, Joscha, additional, Bülow, Robin, additional, Cano, Marta, additional, Cardoner, Narcis, additional, Caseras, Xavier, additional, Dannlowski, Udo, additional, Domschke, Katharina, additional, Fehm, Lydia, additional, Feola, Brandee, additional, Fredrikson, Mats, additional, Goossens, Liesbet, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gur, Raquel E., additional, Hamm, Alfons O., additional, Harrewijn, Anita, additional, Heinig, Ingmar, additional, Herrmann, Martin J., additional, Hofmann, David, additional, Jackowski, Andrea P., additional, Jansen, Andreas, additional, Kaczkurkin, Antonia N., additional, Kindt, Merel, additional, Kingsley, Ellen N., additional, Kircher, Tilo, additional, Klahn, Anna L., additional, Koelkebeck, Katja, additional, Krug, Axel, additional, Kugel, Harald, additional, Larsen, Bart, additional, Leehr, Elisabeth J., additional, Leonhardt, Lieselotte, additional, Lotze, Martin, additional, Margraf, Jürgen, additional, Michałowski, Jarosław, additional, Muehlhan, Markus, additional, Nenadić, Igor, additional, Pan, Pedro M., additional, Pauli, Paul, additional, Peñate, Wenceslao, additional, Pittig, Andre, additional, Plag, Jens, additional, Pujol, Jesus, additional, Richter, Jan, additional, Rivero, Francisco L., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schäfer, Axel, additional, Schäfer, Judith, additional, Schienle, Anne, additional, Schneider, Silvia, additional, Schrammen, Elisabeth, additional, Schruers, Koen, additional, Schulz, Stefan M., additional, Seidl, Esther, additional, Stark, Rudolf M., additional, Stein, Frederike, additional, Straube, Benjamin, additional, Straube, Thomas, additional, Ströhle, Andreas, additional, Suchan, Boris, additional, Thomopoulos, Sophia I., additional, Ventura-Bort, Carlos, additional, Visser, Renee, additional, Völzke, Henry, additional, Wabnegger, Albert, additional, Wannemüller, André, additional, Wendt, Julia, additional, Wiemer, Julian, additional, Wittchen, Hans-Ulrich, additional, Wittfeld, Katharina, additional, Wright, Barry, additional, Yang, Yunbo, additional, Zilverstand, Anna, additional, Zwanzger, Peter, additional, Veltman, Dick J., additional, Winkler, Anderson M., additional, Pine, Daniel S., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Stein, Dan J., additional, Van der Wee, Nic J.A., additional, and Lueken, Ulrike, additional

Published
2024
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17. Risk factors for unexpected infant death among very premature infants in France

Author

Bourneuf, Anne-Laure, primary, Pabic, Estelle Le, additional, de Visme, Sophie, additional, Levieux, Karine, additional, Pladys, Patrick, additional, Cécile, Dubois, additional, Pétronela, Rachieru-Sourisseau, additional, Estelle, Darviot, additional, Alain, De Broca, additional, Clémence, Mougey, additional, Adèle, Schiby, additional, Julia, Pauls-Barsanti, additional, Adeline, Robelin, additional, Stéphane, Rioualen, additional, Anne-Laure, Duigou, additional, Mathilde, Granjon, additional, Anne-Sophie, Trentesaux, additional, Djamel, Sebbouh, additional, Assia, Smail, additional, Noella, Lode, additional, Stéphanie, Perez-Martin, additional, Anne-Pascale, Michard-Lenoir, additional, Adbelihah, Tahir, additional, Christine, Laguille, additional, Delphine, Brouet, additional, Camille, Le Stradic, additional, Béatrice, Kugener, additional, Alice, Cartallas, additional, Patricia, Garcia-Meric, additional, Inge, Harrewijn, additional, Odile, Pidoux, additional, Bénédicte, Vrignaud, additional, Anne, Borsa-Dorion, additional, Mickael, Afanetti, additional, Caroline, Robin, additional, Marie, Lebeau, additional, Mariana, Englender, additional, Célin, Farges, additional, Juliette, Raghani, additional, Maëlle, Monnier, additional, Hugues, Patural, additional, Audrey, Breining, additional, Alexandre, Pupin, additional, Gilles, Duthoit, additional, Lucile, Barnet, additional, Blandine, Cabaret, additional, Yasmine, Plee, additional, Aurélien, Galerne, additional, Camille, Aupiais, additional, Morgane, Dubourg, additional, Marie, Kieffer, additional, Blandine, Muanza, additional, and Guen, Christèle Gras Le, additional

Published
2024
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18. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

Author

Anita Harrewijn, Elise M. Cardinale, Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Moji Aghajani, Kevin Hilbert, Narcis Cardoner, Daniel Porta-Casteràs, Savannah Gosnell, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, Karina S. Blair, James R. Blair, Mira Z. Hammoud, Mohammed R. Milad, Katie L. Burkhouse, K. Luan Phan, Heidi K. Schroeder, Jeffrey R. Strawn, Katja Beesdo-Baum, Neda Jahanshad, Sophia I. Thomopoulos, Randy Buckner, Jared A. Nielsen, Jordan W. Smoller, Jair C. Soares, Benson Mwangi, Mon-Ju Wu, Giovana B. Zunta-Soares, Michal Assaf, Gretchen J. Diefenbach, Paolo Brambilla, Eleonora Maggioni, David Hofmann, Thomas Straube, Carmen Andreescu, Rachel Berta, Erica Tamburo, Rebecca B. Price, Gisele G. Manfro, Federica Agosta, Elisa Canu, Camilla Cividini, Massimo Filippi, Milutin Kostić, Ana Munjiza Jovanovic, Bianca A. V. Alberton, Brenda Benson, Gabrielle F. Freitag, Courtney A. Filippi, Andrea L. Gold, Ellen Leibenluft, Grace V. Ringlein, Kathryn E. Werwath, Hannah Zwiebel, André Zugman, Hans J. Grabe, Sandra Van der Auwera, Katharina Wittfeld, Henry Völzke, Robin Bülow, Nicholas L. Balderston, Monique Ernst, Christian Grillon, Lilianne R. Mujica-Parodi, Helena van Nieuwenhuizen, Hugo D. Critchley, Elena Makovac, Matteo Mancini, Frances Meeten, Cristina Ottaviani, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Murray B. Stein, Raquel E. Gur, Ruben C. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Jennifer Harper, Michael Myers, Michael T. Perino, Chad M. Sylvester, Qiongru Yu, Ulrike Lueken, Dick J. Veltman, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee, Anderson M. Winkler, and Daniel S. Pine

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due to small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging data from children and adults (5–90 years) were processed using FreeSurfer. The main analysis included the regional and vertex-wise cortical thickness, cortical surface area, and subcortical volume as dependent variables, and GAD, age, age-squared, sex, and their interactions as independent variables. Nuisance variables included IQ, years of education, medication use, comorbidities, and global brain measures. The main analysis (1020 individuals with GAD and 2999 healthy controls) included random slopes per site and random intercepts per scanner. A secondary analysis (1112 individuals with GAD and 3282 healthy controls) included fixed slopes and random intercepts per scanner with the same variables. The main analysis showed no effect of GAD on brain structure, nor interactions involving GAD, age, or sex. The secondary analysis showed increased volume in the right ventral diencephalon in male individuals with GAD compared to male healthy controls, whereas female individuals with GAD did not differ from female healthy controls. This mega-analysis combining worldwide data showed that differences in brain structure related to GAD are small, possibly reflecting heterogeneity or those structural alterations are not a major component of its pathophysiology.

Published
2021
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19. Threat-anticipatory psychophysiological response is enhanced in youth with anxiety disorders and correlates with prefrontal cortex neuroanatomy

Author

Abend, Rany, Bajaj, Mira A., Harrewijn, Anita, Matsumoto, Chika, Michalska, Kalina J., Necka, Elizabeth, Palacios-Barrios, Esther E., Leibenluft, Ellen, Atlas, Lauren Y., and Pine, Daniel S.

Subjects
Anxiety in youth -- Research, Anxiety in teenagers -- Research, Neuroanatomy -- Research, Neurological research, Threat (Psychology) -- Research, Prefrontal cortex -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Threat anticipation engages neural circuitry that has evolved to promote defensive behaviours; perturbations in this circuitry could generate excessive threat-anticipation response, a key characteristic of pathological anxiety. Research into such mechanisms in youth faces ethical and practical limitations. Here, we use thermal stimulation to elicit pain-anticipatory psychophysiological response and map its correlates to brain structure among youth with anxiety and healthy youth. Methods: Youth with anxiety (n = 25) and healthy youth (n = 25) completed an instructed threat- anticipation task in which cues predicted nonpainful or painful thermal stimulation; we indexed psychophysiological response during the anticipation and experience of pain using skin conductance response. High-resolution brain-structure imaging data collected in another visit were available for 41 participants. Analyses tested whether the 2 groups differed in their psychophysiological cue-based pain-anticipatory and pain-experience responses. Analyses then mapped psychophysiological response magnitude to brain structure. Results: Youth with anxiety showed enhanced psychophysiological response specifically during anticipation of painful stimulation (b = 0.52, p = 0.003). Across the sample, the magnitude of psychophysiological anticipatory response correlated negatively with the thickness of the dorsolateral prefrontal cortex (pFWE < 0.05); psychophysiological response to the thermal stimulation correlated positively with the thickness of the posterior insula (pFWE < 0.05). Limitations: Limitations included the modest sample size and the cross-sectional design. Conclusion: These findings show that threat-anticipatory psychophysiological response differentiates youth with anxiety from healthy youth, and they link brain structure to psychophysiological response during pain anticipation and experience. A focus on threat anticipation in research on anxiety could delineate relevant neural circuitry., Introduction Anticipation of threat engages conserved neural circuitry that has evolved to facilitate defensive behaviours; (1-3) perturbations in this circuitry could generate excessive anticipatory response, a core element of pathological [...]

Published
2021
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24. Normalization of Fronto-Parietal Activation by Cognitive-Behavioral Therapy in Unmedicated Pediatric Patients With Anxiety Disorders

Author

Haller, Simone P., primary, Linke, Julia O., additional, Grassie, Hannah L., additional, Jones, Emily L., additional, Pagliaccio, David, additional, Harrewijn, Anita, additional, White, Lauren K., additional, Naim, Reut, additional, Abend, Rany, additional, Mallidi, Ajitha, additional, Berman, Erin, additional, Lewis, Krystal M., additional, Kircanski, Katharina, additional, Fox, Nathan A., additional, Silverman, Wendy K., additional, Kalin, Ned H., additional, Bar-Haim, Yair, additional, and Brotman, Melissa A., additional

Published
2024
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25. Threat imminence reveals links among unfolding of anticipatory physiological response, cortical-subcortical intrinsic functional connectivity, and anxiety

Author

Rany Abend, Sonia G. Ruiz, Mira A. Bajaj, Anita Harrewijn, Julia O. Linke, Lauren Y. Atlas, Anderson M. Winkler, and Daniel S. Pine

Subjects
Anxiety, Fear, Threat, Anticipation, Amygdala, Cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495
Abstract

Excessive expression of fear responses in anticipation of threat occurs in anxiety, but understanding of underlying pathophysiological mechanisms is limited. Animal research indicates that threat-anticipatory defensive responses are dynamically organized by threat imminence and rely on conserved circuitry. Insight from basic neuroscience research in animals on threat imminence could guide mechanistic research in humans mapping abnormal function in this circuitry to aberrant defensive responses in pathological anxiety.50 pediatric anxiety patients and healthy-comparisons (33 females) completed an instructed threat-anticipation task whereby cues signaled delivery of painful (threat) or non-painful (safety) thermal stimulation. Temporal changes in skin-conductance indexed anxiety effects on anticipatory responding as function of threat imminence. Multivariate network analyses of resting-state functional connectivity data from a subsample were used to identify intrinsic-function correlates of anticipatory-response dynamics, within a specific, distributed network derived from translational research on defensive responding.By considering threat imminence, analyses revealed specific anxiety effects. Importantly, pathological anxiety was associated with excessive deployment of anticipatory physiological response as threat, but not safety, outcomes became more imminent. Magnitude of increase in threat-anticipatory physiological responses corresponded with magnitude of intrinsic connectivity within a cortical-subcortical circuit. Moreover, more severe anxiety was associated with stronger associations between anticipatory physiological responding and connectivity that ventromedial prefrontal cortex showed with hippocampus and basolateral amygdala, regions implicated in animal models of anxiety.These findings link basic and clinical research, highlighting variations in intrinsic function in conserved defensive circuitry as a potential pathophysiological mechanism in anxiety.

Published
2022
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26. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

Author

Harrewijn, Anita, Cardinale, Elise M., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Aghajani, Moji, Hilbert, Kevin, Cardoner, Narcis, Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed R., Burkhouse, Katie L., Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Jahanshad, Neda, Thomopoulos, Sophia I., Buckner, Randy, Nielsen, Jared A., Smoller, Jordan W., Soares, Jair C., Mwangi, Benson, Wu, Mon-Ju, Zunta-Soares, Giovana B., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca B., Manfro, Gisele G., Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza Jovanovic, Ana, Alberton, Bianca A. V., Benson, Brenda, Freitag, Gabrielle F., Filippi, Courtney A., Gold, Andrea L., Leibenluft, Ellen, Ringlein, Grace V., Werwath, Kathryn E., Zwiebel, Hannah, Zugman, André, Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Völzke, Henry, Bülow, Robin, Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Sylvester, Chad M., Yu, Qiongru, Lueken, Ulrike, Veltman, Dick J., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Winkler, Anderson M., and Pine, Daniel S.

Published
2021
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29. Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents’ Neural Responses to Cognitive Conflict

Author

Elise M. Cardinale, Jessica Bezek, Santiago Morales, Courtney Filippi, Ashley R. Smith, Simone Haller, Emilio A. Valadez, Anita Harrewijn, Dominique Phillips, Andrea Chronis-Tuscano, Melissa A. Brotman, Nathan A. Fox, Daniel S. Pine, Ellen Leibenluft, and Katharina Kircanski

Subjects
Cognitive Neuroscience, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Biological Psychiatry
Abstract

Psychiatric symptoms are commonly comorbid in childhood. The ability to disentangle unique and shared correlates of comorbid symptoms facilitates personalized medicine. Cognitive control is implicated broadly in psychopathology, including in pediatric disorders characterized by anxiety and irritability. To disentangle cognitive control correlates of anxiety versus irritability, the current study leveraged both cross-sectional and longitudinal data from early childhood into adolescence.For this study, 89 participants were recruited from a large longitudinal research study on early-life temperament to investigate associations of developmental trajectories of anxiety and irritability symptoms (from ages 2 to 15) as well as associations of anxiety and irritability symptoms measured cross-sectionally at age 15 with neural substrates of conflict and error processing assessed at age 15 using the flanker task.Results of whole-brain multivariate linear models revealed that anxiety at age 15 was uniquely associated with decreased neural response to conflict across multiple regions implicated in attentional control and conflict adaptation. Conversely, irritability at age 15 was uniquely associated with increased neural response to conflict in regions implicated in response inhibition. Developmental trajectories of anxiety and irritability interacted in relation to neural responses to both error and conflict.Our findings suggest that neural correlates of conflict processing may relate uniquely to anxiety and irritability. Continued cross-symptom research on the neural correlates of cognitive control could stimulate advances in individualized treatment for anxiety and irritability during child and adolescent development.

Published
2023

34. Behavioral and EEG responses to social evaluation: A two-generation family study on social anxiety

Author

Anita Harrewijn, Melle J.W. van der Molen, Irene M. van Vliet, Renaud L.M. Tissier, and P. Michiel Westenberg

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429
Abstract

Social anxiety disorder is an invalidating psychiatric disorder characterized by extreme fear and avoidance of one or more social situations in which patients might experience scrutiny by others. The goal of this two-generation family study was to delineate behavioral and electrocortical endophenotypes of social anxiety disorder related to social evaluation. Nine families of patients with social anxiety disorder (their spouse and children, and siblings of these patients with spouse and children) performed a social judgment paradigm in which they believed to be evaluated by peers. For each peer, participants indicated their expectation about the evaluative outcome, after which they received social acceptance or rejection feedback. Task behavior, as well as the feedback-related EEG brain potentials (N1, FRN, P3) and theta power were tested as candidate endophenotypes based on two criteria: co-segregation with social anxiety disorder within families and heritability. Results indicated that reaction time for indicating acceptance-expectations might be a candidate behavioral endophenotype of social anxiety disorder, possibly reflecting increased uncertainty or self-focused attention and vigilance during the social judgment paradigm. N1 in response to expected rejection feedback and P3 in response to acceptance feedback might be candidate electrocortical endophenotypes of social anxiety disorder, although the heritability analyses did not remain significant after correcting for multiple tests. Increased N1 possibly reflects hypervigilance to socially threatening stimuli, and increased P3 might reflect that positive feedback is more important for, and/or less expected by, participants with social anxiety disorder. Finally, increased feedback-related negativity and theta power in response to unexpected rejection feedback compared to the other conditions co-segregated with social anxiety disorder, but these EEG measures were not heritable. The candidate endophenotypes might play a new and promising role in future research on genetic mechanisms, early detection and/or prevention of social anxiety disorder. Keywords: Endophenotype, Event-related potential, Social anxiety disorder, Social evaluation, Theta power

Published
2018
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35. 384. Cognitive Behavioral Therapy Normalizes Fronto-Parietal Activation in Unmedicated Patients With Pediatric Anxiety Disorders

Author

Haller, Simone, primary, Linke, Julia, additional, Grassie, Hannah, additional, Jones, Emily, additional, Pagliaccio, David, additional, Harrewijn, Anita, additional, White, Lauren, additional, Naim, Reut, additional, Mallidi, Ajitha, additional, Berman, Erin, additional, Lewis, Krystal, additional, Kircanski, Katharina, additional, Silverman, Wendy, additional, Kalin, Ned, additional, Bar-Haim, Yair, additional, and Brotman, Melissa A., additional

Published
2023
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38. Assessing the Degree of Ecological Validity of Your Study

Author

Sandra Naumann, Michelle L. Byrne, Alethia la Fuente, Anita Harrewijn, Tehila Nugiel, Maya Rosen, Nienke Atteveldt, Pawel J. Matusz, Clinical Developmental Psychology, IBBA, LEARN! - Educational neuroscience, learning and development, and Clinical Psychology

Subjects
Cognitive Neuroscience, Developmental and Educational Psychology, Experimental and Cognitive Psychology, Education
Abstract

In cognitive neurosciences, fundamental principles of mental processes and functional brain organization have been established with highly controlled tasks and testing environments. Recent technical advances allowed the investigation of these functions and their brain mechanisms in naturalistic settings. The diversity in those approaches have been recently (Matusz, P. J., Dikker, S., Huth, A. G., & Perrodin, C. (2019). Are we ready for real-world neuroscience? Journal of Cognitive Neuroscience, 31(3), 327–338. doi:10.1162/jocn_e_01276) classified via a three-category cycle, including controlled laboratory, partially naturalistic laboratory, and naturalistic real-world research. Based on this model, we developed the Multidimensional Assessment of Research in Context (MARC) tool to easily delineate the approach researchers have taken in their study. MARC provides means to describe the degree of ecological validity for each component of a study (e.g., sample, stimuli, measures, etc.), and the study's location on the cycle. The tool comprises seven questions concerning a study's characteristics. It outputs a summary of those and a compass plot, which can be used for presentations, preregistration, grant proposals, and papers. It aims to improve drawing conclusions across studies and raise awareness about the generalizability of research findings.

Published
2022

39. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-analysis

Author

Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., Pine, Daniel S., Bas-Hoogendam, J, Bernstein, R, Benson, B, Buss, K, Gunther, K, Pérez-Edgar, K, Salum, G, Jackowski, A, Bressan, R, Zugman, A, Degnan, K, Filippi, C, Fox, N, Henderson, H, Tang, A, Zeytinoglu, S, Harrewijn, A, Hillegers, M, White, T, van IJzendoorn, M, Schwartz, C, Felicione, J, Deyoung, K, Shackman, A, Smith, J, Tillman, R, van den Berg, Y, Cillessen, A, Roelofs, K, Tyborowska, A, Hill, S, Battaglia, M, Tettamanti, M, Dougherty, L, Jin, J, Klein, D, Leung, H, Avery, S, Blackford, J, Clauss, J, Hayden, E, Liu, P, Vandermeer, M, Goldsmith, H, Planalp, E, Nichols, T, Thompson, P, Westenberg, P, van der Wee, N, Groenewold, N, Stein, D, Winkler, A, Pine, D, Bas-Hoogendam, Janna Marie, Bernstein, Rachel A., Benson, Brenda E., Buss, Kristin A., Gunther, Kelley E., Pérez-Edgar, Koraly, Salum, Giovanni A., Jackowski, Andrea, Bressan, Rodrigo A., Zugman, André, Degnan, Kathryn A., Filippi, Courtney A., Fox, Nathan A., Henderson, Heather A., Tang, Alva, Zeytinoglu, Selin, Harrewijn, Anita, Hillegers, Manon H. J., White, Tonya, van IJzendoorn, Marinus H., Schwartz, Carl E., Felicione, Julia M., DeYoung, Kathryn A., Shackman, Alexander J., Smith, Jason F., Tillman, Rachael, van den Berg, Yvonne H. M., Cillessen, Antonius H. N., Roelofs, Karin, Tyborowska, Anna, Hill, Shirley Y., Battaglia, Marco, Tettamanti, Marco, Dougherty, Lea R., Jin, Jingwen, Klein, Daniel N., Leung, Hoi-Chung, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Hayden, Elizabeth P., Liu, Pan, Vandermeer, Matthew R. J., Goldsmith, H. Hill, Planalp, Elizabeth M., Nichols, Thomas E., Thompson, Paul M., Westenberg, P. Michiel, van der Wee, Nic J. A., Groenewold, Nynke A., Stein, Dan J., Winkler, Anderson M., and Pine, Daniel S.

Published
2022

41. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., UCL - SSH/IPSY - Psychological Sciences Research Institute, UCL - SSS/IONS/NEUR - Clinical Neuroscience, Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adulthood.

Published
2023

42. Volume of subcortical brain regions in social anxiety disorder : mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = −0.077, pFWE = 0.037; right: d = −0.104, pFWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = −0.034, pFWE = 0.045). Smaller bilateral putamen volumes (left: d = −0.141, pFWE < 0.001; right: d = −0.158, pFWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, pFWE = 0.006; right: d = 0.099, pFWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adolescence into adul

Published
2023
Full Text
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43. What tools are in your coping toolbox?

Author

Kapoğlu, Naz, Ruiz Y Kärkkäinen, Dalila, Tapio, Laura, ter Haar, Sam B., den Hertog, Marianne, Huijgen, Rowan, Harrewijn, Anita, Godor, Brian, Van der Hallen, Ruth, Kapoğlu, Naz, Ruiz Y Kärkkäinen, Dalila, Tapio, Laura, ter Haar, Sam B., den Hertog, Marianne, Huijgen, Rowan, Harrewijn, Anita, Godor, Brian, and Van der Hallen, Ruth

Abstract

When we face difficult situations, everyone has a different way of managing them. There are many things we can do to help ourselves deal with tough feelings or situations—which is also referred to as coping. Coping means finding ways to deal with tough feelings or situations. For instance, imagine getting a disappointing grade on a school project. You might feel upset and decide to talk about it with your parents, while your classmate might turn to their teacher and ask for a higher grade. Have you ever thought about why each of us responds differently to difficult situations? What exactly is coping, and what are some of the ways people cope? How do we learn to cope? Is there one best way to cope? In this article, we will tell you what scientists have discovered about coping. Matilda is excited about her upcoming field trip. Jamie promised Matilda that he would sit next to her on the school bus. As Matilda gets on the bus, she sees Jamie sitting next to someone else! Now Matilda feels sad. What can Matilda do to deal with this difficult situation? She could avoid Jamie. Or she could confront Jamie and try to get him to sit next to her. What Matilda does to manage the upsetting situation is what scientists call coping.

Published
2023

44. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, Van der Wee, Nic J A, Groenewold, Nynke A, Bas-Hoogendam, Janna Marie, Amod, Alyssa R, Laansma, Max A, Van Velzen, Laura S, Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P, Pan, Pedro M, Salum, Giovanni A, Blair, James R, Blair, Karina S, Hirsch, Joy, Pantazatos, Spiro P, Schneier, Franklin R, Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R K, Thomopoulos, Sophia I, Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C, Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P Michiel, Heeren, Alexandre, Cremers, Henk R, Hofmann, David, Straube, Thomas, Doruyter, Alexander G G, Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E, Kaczkurkin, Antonia N, Larsen, Bart, Satterthwaite, Theodore D, Filippi, Courtney A, Gold, Andrea L, Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J, Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J, Sindermann, Lisa, Ball, Tali M, Fonzo, Gregory A, Paulus, Martin P, Simmons, Alan, Stein, Murray B, Klumpp, Heide, Phan, K Luan, Furmark, Tomas, Månsson, Kristoffer N T, Manzouri, Amirhossein, Avery, Suzanne N, Blackford, Jennifer Urbano, Clauss, Jacqueline A, Feola, Brandee, Harper, Jennifer C, Sylvester, Chad M, Lueken, Ulrike, Veltman, Dick J, Winkler, Anderson M, Jahanshad, Neda, Pine, Daniel S, Thompson, Paul M, Stein, Dan J, and Van der Wee, Nic J A

Abstract

There is limited convergence in neuroimaging investigations into volumes of subcortical brain regions in social anxiety disorder (SAD). The inconsistent findings may arise from variations in methodological approaches across studies, including sample selection based on age and clinical characteristics. The ENIGMA-Anxiety Working Group initiated a global mega-analysis to determine whether differences in subcortical volumes can be detected in adults and adolescents with SAD relative to healthy controls. Volumetric data from 37 international samples with 1115 SAD patients and 2775 controls were obtained from ENIGMA-standardized protocols for image segmentation and quality assurance. Linear mixed-effects analyses were adjusted for comparisons across seven subcortical regions in each hemisphere using family-wise error (FWE)-correction. Mixed-effects d effect sizes were calculated. In the full sample, SAD patients showed smaller bilateral putamen volume than controls (left: d = -0.077, p FWE = 0.037; right: d = -0.104, p FWE = 0.001), and a significant interaction between SAD and age was found for the left putamen (r = -0.034, p FWE = 0.045). Smaller bilateral putamen volumes (left: d = -0.141, p FWE < 0.001; right: d = -0.158, p FWE < 0.001) and larger bilateral pallidum volumes (left: d = 0.129, p FWE = 0.006; right: d = 0.099, p FWE = 0.046) were detected in adult SAD patients relative to controls, but no volumetric differences were apparent in adolescent SAD patients relative to controls. Comorbid anxiety disorders and age of SAD onset were additional determinants of SAD-related volumetric differences in subcortical regions. To conclude, subtle volumetric alterations in subcortical regions in SAD were detected. Heterogeneity in age and clinical characteristics may partly explain inconsistencies in previous findings. The association between alterations in subcortical volumes and SAD illness progression deserves further investigation, especially from adol

Published
2023

45. Cognitive Behavioral Therapy Normalizes FrontoParietal Activation in Unmedicated Patients With Pediatric Anxiety Disorders

Author

Haller, S, Linke, J, Grassie, H, Jones, E, Pagliaccio, D, Harrewijn, A, White, L, Naim, R, Mallidi, A, Berman, E, Lewis, K, Kircanski, K, Silverman, W, Kalin, N, Bar-Haim, Y, Brotman, MA, Haller, S, Linke, J, Grassie, H, Jones, E, Pagliaccio, D, Harrewijn, A, White, L, Naim, R, Mallidi, A, Berman, E, Lewis, K, Kircanski, K, Silverman, W, Kalin, N, Bar-Haim, Y, and Brotman, MA

Published
2023

47. ASSESSMENT OF MASONRY ARCH BRIDGES WITH A SHALLOW OR PILE FOUNDATION

Author

Harrewijn, T., Lantinga, C., and Vergoossen, R.

Subjects
Wooden foundation piles, Residual lifetime, Masonry arch bridge, NLFEA, Foundation Reuse, Assessment, Proof-loading, PLAXIS
Abstract

This paper is about the assessment of masonry arch bridges in the Netherlands, whether or not founded on wooden foundation piles. A large part of the public road network in old city centres is still formed by masonry arch bridges crossing the canals. The general question of the local authorities is: “Can these masonry arch bridges withstand motorised traffic including busses and occasionally heavy trucks?” Nonlinear finite element analysis in PLAXIS is applied for the assessment of the failure behaviour of the masonry structure and its shallow or pile foundation. The structural limits are related to cracking, continuous deformations and instability. A proof-loading of a real bridge increased the reliability of the calculation methodology. With NLFEA it can be demonstrated that these historic bridges still meet the current loads from heavy motorised traffic. With a quick scan method based on the MEXE theory, a large group of arches can be quickly classified, so the assessment with NLFEA can start with the riskiest objects. In many cases lifetime extension of these bridges is possible, whether or not by strengthening the superstructure. This means that the shallow foundation or pile foundation is reused., Paper presentation

Published
2023
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48. Converging Multi-modal Evidence for Implicit Threat-Related Bias in Pediatric Anxiety Disorders

Author

Abend, Rany, Bajaj, Mira A., Matsumoto, Chika, Yetter, Marissa, Harrewijn, Anita, Cardinale, Elise M., Kircanski, Katharina, Lebowitz, Eli R., Silverman, Wendy K., Bar-Haim, Yair, Lazarov, Amit, Leibenluft, Ellen, Brotman, Melissa, and Pine, Daniel S.

Abstract

This report examines the relationship between pediatric anxiety disorders and implicit bias evoked by threats. To do so, the report uses two tasks that assess implicit bias to negative-valence faces, the first by eye-gaze and the second by measuring body-movement parameters. The report contrasts task performance in 51 treatment-seeking, medication-free pediatric patients with anxiety disorders and 36 healthy peers. Among these youth, 53 completed an eye-gaze task, 74 completed a body-movement task, and 40 completed both tasks. On the eye-gaze task, patients displayed longer gaze duration on negative relative to non-negative valence faces than healthy peers, F(1, 174) = 8.27, p= .005. In contrast, on the body-movement task, patients displayed a greater tendency to behaviorally avoid negative-valence faces than healthy peers, F(1, 72) = 4.68, p= .033. Finally, implicit bias measures on the two tasks were correlated, r(38) = .31, p= .049. In sum, we found an association between pediatric anxiety disorders and implicit threat bias on two tasks, one measuring eye-gaze and the other measuring whole-body movements. Converging evidence for implicit threat bias encourages future research using multiple tasks in anxiety.

Published
2024
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49. ANXIETY? STAY AWAY FROM ME!

Author

van der Hoek, Dinand, Muller, Kirsten S., de Zwart, Elize, Pittig, Andre, Harrewijn, Anita, and Wong, Alex H. K.

Subjects
ANXIETY, STUTTERING, EMOTIONS
Abstract

Have you ever felt anxious? How do you usually react when you are afraid of something? Anxiety is a normal feeling that everyone gets from time to time. Since it is an unpleasant feeling, people often try to avoid situations that make them feel that way. For example, skipping school because you have to give a presentation in front of the whole class. Some people can feel too much anxiety. Anxiety makes them nauseous, and they might start to stutter. In our work, we would like to discuss "avoidance of learned fear". In this article, we will explore anxious feelings and whether people tend to avoid things they are anxious about. [ABSTRACT FROM AUTHOR]

Published
2023
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