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Purpose of Review: To summarize the literature on neurologic care for transgender and gender-diverse (TGD) people and provide implications for clinical practice., Recent Findings: There are limited data on the frequency and management of neurologic conditions among TGD people. TGD people have a higher prevalence of various neurologic conditions compared with cisgender or general population cohorts, including migraine, subjective cognitive decline, sleep disturbances, functional disorders, and cerebrovascular disease. Gender-affirming hormone therapy interacts with commonly prescribed neurologic medications and increases stroke risk among transfeminine people. Sex hormones and sex chromosomes may play a role in neurodegeneration and disability progression in neuroimmunologic diseases. Clitoral reduction surgeries on intersex children can cause neurologic disability and sexual dysfunction in adulthood. Socioeconomic disparities among TGD people contribute to health care barriers., Summary: Neurologists should consider the unique experiences and health care needs of TGD people in their clinical practice and research protocols., Competing Interests: G. Zeigler has been reimbursed for travel-related expenses for speaking at the American College of Osteopathic Neurologists and Psychiatrists Mid-Year Meeting. She had honoraria donated for speaking at the American Academy of Neurology Annual Meeting. C.A. Harrington: No financial disclosures. N. Rosendale receives research funding from the American Academy of Neurology and NIH StrokeNet Fellowship. She receives royalties from McGraw Hill for authorship of a chapter in Current Medical Diagnosis and Treatment 2022 and 2023. She is associate editor of DEI for Continuum. C. Ganos receives research support from the VolkswagenStiftung (Freigeist AZ 94268). He also receives honoraria for educational activities from the Movement Disorder Society. V. Roldan: No financial disclosures. A. Pace received compensation from Abbvie for a one-time speaking engagement on including sexual and gender minority individuals in clinical research. S. Alick-Lindstrom: No financial disclosures. C. Orozco-Poore: No financial disclosures. W. Deeb: Fellowship educational grant for movement disorders from Medtronic. He receives royalties from Rose publishing for co-authorship of Living with Parkinson's Disease. M.L. Hansen: No financial disclosures. Z P. L'Erario has served as expert witness for plaintiff for Weiss Law, PC and receives consultancy payments regarding transgender neurologic health care from medical colleges and universities within the United States. They are on the editorial board of Neurology: Clinical Practice. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp., (© 2024 American Academy of Neurology.)