1. Intratympanic Contrast in the Evaluation of Menière Disease: Understanding the Limits
- Author
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Bykowski, J, Harris, JP, Miller, M, Du, J, and Mafee, MF
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Adult ,Contrast Media ,Female ,Gadolinium DTPA ,Humans ,Injection ,Intratympanic ,Magnetic Resonance Imaging ,Male ,Meniere Disease ,Middle Aged ,Neurosciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences ,Physical chemistry - Abstract
Background and purposeStudies describing endolymphatic hydrops in Menière disease after off-label intratympanic gadolinium-based contrast have been limited by long acquisition times. We aimed to demonstrate the feasibility of post-intratympanic imaging on a 3T MR imaging system within a clinically tolerable acquisition time and to address potential pitfalls in acquisition or interpretation.Materials and methodsFDA Investigational New Drug 115,342 and institutional review board approval were obtained for intratympanic injection of 8-fold diluted Gd-DTPA into the more symptomatic ear of 6 adults with Menière disease. 3T MR imaging was performed using a 3-inch surface coil before and up to 28 hours after injection using FLAIR to define the nonenhancing endolymphatic space within the enhancing perilymph. Variable FLAIR TI images were used to determine the impact of fluid-suppression on interpretation. Image quality was assessed for perilymphatic and extralabyrinthine contrast enhancement, definition of endolymphatic anatomy, and other anatomic variants or pathologic findings.ResultsThe surface coil afforded 0.375 × 0.375 mm in-plane FLAIR resolution in
- Published
- 2015