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5 results on '"Harrison, Margaret S."'

1. Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance

Author

Li, Wenjun, Gauthier, Jason M., Tong, Alice Y., Terada, Yuriko, Higashikubo, Ryuji, Frye, Christian C., Harrison, Margaret S., Hashimoto, Kohei, Bery, Amit I., Ritter, Jon H., Nava, Ruben G., Puri, Varun, Wong, Brian W., Lavine, Kory J., Bharat, Ankit, Krupnick, Alexander S., Gelman, Andrew E., and Kreisel, Daniel

Subjects
Immune response -- Genetic aspects, Transcription factors -- Health aspects, Lymph nodes -- Medical examination, Health care industry
Abstract

Tertiary lymphoid organs are aggregates of immune and stromal cells including high endothelial venules and lymphatic vessels that resemble secondary lymphoid organs and can be induced at nonlymphoid sites during inflammation. The function of lymphatic vessels within tertiary lymphoid organs remains poorly understood. During lung transplant tolerance, [Foxp3.sup.+] cells accumulate in tertiary lymphoid organs that are induced within the pulmonary grafts and are critical for the local downregulation of alloimmune responses. Here, we showed that tolerant lung allografts could induce and maintain tolerance of heterotopic donor-matched hearts through pathways that were dependent on the continued presence of the transplanted lung. Using lung retransplantation, we showed that [Foxp3.sup.+] cells egressed from tolerant lung allografts via lymphatics and were recruited into donor-matched heart allografts. Indeed, survival of the heart allografts was dependent on lymphatic drainage from the tolerant lung allograft to the periphery. Thus, our work indicates that cellular trafficking from tertiary lymphoid organs regulates immune responses in the periphery. We propose that these findings have important implications for a variety of disease processes that are associated with the induction of tertiary lymphoid organs., Introduction Tertiary lymphoid organs can be induced in nonlymphoid tissues during states of chronic inflammation or antigen exposure and are structurally similar to secondary lymphoid organs. One such example is [...]

Published
2020
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3. Rotavirus, an overview: from discovery to vaccine

Author

Harrison, Margaret S.

Subjects
Rotaviruses -- Care and treatment
Abstract

Rotavirus is the single most important cause of both nosocomially-acquired and severe, dehydrating diarrhea. It occurs with equal frequency throughout the world, regardless of the level of sanitation. After primary [...]

Published
1998

4. Contributors

Author

Abdulla, Ra-id, Adams, Sherri, Aks, Steven E., Alessi, Lauren J., Anton, Kristin, Arseneau, Micaela, Babiuch, Allison E., Ballan, Wassim, Banderas, Christine A., Barone, Dean, Bates, Elizabeth, Baxter, Hilary W., Black, Elizabeth, Bock, Amber M.R., Boyer, Kenneth M., Brown, Ann-Marie, Budek, Cynthia Etzler, Burda, Anthony M., Burgess, Rachael M., Buzby, Marianne, Byrne, Carly, Calhoun, Jackie, Callow, Louise, Campbell, J. Fallon, Carpenter, Aaron E., Chaisson, Ellen C., Chang, Johanna, Colville, Gillian, Conway, Edward E., Jr., Corlett, Karen, Cortez, Edmundo P., Craig, Vicki L., Dalton, Kristen L., Castillo, Sylvia del, Desimone, Rachel, Dettmer, Kristin, Dickson, Anna, Disabato, Jennifer A., Ditro, Colleen, Eichler, Valarie, Elliott, Elizabeth P., Ellis-Pelletier, Amanda D., Eschbach, Krista, Fagbuyi, Daniel B., Feiteiro, Felipe, Felauer, Ann Marie, Ferdman, Ronald M., Finkbeiner, Kelly, Forbes, Paulette E., Franken, Aimee, Fuchs, Samme, Gambetta, Kathryn, Ganesan, Rani, Gardner, Mary Katherine, Gentry, Ryan W., Gilbert, Megan E., Goldfarb, Samuel B., Goodhue, Catherine J., Goodman, Daniel J., Goreth, Michelle Borzik, Gourineni, Prasad, Goyal, Alka, Green, Angela, Guentensberger, Deborah Lynn, Harrison, Margaret S., Harvey, Helen, Haut, Cathy M., Hawkins, Harriet S., Hedge, Vanessa L., Henderson, Carrie M., Herendeen, Pamela Ann, Heydemann, Peter, Highsmith, Heather Young, Hoffer, Amy, Holleman, Judie, Hopper, Emily, Hornor, Gail, Hough, Rhonda M., Howells, Amy J., Hueckel, Rémi M., Hunter, Jay M., Irving, Sharon Y., Jacobson, Jessica L., Jacobson, Phillip, Jandeska, Sara, Jean, Ashley M., Johnson, Angela M., Johnson, Amanda, Joiner, Jennifer L., Jones, Danielle Laughlin, Jones, Carolyn, Jordan, Jeremy, Justice, Lindsey, Kalis, Vanessa M., Kamath, Sameer, Kane, Jason M., Kent, Paul M., Kesavan, Anil, Kitchen, Bonnie, Kline-Tilford, Andrea M., Koo, Jeannie, Krejci, Maggie, Kubic, Arthur, Kuipers, Jenna, Kuppy, Joanna R., Kuzin, Julia, Lam, Ray, Landman, Matthew P., Large, Belinda J.S., Larson, Austin A., Laws, Deborah Walter, Lee, Samantha, Leggett, Brett D., Lerret, Stacee M., Lesser, Daniel J., Lewis, Kevin R., Limoges, Cassie J., Linsler, Rose, Linzer, Jeffrey F., Sr., Little, Jeanne, Lovett, Marlina E., Lyons, Evelyn M., Mackenburg-Mohn, Mary, Madden, Maureen A., Mahant, Sanjay, Majmundar, Neil, Malhotra, Amisha, Mantis, Stelios, Mariano, Karley J., Marks, Jill, Markus-Rodden, Minnette, Martin, Sarah, Maslonka, Kenneth, Mathur, Mudit, Maurice, Samuel M., Mauricio, Riza V., Mavis, Alisha M., Maymi, Michael A., McAuley, James B., McCann, Sean, McConnie, Randolph M., McDonald, Steven A., McEvoy, Macallagh J., Mackie McMillan, Tracy Lynne, Lee McPeters, Steadman, Mead, John D., Mejia, Rodrigo, Meliones, Christine, Meliones, Jon, Grimason Mills, Michele, Mjaanes, Jeffrey M., Mohr, Lynn, Moore, Sara E., Morales, David L.S., Morris, Kristen A., Mouat, Laurette E., Mubayed, Lamya, Murchie, Wendy E., Nash, Colleen, Newman, Christopher D., Nicoara, Oana M., Noonan, Michal, Nute, Megan M., O’Brien, Nicole F., O’Connor, Nicole R., Oei, Grace, Olivero, Anthony, Olivero, Rosemary, Ong, Hilary, Parker, Holly S., Pasaron, Raquel, Patel, Niraj C., Paul, George W., Payne, Asha S., Peck, Jessica L., Phipps, Amy, Pierce, James, Pike, Megan, Poulakidas, Stathis, Quinones, Saribel Garcia, Rajasekhar, Hariprem, Rake, Alyssa, Rand, Thomas H., Ratz, Natalie B., Reed, Jennifer, Reid, Brenda, Reid, Priscila, Resler, Julia A., Riccioni, Mark, Rich, Christopher C., Riess, Laurel B., Rodts, Mary F., Roth, Jodie, Ruppel, Randall, Russo, Bryce, Sadecki-Lund, Corrinne, Schneider, Deanna, Schoonover, Jennifer J., Schwartz, Stephanie P., Sebbens, Danielle, Seelye, Lukas L., Severin, Paul N., Shah, Ami, Shannon, Katherine K., Shields, Kerry, Siew, Ruth, Siffermann, Emily S.W., Simone, Shari, Simonsen, Kari A., Sorce, Lauren, Spruit, Jessica L., Staebler, Suzanne, Starck, Jessica, Stewart, Heather D., Stojadinovic, Bonnie J., Stone, Suzette Renee, Strokosch, Gary R., Su, Erik R., Suhayda, Rosemarie, Sullivan, Kelly M., Swain, Kelly A., Taggart, Kristie, Tilford, Bradley, Tkaczyk, Rachel, Trimarchi, Tara, Tucker, Dawn, Tumulty, Jamie, Turk, Leanne, Turner, David A., Twombley, Katherine, Upperman, Jeffrey S., Van Waning, Natalie R., Van Wyk, Brynna, Vitola, Bernadette, Wahl, Michael, Waibel, Elizabeth Murphy, Wainwright, Mark S., Watkins, Summer, Weber, Mark D., Weintraub, Barbara, Werner, Jason A., Whitley-Williams, Patricia N., Whitcomb, John J., Wilkerson, Marylouise K., Williams, Brennan M., Wise, Barbara V., Wong, Wai, Worthen, H. Michael, Wright, Karen, Xu, Thomas, Yee-Nevárez, Martha, Zagustin, Tamara, Zakrzewski, Paula, Zielinski, Tresa E., Zonsius, Mary C., and Zubrow, Michael E.

Published
2021
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5. Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance.

Author

Wenjun Li, Gauthier, Jason M., Tong, Alice Y., Terada, Yuriko, Higashikubo, Ryuji, Frye, Christian C., Harrison, Margaret S., Hashimoto, Kohei, Bery, Amit I., Ritter, Jon H., Nava, Ruben G., Puri, Varun, Wong, Brian W., Lavine, Kory J., Bharat, Ankit, Krupnick, Alexander S., Gelman, Andrew E., Kreisel, Daniel, and Li, Wenjun

Subjects
*ALLOIMMUNITY, *LYMPHOID tissue, *HOMOGRAFTS, *LUNG transplantation, *LUNGS
Abstract

Tertiary lymphoid organs are aggregates of immune and stromal cells including high endothelial venules and lymphatic vessels that resemble secondary lymphoid organs and can be induced at nonlymphoid sites during inflammation. The function of lymphatic vessels within tertiary lymphoid organs remains poorly understood. During lung transplant tolerance, Foxp3+ cells accumulate in tertiary lymphoid organs that are induced within the pulmonary grafts and are critical for the local downregulation of alloimmune responses. Here, we showed that tolerant lung allografts could induce and maintain tolerance of heterotopic donor-matched hearts through pathways that were dependent on the continued presence of the transplanted lung. Using lung retransplantation, we showed that Foxp3+ cells egressed from tolerant lung allografts via lymphatics and were recruited into donor-matched heart allografts. Indeed, survival of the heart allografts was dependent on lymphatic drainage from the tolerant lung allograft to the periphery. Thus, our work indicates that cellular trafficking from tertiary lymphoid organs regulates immune responses in the periphery. We propose that these findings have important implications for a variety of disease processes that are associated with the induction of tertiary lymphoid organs. [ABSTRACT FROM AUTHOR]

Published
2020
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